Skip header and navigation

2 records – page 1 of 1.

Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study.

https://arctichealth.org/en/permalink/ahliterature54053
Source
Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):2019-23
Publication Type
Article
Date
Aug-2000
Author
B. Wiman
T. Andersson
J. Hallqvist
C. Reuterwall
A. Ahlbom
U. deFaire
Author Affiliation
Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden. bjorn.wiman@lab.ks.se
Source
Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):2019-23
Date
Aug-2000
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - blood
Case-Control Studies
Female
Fibrinolysis
Humans
Male
Middle Aged
Myocardial Infarction - epidemiology
Plasminogen Activator Inhibitor 1 - blood
Recurrence
Research Support, Non-U.S. Gov't
Risk factors
Sweden - epidemiology
Tissue Plasminogen Activator - blood
von Willebrand Factor - analysis
Abstract
An impaired fibrinolytic function due to elevated plasma levels of plasminogen activator inhibitor (PAI)-1 activity or tissue plasminogen activator (tPA) antigen is correlated with the development of myocardial infarction (MI) in patients with manifest coronary heart disease. Recently, methods for determining the specific tPA/inhibitor complexes constituting tPA antigen in plasma have become available. In the Stockholm Heart Epidemiology Program (SHEEP) study, 86 of 1212 MI patients, subjected to blood sampling in a metabolically stable period, suffered reinfarction before the end of 1996. These individuals have been compared with an approximately equal number of matched MI patients without recurrence and a group of matched healthy control subjects regarding the plasma concentrations of some hemostatic factors. The hemostatic compounds studied (fibrinogen, von Willebrand factor, tPA antigen, PAI-1, and the tPA/PAI-1 complex) were typically higher in the groups (men and women) with recurrence of MI compared with those without. The plasma concentrations were also typically higher in the pooled groups of patients compared with the groups of healthy control subjects. The largest between-group differences were found for the plasma tPA/PAI-1 complex. The crude odds ratio for reinfarction associated with higher concentration (>/=75th percentile among the control subjects) of tPA/PAI-1 was 1.8 (95% CI 1.1 to 3.1); the corresponding crude odds ratio for von Willebrand factor was 2.3 (1. 3 to 4.0). The tPA/PAI-1 complex correlated strongly with PAI-1 and tPA antigen in all groups and with serum triglycerides and body mass index in all groups except for women with reinfarction. An increased plasma level of tPA/PAI-1 complex is a novel risk marker for recurrent MI in men and women. Most likely, increased plasma levels of tPA/PAI-1 complex reflect impaired fibrinolysis, because the correlation with PAI-1 is strong. Further support is obtained indicating that the plasma concentration of von Willebrand factor is also an important risk marker for recurrent MI.
Notes
Comment In: Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1857-910938004
PubMed ID
10938026 View in PubMed
Less detail

The Swedish Adoption Twin Study of Aging: an update.

https://arctichealth.org/en/permalink/ahliterature65115
Source
Acta Genet Med Gemellol (Roma). 1991;40(1):7-20
Publication Type
Article
Date
1991
Author
N L Pedersen
G E McClearn
R. Plomin
J R Nesselroade
S. Berg
U. DeFaire
Author Affiliation
Center for Developmental and Health Genetics, Pennsylvania State University, University Park.
Source
Acta Genet Med Gemellol (Roma). 1991;40(1):7-20
Date
1991
Language
English
Publication Type
Article
Keywords
Adoption
Aged
Aging - genetics - psychology
Cognition
Environment
Female
Health Behavior
Health status
Humans
Longitudinal Studies
Male
Middle Aged
Personality
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Sweden
Twins - genetics - psychology - statistics & numerical data
Twins, Dizygotic - psychology
Twins, Monozygotic - psychology
Abstract
The Swedish Adoption/Twin Study of Aging (SATSA) is a longitudinal program of research in gerontological genetics which is currently in its fifth year. The base population is comprised of 351 pairs of twins reared apart and 407 matched control pairs of twins reared together who responded to a questionnaire (Q1) in 1984. Two additional stages of SATSA have recently been completed: a longitudinal follow-up questionnaire mailed out in 1987 (Q2) and extensive in-person testing (IPT1) which included a health examination and cognitive battery. A second wave of IPT was started in January 1989. A summary of some of the major findings from Q1 and a description of IPT1 are reported.
PubMed ID
1950353 View in PubMed
Less detail