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Adipose tissue density, a novel biomarker predicting mortality risk in older adults.
J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):109-17
Publication Type
Rachel A Murphy
Thomas C Register
Carol A Shively
J Jeffrey Carr
Yaorong Ge
Marta E Heilbrun
Steven R Cummings
Annemarie Koster
Michael C Nevitt
Suzanne Satterfield
Frances A Tylvasky
Elsa S Strotmeyer
Anne B Newman
Eleanor M Simonsick
Ann Scherzinger
Bret H Goodpaster
Lenore J Launer
Gudny Eiriksdottir
Sigurdur Sigurdsson
Gunnar Sigurdsson
Vilmundur Gudnason
Thomas F Lang
Stephen B Kritchevsky
Tamara B Harris
Author Affiliation
Laboratory of Population Science, National Institute on Aging, 7201 Wisconsin Ave, 3C-309 Bethesda, MD 20814.
J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):109-17
Publication Type
Absorptiometry, Photon
Adiponectin - metabolism
Adipose Tissue - metabolism - radiography
Aged, 80 and over
Aging - physiology
Biological Markers - metabolism
Body mass index
Follow-Up Studies
Leptin - metabolism
Macaca fascicularis
Obesity - metabolism - mortality - radiography
Prospective Studies
Risk factors
Survival Rate - trends
Knowledge of adipose composition in relation to mortality may help delineate inconsistent relationships between obesity and mortality in old age. We evaluated relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, mortality, biomarkers, and characteristics.
VAT and SAT density were determined from computed tomography scans in persons aged 65 and older, Health ABC (n = 2,735) and AGES-Reykjavik (n = 5,131), and 24 nonhuman primates (NHPs). Associations between adipose density and mortality (4-13 years follow-up) were assessed with Cox proportional hazards models. In NHPs, adipose density was related to serum markers and tissue characteristics.
Higher density adipose tissue was associated with mortality in both studies with adjustment for risk factors including adipose area, total fat, and body mass index. In women, hazard ratio and 95% CI for the densest quintile (Q5) versus least dense (Q1) for VAT density were 1.95 (1.36-2.80; Health ABC) and 1.88 (1.31-2.69; AGES-Reykjavik) and for SAT density, 1.76 (1.35-2.28; Health ABC) and 1.56 (1.15-2.11; AGES-Reykjavik). In men, VAT density was associated with mortality in Health ABC, 1.52 (1.12-2.08), whereas SAT density was associated with mortality in both Health ABC, 1.58 (1.21-2.07), and AGES-Reykjavik, 1.43 (1.07-1.91). Higher density adipose tissue was associated with smaller adipocytes in NHPs. There were no consistent associations with inflammation in any group. Higher density adipose tissue was associated with lower serum leptin in Health ABC and NHPs, lower leptin mRNA expression in NHPs, and higher serum adiponectin in Health ABC and NHPs.
VAT and SAT density provide a unique marker of mortality risk that does not appear to be inflammation related.
PubMed ID
23707956 View in PubMed
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