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The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.

https://arctichealth.org/en/permalink/ahliterature47878
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Publication Type
Article
Date
Apr-2000
Author
S K Rasmussen
S A Urhammer
J N Jensen
T. Hansen
K. Borch-Johnsen
O. Pedersen
Author Affiliation
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark.
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Weight - genetics
Body constitution
Body mass index
Denmark
Diabetes Mellitus, Type 2 - genetics
Female
Genotype
Humans
Insulin - blood
Insulin Resistance - genetics
Lipids - blood
Male
Obesity - genetics
Polymorphism, Restriction Fragment Length
Promoter Regions (Genetics)
Research Support, Non-U.S. Gov't
Tumor Necrosis Factor-alpha - genetics
Abstract
Recently, two G-->A polymorphisms at positions -308 and -238, in the promoter of the tumor necrosis factor alpha (TNF-alpha) gene, have been identified. These variants have, in different ethnic groups, been linked to estimates of insulin resistance and obesity. The objective of the present study was to investigate whether these genetic variants of TNF-alpha were associated with features of the insulin resistance syndrome or alterations in birth weight in two Danish study populations comprising 380 unrelated young healthy subjects and 249 glucose-tolerant relatives of type 2 diabetic patients, respectively. All study participants underwent an iv glucose tolerance test with the addition of tolbutamide after 20 min. In addition, a number of biochemical and anthropometric measures were performed on each subject. The subjects were genotyped for the polymorphisms by applying PCR restriction fragment length polymorphism. Neither of the variants was related to altered insulin sensitivity index or other features of the insulin resistance syndrome (body mass index, waist to hip ratio, fat mass, fasting serum lipids or fasting serum insulin or C-peptide). Birth weight and the ponderal index were also not associated with the polymorphisms. In conclusion, although the study was carried out on sufficiently large study samples, the study does not support a major role of the -308 or -238 substitutions of the TNF-alpha gene in the pathogenesis of insulin resistance or altered birth weight among Danish Caucasian subjects.
PubMed ID
10770222 View in PubMed
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Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

https://arctichealth.org/en/permalink/ahliterature48195
Source
Diabetes. 1997 Mar;46(3):508-12
Publication Type
Article
Date
Mar-1997
Author
L. Hansen
S M Echwald
T. Hansen
S A Urhammer
J O Clausen
O. Pedersen
Author Affiliation
Steno Diabetes Center and the Hagedorn Research Institute, Glostrup University Hospital, Copenhagen, Denmark.
Source
Diabetes. 1997 Mar;46(3):508-12
Date
Mar-1997
Language
English
Publication Type
Article
Keywords
Adenosine Triphosphate - metabolism
Adult
Blood Glucose - metabolism
C-Peptide - blood
Cohort Studies
DNA Primers
Denmark
Diabetes Mellitus, Type 2 - blood - genetics - physiopathology
European Continental Ancestry Group
Female
Glucose Tolerance Test
Humans
Hypoglycemic Agents - pharmacology
Insulin - blood - secretion
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Potassium Channels - genetics - metabolism
Potassium Channels, Inwardly Rectifying
Reference Values
Research Support, Non-U.S. Gov't
Tolbutamide - pharmacology
Abstract
Kir6.2 is an inwardly rectifying potassium channel that is expressed in pancreatic beta-cells and cardiac and skeletal muscle. Expressed together with the high-affinity sulphonylurea receptor, it reconstitutes a sulphonylurea- and also ATP-sensitive potassium channel resembling the native beta-cell channel. The objective of this study was to search for mutations in the Kir6.2 gene that might be associated with NIDDM or related to altered insulin secretion, insulin action, or glucose metabolism in healthy subjects. Using polymerase chain reaction-single-strand conformation polymorphism analysis (PCR-SSCP) on genomic DNA from 69 Danish NIDDM patients and 66 matched control subjects, we report the finding of three missense polymorphisms in otherwise conserved codons and three silent polymorphisms in the gene encoding Kir6.2: codon 23 (GAG/AAG), Glu-->Lys; codon 190 (GCT/GCC), Ala-->Ala; codon 267 (CTC/CTG), Leu-->Leu; codon 270 (CTG/GTG), Leu-->Val; codon 337 (ATC/GTC), Ile-->Val; codon 381 (AAG/AAA), Lys-->Lys. The codon 23 and codon 337 amino acid polymorphisms were always coupled. The allelic frequencies of the polymorphisms were similar in NIDDM patients and control subjects. The amino acid polymorphisms were not associated with altered insulin secretion after intravenous glucose or tolbutamide injections or with altered glucose effectiveness in a phenotype study of 346 young healthy subjects. However, carriers of the maximal load of amino acid variants, the compound homozygous codon 23/337 and heterozygous codon 270, had on average a 62% higher insulin sensitivity index (P = 0.006), compared with noncarriers. We conclude that a combination of common Kir6.2 amino acid variants may contribute to the genetic background behind the large variation of the insulin sensitivity index in the general population.
PubMed ID
9032110 View in PubMed
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[An informative campaign concerning the significance of the blood pressure and 30,000 blood pressure measurements during Danish Heart Week in 1975]

https://arctichealth.org/en/permalink/ahliterature42374
Source
Ugeskr Laeger. 1976 Feb 16;138(8):491-4
Publication Type
Article
Date
Feb-16-1976

An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males.

https://arctichealth.org/en/permalink/ahliterature148550
Source
Acta Psychiatr Scand. 2009 Oct;120(4):281-7
Publication Type
Article
Date
Oct-2009
Author
P. Koefoed
T V O Hansen
D P D Woldbye
T. Werge
O. Mors
T. Hansen
K D Jakobsen
M. Nordentoft
A. Wang
T G Bolwig
J F Rehfeld
Author Affiliation
Department of Neuroscience and Pharmacology, Laboratory for Neuropsychiatry, University of Copenhagen & Centre of Psychiatry, Rigshospitalet, Denmark. pkoefoed@sund.ku.dk
Source
Acta Psychiatr Scand. 2009 Oct;120(4):281-7
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Chromosomes, Human, Pair 4 - genetics
Denmark - epidemiology
Diagnostic and Statistical Manual of Mental Disorders
Female
Gene Expression - genetics
Humans
International Classification of Diseases
Introns - genetics
Male
Polymorphism, Single Nucleotide - genetics
RNA Splice Sites - genetics
RNA, Messenger - genetics
Receptor, Cholecystokinin A - genetics
Schizophrenia - diagnosis - epidemiology - genetics
Severity of Illness Index
Sex Distribution
Abstract
To identify whether a genetic variation (rs1800857; IVS1-5T>C) in the neuropeptide cholecystokinin-A receptor (CCKAR) gene is a risk factor in the pathogenesis of schizophrenia.
The variation was analysed in a case-control design comprising 508 patients with schizophrenia and 1619 control subjects. A possible functional impact of this variant on CCKAR protein synthesis through alterations in splicing was analysed in an exon-trapping assay.
In males only, the risk variant, IVS1-5C, was associated with a significantly increased risk of schizophrenia. Carrying one risk allele was associated with an increased risk of 1.74 (Odds Ratio, OR) and homozygosity (CC) was associated with an OR of 3.19. The variation had no impact on protein synthesis of CCKAR.
This is the first report associating the CCKAR gene variant with schizophrenia specifically in men. Our study strengthens the conclusion that a CCKAR dysfunction could be involved in the aetiology of schizophrenia.
PubMed ID
19753663 View in PubMed
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An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men.

https://arctichealth.org/en/permalink/ahliterature199665
Source
Diabetologia. 1999 Dec;42(12):1413-6
Publication Type
Article
Date
Dec-1999
Author
L T Dalgaard
T I Sørensen
T. Andersen
T. Hansen
O. Pedersen
Author Affiliation
Steno Diabetes Center, Gentofte, Copenhagen, Denmark.
Source
Diabetologia. 1999 Dec;42(12):1413-6
Date
Dec-1999
Language
English
Publication Type
Article
Keywords
3' Untranslated Regions
Adult
Basal Metabolism - genetics
Body mass index
Body Weight - genetics
DNA Transposable Elements
Denmark
Follow-Up Studies
Humans
Ion Channels
Male
Membrane Transport Proteins
Mitochondrial Proteins
Obesity - genetics
Polymorphism, Genetic
Proteins - genetics
Uncoupling Agents
Abstract
Associations between a 45 bp 3'untranslated insertion polymorphism in the uncoupling protein 2 (UCP2) gene and both body mass index (BMI) and sleeping metabolic rate have previously been reported. We investigated the impact of this polymorphism on BMI and long-term body weight changes.
The allelic frequency of the UCP2 insertion variant was determined in a cohort of 744 obese Danish Caucasian men who had a BMI of at least 31 kg/m2 at the draft-board examinations and a randomly selected control cohort consisting of 872 draftees. Follow-up measurements of BMI were done on average 26 years after the draft-board examinations.
The prevalence of the insertion allele was 30.4% (95% confidence interval: 28.0-32.8%) among the obese and 29.6% (27.4-31.8%) in the control group (p = 0.6). In a lean group selected as the 354 subjects with a BMI less than 25 kg/m2 at 46 years of age from the control group, the frequency of insertion allele was 29.0% (27.2-30.8%) (p = 0.5 compared with the obese cohort). The BMI at the ages of 20 and 46 years did not differ between genotypes either in the obese or the control group. Similarly, the changes in BMI/year between examinations at 20 and 46 years of age did not differ between genotypes in either group.
In a large group of Danish Caucasian men we found no association between a 3'untranslated insertion polymorphism in the UCP2 gene and obesity. Neither did we identify a relation between this variant and BMI changes during adult age.
PubMed ID
10651259 View in PubMed
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Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.

https://arctichealth.org/en/permalink/ahliterature130945
Source
Diabetologia. 2012 Jan;55(1):105-13
Publication Type
Article
Date
Jan-2012
Author
K S Burgdorf
A P Gjesing
N. Grarup
J M Justesen
C H Sandholt
D R Witte
T. Jørgensen
S. Madsbad
T. Hansen
O. Pedersen
Author Affiliation
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Room 1.1.N121, DK-2100 Copenhagen, Denmark. Kristoffer.Burgdorf@sund.ku.dk
Source
Diabetologia. 2012 Jan;55(1):105-13
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
Aminoacyltransferases - genetics
Body mass index
Carrier state
Cross-Sectional Studies
Denmark
Female
Genetic Association Studies
Humans
Hyperinsulinism - complications - genetics
Insulin Resistance
Lysophospholipase - genetics
Male
Middle Aged
Models, Genetic
Obesity - complications - genetics
Polymorphism, Single Nucleotide
Receptors, LDL - genetics
Sex Characteristics
Vascular Endothelial Growth Factor A - genetics
Waist-Hip Ratio
Abstract
Genome-wide association studies have identified novel WHR and BMI susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis, including estimates of insulin release and insulin sensitivity in an epidemiological setting.
By applying an additive genetic model, 14 WHR-associated gene variants and 18 BMI-associated variants were investigated for their relationships with glucose-related metabolic traits in treatment-naive individuals from the population-based Inter99 study sample (n?=?6,039).
Of the variants associated with BMI, the QPCTL rs2287019 C allele was associated with an increased insulinogenic index of 7.4% per risk allele (p?=?4.0?×?10?7) and increased disposition index of 5.6% (p?=?6.4?×?10?5). The LRP1B rs2890652 C allele was associated with insulin resistance, showing a 3.3% increase (p?=?0.0011) using the HOMA-insulin resistance (HOMA-IR) index and a 2.2% reduction (p?=?0.0014) with the Matsuda index. Of the variants associated with WHR, LYPLAL1/SLC30A10 rs4846567 G allele carriers showed a 5.2% lower HOMA-IR (p?=?0.00086) in women, indicating improved insulin sensitivity. Female carriers of the VEGFA rs6905288 A allele were insulin resistant, with a 3.7% increase in HOMA-IR (p?=?0.00036) and 4.0% decrease in Matsuda index (p?=?2?×?10?4).
Our correlative findings from analysing single-locus data suggest that some variation in validated BMI and WHR loci are associated with either increased or decreased insulin sensitivity and thereby potentially with metabolically healthy or metabolically unhealthy subsets of obesity. The results call for testing in larger study samples and for further physiological exploration of the possible metabolic implications of these loci.
PubMed ID
21953277 View in PubMed
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A blood pressure information campaign including mass screening for hypertension in Copenhagen Supermarkets.

https://arctichealth.org/en/permalink/ahliterature42398
Source
Acta Med Scand. 1976;199(4):269-72
Publication Type
Article
Date
1976
Author
P. Schnohr
A T Hansen
Source
Acta Med Scand. 1976;199(4):269-72
Date
1976
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood Pressure Determination
Child
Denmark
Female
Humans
Hypertension - epidemiology - prevention & control
Male
Mass Screening
Middle Aged
Abstract
During its "Heart-week" in Feb. 1975, the Danish Heart Foundation drew the attention of the public to the importance of blood pressure measurements as a vital part of health control and prevention. In all, 24 thousand men and women attending supermarkets in Copenhagen took advantage of an offer to have their BP checked. 23% of the screened, who had systolic BP greater than or equal to age+110 (and this sum exceeded 145) and/or diastolic BP greater than or equal to 100 mmHg for all ages, were advised to contact a general practitioner for further evaluation. The campaign showed that it is possible to measure BP and obtain reliable results in an easy, quick, inexpensive and unorthodox way accepted by a public accustomed to free medical care.
PubMed ID
1266663 View in PubMed
Less detail

Breast cancer and ductal carcinoma in situ among women with prior squamous or glandular precancer in the cervix: a register-based study.

https://arctichealth.org/en/permalink/ahliterature120374
Source
Br J Cancer. 2012 Oct 23;107(9):1451-3
Publication Type
Article
Date
Oct-23-2012
Author
B T Hansen
M. Nygård
R S Falk
S. Hofvind
Author Affiliation
Department of Research, Cancer Registry of Norway, PO Box 5313 Majorstuen, Oslo 0304, Norway. bo.terning.hansen@kreftregisteret.no
Source
Br J Cancer. 2012 Oct 23;107(9):1451-3
Date
Oct-23-2012
Language
English
Publication Type
Article
Keywords
Breast Neoplasms - epidemiology
Carcinoma in Situ - epidemiology
Carcinoma, Squamous Cell - epidemiology
Cervix Uteri - pathology
Female
Follow-Up Studies
Humans
Incidence
Middle Aged
Norway - epidemiology
Precancerous Conditions - epidemiology
Registries
Risk factors
Uterine Cervical Neoplasms - epidemiology
Abstract
Human papillomavirus and hormonal contraceptives may be risk factors for cervical precancer and malignant breast tumours.
Standardised incidence ratios (SIRs) of malignant breast tumours during 1970-2008 were estimated separately for women with prior squamous and glandular cervical precancer.
Women with squamous precancer and women with glandular precancer in the cervix had a significantly higher risk of malignant breast tumours than the general female population (SIR, 95% confidence interval: 1.10, 1.05-1.14 and 1.52, 1.11-2.08, respectively).
Shared risk factors or screening attendance may explain the excess risk of malignant breast tumours among women with a history of cervical precancer.
Notes
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PubMed ID
23011481 View in PubMed
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"But I see old people everywhere": dispelling the myth that eldercare is learned in nongeriatric clerkships.

https://arctichealth.org/en/permalink/ahliterature142491
Source
Acad Med. 2010 Jul;85(7):1221-8
Publication Type
Article
Date
Jul-2010
Author
Laura Diachun
Lisa Van Bussel
Kevin T Hansen
Andrea Charise
Michael J Rieder
Author Affiliation
Department of Medicine, The University of Western Ontario, London, Canada. Laura.Diachun@sjhc.london.on.ca
Source
Acad Med. 2010 Jul;85(7):1221-8
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aging
Attitude of Health Personnel
Clinical Clerkship
Clinical Competence
Cohort Studies
Developed Countries
Education, Medical, Undergraduate - organization & administration
Educational Measurement
Female
Geriatrics - education
Health Care Surveys
Health Services for the Aged - organization & administration - standards
Humans
Male
Ontario
Physician-Patient Relations
Program Evaluation
Questionnaires
Stereotyping
Abstract
To test the assumption that knowledge, attitudes, and skills (KAS) in geriatrics are learned via exposure to elderly patients in nongeriatric clerkships. In the developed world, the proportion of adults > or = 65 years old will soon surpass the proportion of children
PubMed ID
20592520 View in PubMed
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[Carriers of cystic fibrosis are more susceptible to asthma. The Osterbro study]

https://arctichealth.org/en/permalink/ahliterature15640
Source
Ugeskr Laeger. 1999 Aug 9;161(32):4507-9
Publication Type
Article
Date
Aug-9-1999
Author
M. Dahl
A T Hansen
P. Lange
B G Nordestgaard
Author Affiliation
Amtssygehuset i Herlev, klinisk biokemisk afdeling.
Source
Ugeskr Laeger. 1999 Aug 9;161(32):4507-9
Date
Aug-9-1999
Language
Danish
Publication Type
Article
Keywords
Adult
Asthma - diagnosis - genetics - physiopathology
Comparative Study
Cross-Sectional Studies
Cystic Fibrosis - diagnosis - genetics - physiopathology
Denmark - epidemiology
English Abstract
Female
Forced expiratory volume
Genetic Predisposition to Disease
Heterozygote Detection
Humans
Male
Vital Capacity
Abstract
We tested the hypothesis that individuals heterozygous for the common cystic fibrosis delta F508 mutation are at risk of obstructive pulmonary disease. We studied a cross-sectional sample from the general population of Copenhagen, aged 20 years and older. We performed spirometry to measure FEV1 and FVC, and genotyped blood samples from 9141 individuals. We identified 250 carriers of the delta F508 mutation (2.7%; 95% CI: 2.5%-3.1%). Nine precent of carriers reported having asthma compared with 6% of non-carriers (chi 2: p = 0.04). Furthermore, among individuals with airway obstruction, the percentage of predicted FEV1 and FVC were significantly lower in participants heterozygous for delta F508 than in non-carriers (49% vs. 58%, p = 0.004 and 70% vs. 82%, p
PubMed ID
10477965 View in PubMed
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102 records – page 1 of 11.