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Anaplastic ependymoma: treatment of pediatric patients with or without craniospinal radiation therapy.

https://arctichealth.org/en/permalink/ahliterature4023
Source
J Neurosurg. 1997 Jun;86(6):943-9
Publication Type
Article
Date
Jun-1997
Author
T E Merchant
T. Haida
M H Wang
J L Finlay
S A Leibel
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Source
J Neurosurg. 1997 Jun;86(6):943-9
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Brain - radiation effects
Brain Neoplasms - radiotherapy - therapy
Child
Child, Preschool
Combined Modality Therapy
Ependymoma - radiotherapy - therapy
Female
Humans
Male
Neoplasm Recurrence, Local
Retrospective Studies
Spinal Cord - radiation effects
Survival Analysis
Treatment Failure
Abstract
The authors conducted a retrospective review of the clinical and treatment characteristics and outcomes in 28 pediatric patients with anaplastic ependymoma treated with radiation therapy since the advent of computerized tomography (CT) (1978-1994). Twelve patients received craniospinal irradiation followed by a boost to the primary site, two received whole-brain radiation therapy followed by a boost to the primary site, and the remaining 14 were treated with focal radiation therapy. The mean dose to the primary site was 5486 cGy. With a median follow-up period of 86 months for the 14 surviving patients (range 31-201 months), the median disease-free survival, measured from the date of diagnosis to the time of recurrence after radiation therapy, was 40 months. The median disease-free survival measured from the start of radiation therapy was 32 months. The median overall survival rate has not been reached and the actuarial estimates of overall survival rates at 5 and 10 years were 56% and 38%, respectively. According to univariate analysis, the disease-free survival rate was significantly improved (p
PubMed ID
9171172 View in PubMed
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Characterization of malignant colon tumors with 31P nuclear magnetic resonance phospholipid and phosphatic metabolite profiles.

https://arctichealth.org/en/permalink/ahliterature4070
Source
Cancer. 1995 Nov 15;76(10):1715-23
Publication Type
Article
Date
Nov-15-1995
Author
T E Merchant
P M Diamantis
G. Lauwers
T. Haida
J N Kasimos
J. Guillem
T. Glonek
B D Minsky
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Source
Cancer. 1995 Nov 15;76(10):1715-23
Date
Nov-15-1995
Language
English
Publication Type
Article
Keywords
Cell Differentiation
Colonic Neoplasms - metabolism - pathology
Humans
Lymphatic Metastasis
Magnetic Resonance Spectroscopy
Neoplasm Invasiveness
Phosphates - metabolism
Phospholipids - metabolism
Prognosis
Research Support, Non-U.S. Gov't
Abstract
BACKGROUND. To further characterize selected pathologic features on a biochemical level, the authors analyzed the nuclear magnetic resonance metabolite and phospholipid spectra of 30 malignant colon tumors using 31P magnetic resonance spectroscopy. METHODS. Eleven individual generic phospholipids were identified in the spectra of 17 phospholipid extracts, and 31 individual phosphatic metabolites were identified in the spectra of 13 perchloric acid extracts. The metabolites and lipids were quantified for statistical intergroup comparisons based on tumor stage, lymph node status, differentiation, mucin production, blood vessel invasion (BVI), and lymphatic vessel invasion (LVI). RESULTS. Significant elevations in the relative concentration of alpha-glycerol phosphate were noted when comparing AJCC tumor classification (T3 vs. T2, 0.92 +/- 0.14 vs. 0.46 +/- 0.11, P
PubMed ID
8625039 View in PubMed
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Esophageal cancer phospholipids correlated with histopathologic findings: a 31P NMR study.

https://arctichealth.org/en/permalink/ahliterature3994
Source
NMR Biomed. 1999 Jun;12(4):184-8
Publication Type
Article
Date
Jun-1999
Author
T E Merchant
B D Minsky
G Y Lauwers
P M Diamantis
T. Haida
T. Glonek
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA. thomas.merchant@stjude.org
Source
NMR Biomed. 1999 Jun;12(4):184-8
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Esophageal Neoplasms - metabolism - pathology
Humans
Magnetic Resonance Spectroscopy
Phospholipids - metabolism
Abstract
We analyzed 36 esophageal tumor specimens for phospholipid content using phosphorus nuclear magnetic resonance spectroscopy (31P NMR) and correlated the individual phospholipid profiles with specific clinical and histopathologic features. Among the 18 phospholipids identified in the esophageal tumor specimens, the mean mole percentage concentration of dimethylphosphatidylethanolamine, lysoalkylacylphosphatidylcholine, lysophosphatidic acid, lysophosphatidylcholine (deacylated at the glycerol-1 carbon), and lysoethanolamine plasmalogen correlated with pathologic T stage, nuclear grade, or the presence of lymphatic invasion. 31P NMR produces well-dispersed phospholipid spectra and a precise determination of phospholipid relative mole percentages. These data provide a statistical correlation between histopathologic features and molecules known to play an important role in cellular activities and processes unique to malignant tissues.
PubMed ID
10421909 View in PubMed
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Medulloblastoma: long-term results for patients treated with definitive radiation therapy during the computed tomography era.

https://arctichealth.org/en/permalink/ahliterature4043
Source
Int J Radiat Oncol Biol Phys. 1996 Aug 1;36(1):29-35
Publication Type
Article
Date
Aug-1-1996
Author
T E Merchant
M H Wang
T. Haida
K L Lindsley
J. Finlay
I J Dunkel
M K Rosenblum
S A Leibel
Author Affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Source
Int J Radiat Oncol Biol Phys. 1996 Aug 1;36(1):29-35
Date
Aug-1-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cerebellar Neoplasms - diagnosis - drug therapy - radiotherapy - surgery
Child
Child, Preschool
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Infant
Male
Medulloblastoma - diagnosis - drug therapy - radiotherapy - surgery
Prognosis
Survival Analysis
Time Factors
Tomography, X-Ray Computed
Abstract
PURPOSE: We performed a retrospective evaluation of the patterns of failure and outcome for medulloblastoma patients treated with craniospinal irradiation therapy during the computed tomography (CT) era. MATERIALS AND METHODS: The records of 100 patients treated at Memorial Sloan-Kettering Cancer Center between 1979 and 1994 were reviewed. CT scans or magnetic resonance imaging were used to guide surgical intervention and evaluate the extent of resection postoperatively. All patients were treated with conventional fractionation (1.8 Gy/day) and the majority received full-dose neuraxis radiation therapy and > 50 Gy to the primary site. RESULTS: With a median follow-up of 100 months, the median, 5-year, and 10-year actuarial overall survival for the entire group were 58 months, 50%, and 25%, respectively. The median, 5- and 10-year actuarial disease-free survivals were 37 months, 41%, and 27%, respectively. Patients with localized disease (no evidence of disease beyond the primary site) had significantly improved overall (p
PubMed ID
8823256 View in PubMed
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No difference in seroprevalences of Helicobacter pylori infection between patients with pulmonary tuberculosis and those without.

https://arctichealth.org/en/permalink/ahliterature6444
Source
J Clin Gastroenterol. 1998 Dec;27(4):331-4
Publication Type
Article
Date
Dec-1998
Author
M. Sanaka
Y. Kuyama
M. Iwasaki
Y. Hanada
A. Tsuchiya
T. Haida
S. Hirama
S. Yamaoka
M. Yamanaka
Author Affiliation
Department of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan.
Source
J Clin Gastroenterol. 1998 Dec;27(4):331-4
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antibodies, Bacterial - blood
Case-Control Studies
Female
Helicobacter Infections - epidemiology - immunology - microbiology
Helicobacter pylori - immunology - isolation & purification
Humans
Immunoglobulin G - blood
Japan - epidemiology
Male
Middle Aged
Seroepidemiologic Studies
Tuberculosis, Pulmonary - etiology - microbiology
Abstract
A previous article reported a possible relationship between a history of tuberculosis and Helicobacter pylori infection. Epidemiologic similarities exist between the two infections: Mycobacterium tuberculosis and H. pylori are transmitted from person to person and the risk of acquiring them is elevated in underprivileged environment. This study was conducted to investigate the relationship between the two infections. Serum concentrations of anti-H. pylori IgG antibody were measured in 40 tuberculosis inpatients on antituberculosis chemotherapy for no more than 3 months (group I; 52.4 +/- 21.4 years of age), 43 tuberculosis inpatients on it for more than 3 months (group II; 57.3 +/- 16.3 years), and 60 nontuberculosis outpatients (control subjects; 55.9 +/- 16.7 years). H. pylori seropositivities were similar among control subjects (73.3%), group I (65%), and group II (69.8%). The difference in the antibody concentrations was significant between control subjects and group I (353.7 +/- 321.2 vs. 176.5 +/- 197.9 U/ml) but was not significant between control subjects and group II (353.7 +/- 321.2 vs. 229.9 +/- 249.5 U/ml). The seroprevalences may not be different between patients with pulmonary tuberculosis and those without, and antituberculosis therapy may not decrease the antibody concentrations.
PubMed ID
9855263 View in PubMed
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