Skip header and navigation

Refine By

24 records – page 1 of 3.

Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes.

https://arctichealth.org/en/permalink/ahliterature34833
Source
BMJ. 1996 Apr 6;312(7035):871-4
Publication Type
Article
Date
Apr-6-1996
Author
T. Deckert
H. Yokoyama
E. Mathiesen
B. Rønn
T. Jensen
B. Feldt-Rasmussen
K. Borch-Johnsen
J S Jensen
Author Affiliation
Steno Diabetes Center, Gentofte, Denmark.
Source
BMJ. 1996 Apr 6;312(7035):871-4
Date
Apr-6-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Albuminuria - metabolism
Arteriosclerosis - urine
Child
Cohort Studies
Diabetes Mellitus, Type 1 - complications - metabolism
Diabetic Nephropathies - complications - metabolism
Follow-Up Studies
Humans
Middle Aged
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: To examine whether slightly elevated urinary albumin excretion precedes development of atherosclerotic vascular disease in patients with insulin dependent diabetes independently of conventional atherogenic risk factors and of diabetic nephropathy. DESIGN: Cohort study with 11 year follow up. SETTING: Diabetes centre in Denmark. SUBJECTS: 259 patients aged 19-51 with insulin dependent diabetes of 6-34 years' duration and without atherosclerotic vascular disease or diabetic nephropathy at baseline. MAIN OUTCOME MEASURES: Baseline variables: urinary albumin excretion, blood pressure, smoking habits, and serum concentrations of total cholesterol, high density lipoprotein cholesterol, sialic acid, and von Willebrand factor. End point: atherosclerotic vascular disease assessed by death certificates, mailed questionnaires, and hospital records. RESULTS: Thirty patients developed atherosclerotic vascular disease during follow up of 2457 person year. Elevated urinary albumin excretion was significantly predictive of atherosclerotic vascular disease (hazard ratio 1.06 (95% confidence interval 1.02 to 1.18) per 5 mg increase in 24 hour urinary albumin excretion, P = 0.002). Predictive effect was independent of age; sex; blood pressure; smoking; serum concentrations of total cholesterol, high density lipoprotein cholesterol, sialic acid, and von Willebrand factor; level of haemoglobin A(lc); insulin dose, duration of diabetes, and diabetic nephropathy (hazard ratio 1.04 (1.01 to 1.08) per 5 mg increase
PubMed ID
8611873 View in PubMed
Less detail

A Cox regression model for the relative mortality and its application to diabetes mellitus survival data.

https://arctichealth.org/en/permalink/ahliterature39429
Source
Biometrics. 1985 Dec;41(4):921-32
Publication Type
Article
Date
Dec-1985
Author
P K Andersen
K. Borch-Johnsen
T. Deckert
A. Green
P. Hougaard
N. Keiding
S. Kreiner
Source
Biometrics. 1985 Dec;41(4):921-32
Date
Dec-1985
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Analysis of Variance
Child
Child, Preschool
Diabetes Mellitus - mortality
Diabetes Mellitus, Type 1 - mortality
Female
Humans
Infant
Male
Middle Aged
Regression Analysis
Research Support, Non-U.S. Gov't
Sex Factors
Abstract
A Cox-type regression model for the ratio between the mortality in a cohort and that in a reference population is introduced. By means of the model it is possible to include in the survival analysis both individual (possibly time-dependent) characteristics for the study cohort and changing trends in the mortality in the reference population. This is particularly relevant in long-term follow-up studies where there may be considerable changes in the mortality in the reference population. Estimation procedures in the model are discussed and large-sample properties of the estimators are outlined. The model is applied to the analysis of two sets of data concerning the survival among insulin-dependent diabetics in Denmark.
PubMed ID
3830258 View in PubMed
Less detail

Declining incidence of persistent proteinuria in type I (insulin-dependent) diabetic patients in Denmark.

https://arctichealth.org/en/permalink/ahliterature48822
Source
Diabetes. 1987 Feb;36(2):205-9
Publication Type
Article
Date
Feb-1987
Author
A. Kofoed-Enevoldsen
K. Borch-Johnsen
S. Kreiner
J. Nerup
T. Deckert
Source
Diabetes. 1987 Feb;36(2):205-9
Date
Feb-1987
Language
English
Publication Type
Article
Keywords
Denmark
Diabetes Mellitus, Type 1 - complications - mortality
Diabetic Nephropathies - epidemiology
Female
Humans
Male
Prognosis
Proteinuria - epidemiology
Research Support, Non-U.S. Gov't
Abstract
The decreasing relative mortality among type I (insulin-dependent) diabetic patients during the last 50 years might be related to the incidence of clinical diabetic nephropathy. We therefore followed 2890 type I diabetic patients (1607 males and 1283 females) diagnosed between 1933 and 1972 and before the age of 31, from admission to death, emigration, or January 1, 1984. All patients had been admitted to the Steno Memorial Hospital. Information on development of proteinuria was obtained in 2658 patients (92%). Five hundred twenty-five patients developed proteinuria due to diabetes and 49 developed nondiabetic proteinuria. When comparing patients diagnosed between 1933 and 1942 with those diagnosed between 1953 and 1962, the incidence of proteinuria decreased by 30% (P less than .03). This might explain the decrease of relative mortality in type I diabetic patients. The incidence decreased with increasing age at onset but was always highest in males. Insulin dose (U/kg) and diabetes duration at admission did not influence the incidence of proteinuria. The incidence peaked after 15-17 yr of diabetes duration independent of sex, age at diagnosis, or calendar year of diagnosis. However, the majority of patients did not develop proteinuria during 40 yr of diabetes. This suggests individual renal susceptibility to the deleterious effect of hyperglycemia.
PubMed ID
3803732 View in PubMed
Less detail

Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study.

https://arctichealth.org/en/permalink/ahliterature48904
Source
Diabetologia. 1983 Dec;25(6):496-501
Publication Type
Article
Date
Dec-1983
Author
A R Andersen
J S Christiansen
J K Andersen
S. Kreiner
T. Deckert
Source
Diabetologia. 1983 Dec;25(6):496-501
Date
Dec-1983
Language
English
Publication Type
Article
Keywords
Age Factors
Denmark
Diabetes Mellitus, Type 1 - drug therapy - physiopathology
Diabetic Nephropathies - epidemiology - mortality
Female
Follow-Up Studies
Humans
Insulin - administration & dosage
Male
Proteinuria - epidemiology
Research Support, Non-U.S. Gov't
Sex Factors
Time Factors
Abstract
A follow-up of 1475 Type 1 (insulin-dependent) diabetic patients diagnosed before 1953 (815 males, 660 females) and before the age of 31 years was conducted. All patients were seen at the Steno Memorial Hospital and were referred from all parts of Denmark; 91 (6%) could not be traced. The rest (94%) were followed until death or for at least 25 years; 249 (17%) were followed for greater than 40 years. Clinical diabetic nephropathy developed in 531 (41%) of the 1303 patients in whom sufficient information was available regarding proteinuria. Other causes of proteinuria were found in 3%, and 57% did not develop persistent proteinuria. The prevalence of diabetic nephropathy was 21% after 20-25 years of diabetes duration followed by a decline to 10% after 40 years. Two incidence peaks of the onset of proteinuria were seen, one after 16 and another after 32 years duration of diabetes and was low after 35 years duration. The cumulative incidence was 45% after 40 years of diabetes. A male preponderance was seen among patients with nephropathy. A significant difference in the pattern of annual incidence rates of diabetic nephropathy was seen, when groups with onset of diabetes before 1933, between 1933-1942, and 1943-1952, respectively, were compared. An association between daily insulin requirement and nephropathy incidence was found. Patients with nephropathy had a much poorer survival than those without proteinuria; 40 years after onset of diabetes, only 10% of patients who developed nephropathy were alive, whereas greater than 70% of patients who did not develop nephropathy survived.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
6363177 View in PubMed
Less detail

Diet versus average Danish food in insulin-dependent diabetes mellitus. An evaluation during treatment with an artificial betacell.

https://arctichealth.org/en/permalink/ahliterature48927
Source
Scand J Clin Lab Invest. 1982 Dec;42(8):603-6
Publication Type
Article
Date
Dec-1982
Author
A. Krarup-Hansen
T. Lauritzen
J S Christiansen
P A Svendsen
T. Deckert
Source
Scand J Clin Lab Invest. 1982 Dec;42(8):603-6
Date
Dec-1982
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Blood Glucose - analysis
Denmark
Diabetes Mellitus - blood - therapy
Diabetic diet
Female
Food
Humans
Insulin - therapeutic use
Islets of Langerhans Transplantation
Male
Middle Aged
Abstract
Ten randomly selected insulin-dependent diabetics with minimal betacell function were studied during treatment with an artificial betacell during two consecutive 24-hour periods. Patients were randomly served diabetic diet for one 24-hour period and average Danish food during the other 24-hour period. No significant (P greater than 0.05) difference was found between the mean blood glucose concentrations, nor insulin requirements on average Danish food compared to diet. However, the mean amplitude of glucose excursions was significantly higher on average Danish food than on diabetic diet (median 3.6 versus 2.7 mmol/l, P less than 0.05). Thus insulin-dependent patients not following their diabetes diet will show increased blood glucose fluctuations.
PubMed ID
6820183 View in PubMed
Less detail

The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature48861
Source
Diabetologia. 1985 Aug;28(8):590-6
Publication Type
Article
Date
Aug-1985
Author
K. Borch-Johnsen
P K Andersen
T. Deckert
Source
Diabetologia. 1985 Aug;28(8):590-6
Date
Aug-1985
Language
English
Publication Type
Article
Keywords
Denmark
Diabetes Mellitus, Type 1 - mortality - urine
Female
Humans
Male
Proteinuria - complications
Research Support, Non-U.S. Gov't
Abstract
We followed 1,134 patients with Type 1 (insulin-dependent) diabetes, diagnosed between 1933 and 1952, until 1982 or death or until their emigration. Their age at onset of diabetes was under 31 years. Information concerning the development of persistent proteinuria was sought in every case. In 104 cases, the data were either questionable or the patient could not be traced. Twenty-nine patients developed non-diabetic proteinuria. Among the remaining 1,001 patients, 406 developed persistent proteinuria (350 died) and 595 did not (166 died). The incidence of persistent proteinuria was highest among men; it decreased with increasing year of diabetes onset from 1933 to 1952, and decreased with increasing age at onset. The relative mortality was extremely high among patients with persistent proteinuria, increasing to a maximum of about 100 at age 35 years. Patients not developing proteinuria had a relatively constant low relative mortality of about 2. The decreasing incidence of persistent proteinuria and the decreasing mortality with increasing calendar year of diabetes onset resulted in a 50% increase in life-expectancy among patients diagnosed in 1950 compared with patients diagnosed in 1935. In patients who developed persistent proteinuria, relative mortality was higher in women than men at all ages. In patients who did not develop proteinuria, relative mortality was similar in men and women after the age of 35. Uraemia was the main cause of death in patients with persistent proteinuria, although cardiovascular deaths were more frequent than in patients without proteinuria. Thus, proteinuria is associated not only with death from uraemia but also from cardiovascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
4054448 View in PubMed
Less detail

Genetic variation of a collagen IV alpha 1-chain gene polymorphism in Danish insulin-dependent diabetes mellitus (IDDM) patients: lack of association to nephropathy and proliferative retinopathy.

https://arctichealth.org/en/permalink/ahliterature48204
Source
Diabet Med. 1997 Feb;14(2):143-7
Publication Type
Article
Date
Feb-1997
Author
J W Chen
P M Hansen
L. Tarnow
A. Hellgren
T. Deckert
F. Pociot
Author Affiliation
Steno Diabetes Center, Gentofte, Denmark.
Source
Diabet Med. 1997 Feb;14(2):143-7
Date
Feb-1997
Language
English
Publication Type
Article
Keywords
Adult
Albuminuria
Alleles
Collagen - genetics
Denmark - epidemiology
Diabetes Mellitus, Type 1 - epidemiology - genetics - physiopathology
Diabetic Nephropathies - epidemiology - genetics
Diabetic Retinopathy - epidemiology - genetics
Female
Follow-Up Studies
Genotype
Hemoglobins
Humans
Male
Polymorphism, Genetic
Restriction Mapping
Time Factors
Abstract
In insulin-dependent (Type 1) diabetes mellitus (IDDM) the development of nephropathy is partly due to genetic susceptibility. Previously one study has demonstrated a relationship between a HindIII restriction polymorphism of the collagen IV alpha 1-chain gene and diabetic nephropathy. The aim of the present study was to evaluate such as association in a case-control study including 207 Danish IDDM patients: 116 with nephropathy (urinary albumin excretion rate (AER) > 300 mg 24 h-1) and 91 without nephropathy (AER
PubMed ID
9047092 View in PubMed
Less detail

Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene). Association with urinary albumin excretion in IDDM patients.

https://arctichealth.org/en/permalink/ahliterature48150
Source
Diabetes. 1997 Oct;46(10):1658-9
Publication Type
Article
Date
Oct-1997

HLA associations in insulin-dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population.

https://arctichealth.org/en/permalink/ahliterature48844
Source
Tissue Antigens. 1986 Oct;28(4):237-44
Publication Type
Article
Date
Oct-1986
Author
A. Svejgaard
B K Jakobsen
P. Platz
L P Ryder
J. Nerup
M. Christy
K. Borch-Johnsen
H H Parving
T. Deckert
L. Mølsted-Pedersen
Source
Tissue Antigens. 1986 Oct;28(4):237-44
Date
Oct-1986
Language
English
Publication Type
Article
Keywords
Age Factors
Comparative Study
Denmark
Diabetes Mellitus, Type 1 - genetics - immunology - mortality
Disease Susceptibility
HLA Antigens - analysis - immunology
HLA-DR Antigens - analysis
HLA-DR3 Antigen
HLA-DR4 Antigen
Histocompatibility testing
Humans
Phenotype
Research Support, Non-U.S. Gov't
Abstract
A total of 317 unrelated Danish patients with insulin-dependent diabetes mellitus (IDDM) have been HLA-DR typed and the antigen and phenotype frequencies compared with those in 1177 unrelated Danish controls. The strong positive associations with DR3 and 4 and the strong negative one with DR2 were confirmed, and the remaining antigens showed a hierarchy from weakly positive to strongly negative associations: DRw9, w8, 1, 5, w6, 7. The study population included various special groups of patients selected in order to study heterogeneity: very early (less than 5 years) and very late (greater than 40 years) onset IDDM, pregnancy-induced IDDM, IDDM nephropathy, and long-term (greater than 40 years) survivors without complications. When comparing these groups, the following minor differences were seen: the DR3,4 phenotype is significantly (p = .02) more frequent in IDDM with onset before age 20 (35%) than in other cases (24%), and in familial IDDM (48%) than in other cases (28%); the frequency of the DR4 antigen was significantly (p = .008) more frequent in long-term survivors (86%) than in other patients (69%), while it was significantly (p = .02) less frequent in IDDM nephropathy (63%) than in long-term survivors. However, apart from the age-at-onset heterogeneity, which was suspected a priori, these differences may be due to chance, and the main conclusion of this study is that the HLA-DR associations in IDDM are indeed extraordinarily homogeneous irrespective of the clinical characteristics at onset and course of the disease.
PubMed ID
3492782 View in PubMed
Less detail

24 records – page 1 of 3.