Ischemic heart desease (IHD) remains actual issue of the current clinical medicine, because, IHD takes a leading position among reasons of death rate of population. Purpose of the study was to find diagnostic features of fat-acid composition of lipid of thrombocytes in patients with stable and unstable course of ischemic heart disease (IHD). 52 patients with an unstable angina pectoris aged 42-65 years and 31 patients with stable angina aged 41-66 years have been observed. Reliable changes in relation of the sum of saturated, unsaturated and poli-unsaturated of fat acids of phosphotides of thrombocytes in patients with unstable course of ischemic heart disease (IHD) have been detected. It improves knowledge about the mechanisms of destabilization of coronal circulation of blood.
A fat-acid compound of lipids in the subpalatine tonsils was studied by gas chromatography in normal state, chronic tonsillitis and hypertrophy of tonsils. We have determined that in saturation of the lipid complex raised in the subpalatine tonsils due to an increase in the level of arachidonic acid. It gives evidence for an activation of the lipid peroxidation leading to a pathological process.
The functional and structural manifestations of lipid metabolism disorders in the lungs were studied in comparison with the changes of fatty acid composition of lipids of pulmonary tissue, venous and arterial blood, expirated air condensate and sweat during the development of cardiogenic shock in patients with myocardial infarction. It has been established that the lungs accumulate neutral lipids and lose phospholipids and polyunsaturated fatty acids. These changes are combined with intracellular lesion of osmiophilic lamellated corpuscles and disturbance of their excretion into alveolar cavities. At the same time the increase of polyunsaturated fatty acids content in expirated air condensate and sweat of patients is noted can be related to the elimination of the excess of these substrates from intercellular space.
Fatty acid spectrum of phospholipids and free cholesterol level in the myocardium, liver and erythrocytes were studied in dogs with the experimental lung-heart insufficiency (LHI). The content of polyunsaturated fatty acids of phospholipids in erythrocytes from peripheric blood and in free cholesterol level (2-3 times) in myocardium, liver and erythrocytes of dogs under investigated conditions decreased. It is shown that pharmacotherapy with alpha-adrenoblockers (thropaphen and prasozin) has led to the normalization of disturbances of the erythrocytic lipid complex and had caused inhibition of peroxidase reactions in the myocardium and liver of the dogs with LHI.