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[Actual problem of methodology and development of evidence-based health risk assessment associated with chemical exposure].

https://arctichealth.org/en/permalink/ahliterature290154
Source
Gig Sanit. 2016; 95(8):711-6
Publication Type
Journal Article
Author
S M Novikov
M V Fokin
T N Unguryanu
Source
Gig Sanit. 2016; 95(8):711-6
Language
Russian
Publication Type
Journal Article
Keywords
Environmental Exposure - prevention & control - standards
Environmental Pollutants - analysis - standards
Evidence-Based Practice
Hazardous Substances - analysis - standards
Humans
Hygiene - standards
Public Health - methods
Risk Assessment - methods - standards
Russia
Abstract
Paramount problems of the development of the assessment of population health risks associated with the chemical exposure in Russia are considered on the ground of critical analysis of reports devoted to methodological issues of the risk assessment and guidelines published since 2010. Causes of the lack in progress of risk assessment are discussed. The information of executed research revealed the significant retardation number of Russian publications devoted to the evidence-based health risk assessment compare to worldwide trend. The analysis of publications according to evidence-based health risk assessment in Russia in 1998 - 2012 demonstrated methodical problems to be leading to the underestimation of the real risk to population’s health. There are demonstrated directions in the renewal of methodology and practice of hygienic standardization on the basis of the risk assessment. The comparative analysis of values of uncertainty factors (modifying factors, conversion factors) used for extrapolation and accepted in different countries and organizations was made. The system of extrapolation coefficients of DNEL (Derive No-Effect Level) is presented. The leading principles of modern toxicology and risk assessment based on strict scientific proofs are showed. Criteria of evidence-based toxicology and risk assessment are presented.Among actual problems which demand their decision there are considered: the assessment of combined action in regulatory toxicology; expansion of spheres of the application of health risk assessment methodology; the improvement ofpreparation and certification of experts in the field of health risk assessment; need of check of dispersion models and their replacement by more modern models; the improvement of exposure assessment with taking into account the international requirements; the assessment of regional exposure factors; expansion of atmospheric air monitoring in all the large cities of Russia.
PubMed ID
29430892 View in PubMed
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[Assessment of the effect of environmental chemicals on the working population in mono-cities].

https://arctichealth.org/en/permalink/ahliterature263384
Source
Gig Sanit. 2014 Sep-Oct;(5):74-8
Publication Type
Article
Author
S M Novikov
T N Unguryanu
Source
Gig Sanit. 2014 Sep-Oct;(5):74-8
Language
Russian
Publication Type
Article
Keywords
Air Pollutants, Occupational - adverse effects - analysis
Health Status Indicators
Humans
Industry
Inhalation Exposure - adverse effects - analysis
Occupational Exposure - adverse effects - analysis
Paper
Risk assessment
Russia
Urban Health - standards
Workplace - standards
Abstract
There was made the characterization of the health risk for workers' of pulp and paper industry, under the simultaneous effects of chemicals in the residential and working area. The main adverse effect of chemicals that pollute the air and work environment is related with the impact on the respiratory system. Under the successive exposure (ambient air--air in the workplace) in the adult population working at the Arkhangelsk Pulp and Paper Mill, the risk of occurrence of respiratory diseases (HI = 18.5) and individual carcinogenic risk (CR = 9.7 x 10(-3)) have been rated as high and constitute 86-99% of the total risk.
PubMed ID
25831935 View in PubMed
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[Results of health risk assessment due to exposure to contaminants in drinking water in Russia population (review of literature)].

https://arctichealth.org/en/permalink/ahliterature104477
Source
Gig Sanit. 2014 Jan-Feb;(1):19-24
Publication Type
Article
Author
T N Unguryanu
S M Novikov
Source
Gig Sanit. 2014 Jan-Feb;(1):19-24
Language
Russian
Publication Type
Article
Keywords
Age Factors
Carcinogens - toxicity
Drinking Water - adverse effects - standards
Environmental Exposure - adverse effects
Humans
Public Health
Risk assessment
Russia
Water Pollutants, Chemical - chemistry - toxicity
Water Supply - standards
Abstract
With the purpose of the analysis of general trends in the development of risk assessment methodology in Russia the results obtained with the her help, as well as existing methodological problems, there was performed a review of 68 published works concerning the assessment of the health risk for population under the exposure to chemicals in drinking water carried out in 42 cities and regions of the country. There was made the grouping of Russian cities on individual carcinogenic risk level and ranking on the values for the population carcinogenic risk. A list of prioritized carcinogens in tap water has been made. By the values of the risk indices to adverse effects of chemicals tap water there are exposed central nervous system, kidneys, liver, skin and mucous membranes, blood, bone, immune system, hormone homeostasis, blood circulation and digestion organs. There are identified methodological problems leading to an underestimation of the actual risk to public health under exposure of chemicals in drinking water: there are no used regional and age differences in exposure factors, virtually there is no assessed health risk for children population; there is ignored age sensitivity to carcinogens, there is rarely estimated exposure for all the real exposing routes of income and there are no carried out risk calculations at the upper limit (90- 95th percentile) of the exposure.
PubMed ID
24749275 View in PubMed
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