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Association of Phosphodiesterase 4D Polymorphisms With Ischemic Stroke in a US Population Stratified by Hypertension Status.

https://arctichealth.org/en/permalink/ahliterature76235
Source
Stroke. 2006 May 4;
Publication Type
Article
Date
May-4-2006
Author
Victoria H Brophy
Sunhee K Ro
Brian K Rhees
Li-Yung Lui
Jocelyn M Lee
Nanette Umblas
L Gordon Bentley
Jia Li
Suzanne Cheng
Warren S Browner
Henry A Erlich
Author Affiliation
From Roche Molecular Systems, Alameda, Calif; and California Pacific Medical Center Research Institute, San Francisco, Calif.
Source
Stroke. 2006 May 4;
Date
May-4-2006
Language
English
Publication Type
Article
Abstract
BACKGROUND AND PURPOSE: Phosphodiesterase 4D (PDE4D) underlies the STRK1 linkage peak for stroke on chromosome 5q12 identified in Iceland. We tested association of 13 single-nucleotide polymorphisms (SNPs) and 1 microsatellite in a nested case-control sample of elderly white women (>65 years of age) from the Study of Osteoporotic Fractures (SOF) in the United States. METHODS: The genotypes of 248 women who experienced an incident ischemic stroke during an average of 5.4 years of follow-up were compared with 560 controls. RESULTS: Marginal associations with stroke (P
PubMed ID
16675738 View in PubMed
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