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Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature84568
Source
Stroke. 2007 Nov;38(11):2873-80
Publication Type
Article
Date
Nov-2007
Author
Johnsen Stein Harald
Mathiesen Ellisiv B
Joakimsen Oddmund
Stensland Eva
Wilsgaard Tom
Løchen Maja-Lisa
Njølstad Inger
Arnesen Egil
Author Affiliation
Department of Neurology, University Hospital North-Norway, N-9038 Tromsø, Norway. Stein.Johnsen@ism.uit.no
Source
Stroke. 2007 Nov;38(11):2873-80
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Carotid Arteries - pathology - ultrasonography
Carotid Artery Diseases - epidemiology - pathology - ultrasonography
Carotid Artery, Common - pathology - ultrasonography
Carotid Artery, Internal - pathology - ultrasonography
Cholesterol, HDL
Cohort Studies
Comorbidity
Female
Follow-Up Studies
Humans
Incidence
Kaplan-Meiers Estimate
Longitudinal Studies
Male
Middle Aged
Myocardial Infarction - epidemiology
Norway - epidemiology
Predictive value of tests
Prospective Studies
Risk factors
Sex Distribution
Sex Factors
Tunica Intima - pathology - ultrasonography
Abstract
BACKGROUND AND PURPOSE: Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascular disease has been conflicting. In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI). METHODS: IMT, total plaque area, and plaque echogenicity were measured in 6226 men and women aged 25 to 84 years with no previous MI. The subjects were followed for 6 years and incident MI was registered. RESULTS: During follow-up, MI occurred in 6.6% of men and 3.0% of women. The adjusted relative risk (RR; 95% CI) between the highest plaque area tertile versus no plaque was 1.56 (1.04 to 2.36) in men and 3.95 (2.16 to 7.19) in women. In women, there was a significant trend toward a higher MI risk with more echolucent plaque. The adjusted RR (95% CI) in the highest versus lowest IMT quartile was 1.73 (0.98 to 3.06) in men and 2.86 (1.07 to 7.65) in women. When we excluded bulb IMT from analyses, IMT did not predict MI in either sex. CONCLUSIONS: In a general population, carotid plaque area was a stronger predictor of first-ever MI than was IMT. Carotid atherosclerosis was a stronger risk factor for MI in women than in men. In women, the risk of MI increased with plaque echolucency.
PubMed ID
17901390 View in PubMed
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Lack of significant association between intima-media thickness in the carotid artery and serum TSH level. The Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature87265
Source
Thyroid. 2008 Jan;18(1):21-5
Publication Type
Article
Date
Jan-2008
Author
Jorde Rolf
Joakimsen Oddmund
Stensland Eva
Mathiesen Ellisiv B
Author Affiliation
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. rolf.jorde@unn.no
Source
Thyroid. 2008 Jan;18(1):21-5
Date
Jan-2008
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cardiovascular Diseases - blood - pathology
Carotid Arteries - pathology - ultrasonography
Cohort Studies
Female
Humans
Linear Models
Male
Middle Aged
Norway
Thyrotropin - blood
Tunica Intima - pathology - ultrasonography
Tunica Media - pathology - ultrasonography
Ultrasonography, Doppler, Pulsed
Abstract
BACKGROUND: Increased arterial wall intima-media thickness (IMT) is an early feature of atherosclerosis and has been reported to be altered in patients with thyroid dysfunction. The present study was performed to examine the relation between carotid artery intima-media thickness and possible variations in thyroid function in normal subjects using serum TSH as a surrogate index of thyroid function. DESIGN: A total of 2034 subjects (974 males) were studied, 1856 or whom were non-users of thyroxine. The subjects not taking thyroxine were classified into three groups, those with a low serum TSH (0.48 mIU/L (2.5 percentile, those with serum TSH from 0.48 to 4.16 mIU/L, and those with high serum TSH of >4.16 mIU/L (97.5 percentile). Carotid ultrasound was performed in each all 2034 subjects to determine IMT. RESULTS: Among those not taking thyroxine, subjects in the low serum TSH group had a higher mean IMT as compared to those in the normal and high serum TSH groups but the differences were not significant when adjusted for gender, age, smoking status, body mass index, systolic blood pressure and serum cholesterol (0.88 +/- 0.15 mm, 0.84 +/- 0.16 mm, and 0.84 +/- 0.24 mm respectively). Subjects taking thyroxine had significantly higher IMT than those not taking thyroxine (0.89 + 0.20 mm versus 0.84 + 0.17 mm, p
PubMed ID
17985996 View in PubMed
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Relation of common carotid artery lumen diameter to general arterial dilating diathesis and abdominal aortic aneurysms: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature90897
Source
Am J Epidemiol. 2009 Feb 1;169(3):330-8
Publication Type
Article
Date
Feb-1-2009
Author
Johnsen Stein Harald
Joakimsen Oddmund
Singh Kulbir
Stensland Eva
Forsdahl Signe Helene
Jacobsen Bjarne Koster
Author Affiliation
Department of Neurology, University Hospital of North Norway, Tromsø, Norway. stein.harald.johnsen@unn.no
Source
Am J Epidemiol. 2009 Feb 1;169(3):330-8
Date
Feb-1-2009
Language
English
Publication Type
Article
Keywords
Aged
Aorta, Abdominal - pathology - ultrasonography
Aortic Aneurysm, Abdominal - epidemiology - pathology - ultrasonography
Carotid Artery, Common - pathology - ultrasonography
Comorbidity
Cross-Sectional Studies
Diabetes Mellitus - epidemiology
Dilatation, Pathologic - epidemiology - pathology - ultrasonography
Disease Susceptibility - epidemiology - pathology - ultrasonography
Female
Femoral Artery - pathology - ultrasonography
Hemorrhagic Disorders - epidemiology - pathology - ultrasonography
Humans
Male
Middle Aged
Norway - epidemiology
Risk factors
Smoking - epidemiology
Abstract
In a cross-sectional, population-based study in Tromsø, Norway, the authors investigated correlations between lumen diameter in the right common carotid artery (CCA) and the diameters of the femoral artery and abdominal aorta and whether CCA lumen diameter was a risk factor for abdominal aortic aneurysm (AAA). Ultrasonography was performed in 6,400 men and women aged 25-84 years during 1994-1995. An AAA was considered present if the aortic diameter at the level of renal arteries was greater than or equal to 35 mm, the infrarenal aortic diameter was greater than or equal to 5 mm larger than the diameter of the level of renal arteries, or a localized dilation of the aorta was present. CCA lumen diameter was positively correlated with abdominal aortic diameter (r = 0.3, P
PubMed ID
19066307 View in PubMed
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