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6TH NORWEGIAN ENVIRONMENTAL TOXICOLOGY SYMPOSIUM: Assessing and solving environmental challenges in a multiple stressor world.

https://arctichealth.org/en/permalink/ahliterature296704
Source
J Toxicol Environ Health A. 2017; 80(16-18):805-806
Publication Type
Introductory Journal Article
Date
2017
Author
Knut Erik Tollefsen
Sam Kacew
Author Affiliation
a Section for Ecotoxicology and Risk Assessment, Norwegian Institute for Water Research (NIVA) , Oslo , Norway.
Source
J Toxicol Environ Health A. 2017; 80(16-18):805-806
Date
2017
Language
English
Publication Type
Introductory Journal Article
Keywords
Ecotoxicology
Environmental Exposure
Environmental Monitoring - methods
Environmental Pollutants - toxicity
Norway
Risk Assessment - methods
PubMed ID
28829685 View in PubMed
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Assessing and managing risks arising from exposure to endocrine-active chemicals.

https://arctichealth.org/en/permalink/ahliterature158096
Source
J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):351-72
Publication Type
Article
Date
Mar-2008
Author
Karen P Phillips
Warren G Foster
William Leiss
Vanita Sahni
Nataliya Karyakina
Michelle C Turner
Sam Kacew
Daniel Krewski
Author Affiliation
Faculty of Health Sciences, University of Ottawa, Ontario, Canada. Karen.Phillips@uottawa.ca
Source
J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):351-72
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Canada
Endocrine Disruptors - adverse effects
Environmental Exposure - adverse effects
Environmental Monitoring - methods
European Union
Humans
Risk assessment
United States
Abstract
Managing risks to human health and the environment produced by endocrine-active chemicals (EAC) is dependent on sound principles of risk assessment and risk management, which need to be adapted to address the uncertainties in the state of the science of EAC. Quantifying EAC hazard identification, mechanisms of action, and dose-response curves is complicated by a range of chemical structure/toxicology classes, receptors and receptor subtypes, and nonlinear dose-response curves with low-dose effects. Advances in risk science including toxicogenomics and quantitative structure-activity relationships (QSAR) along with a return to the biological process of hormesis are proposed to complement existing risk assessment strategies, including that of the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC 1998). EAC represents a policy issue that has captured the public's fears and concerns about environmental health. This overview describes the process of EAC risk assessment and risk management in the context of traditional risk management frameworks, with emphasis on the National Research Council Framework (1983), taking into consideration the strategies for EAC management in Canada, the United States, and the European Union.
PubMed ID
18368561 View in PubMed
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