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63 records – page 1 of 7.

Absence of LKM-1 antibody reactivity in autoimmune and hepatitis-C-related chronic liver disease in Sweden. Swedish Internal Medicine Liver club.

https://arctichealth.org/en/permalink/ahliterature34389
Source
Scand J Gastroenterol. 1997 Feb;32(2):175-8
Publication Type
Article
Date
Feb-1997
Author
S. Lindgren
H B Braun
G. Michel
A. Nemeth
S. Nilsson
B. Thome-Kromer
S. Eriksson
Author Affiliation
Dept. of Medicine, University of Lund, Malmö General Hospital, Sweden.
Source
Scand J Gastroenterol. 1997 Feb;32(2):175-8
Date
Feb-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Autoantibodies - blood
Autoimmunity - immunology
Child
Cholangitis, Sclerosing - immunology
Chronic Disease
Cytochrome P-450 Enzyme System
Female
Fluorescent Antibody Technique, Indirect
Hepatitis - immunology
Hepatitis C - immunology
Humans
Liver Cirrhosis, Biliary - immunology
Liver Diseases - immunology
Male
Middle Aged
Research Support, Non-U.S. Gov't
Sweden
Abstract
BACKGROUND: Type-2 autoimmune hepatitis is a subgroup of chronic hepatitis characterized by the presence of liver/kidney microsomal autoantibodies type 1 (LKM-1). A frequent association with chronic hepatitis C suggests that hepatitis virus might trigger autoimmune reactivity. LKM-1-positive chronic hepatitis is not uncommon in southern Europe but is rarely seen in the USA and the UK. The prevalence in Scandinavia is hitherto unknown. METHODS: We used an automated prototype LKM-1 immunometry-based assay (IMx) to detect LKM-1 antibodies in sera from 350 Swedish patients with chronic liver diseases (100 with primary biliary cirrhosis, 80 with primary sclerosing cholangitis, 100 with hepatitis C, and 70 patients with various forms of chronic hepatitis, including 36 autoimmune cases), and from 17 children with autoimmune hepatitis. Sera reactive in the IMx assay were subjected to immunofluorescence testing. RESULTS: No clearly LKM-reactive sera were detected. Serum samples from 29 patients were borderline reactive in the IMx assay but tested negative in the confirmatory immunofluorescence test. Positive tests in the former assay were likely caused by reactivity against microsomal antigens other than LKM-1/cytochrome P450IID6. CONCLUSIONS: LKM-1-positive type-2 autoimmune hepatitis is very rare in Sweden. Furthermore, chronic hepatitis C did not trigger this type of autoimmune reactivity in our patients, probably owing to genetic insusceptibility.
PubMed ID
9051879 View in PubMed
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Adverse reactions in connection with zimeldine treatment--a review.

https://arctichealth.org/en/permalink/ahliterature242565
Source
Acta Psychiatr Scand Suppl. 1983;308:115-9
Publication Type
Article
Date
1983
Author
B S Nilsson
Source
Acta Psychiatr Scand Suppl. 1983;308:115-9
Date
1983
Language
English
Publication Type
Article
Keywords
Clinical Trials as Topic
Drug Hypersensitivity - etiology
Great Britain
Humans
Sweden
Zimeldine - adverse effects
Abstract
The results of clinical trials have shown that the general level of side-effects is substantially lower with zimeldine than with tricyclic antidepressants. Data from ordinary clinical usage in Sweden and the U.K. (as opposed to clinical research experience) shows a similar picture. Hypersensitivity reactions, characterized by fever, myalgia and/or arthralgia, and transient increases in transaminases, occur in approximately 1.5% of patients. In rare cases potentially serious neuropathies have been reported.
PubMed ID
6230884 View in PubMed
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Androgenic anabolic steroid use among male adolescents in Falkenberg.

https://arctichealth.org/en/permalink/ahliterature216536
Source
Eur J Clin Pharmacol. 1995;48(1):9-11
Publication Type
Article
Date
1995
Author
S. Nilsson
Source
Eur J Clin Pharmacol. 1995;48(1):9-11
Date
1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Anabolic Agents
Female
Humans
Male
Sex Factors
Substance-Related Disorders - epidemiology
Sweden
Abstract
Recent reports show that androgenic anabolic steroids are used by many teenagers, not as a deliberate attempt to give them strength, better athletic performance, etc., but to improve their looks. The so-called macho cult among young boys tempts them into using androgenic anabolic steroids to give them bigger muscles and a more powerful appearance. This study was undertaken to investigate the prevalence of androgenic anabolic steroid use among teenagers in a small town and to create a platform for future work with the aim of decreasing the misuse of these drugs. In Falkenberg, a town in the county of Halland in the west of Sweden, the pupils at two high schools were investigated by means of an anonymous multiple-choice questionnaire. A total of 1383 students (688 males and 695 females) aged 14-19 years participated in the study, giving a participation rate of 96%. The number of answers completed was 99%. The use of androgenic anabolic steroids is a reality among male teenagers in Falkenberg, with 5.8% of them using the drugs. Among 15- to 16-year-old boys misuse of these drugs is as high as 10%, and of these 50% (5.0% of total) also inject ampoules of the drugs. This prevalence is alarming since the adverse effects of androgenic anabolic steroids are more serious in teenagers. Serious action must be taken to inform teenagers of the consequences of misusing drugs.
PubMed ID
7621856 View in PubMed
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[A pilot study shows: a survey of surgical complications can diminish the risk--a primary study has been started].

https://arctichealth.org/en/permalink/ahliterature229785
Source
Lakartidningen. 1989 Nov 22;86(47):4114, 4117-8
Publication Type
Article
Date
Nov-22-1989

Applied diagnostic techniques: a decisive factor in the long-term T-year survival rate in prostatic carcinoma.

https://arctichealth.org/en/permalink/ahliterature27444
Source
Br J Urol. 1979 Apr;51(2):135-9
Publication Type
Article
Date
Apr-1979
Author
H. Trasti
S. Nilsson
L E Peterson
Source
Br J Urol. 1979 Apr;51(2):135-9
Date
Apr-1979
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biopsy, Needle
Cytological Techniques
Humans
Male
Methods
Middle Aged
Prostatic Neoplasms - diagnosis - epidemiology - mortality
Registries
Risk
Sweden
Time Factors
Abstract
Ii is shown from statistical data reported to the Swedish Cancer Registry that in cases of prostatic carcinoma the long-term T-year survival rate is the final outcome of a complex interplay of multiple factors including diagnostic technology and techniques for staging and grading. Assessment of the value of specific therapy is not possible except in controlled clinical trials. The T-year survival rate per se does not give an accurate estimate of the effect of treatment.
PubMed ID
380727 View in PubMed
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Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.

https://arctichealth.org/en/permalink/ahliterature179471
Source
Psychoneuroendocrinology. 2004 Sep;29(8):993-8
Publication Type
Article
Date
Sep-2004
Author
L. Westberg
A. Håkansson
J. Melke
H Niazi Shahabi
S. Nilsson
S. Buervenich
A. Carmine
J. Ahlberg
M B Grundell
B. Schulhof
K. Klingborg
B. Holmberg
O. Sydow
L. Olson
E B Johnels
E. Eriksson
H. Nissbrandt
Author Affiliation
Department of Pharmacology, Göteborg University, Göteborg, Sweden. lars.westberg@pharm.gu.se
Source
Psychoneuroendocrinology. 2004 Sep;29(8):993-8
Date
Sep-2004
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Aged
Case-Control Studies
Chi-Square Distribution
Chromosomes, Human, Pair 14 - genetics
Estrogen Receptor beta
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Odds Ratio
Parkinson Disease - epidemiology - genetics
Polymorphism, Single Nucleotide - genetics
Receptors, Estrogen - genetics
Sweden - epidemiology
Abstract
The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.
PubMed ID
15219649 View in PubMed
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[A study among teenagers in Falkenberg: frightening abuse of anabolic steroids].

https://arctichealth.org/en/permalink/ahliterature217542
Source
Lakartidningen. 1994 Aug 10;91(32-33):2877-8
Publication Type
Article
Date
Aug-10-1994
Author
S. Nilsson
Author Affiliation
Tångaskolan, distriktsläkare, vårdcentralen Centrum I, Falkenberg.
Source
Lakartidningen. 1994 Aug 10;91(32-33):2877-8
Date
Aug-10-1994
Language
Swedish
Publication Type
Article
Keywords
Adolescent
Anabolic Agents - administration & dosage - adverse effects
Beauty Culture
Body Image
Female
Humans
Male
Personality Disorders - chemically induced - epidemiology
Questionnaires
Risk factors
Substance-Related Disorders - epidemiology
Sweden - epidemiology
Notes
Comment In: Lakartidningen. 1994 Sep 14;91(37):32447934325
PubMed ID
7983929 View in PubMed
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Autopsy findings in 27 children with haemophagocytic lymphohistiocytosis.

https://arctichealth.org/en/permalink/ahliterature33888
Source
Histopathology. 1998 Apr;32(4):310-6
Publication Type
Article
Date
Apr-1998
Author
A. Ost
S. Nilsson-Ardnor
J I Henter
Author Affiliation
Department of Pathology and Cytology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Source
Histopathology. 1998 Apr;32(4):310-6
Date
Apr-1998
Language
English
Publication Type
Article
Keywords
Autopsy
Bone Marrow - pathology
Child
Child, Preschool
Female
Hepatitis, Chronic - epidemiology
Histiocytosis, Non-Langerhans-Cell - epidemiology - pathology
Humans
Infant
Liver - pathology
Lymph Nodes - pathology
Male
Research Support, Non-U.S. Gov't
Spleen - pathology
Abstract
AIMS: Primary haemophagocytic lymphohistiocytosis (HLH) is a fatal childhood disorder. The diagnosis is difficult to establish, clinically as well as histopathologically, and it is markedly underdiagnosed. Because of these difficulties, we wanted to elucidate the histopathological findings in population-based patient material. METHODS AND RESULTS: The post-mortem findings in 27 children with primary HLH diagnosed in Sweden between 1971 and 1986 was reviewed. Twelve of these patients had an affected sibling and three additional children had parental consanguinity. Some of the children showed generalized disease, whereas in others only one or a few organs were affected. The major histological alteration was an accumulation of primarily lymphocytes, but also of histiocytes, some of which exhibited evidence of haemophagocytosis. The haemophagocytic activity may be difficult to detect if there are pronounced post-mortem changes, particularly in the spleen, and it is therefore preferable to perform the autopsy as soon as possible after death in order to minimize autolysis. Haemophagocytosis was most commonly observed in the spleen (17/24), the lymph nodes (17/23) and the bone marrow (9/23), indicating that a negative bone marrow examination does not rule out this diagnosis. Three additional patients had discrete signs of haemophagocytosis in the bone marrow. In the spleen, the lymph nodes and the bone marrow, lymphocytic depletion, pronounced in some cases, could be observed, even without prior treatment with steroids or cytostatics. In the liver, most of the patients demonstrated an infiltration of lymphocytes into the portal tracts similar to that seen in chronic persistent hepatitis (22/27), a finding which is uncommon in infancy and therefore suggestive of the diagnosis HLH. Other organs involved included the thymus, lungs intestine, pancreas, kidney, heart and striated muscle. CONCLUSIONS: The diagnosis of HLH must be based on clinical, histological and additional laboratory findings. A negative bone marrow examination is common. Previous treatment with steroids and/or cytostatic drugs may attenuate or even eliminate the typical histological findings. Liver findings similar to those in chronic persistent hepatitis are common.
PubMed ID
9602326 View in PubMed
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Chest pain and ischaemic heart disease in primary care.

https://arctichealth.org/en/permalink/ahliterature49743
Source
Br J Gen Pract. 2003 May;53(490):378-82
Publication Type
Article
Date
May-2003
Author
S. Nilsson
M. Scheike
D. Engblom
L G Karlsson
S. Mölstad
I. Akerlind
K. Ortoft
E. Nylander
Author Affiliation
Department of General Practice and Primary Care, Faculty of Health Sciences, University of Linköping, Sweden. staffan.nilsson@lio.se
Source
Br J Gen Pract. 2003 May;53(490):378-82
Date
May-2003
Language
English
Publication Type
Article
Keywords
Adult
Aged
Chest Pain - epidemiology
Emergencies
Emergency Medical Services - methods
Exercise Test - methods
Family Practice - statistics & numerical data
Humans
Middle Aged
Myocardial Ischemia - diagnosis - epidemiology
Prospective Studies
Questionnaires
Referral and Consultation
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
BACKGROUND: Chest pain is the main symptom of first presentation with ischaemic heart disease (IHD). Little is known about the incidence of IHD among patients consulting the general practitioner (GP) for chest pain. AIMS: To estimate the occurrence of IHD among patients consulting for chest pain, to study the results of the bicycle exercise test, and to estimate the incidence of IHD in the population. DESIGN OF STUDY: Prospective descriptive study. SETTING: Three primary health centres in south-eastern Sweden. METHOD: All patients without a current IHD diagnosis, aged 20 to 79 years, and consulting for a new episode of chest pain, were included consecutively. The outcome was classified as IHD, possible IHD or not IHD, according to the results of a postal questionnaire, an exercise test or hospital care. Data from the hospital registry on patients with a diagnosis of IHD were analysed retrospectively. RESULTS: Out of 38,075 GP consultations, 577 (1.5%) were for chest pain. IHD was diagnosed in 41 (8%) of the chest pain patients, in 441 (83%) the diagnosis was excluded, and in 50 (9%) the diagnosis was judged as being uncertain. Even though the diagnostic criteria were strict, the exercise tests led to a diagnostic conclusion in 77% of the cases, most frequently a normal test result. Combining data from primary and hospital care, the yearly incidence of IHD was 6.5 diagnosed per 1000 inhabitants (aged 20 to 79 years old). CONCLUSION: The incidence of a new episode of chest pain bringing the patients to the GP was low. Eight per cent of the patients received an IHD diagnosis, and in 9% further investigation or clinical assessment is needed.
PubMed ID
12830565 View in PubMed
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63 records – page 1 of 7.