Skip header and navigation

3 records – page 1 of 1.

A cluster of cases of juvenile mediastinal lymphoma in a ferret colony.

https://arctichealth.org/en/permalink/ahliterature4048
Source
Lab Anim Sci. 1996 Jun;46(3):271-4
Publication Type
Article
Date
Jun-1996
Author
M A Batchelder
S E Erdman
X. Li
J G Fox
Author Affiliation
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA.
Source
Lab Anim Sci. 1996 Jun;46(3):271-4
Date
Jun-1996
Language
English
Publication Type
Article
Keywords
Animals
Female
Ferrets
Hematologic Tests
Housing, Animal
Lymphoma, Lymphoblastic - pathology - radiography - veterinary
Male
Mediastinal Neoplasms - pathology - radiography - veterinary
Neoplasm Staging
Pedigree
Research Support, U.S. Gov't, P.H.S.
Space-Time Clustering
Abstract
Three cases of juvenile mediastinal lymphoma developed in a laboratory colony of ferrets. Two ferrets became acutely moribund, and one was found dead with no preceding signs of illness. Splenomegaly, hepatomegaly, and a large thoracic mass were the primary features in each case. All three ferrets had multiorgan metastasis of the tumor. Two ferrets were tested for feline leukemia virus and Aleutian disease virus with negative results.
PubMed ID
8799931 View in PubMed
Less detail
Source
Cancer Invest. 1996;14(3):225-30
Publication Type
Article
Date
1996
Author
S E Erdman
P J Kanki
F M Moore
S A Brown
T A Kawasaki
K W Mikule
K U Travers
S F Badylak
J G Fox
Author Affiliation
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA.
Source
Cancer Invest. 1996;14(3):225-30
Date
1996
Language
English
Publication Type
Article
Keywords
Aleutian Mink Disease Virus - genetics
Animals
Base Sequence
DNA Primers - chemistry
DNA, Viral - analysis
Disease Outbreaks
Ferrets
Leukemia Virus, Feline - genetics
Lymphoma - epidemiology - microbiology - veterinary
Molecular Sequence Data
Research Support, U.S. Gov't, P.H.S.
Abstract
Cluster outbreaks of lymphoma and leukemia have been associated with viral infections in many species including humans, cattle, and cats. This study describes epidemiological, clinical, and pathological features of cluster outbreaks of lymphoma in multiferret households and examines and compares the Aleutian disease virus (ADV) and feline leukemia virus (FeLV) status of cases, ferrets at risk, and controls. Three ferret groups with 21 cases of histologically diagnosed lymphoma (12.6% cumulative incidence) and their cohabitants (n = 35) were examined and compared with three control groups (n = 52) of cohabitating ferrets without lymphoma. A familial distribution was observed in one group but most cases were not consanguinous. Ferrets greater than 3 years of age developed chronic disease in two of the groups and 2-year-old adults had acute disease in the remaining group. Lymphocytosis, splenomegaly, and lymphadenopathy were prominent features. Histologically, predominantly small noncleaved cell and polymorphous lymphoid lesions were observed. All of the ferrets with lymphoma that were tested for ADV and FeLV using serology or PCR were negative. The rate of ADV antibody among cases or ferrets at risk was not significantly different from controls. None of the cluster ferrets were seropositive for FeLV p27 antigen using a monoclonal ELISA. Infection with a novel ferret virus is suspected, but an etiological agent has not yet been identified.
PubMed ID
8630683 View in PubMed
Less detail

Malignant lymphoma in ferrets: clinical and pathological findings in 19 cases.

https://arctichealth.org/en/permalink/ahliterature4127
Source
J Comp Pathol. 1992 Jan;106(1):37-47
Publication Type
Article
Date
Jan-1992
Author
S E Erdman
F M Moore
R. Rose
J G Fox
Author Affiliation
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
Source
J Comp Pathol. 1992 Jan;106(1):37-47
Date
Jan-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Viral - analysis
Enzyme-Linked Immunosorbent Assay
Female
Ferrets
Incidence
Lymphocytes - pathology
Lymphoma, Lymphoblastic - epidemiology - pathology - veterinary
Lymphoma, Small Lymphocytic - epidemiology - pathology - veterinary
Lymphoma, Small-Cell - epidemiology - pathology - veterinary
Male
Neoplasm Staging - veterinary
Research Support, U.S. Gov't, P.H.S.
Abstract
The clinical and pathological findings in 19 ferrets (Mustela putorius furo) with malignant lymphoma are reviewed. Peripubescent ferrets had rapidly progressive stage IV high grade immunoblastic or small non-cleaved cell lymphoma. Adult ferrets had stage II or IV low grade diffuse small lymphocytic (DSL) lymphoma, stage IV high grade small non-cleaved cell lymphoma, or stage IV high grade immunoblastic polymorphous (IBP) lymphoma. Three ferrets had concurrent IBP and DSL lymphoma involving different organs. The IBP admixture of immunoblasts, large atypical lymphocytes, Reed-Sternberg-like cells, lymphoblasts and small lymphocytes has been associated with certain retrovirally associated lymphomas and nodal hyperplasias in man, non-human primates and cats. Aleutian disease, a parvovirus-induced lymphoproliferative disease, also involves clinical and histological features similar to certain lymphomas in ferrets. Seven ferrets tested were seronegative for feline leukaemia virus antigen. Only one of eight ferrets was positive for Aleutian parvovirus antibody. The clinical and pathological findings are suggestive of a viral aetiology for certain lymphomas in ferrets.
PubMed ID
1556256 View in PubMed
Less detail