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Comparing risk profiles of individuals diagnosed with diabetes by OGTT and HbA1c The Danish Inter99 study.

https://arctichealth.org/en/permalink/ahliterature141965
Source
Diabet Med. 2010 Aug;27(8):906-10
Publication Type
Article
Date
Aug-2010
Author
R. Borg
D. Vistisen
D R Witte
K. Borch-Johnsen
Author Affiliation
Steno Diabetes Center, Gentofte, Denmark.
Source
Diabet Med. 2010 Aug;27(8):906-10
Date
Aug-2010
Language
English
Publication Type
Article
Keywords
Blood Glucose - metabolism
Denmark - epidemiology
Diabetes Mellitus, Type 2 - diagnosis - epidemiology
Diabetic Angiopathies - diagnosis - epidemiology
Fasting
Female
Glucose Tolerance Test - methods
Hemoglobin A, Glycosylated - metabolism
Humans
Male
Middle Aged
Myocardial Ischemia - diagnosis - epidemiology
Prevalence
Risk assessment
Abstract
Glycated haemoglobin (HbA(1c)) has been proposed as an alternative to the oral glucose tolerance test for diagnosing diabetes. We compared the cardiovascular risk profile of individuals identified by these two alternative methods.
We assessed the prevalence of cardiovascular risk factors in individuals with undiagnosed diabetes according to the World Health Organization classification or by the newly proposed HbA(1c) level >or= 6.5% among 6258 participants of the Danish Inter99 study. Receiver operating curve analysis assessed the ability of fasting: 2-h plasma glucose and HbA(1c) to distinguish between individuals at high and low risk of ischemic heart disease, predicted by the PRECARD program.
Prevalence of undiagnosed diabetes was 4.1% [95% confidence interval (CI) 3.7-4.7%] by the current oral glucose tolerance test definition, whereas 6.6% (95% CI 6.0-7.2%) had diabetes by HbA(1c) levels. HbA(1c)-defined individuals were relatively older with higher proportions of men, smokers, lipid abnormalities and macro-albuminuria, but they were leaner and had lower blood pressure. HbA(1c) was better than fasting- and 2-h plasma glucose at distinguishing between individuals of high and low predicted risk of ischaemic heart disease; however, the difference between HbA(1c) and fasting- and 2-h plasma glucose was not statistically significant.
Compared with the current oral glucose tolerance test definition, more individuals were classified as having diabetes based on the HbA(1c) criteria. This group had as unfavourable a risk profile as those identified by the oral glucose tolerance test.
PubMed ID
20653748 View in PubMed
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