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Obtaining tomato plants transgenic for the preS2-S-HDEL gene, which synthesize the major hepatitis B surface antigen.

https://arctichealth.org/en/permalink/ahliterature99226
Source
Dokl Biochem Biophys. 2010 Jul-Aug;433:187-90
Publication Type
Article
Author
R K Salyaev
A S Stolbikov
N I Rekoslavskaya
S N Shchelkunov
S G Pozdnyakov
A V Chepinoga
R V Hammond
Author Affiliation
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, ul. Lermontova 132, Irkutsk, 664033, Russia.
Source
Dokl Biochem Biophys. 2010 Jul-Aug;433:187-90
Language
English
Publication Type
Article
PubMed ID
20714853 View in PubMed
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Study of the mucosal immune response duration in mice after administration of a candidate edible vaccine based on transgenic tomato plants carrying the TBI-HBS gene.

https://arctichealth.org/en/permalink/ahliterature100399
Source
Dokl Biochem Biophys. 2009 Sep-Oct;428:232-4
Publication Type
Article

Using the omega leader sequence of tobacco mosaic virus to transform tomato fruits with the papillomavirus hpv16 L1 gene to enhance production of the antigenic protein HPV16 L11.

https://arctichealth.org/en/permalink/ahliterature274553
Source
Dokl Biochem Biophys. 2016 May;468(1):187-9
Publication Type
Article
Date
May-2016
Author
R K Salyaev
N I Rekoslavskaya
A S Stolbikov
A V Tret'yakova
Source
Dokl Biochem Biophys. 2016 May;468(1):187-9
Date
May-2016
Language
English
Publication Type
Article
Abstract
To enhance translation of the L1 protein antigen of the oncogenic human papillomavirus type HPV16 L1, the O sequence of the 5'-untranslated region of tobacco mosaic virus was inserted into a genetic construct as an enhancer. To transform plants, A. tumefaciens EHA105 cells were transfected with this construct. After the genetic transformation, the HPV16 L1 protein antigen was detected in tomato fruit in amounts of 287-2330 ng per 1 mg total soluble protein, which significantly exceeds the amount of the protein antigen obtained in our previous studies without using the omega leader sequence.
PubMed ID
27417716 View in PubMed
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