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Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries.

https://arctichealth.org/en/permalink/ahliterature101566
Source
Acta Paediatr. 2011 Jul 1;
Publication Type
Article
Date
Jul-1-2011
Author
Stine Dydensborg
Peter Toftedal
Matteo Biaggi
Søren T Lillevang
Dorte G Hansen
Steffen Husby
Author Affiliation
.Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense C, Denmark .Department of Pathology, Odense University Hospital, Odense C, Denmark .Department of Clinical Immunology, Odense University Hospital, Odense C, Denmark .Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, Odense C, Denmark.
Source
Acta Paediatr. 2011 Jul 1;
Date
Jul-1-2011
Language
English
Publication Type
Article
Abstract
Aim: To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. Methods: All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. Results: Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100 000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100 000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100 000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. Conclusion: The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.
PubMed ID
21722173 View in PubMed
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Questionnaire-based case finding of celiac disease in a population of 8- to 9-year-old children.

https://arctichealth.org/en/permalink/ahliterature98182
Source
Pediatrics. 2010 Mar;125(3):e518-24
Publication Type
Article
Date
Mar-2010
Author
Peter Toftedal
Dorte Gilså Hansen
Christian Nielsen
Søren Thue Lillevang
Tine Plato Hansen
Steffen Husby
Author Affiliation
DMSc, Hans Christian Andersen Children's Hospital, Sdr Boulevard 29, DK-5000 Odense C, Denmark.
Source
Pediatrics. 2010 Mar;125(3):e518-24
Date
Mar-2010
Language
English
Publication Type
Article
Keywords
Celiac Disease - diagnosis
Child
Female
Humans
Male
Questionnaires
Retrospective Studies
Abstract
OBJECTIVE: Antibody screenings and diagnosis of celiac disease (CD) among children with type 1 diabetes have suggested that a considerable proportion of children with CD may, in fact, have preclinical (undiagnosed) symptoms. We aimed to test if a questionnaire would lead to significant case finding in an unselected population of 8- to 9-year-old children. PATIENTS AND METHODS: The study population included 9880 children aged 8 to 9 years. Before the study, 13 children from the study population were known to have CD. We developed a questionnaire on the basis of 5 simple items suggestive of CD and mailed the questionnaire to the families of all children in the study population who resided in the County of Funen, Denmark. In total, 7029 respondents returned the questionnaire (70%); among them, 2835 children had 1 or more symptoms. These children were invited for a blood test to determine their human serum immunoglobulin A (IgA) anti-tissue transglutaminase antibody (anti-tTG) levels. RESULTS: Of the 1720 children who were tested for the human serum IgA anti-tTG, 24 participants had a positive result (range: 20 to >150 U). Seventeen of these children underwent an upper endoscopy procedure. Fourteen children had histologic signs of CD (Marsh classification stage III). Fourteen children met the diagnostic criteria for CD. The prevalence proportion of patients who were newly diagnosed with CD was 0.14% (95% CI: 0.08-0.24) (14 of 9967), and the estimate of the minimum total prevalence proportion of children with CD was 0.27% (95% CI: 0.18-0.39) (27 of 9980). The maximal prevalence proportion of patients with newly diagnosed CD was 1.22% (95% CI: 0.76-1.90) (21 of 1720), including those participants who had a positive anti-tTG result but not a final diagnosis of CD. The ratio of known to minimally symptomatic CD was approximately 1:1. CONCLUSION: A number of preclinical and low-grade symptomatic patients with CD may be identified by their responses to a mailed questionnaire.
PubMed ID
20123763 View in PubMed
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