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Pregnant Inuit Women's Exposure to Metals and Association with Fetal Growth Outcomes: ACCEPT 2010?2015.

https://arctichealth.org/en/permalink/ahliterature302606
Source
Int J Environ Res Public Health. 2019 04 01; 16(7):
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
04-01-2019
Author
Per I Bank-Nielsen
Manhai Long
Eva C Bonefeld-Jørgensen
Author Affiliation
Centre for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark.
Source
Int J Environ Res Public Health. 2019 04 01; 16(7):
Date
04-01-2019
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Birth weight
Cross-Sectional Studies
Diet
Environmental pollutants - blood
Female
Fetal Development
Greenland
Humans
Infant, Newborn
Inuits
Metals - blood
Pregnancy - blood
Smoking - blood
Young Adult
Abstract
Environmental contaminants such as heavy metals are transported to the Arctic regions via atmospheric and ocean currents and enter the Arctic food web. Exposure is an important risk factor for health and can lead to increased risk of a variety of diseases. This study investigated the association between pregnant women's levels of heavy and essential metals and the birth outcomes of the newborn child. This cross-sectional study is part of the ACCEPT birth cohort (Adaption to Climate Change, Environmental Pollution, and dietary Transition) and included 509 pregnant Inuit women =18 years of age. Data were collected in five Greenlandic regions during 2010?2015. Population characteristics and birth outcomes were obtained from medical records and midwives, respectively, and blood samples were analyzed for 13 metals. Statistical analysis included one-way ANOVA, Spearman's rho, and multiple linear and logistic regression analyses. The proportion of current smokers was 35.8%. The levels of cadmium, chromium, and nickel were higher compared to reported normal ranges. Significant regional differences were observed for several metals, smoking, and parity. Cadmium and copper were significantly inversely related to birth outcomes. Heavy metals in maternal blood can adversely influence fetal development and growth in a dose?response relationship. Diet and lifestyle factors are important sources of toxic heavy metals and deviant levels of essential metals. The high frequency of smokers in early pregnancy is of concern, and prenatal exposure to heavy metals and other environmental contaminants in the Greenlandic Inuit needs further research.
PubMed ID
30939809 View in PubMed
Less detail

Pregnant Inuit Women's Exposure to Metals and Association with Fetal Growth Outcomes: ACCEPT 2010?2015.

https://arctichealth.org/en/permalink/ahliterature299056
Source
Int J Environ Res Public Health. 2019 Apr 01; 16(7):
Publication Type
Journal Article
Date
Apr-01-2019
Author
Per I Bank-Nielsen
Manhai Long
Eva C Bonefeld-Jørgensen
Author Affiliation
Centre for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark.
Source
Int J Environ Res Public Health. 2019 Apr 01; 16(7):
Date
Apr-01-2019
Language
English
Publication Type
Journal Article
Abstract
Environmental contaminants such as heavy metals are transported to the Arctic regions via atmospheric and ocean currents and enter the Arctic food web. Exposure is an important risk factor for health and can lead to increased risk of a variety of diseases. This study investigated the association between pregnant women's levels of heavy and essential metals and the birth outcomes of the newborn child. This cross-sectional study is part of the ACCEPT birth cohort (Adaption to Climate Change, Environmental Pollution, and dietary Transition) and included 509 pregnant Inuit women =18 years of age. Data were collected in five Greenlandic regions during 2010?2015. Population characteristics and birth outcomes were obtained from medical records and midwives, respectively, and blood samples were analyzed for 13 metals. Statistical analysis included one-way ANOVA, Spearman's rho, and multiple linear and logistic regression analyses. The proportion of current smokers was 35.8%. The levels of cadmium, chromium, and nickel were higher compared to reported normal ranges. Significant regional differences were observed for several metals, smoking, and parity. Cadmium and copper were significantly inversely related to birth outcomes. Heavy metals in maternal blood can adversely influence fetal development and growth in a dose?response relationship. Diet and lifestyle factors are important sources of toxic heavy metals and deviant levels of essential metals. The high frequency of smokers in early pregnancy is of concern, and prenatal exposure to heavy metals and other environmental contaminants in the Greenlandic Inuit needs further research.
PubMed ID
30939809 View in PubMed
Less detail