Skip header and navigation

Refine By

3 records – page 1 of 1.

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome.

https://arctichealth.org/en/permalink/ahliterature90739
Source
Genes Immun. 2009 Jan;10(1):68-76
Publication Type
Article
Date
Jan-2009
Author
Nordmark G.
Kristjansdottir G.
Theander E.
Eriksson P.
Brun J G
Wang C.
Padyukov L.
Truedsson L.
Alm G.
Eloranta M-L
Jonsson R.
Rönnblom L.
Syvänen A-C
Author Affiliation
Section of Rheumatology, Uppsala University, Uppsala, Sweden. Gunnel.Nordmark@medsci.uu.se
Source
Genes Immun. 2009 Jan;10(1):68-76
Date
Jan-2009
Language
English
Publication Type
Article
Keywords
Aged
Alleles
Asian Continental Ancestry Group - genetics - statistics & numerical data
Case-Control Studies
Cohort Studies
Confidence Intervals
European Continental Ancestry Group - genetics - statistics & numerical data
Female
Gene Frequency
Haplotypes
Heterozygote
Humans
Interferon Regulatory Factors - genetics - immunology
Linear Models
Linkage Disequilibrium
Male
Middle Aged
Norway
Odds Ratio
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Probability
Risk factors
STAT4 Transcription Factor - genetics - immunology
Sjogren's Syndrome - genetics - immunology
Sweden
Abstract
Primary Sj?gren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in IRF5 and STAT4 found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of IRF5, the single nucleotide polymorphism (SNP) rs10488631 downstream of IRF5 and the STAT4 SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and P-values
PubMed ID
19092842 View in PubMed
Less detail

Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies.

https://arctichealth.org/en/permalink/ahliterature93056
Source
Ann Rheum Dis. 2009 Feb;68(2):222-7
Publication Type
Article
Date
Feb-2009
Author
Källberg H.
Jacobsen S.
Bengtsson C.
Pedersen M.
Padyukov L.
Garred P.
Frisch M.
Karlson E W
Klareskog L.
Alfredsson L.
Author Affiliation
Institute of Environmental Medicine, Box 210, Karolinska Institutet, 17177 Stockholm, Sweden. henrik.kallberg@ki.se
Source
Ann Rheum Dis. 2009 Feb;68(2):222-7
Date
Feb-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Alcohol Drinking - epidemiology - genetics - immunology
Arthritis, Rheumatoid - epidemiology - genetics - immunology - prevention & control
Autoantibodies - blood
Biological Markers - blood
Case-Control Studies
Denmark - epidemiology
Female
HLA-DR Antigens - genetics
Humans
Male
Middle Aged
Peptides, Cyclic - immunology
Risk assessment
Smoking - adverse effects - epidemiology - genetics
Sweden - epidemiology
Young Adult
Abstract
OBJECTIVES: To determine the association between risk of rheumatoid arthritis (RA) and alcohol consumption in combination with smoking and HLA-DRB1 shared epitope (SE). METHODS: Data from two independent case-control studies of RA, the Swedish EIRA (1204 cases and 871 controls) and the Danish CACORA (444 cases and 533 controls), were used to estimate ORs of developing RA for different amounts of alcohol consumed. RESULTS: Alcohol consumption was significantly more common in controls (p
PubMed ID
18535114 View in PubMed
Less detail

Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis.

https://arctichealth.org/en/permalink/ahliterature93918
Source
Ann Rheum Dis. 2008 Aug;67(8):1111-5
Publication Type
Article
Date
Aug-2008
Author
Kling A.
Seddighzadeh M.
Arlestig L.
Alfredsson L.
Rantapää-Dahlqvist S.
Padyukov L.
Author Affiliation
Division of Clinical Pharmacology, University Hospital, SE-901 85 Umeå, Sweden. anders.kling@pharm.umu.se
Source
Ann Rheum Dis. 2008 Aug;67(8):1111-5
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Adult
Arthritis, Rheumatoid - genetics - metabolism
Biological Specimen Banks
Case-Control Studies
Chi-Square Distribution
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT2A - genetics
Reproducibility of Results
Sweden
Abstract
OBJECTIVES: To analyse the association between the genetic polymorphisms within the HTR2A gene for the serotonin receptor and rheumatoid arthritis (RA). METHODS: HTR2A gene polymorphisms were analysed in patients with RA and controls from two study populations using PCR based restriction endonuclease mapping or TaqMan allelic discrimination with more than 4000 individuals included in the current study. RESULTS: At the discovery stage we detected significant differences in frequency of rs6313 (T102C polymorphism) between the patients with RA and controls (p = 0.006). Following validation with an extended set of single nucleotide polymorphisms (SNPs) and number of DNA samples, a trend in associations in allelic model for SNPs rs6314, rs1328674, rs6313 and rs6311 (p = 0.006, 0.002, 0.006, 0.009) was seen, although it was lost after correction for multi-comparison for all but rs1328674 (empirical p value = 0.021). However, haplotype frequency analysis based on these four SNPs showed significantly low representation of TCTT combination in patients with RA in comparison with controls (3.6% and 5.6%, p
PubMed ID
18006541 View in PubMed
Less detail