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Antibodies against Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion during early phase of acute otitis media.

https://arctichealth.org/en/permalink/ahliterature37907
Source
Acta Otolaryngol. 1990 Jan-Feb;109(1-2):111-8
Publication Type
Article
Author
H. Karjalainen
M. Koskela
J. Luotonen
E. Herva
P. Sipilä
Author Affiliation
Department of Otolaryngology, University of Oulu, Finland.
Source
Acta Otolaryngol. 1990 Jan-Feb;109(1-2):111-8
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Antibodies, Bacterial - analysis
Child
Child, Preschool
Female
Haemophilus influenzae - immunology - isolation & purification
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infant
Male
Moraxella (Branhamella) catarrhalis - immunology - isolation & purification
Otitis Media with Effusion - immunology - microbiology
Streptococcus pneumoniae - immunology - isolation & purification
Abstract
Serum type (IgG, IgM and IgA-class) and secretory type antibodies specific to Streptococcus pneumoniae (Pn), Haemophilus influenzae (Hi) and Branhamella catarrhalis (Br) were measured by enzyme-linked immunosorbent assay (ELISA) in 46 serum and 114 middle ear effusion (MEE) samples from 85 children with acute otitis media (AOM). The samples were obtained within 12 h from the onset of the ear symptoms. Serum (but not secretory) type antibodies to the infecting Pn serotype were found in 24% of the MEE samples of the patients with Pn AOM and, correspondingly, serum and/or secretory type antibodies to Hi and Br were seen in 54% and 63% of the MEE samples of the patients with Hi or Br AOM, respectively. Moreover, antibodies against bacteria other than the causative one could also be found in the MEE. The occurrence of the serum type antibodies against these bacteria in the MEE was closely correlated with their serum levels. The findings of this study indicate that during the very early phase of AOM, the MEE contains both serum type antibodies originating from the serum, and secretory antibodies of middle ear origin. Among them there are antibodies specific to the three most common bacteria causing AOM (Pn, Hi, and Br) regardless of the bacterial etiology of the AOM attack in question.
PubMed ID
2106760 View in PubMed
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Changes in prognosis of twin births over 20 years.

https://arctichealth.org/en/permalink/ahliterature59858
Source
Ann Med. 1990 Apr;22(2):131-5
Publication Type
Article
Date
Apr-1990
Author
A L Hartikainen-Sorri
P. Rantakallio
P. Sipilä
Author Affiliation
Department of Public Health Sciences, University of Oulu, Finland.
Source
Ann Med. 1990 Apr;22(2):131-5
Date
Apr-1990
Language
English
Publication Type
Article
Keywords
Adult
Female
Fetal Death - epidemiology
Finland - epidemiology
Humans
Infant mortality
Infant, Newborn
Pregnancy
Prenatal Care - economics
Prospective Studies
Socioeconomic Factors
Twins
Abstract
The study is based on two birth cohorts from the years 1966 and 1985-1986. Perinatal mortality of twins has fallen over 20 years from 9.2% to 3.1%. Improvement is particularly remarkable in neonatal mortality (less than 28 days) of preterm (less than 34 gestational weeks) twins, from 47.4% to 8.6%, whereas the incidence of stillbirths has not fallen greatly. The proportion of preterm births has not fallen significantly, 48.4% vs. 38.1%. Many factors, considered favourable to the course and outcome of pregnancy have improved simultaneously: women are taller, less overweight, and more educated; pregnancies are wanted and sick and maternity leave provisions have improved. The follow-up of twin pregnancies and deliveries has been centralized and is more effective. In particular, neonatal care is also better than 20 years ago. The prognosis of twins has improved in parallel with the singletons, but the perinatal mortality is still approximately four time and the incidence of prematurity ten times more than in singletons.
PubMed ID
2361008 View in PubMed
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Changes in risk factors for unfavorable pregnancy outcome among singletons over twenty years.

https://arctichealth.org/en/permalink/ahliterature59368
Source
Acta Obstet Gynecol Scand. 1994 Sep;73(8):612-8
Publication Type
Article
Date
Sep-1994
Author
P. Sipilä
A L Hartikainen
L. von Wendt
H. Oja
Author Affiliation
Department of Public Health Science, University of Oulu, Finland.
Source
Acta Obstet Gynecol Scand. 1994 Sep;73(8):612-8
Date
Sep-1994
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Female
Fetal Death - epidemiology
Finland - epidemiology
Humans
Infant mortality
Infant, Low Birth Weight
Infant, Newborn
Maternal Age
Parity
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy outcome
Prevalence
Prognosis
Prospective Studies
Research Support, Non-U.S. Gov't
Risk factors
Abstract
OBJECTIVES. To examine the change in the prevalence and relative effect of pre-pregnancy risk factors for low birthweight and/or stillbirth and/or neonatal mortality over a period of twenty years. DESIGN. Two prospectively collected one year birth cohorts. SETTING. The two northernmost administrative districts of Finland. PATIENTS. A birth cohort for 1966 comprising 11905 singleton births and a cohort for 1985-86 containing a further 9247. MAIN OUTCOME MEASURES. Risk factors for poor pregnancy outcome. RESULTS. In twenty years the prevalence of low birthweight infants among singletons decreased from 4.2% to 3.1% and that of stillbirths and neonatal deaths from 2.4% to 0.9%. The impact of single marital status decreased and while maternal age or = 35 years related more to poor pregnancy outcome. The proportion of multiparous women was halved but multiparity had a protective influence on pregnancy outcome meanwhile the impact of primiparity decreased markedly. In spite of more effective health education, the prevalence of heavy smokers was 4 times higher in the 1980s as compared with the 1960s, and its impact on adverse outcomes increased, with odds ratio (OR) 1.72 (confidence interval (CI) 1.14-2.61) in 1966 and OR 2.15 (CI 1.61-2.88) in 1985-86. The number of mothers with a previous low birthweight baby was halved but the impact of low birth weight was still great in the latter cohort (OR 2.47; CI 1.64-3.71). The impact of an earlier stillbirth and/or neonatal death increased significantly, with an OR 1.53 (CI 1.10-2.14) in 1966 and OR 2.95 (CI 1.81-4.81) in 1985-86, but the number of mothers concerned was halved from that in 1966. CONCLUSIONS. The prevalence of pregnancies with an adverse outcome decreased markedly, as did the prevalence of many of the risk factors. The proportion of > or = 35 years old parturients and of heavy smokers increased. The impact of primiparity decreased, while that of a previous outcome as assessed from pre-pregnancy factors has not improved in these twenty years, especially where primiparous parturients are concerned.
PubMed ID
7941984 View in PubMed
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Dental caries risk in relation to dietary habits and dental services in two industrial populations.

https://arctichealth.org/en/permalink/ahliterature219416
Source
J Public Health Dent. 1994;54(3):160-6
Publication Type
Article
Date
1994
Author
K E Masalin
H T Murtomaa
K P Sipilä
Author Affiliation
Department of Dental Public Health, University of Helsinki, Finland.
Source
J Public Health Dent. 1994;54(3):160-6
Date
1994
Language
English
Publication Type
Article
Keywords
Adult
Candida albicans - isolation & purification
Candy
Chi-Square Distribution
DMF Index
Dental Caries - epidemiology - etiology
Dental Caries Susceptibility
Dental Health Services - economics - utilization
Diet, Cariogenic
Female
Finland - epidemiology
Food Habits
Humans
Lactobacillus - isolation & purification
Likelihood Functions
Linear Models
Male
Multivariate Analysis
Occupational Exposure
Oral Hygiene
Risk factors
Saliva - microbiology
Sex Factors
Ships
Streptococcus mutans - isolation & purification
Abstract
Environmental hazards contribute to the poor oral health in many occupations. Among the earliest occupations mentioned are those of the baker and confectionery worker. To determine appropriate ways of promoting oral health in places of work, factors affecting caries susceptibility were studied.
Dental caries status, dietary and dental health behaviors, and salivary microbiologic findings in 338 confectionery and 101 shipyard workers were compared. A caries risk index based on salivary findings was used in log-linear models where the effects of sex, diet, use of dental services, and work environment were studied.
Caries experience was found to be high in both populations. Dietary habits were the most important factor affecting caries occurrence and susceptibility. Similar dietary behaviors were found in both groups.
The confectionery industry did not seem to be an exceptionally hazardous environment for dental health in general. However, the screening of high-risk workers should be organized. Reimbursement of costs had no major effect on use of dental services or caries risk. Oral health promotion should be integrated with existing occupational health services to improve oral health in industrial populations.
PubMed ID
7932352 View in PubMed
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Double-blind comparison of nedocromil sodium (1% nasal spray) and placebo in rhinitis caused by birch pollen.

https://arctichealth.org/en/permalink/ahliterature234676
Source
Clin Otolaryngol Allied Sci. 1987 Oct;12(5):365-70
Publication Type
Article
Date
Oct-1987
Author
P. Sipilä
M. Sorri
J. Pukander
Author Affiliation
Department of Otolaryngology, University of Oulu, Finland.
Source
Clin Otolaryngol Allied Sci. 1987 Oct;12(5):365-70
Date
Oct-1987
Language
English
Publication Type
Article
Keywords
Administration, Intranasal
Clinical Trials as Topic
Double-Blind Method
Humans
Nedocromil
Pollen
Quinolines - administration & dosage
Rhinitis, Allergic, Seasonal - drug therapy
Trees
Abstract
A double-blind parallel group study was undertaken during May and June 1985 to compare the effect of nedocromil sodium (1% nasal spray) and placebo, taken twice daily, in relieving the symptoms of rhinitis caused by birch pollen. Two centres were involved. The 54 patients studied had a history of rhinitis in 2 previous birch pollen seasons and positive skin tests to birch pollen. Patients were treated for 4 weeks, but to compare the effects of the 2 treatments the peak pollen periods were used. For dairy card symptoms, results in the 2 centres differed: in Tampere, there were trends in favour of nedocromil sodium with respect to itching (P = 0.04, sneezing (P = 0.06) and total symptoms (P = 0.09); in Oulu no significant differences were seen. Nasal peak expiratory flow rates were slightly better in the nedocromil sodium group. In respect of antihistamine usage, results in the 2 centres were similar and significantly more were used in the placebo group (P less than 0.01). At the end of the trial, both the patients' and the investigators' opinions of treatment effect favoured nedocromil sodium. There were no serious side effects. The results suggest that nedocromil sodium 1% nasal spray, when given twice daily, is effective in the treatment of seasonal allergic rhinitis.
PubMed ID
2827920 View in PubMed
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Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch.

https://arctichealth.org/en/permalink/ahliterature285662
Source
Nat Genet. 2017 Jun;49(6):904-912
Publication Type
Article
Date
Jun-2017
Author
Jarkko Salojärvi
Olli-Pekka Smolander
Kaisa Nieminen
Sitaram Rajaraman
Omid Safronov
Pezhman Safdari
Airi Lamminmäki
Juha Immanen
Tianying Lan
Jaakko Tanskanen
Pasi Rastas
Ali Amiryousefi
Balamuralikrishna Jayaprakash
Juhana I Kammonen
Risto Hagqvist
Gugan Eswaran
Viivi Helena Ahonen
Juan Alonso Serra
Fred O Asiegbu
Juan de Dios Barajas-Lopez
Daniel Blande
Olga Blokhina
Tiina Blomster
Suvi Broholm
Mikael Brosché
Fuqiang Cui
Chris Dardick
Sanna E Ehonen
Paula Elomaa
Sacha Escamez
Kurt V Fagerstedt
Hiroaki Fujii
Adrien Gauthier
Peter J Gollan
Pauliina Halimaa
Pekka I Heino
Kristiina Himanen
Courtney Hollender
Saijaliisa Kangasjärvi
Leila Kauppinen
Colin T Kelleher
Sari Kontunen-Soppela
J Patrik Koskinen
Andriy Kovalchuk
Sirpa O Kärenlampi
Anna K Kärkönen
Kean-Jin Lim
Johanna Leppälä
Lee Macpherson
Juha Mikola
Katriina Mouhu
Ari Pekka Mähönen
Ülo Niinemets
Elina Oksanen
Kirk Overmyer
E Tapio Palva
Leila Pazouki
Ville Pennanen
Tuula Puhakainen
Péter Poczai
Boy J H M Possen
Matleena Punkkinen
Moona M Rahikainen
Matti Rousi
Raili Ruonala
Christiaan van der Schoot
Alexey Shapiguzov
Maija Sierla
Timo P Sipilä
Suvi Sutela
Teemu H Teeri
Arja I Tervahauta
Aleksia Vaattovaara
Jorma Vahala
Lidia Vetchinnikova
Annikki Welling
Michael Wrzaczek
Enjun Xu
Lars G Paulin
Alan H Schulman
Martin Lascoux
Victor A Albert
Petri Auvinen
Ykä Helariutta
Jaakko Kangasjärvi
Source
Nat Genet. 2017 Jun;49(6):904-912
Date
Jun-2017
Language
English
Publication Type
Article
Keywords
Adaptation, Biological - genetics
Betula - genetics - physiology
Finland
Gene Duplication
Genetics, Population
Genome, Plant
Phylogeny
Plant Proteins - genetics
Polymorphism, Single Nucleotide
Population Density
Abstract
Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within 1 year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make birch an attractive model for forest biotechnology. We assembled and chromosomally anchored the nuclear genome of an inbred B. pendula individual. Gene duplicates from the paleohexaploid event were enriched for transcriptional regulation, whereas tandem duplicates were overrepresented by environmental responses. Population resequencing of 80 individuals showed effective population size crashes at major points of climatic upheaval. Selective sweeps were enriched among polyploid duplicates encoding key developmental and physiological triggering functions, suggesting that local adaptation has tuned the timing of and cross-talk between fundamental plant processes. Variation around the tightly-linked light response genes PHYC and FRS10 correlated with latitude and longitude and temperature, and with precipitation for PHYC. Similar associations characterized the growth-promoting cytokinin response regulator ARR1, and the wood development genes KAK and MED5A.
Notes
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PubMed ID
28481341 View in PubMed
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The grand multipara--still an obstetrical challenge?

https://arctichealth.org/en/permalink/ahliterature59891
Source
Arch Gynecol Obstet. 1990;247(4):187-95
Publication Type
Article
Date
1990
Author
P. Sipilä
L. von Wendt
A L Hartikainen-Sorri
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Arch Gynecol Obstet. 1990;247(4):187-95
Date
1990
Language
English
Publication Type
Article
Keywords
Abnormalities - epidemiology
Cohort Studies
Cross-Sectional Studies
Female
Fetal Growth Retardation - epidemiology
Finland - epidemiology
Humans
Incidence
Infant, Newborn
Obstetric Labor Complications - epidemiology
Parity - physiology
Pregnancy
Pregnancy Complications - epidemiology
Prenatal Care - utilization
Research Support, Non-U.S. Gov't
Risk factors
Abstract
To study whether grand multiparity (parity of 6 or more) still carries risk, we studied two birth cohorts in northern Finland: the first comprised 12,231 births to 12,068 mothers in 1966 and the second comprised 9478 births to 9362 mothers in 1985/86. The percentage of grand multipara decreased from 7.7 to 4.0. The grand multipara made fewer antenatal visits than the others. The proportion of grand multipara referred to maternity outpatient clinics of hospitals was smaller, but the mean number of visits was higher than of lower parity women. The mean number of admissions to hospital was similar in both groups but grand multipara stayed longer in hospital, smoked less (4.3% vs. 22.7%) and had a higher incidence of essential hypertension than women of lower parity. The grand multipara had fewer caesarean sections (7.5% vs. 14.1%) and vacuum extractions (0.5% vs. 5.1%) but more inductions of labour (33.1% vs. 23.5%) than mothers of lower parity. The number of low birth weight (LBW) infants (less than 2500 grams), stillbirths and neonatal deaths (before 28 days) was significantly lower in 1985/86 than in 1966 in women of lower parity but there was no such change in grand multipara. However, the percentage of LBW infants was smaller among grand multipara than among women of lower parity in both cohorts (2.7% vs. 4.1%, NS). The stillbirth plus neonatal death rate in grand multipara was higher than in women of lower parity (1.9% vs. 0.9%, P less than 0.05) partly because of a higher incidence of major congenital anomalies.
PubMed ID
2221992 View in PubMed
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Intracavitary irradiation of endometrial cancer of large uteri using a two-phase afterloading technique.

https://arctichealth.org/en/permalink/ahliterature26045
Source
Br J Radiol. 1987 Nov;60(719):1093-7
Publication Type
Article
Date
Nov-1987
Author
A. Kauppila
P. Sipilä
A. Koivula
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Br J Radiol. 1987 Nov;60(719):1093-7
Date
Nov-1987
Language
English
Publication Type
Article
Keywords
Brachytherapy - methods
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Neoplasm Staging
Radiotherapy Dosage
Time Factors
Uterine Neoplasms - pathology - radiotherapy - surgery
Abstract
A specific intracavitary two-phase technique was developed for irradiation of endometrial cancer located in uteri with a large uterine cavity. In this technique an insertion catheter (external diameter 9 mm) was used for the introduction and precise location of the treatment catheter (external diameter 6.4 mm). During the first phase of the therapy, one lateral half of the uterine body was irradiated. Thereafter the positions of the catheters were changed by 180 degrees, followed by irradiation of the other lateral half of the uterine body. Using a wax phantom and extirpated uteri as models, we observed that the dose distributions followed the uterine shape and the calculated doses in the radiographs. Clinical observations from 34 patients treated so far, and followed-up for periods of 3 months to 6 years, prove that this method yields similar results to those observed in previous studies employing the Heyman packing method or afterloading techniques with a one-source tandem in the intracavitary irradiation of endometrial cancer.
PubMed ID
3690150 View in PubMed
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Intracavitary irradiation of endometrial carcinoma using a high-intensity 60Co afterloading method.

https://arctichealth.org/en/permalink/ahliterature25623
Source
Acta Oncol. 1989;28(4):601-5
Publication Type
Article
Date
1989
Author
P. Sipilä
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynaecology, Oulu University Central Hospital, Finland.
Source
Acta Oncol. 1989;28(4):601-5
Date
1989
Language
English
Publication Type
Article
Keywords
Aged
Brachytherapy - methods
Cobalt Radioisotopes - administration & dosage - therapeutic use
Female
Humans
Neoplasm Staging
Pelvis - radiation effects
Survival Rate
Uterine Neoplasms - mortality - radiotherapy
Abstract
Intracavitary irradiation of endometrial carcinoma with an afterloading technique, employing Cathetron equipment, was used preoperatively and in patients with inoperable disease as a single therapy or together with external pelvic irradiation. In clinical stages I and II, the survival rates of patients treated preoperatively with afterloading techniques and with the manual Heyman method were quite similar, and the radiation induced complications were less frequent with the afterloading technique. In cases with a large uterine cavity, the one-source tandem method was replaced with a specific two-phase intracavitary irradiation technique. In this method the treatment catheter was positioned against one lateral uterine wall in the first phase, and against the opposite lateral uterine wall in the second phase of irradiation. In experimental studies the shape of the dose distribution curves resembled the uterine shape, and the measured doses were quite similar to those calculated from the radiograms. The treatment results of 32 patients irradiated by this method confirmed its clinical usefulness. Our results show that the afterloading technique is a practical alternative to the manual packing method in the preoperative irradiation of endometrial cancer. With specific instrument modifications the new technique is also useful in cases with a large uterine cavity, whereas the details in the treatment strategies using remote intracavitary irradiation alone or in combination with external radiotherapy need further development.
PubMed ID
2789840 View in PubMed
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Occurrences of antibodies against Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion and serum during the course of acute otitis media.

https://arctichealth.org/en/permalink/ahliterature37335
Source
Acta Otolaryngol. 1991;111(1):112-9
Publication Type
Article
Date
1991
Author
H. Karjalainen
M. Koskela
J. Luotonen
E. Herva
P. Sipilä
Author Affiliation
Department of Otolaryngology, University of Oulu, Finland.
Source
Acta Otolaryngol. 1991;111(1):112-9
Date
1991
Language
English
Publication Type
Article
Keywords
Acute Disease
Antibodies, Bacterial - analysis
Antibody Specificity - immunology
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Haemophilus Infections - immunology
Haemophilus influenzae - immunology
Humans
Male
Moraxella (Branhamella) catarrhalis - immunology
Otitis Media with Effusion - immunology - microbiology
Pneumococcal Infections - immunology
Research Support, Non-U.S. Gov't
Streptococcus pneumoniae - immunology
Time Factors
Abstract
The occurrence of IgG, IgM and IgA class antibodies against a type-specific capsular polysaccharide of Streptococcus pneumoniae (Pn) and against a whole cell antigen of Haemophilus influenzae (Hi) and Branhamella catarrhalis (Br) was studied using the ELISA method on middle ear effusion (MEE) samples of 85 patients and paired serum samples of 40 patients during the course of acute otitis media (AOM). Although specific antibodies to all of these three bacteria appeared in MEE during the course of an AOM episode, antibodies against the infecting bacteria of that particular AOM episode were more often prominent. The antibodies were also detectable in the MEE without simultaneous presence in the serum. The middle ear infection was prolonged more often if specific antibodies to the infecting bacterium could not be detected in the MEE obtained at the beginning of the AOM attack. The present study indicates that AOM caused by Pn, Hi or Br may induce both a systemic and a local production of specific antibodies against the causative organisms during the course of otitis media. The occurrence of such antibodies in MEE seems to play a major role in the resolution of AOM.
PubMed ID
1901685 View in PubMed
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15 records – page 1 of 2.