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13 records – page 1 of 2.

Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in experimental hypertension.

https://arctichealth.org/en/permalink/ahliterature54511
Source
Endocrinology. 1997 Jun;138(6):2636-9
Publication Type
Article
Date
Jun-1997
Author
H. Romppanen
M. Marttila
J. Magga
O. Vuolteenaho
P. Kinnunen
I. Szokodi
H. Ruskoaho
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Endocrinology. 1997 Jun;138(6):2636-9
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Animals
Argipressin - pharmacology
Atrial Natriuretic Factor - biosynthesis
Blood Pressure - drug effects
Heart - physiology - physiopathology
Heart Failure, Congestive - metabolism
Heart Ventricles
Humans
Hypertension - metabolism - physiopathology
Male
Myocardium - metabolism
Natriuretic Peptide, Brain
Peptide Biosynthesis
Peptides
RNA, Messenger - biosynthesis
Rats
Rats, Inbred Strains
Rats, Sprague-Dawley
Research Support, Non-U.S. Gov't
Time Factors
Transcription, Genetic - drug effects
Abstract
The levels of adrenomedullin (ADM), a newly discovered vasodilating and natriuretic peptide, are elevated in plasma and ventricular myocardium in human congestive heart failure suggesting that cardiac synthesis may contribute to the plasma concentrations of ADM. To examine the time course of induction and mechanisms regulating cardiac ADM gene expression, we determined the effect of acute and short-term cardiac overload on ventricular ADM mRNA and immunoreactive ADM (ir-ADM) levels in conscious rats. Acute pressure overload was produced by infusion of arginine8-vasopressin (AVP, 0.05 microg/kg/min, i.v.) for 2 h into 12-week-old hypertensive TGR(mREN-2)27 rats and normotensive Sprague-Dawley (SD) rats. Hypertension and marked left ventricular hypertrophy were associated with 2.2-times higher ir-ADM levels in the left ventricular epicardial layer (178 +/- 36 vs. 81 +/- 23 fmol/g, P
PubMed ID
9165059 View in PubMed
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Arthroscopy in the diagnostics and treatment of non-acute knee disorders in children.

https://arctichealth.org/en/permalink/ahliterature14308
Source
Eur J Pediatr Surg. 1996 Feb;6(1):25-8
Publication Type
Article
Date
Feb-1996
Author
V. Vähäsarja
P. Kinnunen
W. Serlo
Author Affiliation
Department of Paediatrics, University of Oulu, Finland.
Source
Eur J Pediatr Surg. 1996 Feb;6(1):25-8
Date
Feb-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Anesthesia
Arthroscopy
Child
Chronic Disease
Comparative Study
Evaluation Studies
Female
Humans
Joint Diseases - diagnosis - surgery
Knee Joint - radiography - surgery
Male
Research Support, Non-U.S. Gov't
Abstract
199 arthroscopies were performed on children with non-acute knee problems during 1985-1992 at the University Hospital of Oulu (76 boys and 123 girls). The mean age was 13 (2-15) years. The ratio between boys and girls was 1:1.6 showing the incidence among girls to be greater. The mean duration of symptoms was 16 (0.3-96) months before the arthroscopy. Major diagnostic groups were plica syndrome (43 cases), malalignment of the patella (29 cases), osteochondritis dissecans (28 cases) and arthritis of the knee (28 cases). The accuracy of clinical diagnosis was 47% in preadolescents and 51% in adolescents. Operations were performed arthroscopically in 71 cases, by open arthrotomy in 15 and by other extra-articular operations in 39. These children were followed until no further treatment was needed. The mean follow-up time was 4 years and 6 months (20-97 months). A total of 172 (87%) patients needed no further treatment, while 27 (13%) children were rearthroscopied and a reoperation was performed on 15 of these.
PubMed ID
8721174 View in PubMed
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Effect of phorbol ester on the release of atrial natriuretic peptide from the hypertrophied rat myocardium.

https://arctichealth.org/en/permalink/ahliterature55275
Source
Br J Pharmacol. 1991 Feb;102(2):453-61
Publication Type
Article
Date
Feb-1991
Author
P. Kinnunen
T. Taskinen
M. Järvinen
H. Ruskoaho
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Pharmacol. 1991 Feb;102(2):453-61
Date
Feb-1991
Language
English
Publication Type
Article
Keywords
Animals
Atrial Natriuretic Factor - genetics - secretion
Cardiomegaly - genetics - physiopathology
Gene Expression
Heart - drug effects - physiology
Hemodynamic Processes - drug effects
In Vitro
Male
Perfusion
RNA, Messenger - genetics - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Research Support, Non-U.S. Gov't
Tetradecanoylphorbol Acetate - pharmacology
Abstract
1. To determine the cellular mechanisms of atrial natriuretic peptide (ANP) release from ventricular cardiomyocytes, the secretory and the cardiac effects of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate protein kinase C activity in heart cells, were studied in isolated, perfused heart preparations from 2- and 21-month-old Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. TPA was added to the perfusion fluid for 30 min at a concentration of 46 nM after removal of atrial tissue. Additionally, atrial and ventricular levels of immunoreactive ANP (IR-ANP) and ANP mRNA, the distribution of ANP within ventricles as well as the relative contribution of atria and ventricles in the release of ANP were studied. 2. Ventricular hypertrophy that gradually developed in hypertensive rats resulted in remarkable augmentation of ANP gene expression, as reflected by elevated levels of immunoreactive ANP and ANP mRNA. The total amount of IR-ANP in the ventricles of the SHR rats increased 41 fold and ANP mRNA levels 12.9 fold from the age of 2 to 21 months. At the age of 21 months, levels of IR-ANP and ANP mRNA in the ventricles of SHR rats were 5.4 fold and 3.7 fold higher, respectively, than in the normotensive WKY rats. Immunohistochemical studies demonstrated ANP granules within the hypertrophic ventricles of the old SHR rats, but not within normal ventricular tissue. 3. In isolated perfused heart preparations, the severely hypertrophied ventricular tissue of SHR rats after atrialectomy secreted more ANP into the perfusate than did the control hearts.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1826618 View in PubMed
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Lateral release and proximal realignment for patellofemoral malalignment. A prospective study of 40 knees in 36 adolescents followed for 1-8 years.

https://arctichealth.org/en/permalink/ahliterature33887
Source
Acta Orthop Scand. 1998 Apr;69(2):159-62
Publication Type
Article
Date
Apr-1998
Author
V. Vähäsarja
P. Kinnunen
W. Serlo
Author Affiliation
Department of Paediatric Orthopaedics, Oulu University Central Hospital, Finland.
Source
Acta Orthop Scand. 1998 Apr;69(2):159-62
Date
Apr-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Female
Humans
Joint Deformities, Acquired - surgery
Knee Joint
Ligaments, Articular - surgery
Male
Retrospective Studies
Treatment Outcome
Abstract
We performed lateral release and proximal realignment for painful patellofemoral malalignment in 36 adolescents (40 knees), with a mean age of 14 (9-16) years. The mean follow-up was 4 (1-8) years. The subjective outcome was excellent in 20 knees, good in 13, fair in 5, and poor in 2. The mean radiographic correction of the lateral patellar shift was 75%, and of the tilting angle of the patellar 27%. There was a positive association between the realignment effect and the subjective outcome.
PubMed ID
9602774 View in PubMed
Less detail
Source
Duodecim. 1992;108(18):1613-21
Publication Type
Article
Date
1992
Author
P. Kinnunen
Author Affiliation
OYKS:n lastentautien klinikka, Oulu.
Source
Duodecim. 1992;108(18):1613-21
Date
1992
Language
Finnish
Publication Type
Article
Keywords
Bone Lengthening - methods
Child
External Fixators
Humans
Leg Length Inequality - surgery
Postoperative Complications - etiology
PubMed ID
1366187 View in PubMed
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Multilocular cystic nephroma simulating Wilms' tumour.

https://arctichealth.org/en/permalink/ahliterature26072
Source
Rofo. 1987 Oct;147(4):463-5
Publication Type
Article
Date
Oct-1987
Author
P. Lanning
M. Lanning
E. Heikkinen
P. Kinnunen
Author Affiliation
Department of Diagnostic Radiology, University of Oulu, Finland.
Source
Rofo. 1987 Oct;147(4):463-5
Date
Oct-1987
Language
English
Publication Type
Article
Keywords
Diagnosis, Differential
Humans
Infant
Kidney Neoplasms - diagnosis - radiography
Male
Ultrasonography
Wilms Tumor - diagnosis - radiography
PubMed ID
2825277 View in PubMed
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Operative realignment of patellar malalignment in children.

https://arctichealth.org/en/permalink/ahliterature35313
Source
J Pediatr Orthop. 1995 May-Jun;15(3):281-5
Publication Type
Article
Author
V. Vähäsarja
P. Kinnunen
P. Lanning
W. Serlo
Author Affiliation
Department of Paediatric Surgery, University of Oulu, Finland.
Source
J Pediatr Orthop. 1995 May-Jun;15(3):281-5
Language
English
Publication Type
Article
Keywords
Adolescent
Bone Malalignment - radiography - surgery
Child
Dislocations - surgery
Female
Follow-Up Studies
Humans
Joint Instability - radiography - surgery
Male
Patella - radiography - surgery
Reoperation
Abstract
Realignment operations were performed on 57 knees to correct patellar malalignment in children between 1985 and 1991. Three different operative techniques were used: the lateral release, the lateral release and medial reefment, and the Roux-Goldthwait patellar tendon transposition. Roentgenographic values were measured before and after the operation by Laurin's method. The mean follow-up time was 4 years 2 months, after which 20 knees were excellent, 20 good, 11 fair, and six poor, according to Insall's criteria. The effect of the operation on pathological roentgenographic values was obvious, and the malalignment of the patella was in most cases corrected. There are differences in the improvement effected by these three techniques. The lateral release and medial reefment correct the patellar tilt most effectively, and the Roux-Goldthwait operation, the lateral patellar deviation. The lateral release seems to be the appropriate technique for mild malalignment.
Notes
Comment In: J Pediatr Orthop. 1995 May-Jun;15(3):279-807790477
PubMed ID
7790478 View in PubMed
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Passive mechanical stretch releases atrial natriuretic peptide from rat ventricular myocardium.

https://arctichealth.org/en/permalink/ahliterature55134
Source
Circ Res. 1992 Jun;70(6):1244-53
Publication Type
Article
Date
Jun-1992
Author
P. Kinnunen
O. Vuolteenaho
P. Uusimaa
H. Ruskoaho
Author Affiliation
Department of Pharmacology, University of Oulu, Finland.
Source
Circ Res. 1992 Jun;70(6):1244-53
Date
Jun-1992
Language
English
Publication Type
Article
Keywords
Animals
Atrial Natriuretic Factor - analysis - secretion
Cardiomegaly - physiopathology
Chromatography, High Pressure Liquid
Comparative Study
Heart Ventricles - secretion
Hemodynamic Processes
In Vitro
L-Lactate Dehydrogenase - analysis
Male
Perfusion
RNA, Messenger - analysis
Radioimmunoassay
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Research Support, Non-U.S. Gov't
Abstract
Ventricular hypertrophy is characterized by augmentation of synthesis, storage, and release of atrial natriuretic peptide (ANP) from ventricular tissue, but the physiological stimulus for ANP release from ventricles is not known. We determined the effect of graded, passive myocardial stretch on ANP release in isolated, arrested, perfused heart preparations after removal of the atria in 13-20-month-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). By this age, ANP gene expression was increased in the hypertrophic ventricular cells of SHR, as reflected by elevated levels of immunoreactive ANP and ANP mRNA and the increased ANP secretion (SHR, 93 +/- 14 pg/ml, n = 22; WKY rats, 22 +/- 2 pg/ml, n = 20; p less than 0.001) from perfused ventricles after removal of the atria. The release of ANP from ventricles was examined at two levels of left ventricular pressure by increasing the volume of the intraventricular balloon for 10 minutes. Stretching of the ventricles produced a rapid but transient increase in ANP secretion. As left ventricular pressure rose from 0 to 14 and 26 mm Hg in WKY rats and from 0 to 13 and 27 mm Hg in SHR, increases in ANP release into the perfusate of 1.4 +/- 0.1-fold and 1.5 +/- 0.2-fold (p less than 0.05) in WKY rats and 1.1 +/- 0.1-fold and 1.6 +/- 0.2-fold (p less than 0.05) in SHR, respectively, were observed. There was a highly significant correlation between the left ventricular pressure level and the maximal concentration of ANP in the perfusate during stretching (p less than 0.001, r = 0.59, n = 42), as well as between the maximal ANP concentrations in perfusate during stretching and the ventricular weight/body weight ratios of the corresponding animals (r = 0.38, p less than 0.05, n = 42). High performance liquid chromatographic analysis revealed that the ventricles both before and during stretch primarily released the processed, active, 28-amino acid ANP-like peptide into the perfusate. These results indicate that stretching is a direct stimulus for ventricular ANP release and show that ANP is also a ventricular hormone.
PubMed ID
1533577 View in PubMed
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Regulation of ventricular atrial natriuretic peptide release in hypertrophied rat myocardium. Effects of exercise.

https://arctichealth.org/en/permalink/ahliterature50335
Source
Circulation. 1989 Aug;80(2):390-400
Publication Type
Article
Date
Aug-1989
Author
H. Ruskoaho
P. Kinnunen
T. Taskinen
O. Vuolteenaho
J. Leppäluoto
T E Takala
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Circulation. 1989 Aug;80(2):390-400
Date
Aug-1989
Language
English
Publication Type
Article
Keywords
Animals
Atrial Natriuretic Factor - metabolism
Cardiomegaly - metabolism
Catecholamines - blood
Exertion
Heart Ventricles
Hypertension - metabolism
Lactates - blood
Lactic Acid
Male
Myocardium - metabolism
RNA, Messenger - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Research Support, Non-U.S. Gov't
Swimming
Abstract
Left ventricular hypertrophy is characterized by stimulation of ventricular synthesis of atrial natriuretic peptide (ANP). This study was designed to test the hypothesis that the increased ventricular ANP levels participate in the release of ANP into the circulation. Swimming was used as a physiologic model to induce ANP release from the heart, and atrial and ventricular levels of immunoreactive ANP (IR-ANP) and ANP messenger RNA (mRNA) were measured simultaneously in the spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats at rest and after swimming. IR-ANP concentration in the left ventricle of 1-year-old SHR with severe left ventricular hypertrophy was increased in association with the augmentation of ANP mRNA levels, whereas right ventricular levels of ANP were reduced in SHR compared with normotensive controls. A 30-minute exercise in hypertensive and in normotensive rats resulted in marked increases in mean arterial pressure, heart rate, plasma catecholamine levels, blood lactate levels, and plasma IR-ANP concentration. The increased ANP secretion was associated with a decrease in left (34-39%) and right (24%) ventricular concentration of IR-ANP; transmurally, this depletion of ventricular IR-ANP was greatest (28%) in the endocardial layer of the left ventricle of SHR. No significant differences were noted in total atrial and left or right auricular IR-ANP concentration between SHR and WKY rats or between the resting and swimming rats. When studied in vitro with an isolated, perfused heart preparation, the hypertrophic ventricular tissue after atrialectomy secreted more ANP into the perfusate than did control hearts; in SHR, ventricles contributed 28% of the total ANP release to perfusate, and in normotensive control rats, ventricles contributed 8%. These studies show that stimulated release of ANP is associated with depletion of endocardial left ventricular stores. The amount of ANP released in vitro and in vivo correlated with the degree of hypertrophy of the ventricle. Finally, the phorbol ester, known to increase ANP secretion from intact perfused hearts, had only a limited effect on ANP release after atrialectomy, suggesting that the secretion of ANP from ventricular cells may be mainly of the constitutive type.
PubMed ID
2526698 View in PubMed
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Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy.

https://arctichealth.org/en/permalink/ahliterature12198
Source
Br J Pharmacol. 1990 Apr;99(4):701-8
Publication Type
Article
Date
Apr-1990
Author
P. Kinnunen
T. Taskinen
J. Leppäluoto
H. Ruskoaho
Author Affiliation
Department of Pharmacology, University of Oulu, Finland.
Source
Br J Pharmacol. 1990 Apr;99(4):701-8
Date
Apr-1990
Language
English
Publication Type
Article
Keywords
Animals
Atrial Natriuretic Factor - blood - genetics - metabolism
Body Weight - drug effects
Cardiomegaly - chemically induced - metabolism
Hemodynamic Processes - drug effects
In Vitro
Kidney - drug effects
Male
Minoxidil
Myocardium - metabolism
Norepinephrine - blood
Organ Size - drug effects
Osmolar Concentration
RNA, Messenger - analysis
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Research Support, Non-U.S. Gov't
Sodium - blood
Abstract
1. Ventricular hypertrophy is characterized by stimulation of ventricular synthesis of atrial natriuretic peptide (ANP). To examine the role of ventricular ANP levels in the secretion of ANP into the circulation, atrial and ventricular levels of immunoreactive-ANP (IR-ANP) as well as ANP messenger RNA (mRNA), and the release of IR-ANP from isolated perfused hearts, both before and after atrialectomy, were measured simultaneously in control and minoxidil-treated Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. 2. IR-ANP levels in the ventricles of untreated, 12 month-old SHR with severe ventricular hypertrophy were increased when compared to age-matched WKY rats. Minoxidil treatment for 8 weeks in both strains resulted in a decrease in mean arterial pressure and increases in ventricular weight to body weight ratios, plasma IR-ANP concentrations (in WKY from 133 +/- 20 to 281 +/- 34 pg ml-1, P less than 0.01; in SHR from 184 +/- 38 to 339 +/- 61 pg ml-1, P less than 0.05), and in ventricular IR-ANP contents (in WKY: 53%; in SHR: 41%). A highly significant correlation was found between ventricular IR-ANP content and ventricular weight to body weight ratio (r = 0.59, P less than 0.001, n = 26). 3. When studied in vitro, in isolated perfused heart preparations, the hypertrophied ventricular tissue after atrialectomy secreted more ANP into the perfusate than ventricles of the control hearts; ventricles contributed 28%, 22%, 18% and 15% of the total ANP release to perfusate in the minoxidil-treated SHR, control SHR, minoxidil-treated WKY and control WKY, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
2141796 View in PubMed
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13 records – page 1 of 2.