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Aclarubicin plus cytosine arabinoside versus daunorubicin plus cytosine arabinoside in previously untreated patients with acute myeloid leukemia: a Danish national phase III trial. The Danish Society of Hematology Study Group on AML, Denmark.

https://arctichealth.org/en/permalink/ahliterature24824
Source
Leukemia. 1991 Jun;5(6):510-6
Publication Type
Article
Date
Jun-1991
Author
O P Hansen
J. Pedersen-Bjergaard
J. Ellegaard
H. Brincker
A M Boesen
B E Christensen
A. Drivsholm
E. Hippe
H. Jans
K B Jensen
Author Affiliation
Finsen Institute-Rigshospitalet, Department of Hematology L, Copenhagen, Denmark.
Source
Leukemia. 1991 Jun;5(6):510-6
Date
Jun-1991
Language
English
Publication Type
Article
Keywords
Aclarubicin - administration & dosage
Adolescent
Adult
Aged
Amsacrine - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chi-Square Distribution
Comparative Study
Cytarabine - administration & dosage
Daunorubicin - administration & dosage
Denmark
Drug Administration Schedule
Etoposide - administration & dosage
Humans
Leukemia, Myelocytic, Acute - drug therapy - mortality
Middle Aged
Regression Analysis
Remission Induction
Survival Rate
Abstract
A regimen of aclarubicin (ACR) of 75 mg/m2 daily for 3 days plus a continuous intravenous infusion of cytosine arabinoside (ara-C) of 100 mg/m2 per day for 7 days was compared with daunorubicin (DNR) 45 mg/m2/day for 3 days plus ara-C for 7 days as first-line chemotherapy of de novo acute myeloid leukemia (AML) in a randomized, nationwide Danish study. A total of 180 patients aged between 17 and 65 years were entered onto the protocol. Patients who achieved complete remission (CR) were given five courses of intensive consolidation therapy consisting of two courses of high dose ara-C, two courses of amsacrine plus etoposide, and one course of DNR plus ara-C. Of 174 evaluable patients, 99 achieved CR. The rate of CR was significantly higher on ACR plus ara-C than on DNR plus ara-C [66% versus 50% (p = 0.043)] and decreased significantly with increasing age. The hematological toxicity was identical for the two regimens. A total of 83 patients entered consolidation therapy. At 4 years, 37% of patients with CR following ACR were still in remission compared with 33% following DNR (p = 0.48), and the total survival at 4 years was 29% versus 20% (p = 0.26). The duration of remission and total survival both decreased with increasing age. ACR plus ara-C seem at least as good or better than DNR plus ara-C as first-line chemotherapy of AML.
PubMed ID
2056774 View in PubMed
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Source
Ugeskr Laeger. 1991 Nov 4;153(45):3157-8
Publication Type
Article
Date
Nov-4-1991
Author
O P Hansen
Source
Ugeskr Laeger. 1991 Nov 4;153(45):3157-8
Date
Nov-4-1991
Language
Danish
Publication Type
Article
Keywords
Denmark
Female
Humans
Mammography - economics - statistics & numerical data
Mass Screening - economics - statistics & numerical data
Notes
Comment On: Ugeskr Laeger. 1991 Jul 15;153(29):2074-51858195
PubMed ID
1957366 View in PubMed
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[Treatment of primary breast cancer. Consequences of mammographic screening in the municipality of Copenhagen]

https://arctichealth.org/en/permalink/ahliterature22754
Source
Ugeskr Laeger. 1996 Feb 26;158(9):1218-21
Publication Type
Article
Date
Feb-26-1996
Author
F R Hirsch
H T Mouridsen
O P Hansen
T. Jørgensen
M. Blichert-Toft
F E Rank
M B Jensen
Author Affiliation
Danish Breast Cancer Cooperative Group (DBCCG), Rigshospitalet, København.
Source
Ugeskr Laeger. 1996 Feb 26;158(9):1218-21
Date
Feb-26-1996
Language
Danish
Publication Type
Article
Keywords
Aged
Breast Neoplasms - epidemiology - pathology - surgery
Denmark - epidemiology
English Abstract
Female
Humans
Incidence
Mammography
Mass Screening
Mastectomy - methods
Middle Aged
Prognosis
Retrospective Studies
Abstract
In order to analyse changes in the pattern of primary treatment of breast cancer after introduction of mammography screening in the Copenhagen municipal area every second year, retrospective analyses of data from the Danish Breast Cancer Cooperative Group were performed. Newly diagnosed patients with breast cancer of the age of 50-69 years from the Copenhagen municipal area (1040 patients) were compared to a similar group of patients from the rest of Denmark (7353 patients). Parameters such as tumour size, lymph node status, grade of anaplasia, frequency of breast preserving surgery and adjuvant treatment were analysed. Introduction of mammography screening resulted in almost a doubling of newly diagnosed patients with invasive breast cancer during the prevalence phase, and a significant increase in the number of patients with tumour size
Notes
Comment In: Ugeskr Laeger. 1996 Feb 26;158(9):1212-78644425
PubMed ID
8644426 View in PubMed
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[Vitamin B 12 and folic acid concentrations in the blood of patients in a long-term care medical department in Cophenhagen].

https://arctichealth.org/en/permalink/ahliterature248359
Source
Ugeskr Laeger. 1978 Aug 21;140(34):2034-7
Publication Type
Article
Date
Aug-21-1978