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A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus.

https://arctichealth.org/en/permalink/ahliterature84765
Source
Tissue Antigens. 2007 Nov;70(5):412-4
Publication Type
Article
Date
Nov-2007
Author
Linga-Reddy M V Prasad
Gunnarsson I.
Svenungsson E.
Sturfelt G.
Jönsen A.
Truedsson L.
Nordmark G.
Rönnblom L.
Alarcón-Riquelme M E
Author Affiliation
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Source
Tissue Antigens. 2007 Nov;70(5):412-4
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Alleles
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Histocompatibility Antigens Class II
Humans
Lupus Erythematosus, Systemic - genetics
Male
Multiple Sclerosis - genetics
Myocardial Infarction - genetics
Nuclear Proteins - genetics
Polymorphism, Single Nucleotide
Sweden
Trans-Activators - genetics
Abstract
Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.
PubMed ID
17711409 View in PubMed
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