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A 10-year follow-up study of penicillin-non-susceptible S. pneumoniae during an intervention programme in Malmö, Sweden.

https://arctichealth.org/en/permalink/ahliterature80473
Source
Scand J Infect Dis. 2006;38(10):838-44
Publication Type
Article
Date
2006
Author
Nilsson Percy
Laurell Martin H
Author Affiliation
Department of Pediatrics, Malmö University Hospital, Lund University, Malmö, Sweden. percy.nilsson@pediatrik.mas.lu.se
Source
Scand J Infect Dis. 2006;38(10):838-44
Date
2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Child
Child, Preschool
Drug Utilization
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Middle Aged
Penicillin resistance
Physician's Practice Patterns
Pneumococcal Infections - drug therapy - epidemiology - microbiology
Practice Guidelines
Streptococcus pneumoniae - drug effects
Sweden - epidemiology
Abstract
Changes in the proportion of penicillin-non-susceptible Streptococcus pneumoniae (PNSP) isolates during an intervention programme were evaluated by phenotypic analysis of all initial isolates with penicillin MIC > or =0.5 microg/ml (n=1248) collected 1995-2004. During the study period, the proportion of such isolates was fairly constant (12-19%), and there was no statistically significant variation in the proportion of total PNSP cases (MIC > or =0.12 microg/ml) or PNSP with MIC > or =0.5 microg/ml, with the exception of an increase in 2004. Analysis restricted to clinical cases revealed no statistically significant changes. 23 different serogroups were found, and serogroup 9 isolates accounted for almost half of the PNSP cases. Only minor changes in phenotypic characteristics occurred in the other serogroups, which indicates that the increase in PNSP in 2004 was not due to import of a new resistant clone. Antibiotic consumption is considered to be an important risk factor for penicillin resistance in S. pneumoniae. After initiation of the intervention programme in Malmö, overall prescribing of antibiotics decreased 28%, and the reduction was even greater among children (52%). In conclusion, the proportion of PNSP isolates in Malmö has remained stable, despite the intervention programme and decreased consumption of antibiotics.
PubMed ID
17008226 View in PubMed
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Children exposed to environmental smoking have a higher antibiotic consumption.

https://arctichealth.org/en/permalink/ahliterature80150
Source
Vaccine. 2007 Mar 22;25(13):2533-5
Publication Type
Article
Date
Mar-22-2007
Author
Nilsson Percy
Köhler Marie
Ostergren Per-Olof
Khan Farhad Ali
Author Affiliation
Department of Pediatrics, Malmö University Hospital, Lund University, SE-205 02 Malmö, Sweden. percy.nilsson@med.lu.se
Source
Vaccine. 2007 Mar 22;25(13):2533-5
Date
Mar-22-2007
Language
English
Publication Type
Article
Abstract
In order to investigate what factors influence antibiotic prescribing, a questionnaire answered by 8700 parents to 4-year-old children in Malmö between 1999 and 2004 was analyzed. 51.3% of the 4-year-old children had been treated with antibiotics. Exposure to environmental smoking, attending day care centers, employment of parents and parents born in Sweden was found to be statistically significant risk factor for antibiotic prescribing. The association between environmental smoking and antibiotic treatment found in this study could be used in information campaigns which might not only lead to a decreased antibiotic prescribing among the children, but also future positive health effects for their parents.
PubMed ID
17052821 View in PubMed
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