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Alaska sentinel surveillance for antimicrobial resistance in Helicobacter pylori isolates from Alaska native persons, 1999-2003.

https://arctichealth.org/en/permalink/ahliterature83379
Source
Helicobacter. 2006 Dec;11(6):581-8
Publication Type
Article
Date
Dec-2006
Author
Bruce Michael G
Bruden Dana L
McMahon Brian J
Hennessy Thomas W
Reasonover Alisa
Morris Julie
Hurlburt Debby A
Peters Helen
Sacco Frank
Martinez Patrick
Swenson Michael
Berg Douglas E
Parks Debra
Parkinson Alan J
Author Affiliation
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK 99508, USA. zwa8@cdc.gov
Source
Helicobacter. 2006 Dec;11(6):581-8
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alaska - epidemiology
Amoxicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Biopsy
Clarithromycin - pharmacology
Drug Resistance, Multiple, Bacterial
Female
Helicobacter Infections - epidemiology - microbiology - pathology
Helicobacter pylori - drug effects
Humans
Male
Metronidazole - pharmacology
Microbial Sensitivity Tests
Middle Aged
Population Groups
Sentinel Surveillance
Stomach - microbiology - pathology
Tetracycline - pharmacology
Abstract
BACKGROUND: Previous studies in Alaska have demonstrated elevated proportions of antimicrobial resistance among Helicobacter pylori isolates. MATERIALS AND METHODS: We analyzed H. pylori data from the Centers for Disease Control and Prevention (CDC)'s sentinel surveillance in Alaska from July 1999 to June 2003 to determine the proportion of culture-positive biopsies from Alaska Native persons undergoing routine upper-endoscopy, and the susceptibility of H. pylori isolates to metronidazole [minimum inhibitory concentration (MIC) of > 8 g metronidazole/mL), clarithromycin (MIC > or = 1), tetracycline (MIC > or = 2) and amoxicillin (MIC > or = 1)] using agar dilution. RESULTS: Nine-hundred sixty-four biopsy specimens were obtained from 687 participants; 352 (51%) patients tested culture positive. Mean age of both culture-positive and culture-negative patients was 51 years. Metronidazole resistance was demonstrated in isolates from 155 (44%) persons, clarithromycin resistance from 108 (31%) persons, amoxicillin resistance from 8 (2%) persons, and 0 for tetracycline resistance. Metronidazole and clarithromycin resistance varied by geographic region. Female patients were more likely than male subjects to show metronidazole resistance (p
PubMed ID
17083381 View in PubMed
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