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Cell surface glycan-lectin interactions in tumor metastasis.

https://arctichealth.org/en/permalink/ahliterature101066
Source
Acta Histochem. 2011 Oct;113(6):591-600
Publication Type
Article
Date
Oct-2011
Author
Neela D S Rambaruth
Miriam V Dwek
Author Affiliation
Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish St., London W1W 6UW, United Kingdom.
Source
Acta Histochem. 2011 Oct;113(6):591-600
Date
Oct-2011
Language
English
Publication Type
Article
Abstract
The development of secondary cancers, metastases, requires that a multitude of events are completed in an ordered and sequential manner. This review focuses on the role of cell surface glycans and their binding partners in the metastatic process. A common feature of metastasis is that the steps require adhesive interactions; many of these are mediated by cell surface glycans and their interactions with endogenous carbohydrate binding proteins (lectins). Aberrant glycosylation is a key feature of malignant transformation and the glycans involved influence the adhesive interactions of cancer cells often providing favorable conditions for tumor dissemination. This review focuses on glycans on the cancer cell surface and their association with endogenous lectins. In particular, E-cadherin and siglec-mediated disaggregation of tumor cells from the primary tumor mass; integrins, laminin and CD44-mediated invasion and migration of tumor cells through the connective tissue; the involvement of heparan sulphate in tumor angiogenesis and C-/S-type lectin interactions with the vasculature. The potential role of glycans in cancer cell evasion of immune surveillance is considered.
PubMed ID
21501858 View in PubMed
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