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Antimicrobial resistance among Helicobacter pylori isolates in Alaska, 2000-2016.

https://arctichealth.org/en/permalink/ahliterature292657
Source
J Glob Antimicrob Resist. 2018 Jun 30; :
Publication Type
Journal Article
Date
Jun-30-2018
Author
Emily Mosites
Dana Bruden
Julie Morris
Alisa Reasonover
Karen Rudolph
Debra Hurlburt
Thomas Hennessy
Brian McMahon
Michael Bruce
Author Affiliation
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Centre Dr, Anchorage, Alaska 99508. Electronic address: lwx7@cdc.gov.
Source
J Glob Antimicrob Resist. 2018 Jun 30; :
Date
Jun-30-2018
Language
English
Publication Type
Journal Article
Abstract
Alaska Native people experience a high burden of Helicobacter pylori infection and concomitant high rates of gastric cancer. Additionally, the prevalence of antimicrobial resistant strains of H. pylori has been shown to be high in Alaska. We evaluated antimicrobial resistance over time among sentinel surveillance isolates and assessed risk factors for carrying resistant H. pylori.
Through Alaska's H. pylori sentinel surveillance system, we collected and cultured antral and fundal biopsies from Alaska Native patients undergoing esophagogastroduodenoscopy for clinical indications during 2000-2016. For positive cultures, we performed minimum inhibitory concentration (MIC) testing for metronidazole, amoxicillin, clarithromycin, tetracycline, and levofloxacin.
We tested 800H. pylori isolates obtained from 763 patients. Metronidazole resistance was most common (342/800; 43%), followed by clarithromycin resistance (238/800; 30%), resistance to both clarithromycin and metronidazole (128/800; 16%), and levofloxacin resistance (113/800; 15%). Low proportions of isolates were resistant to amoxicillin and tetracycline. Levofloxacin resistance increased between 2000 and 2016 (p
PubMed ID
29969753 View in PubMed
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Characterization of Helicobacter pylori cagA and vacA genotypes among Alaskans and their correlation with clinical disease.

https://arctichealth.org/en/permalink/ahliterature132984
Source
J Clin Microbiol. 2011 Sep;49(9):3114-21
Publication Type
Article
Date
Sep-2011
Author
Karen Miernyk
Julie Morris
Dana Bruden
Brian McMahon
Debby Hurlburt
Frank Sacco
Alan Parkinson
Thomas Hennessy
Michael Bruce
Author Affiliation
Arctic Investigations Program, Centers for Disease Control and Prevention, 4055 Tudor Centre Dr., Anchorage, AK 99517, USA. kmiernyk@cdc.gov
Source
J Clin Microbiol. 2011 Sep;49(9):3114-21
Date
Sep-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Alaska
Antigens, Bacterial - genetics
Bacterial Proteins - genetics
Biopsy
Esophagitis - epidemiology - microbiology
Female
Gastric Mucosa - microbiology
Genotype
Helicobacter Infections - complications - microbiology - pathology
Helicobacter pylori - genetics - isolation & purification
Humans
Male
Middle Aged
Peptic Ulcer - epidemiology - microbiology
Polymerase Chain Reaction
Virulence Factors - genetics
Young Adult
Abstract
Helicobacter pylori infection is common in Alaska. The development of severe H. pylori disease is partially determined by the virulence of the infecting strain. Here we present vacA and cagA genotype data for H. pylori strains isolated from Alaskans and their correlation with clinical disease. We enrolled patients scheduled for esophagogastroduodenoscopy and positive for H. pylori infection. Gastric biopsy specimens from the stomach antrum and fundus were cultured. We performed PCR analysis of the H. pylori vacA gene and for the presence of the cagA gene and cagA empty site. We genotyped 515 H. pylori samples from 220 Native and 66 non-Native Alaskans. We detected the cagA gene in 242/286 (85%) persons; of 222 strains that could be subtyped, 95% (212) were non-Asian cagA and 3% (6) were East Asian cagA. After removing mixed infections (n = 17), 83% of H. pylori strains had either the vacA s1m1 (120/269) or s2m2 (103/269) genotype. Sixty-six percent (68/103) of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. Infection with an H. pylori strain having the cagA gene or vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with a decreased risk of esophagitis (P = 0.003 and 0.0003, respectively). Infection with an H. pylori strain having the vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with an increased risk of peptic ulcer disease (PUD) (P = 0.003). The majority of H. pylori strains in this study carried the non-Asian cagA gene and either the vacA s1m1 or s2m2 genotype. A majority of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. There was an association of H. pylori genotype with esophagitis and PUD.
Notes
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PubMed ID
21752979 View in PubMed
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Characterizing wild bird contact and seropositivity to highly pathogenic avian influenza A (H5N1) virus in Alaskan residents.

https://arctichealth.org/en/permalink/ahliterature263027
Source
Influenza Other Respir Viruses. 2014 Sep;8(5):516-23
Publication Type
Article
Date
Sep-2014
Author
Carrie Reed
Dana Bruden
Kathy K Byrd
Vic Veguilla
Michael Bruce
Debby Hurlburt
David Wang
Crystal Holiday
Kathy Hancock
Justin R Ortiz
Joe Klejka
Jacqueline M Katz
Timothy M Uyeki
Source
Influenza Other Respir Viruses. 2014 Sep;8(5):516-23
Date
Sep-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Alaska - epidemiology
Animal Migration
Animals
Animals, Wild - physiology - virology
Antibodies, Viral - blood
Birds - physiology - virology
Child
Contact Tracing
Cross-Sectional Studies
Female
Humans
Influenza A Virus, H5N1 Subtype - immunology - physiology
Influenza in Birds - epidemiology - transmission - virology
Influenza, Human - blood - epidemiology - transmission - virology
Male
Middle Aged
Young Adult
Zoonoses - blood - epidemiology - transmission - virology
Abstract
Highly pathogenic avian influenza A (HPAI) H5N1 viruses have infected poultry and wild birds on three continents with more than 600 reported human cases (59% mortality) since 2003. Wild aquatic birds are the natural reservoir for avian influenza A viruses, and migratory birds have been documented with HPAI H5N1 virus infection. Since 2005, clade 2.2 HPAI H5N1 viruses have spread from Asia to many countries.
We conducted a cross-sectional seroepidemiological survey in Anchorage and western Alaska to identify possible behaviors associated with migratory bird exposure and measure seropositivity to HPAI H5N1.
We enrolled rural subsistence bird hunters and their families, urban sport hunters, wildlife biologists, and a comparison group without bird contact. We interviewed participants regarding their exposures to wild birds and collected blood to perform serologic testing for antibodies against a clade 2.2 HPAI H5N1 virus strain.
Hunters and wildlife biologists reported exposures to wild migratory birds that may confer risk of infection with avian influenza A viruses, although none of the 916 participants had evidence of seropositivity to HPAI H5N1.
We characterized wild bird contact among Alaskans and behaviors that may influence risk of infection with avian influenza A viruses. Such knowledge can inform surveillance and risk communication surrounding HPAI H5N1 and other influenza viruses in a population with exposure to wild birds at a crossroads of intercontinental migratory flyways.
Notes
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PubMed ID
24828535 View in PubMed
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Clinical management of chronic hepatitis B infection in Alaska Native People: outcome and effectiveness of surveillance for early detection of hepatocellular carcinoma and antiviral therapy to prevent cirrhosis

https://arctichealth.org/en/permalink/ahliterature284367
Source
Pages 700-701 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):700-701
Publication Type
Article
Date
2013
  1 document  
Author
Brian J. McMahon
Susan Negus
Mary Snowball
Chriss Homan
Lisa Bulkow
Michael Bruce
Brenna Simons
Stephen Livingston
Author Affiliation
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK, USA
Arctic Investigations Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA
Source
Pages 700-701 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):700-701
Date
2013
Language
English
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
Abstract
Alaska Native (AN) people were found to have high rates of acute and chronic hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) in the 1970s. AN children and young adults had the highest rate of HBV-related HCC ever recorded, reaching 3/100,000 in the early 1980s.
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Community water service and incidence of respiratory, skin, and gastrointestinal infections in rural Alaska, 2013-2015.

https://arctichealth.org/en/permalink/ahliterature306919
Source
Int J Hyg Environ Health. 2020 04; 225:113475
Publication Type
Journal Article
Date
04-2020
Author
Emily Mosites
Brian Lefferts
Sara Seeman
Gerald January
Jennifer Dobson
David Fuente
Michael Bruce
Timothy Thomas
Thomas Hennessy
Author Affiliation
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Zoonotic and Emerging Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA. Electronic address: lwx7@cdc.gov.
Source
Int J Hyg Environ Health. 2020 04; 225:113475
Date
04-2020
Language
English
Publication Type
Journal Article
Keywords
Adult
Alaska - epidemiology
Communicable Diseases - epidemiology
Female
Gastrointestinal Diseases - epidemiology
Humans
Incidence
Male
Respiratory Tract Diseases - epidemiology
Rural Population
Skin Diseases - epidemiology
Water supply
Young Adult
Abstract
Communities in rural Alaska have access to multiple types of water service (piped, vehicle-hauled, and self-hauled) and experience varying levels of water service coverage. We assessed the incidence rate of inpatient and outpatient infectious disease visits among communities with different water service types and coverage levels.
We classified ICD-9 codes for inpatient and outpatient visits to the Yukon-Kuskokwim Health Corporation facilities between 2013 and 2015 into six infectious disease categories. Using Poisson models, we compared the incidence of visits in each category across communities with differing water service coverage levels as defined by water service billing data for the same years. Using census data, we adjusted for community median household income, median age, crowding, and health aide staffing.
We included 48 communities in this analysis. After adjusting for possible confounders, each 10% increase in piped water coverage was associated with a 4% lower incidence of pneumonia/influenza visits (adjusted incidence rate ratio [IRR] 0.96, 95% CI 0.93-0.98), a 2% lower incidence of other respiratory infection visits (adjusted IRR 0.98, 95% CI 0.97-0.99), an 8% lower incidence of methicillin-resistant Staphylococcus visits (adjusted IRR 0.92, 95% CI 0.87-0.97), and a 4% lower incidence of other skin infections visits (adjusted IRR 0.96, 95% CI 0.95-0.98). Each 10% increase in vehicle-hauled water coverage was associated with a 2% lower incidence of respiratory infection visits (adjusted IRR 0.98, 95% CI 0.97-0.996) and a 3% lower incidence of skin infection visits (adjusted IRR 0.97, 95% CI 0.95-0.99), also after adjustment.
Higher levels of water service coverage were associated with lower incidence rates of visits for several infectious disease categories. These associations were more pronounced for communities with piped water service compared to vehicle-hauled water service.
PubMed ID
32058938 View in PubMed
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The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults

https://arctichealth.org/en/permalink/ahliterature312340
Source
Helicobacter . 2013 Jun;18(3):222-8.
Publication Type
Article
Date
2013
  1 document  
Author
Karen Miernyk
Dana Bruden
Carolyn Zanis
Brian McMahon
Frank Sacco
Thomas Hennessy
Alan Parkinson
Michael Bruce
Source
Helicobacter . 2013 Jun;18(3):222-8.
Date
2013
Language
English
Geographic Location
U.S.
Publication Type
Article
File Size
131252
Keywords
Alaska
Adult
Anemia, Iron-Deficiency
Complications
Drug Therapy
Epidemiology
Etiology
Anti-Bacterial Agents
Therapeutic use
Female
Ferritins
Blood
Helicobacter Infections
Microbiology
Helicobacter pylori
Isolation and purification
Humans
Indians, North American
Inuits
Iron
Metabolism
Male
Middle Aged
Urban Population
Abstract
Background: Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency.
Methods: Alaska Native adults undergoing esophagogastroduodenoscopy had sera collected and a (13) C urea breath test (UBT) was performed. Those H. pylori positive were treated with an antibiotic regimen; those who tested negative 2 months after treatment were evaluated at 4, 6, 12, and 24 months by UBT and serum ferritin with an immunoradiometric assay. We excluded persons from further analysis if they were prescribed iron by their provider.
Results: We measured serum ferritin for 241 persons; 121/241 were H. pylori positive. The geometric mean ferritin (GMF) for persons with and without H. pylori infection was 37 µg/L and 50 µg/L, respectively (p = .04). At enrollment, 19/121 H. pylori-positive persons had iron deficiency compared with 8/120 H. pylori negative (p = .02). Among 66 persons tested at 24 months, the GMF was higher at 24 months (49.6 µg/L) versus enrollment (36.5 µg/L; p = .02). Six of 11 persons with iron deficiency at enrollment no longer had iron deficiency and had a higher GMF (p = .02) 24 months after treatment.
Conclusions: H. pylori infection was correlated with lower serum ferritin and iron deficiency. After H. pylori eradication, serum ferritin increased and approximately half of persons resolved their iron deficiency. Testing for H. pylori infection and subsequent treatment of those positive could be considered in persons with unexplained iron deficiency.
PubMed ID
23316928 View in PubMed
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Epidemiology of pneumococcal serotype 6A and 6C among invasive and carriage isolates from Alaska, 1986-2009.

https://arctichealth.org/en/permalink/ahliterature117652
Source
Diagn Microbiol Infect Dis. 2013 Mar;75(3):271-6
Publication Type
Article
Date
Mar-2013
Author
Karen Rudolph
Michael Bruce
Dana Bruden
Tammy Zulz
Jay Wenger
Alisa Reasonover
Marcella Harker-Jones
Debby Hurlburt
Thomas Hennessy
Author Affiliation
Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK 99508, USA.
Source
Diagn Microbiol Infect Dis. 2013 Mar;75(3):271-6
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Alaska - epidemiology
Anti-Bacterial Agents - pharmacology
Carrier State - microbiology
Child
Child, Preschool
Genetic Variation
Genotype
Humans
Incidence
Microbial Sensitivity Tests
Multilocus Sequence Typing
Penicillins - pharmacology
Pneumococcal Infections - epidemiology - microbiology - prevention & control
Pneumococcal Vaccines - administration & dosage
Rural Population
Streptococcus pneumoniae - classification - drug effects - genetics - isolation & purification
Abstract
We investigated serotype 6A/6C invasive pneumococcal disease (IPD) incidence, genetic diversity, and carriage before and after 7-valent pneumococcal conjugate vaccine (PCV7) introduction in Alaska. IPD cases (1986-2009) were identified through population-based laboratory surveillance. Isolates were initially serotyped by conventional methods, and 6C isolates were differentiated from 6A by polymerase chain reaction. Among invasive and carriage isolates initially typed as 6A, 35% and 50% were identified as 6C, respectively. IPD rates caused by serotype 6A or 6C among children
PubMed ID
23276772 View in PubMed
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Factors affecting antimicrobial resistance among colonising Streptococcus pneumoniae in rural Alaska villages over 10 years

https://arctichealth.org/en/permalink/ahliterature284366
Source
Pages 702-703 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):702-703
Publication Type
Article
Date
2013
  1 document  
Author
Christina Hedlund
Dana Bruden
Michael Bruce
Debby Hurlburt
Karen Rudolph
Alan Parkinson
Birgitta Evengard
Thomas Hennessy
Author Affiliation
Division for Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
Arctic Investigations Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), Anchorage, AK, USA
Source
Pages 702-703 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):702-703
Date
2013
Language
English
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
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Factors associated with the progression of fibrosis on liver biopsy in Alaska Native and American Indian persons with chronic hepatitis C.

https://arctichealth.org/en/permalink/ahliterature96274
Source
Can J Gastroenterol. 2010 Jul;24(7):445-51
Publication Type
Article
Date
Jul-2010
Author
Stephen Livingston
Heike Deubner
Dana Bruden
Brian McMahon
Chriss Homan
Lisa Townshend-Bulson
Michael Bruce
Thomas Hennessy
James Williams
David Gretch
Source
Can J Gastroenterol. 2010 Jul;24(7):445-51
Date
Jul-2010
Language
English
Publication Type
Article
Abstract
BACKGROUND: Various factors influence the development and rate of fibrosis progression in chronic hepatitis C virus (HCV) infection. OBJECTIVES: To examine factors associated with fibrosis in a longterm outcomes study of Alaska NativeAmerican Indian persons who underwent liver biopsy, and to examine the rate of fibrosis progression in persons with subsequent biopsies. METHODS: A cross-sectional analysis of the demographic, inflammatory and viral characteristics of persons undergoing liver biopsy compared individuals with early (Ishak fibrosis score of lower than 3) with those with advanced (Ishak score of 3 or greater) fibrosis. Persons who underwent two or more biopsies were analyzed for factors associated with fibrosis progression. RESULTS: Of 253 HCV RNA-positive persons who underwent at least one liver biopsy, 76 (30%) had advanced fibrosis. On multivariate analysis, a Knodell histological activity index score of 10 to 14 and an alpha-fetoprotein level of 8 ngmL or higher were found to be independent predictors of advanced liver fibrosis (P
PubMed ID
20652161 View in PubMed
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27 records – page 1 of 3.