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Mechanisms of stimulation of granulocytopoiesis with neupogen in patients with breast cancer during chemotherapy.

https://arctichealth.org/en/permalink/ahliterature90624
Source
Bull Exp Biol Med. 2008 Apr;145(4):467-71
Publication Type
Article
Date
Apr-2008
Author
Khrichkova T Yu
Gol'dberg V E
Zhdanov V V
Matyash M G
Vysotckaya V V
Simolina E I
Shatalova V A
Popova N O
Miroshnichenko L A
Dygai A M
Author Affiliation
Institute of Pharmacology and Institute of Oncology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Source
Bull Exp Biol Med. 2008 Apr;145(4):467-71
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - blood - drug therapy - pathology
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Doxorubicin - administration & dosage
Female
Filgrastim - administration & dosage - pharmacology
Granulocytes - drug effects - pathology - physiology
Hematopoiesis - drug effects
Humans
Middle Aged
Taxoids - administration & dosage
Treatment Outcome
Up-Regulation - drug effects
Abstract
The mechanisms of granulocytopoiesis stimulation with granulocytic CSF (neupogen), added to chemotherapy protocol (adriablastine+taxotere) in patients with stages III-IV breast cancer, were studied. The hemostimulatory effect of granulocytic CSF preparation is based on stimulation of proliferation and differentiation of granulomonocytopoisis precursor cell in the hemopoietic tissue, due to neupogen effects on hemopoietic elements and on the hemopoiesis-inducing microenvironment cells.
PubMed ID
19110596 View in PubMed
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State of central and peripheral pools of hemopoietic precursor cells in patients with malignant neoplasms during chemotherapy.

https://arctichealth.org/en/permalink/ahliterature81939
Source
Bull Exp Biol Med. 2005 Nov;140(5):635-9
Publication Type
Article
Date
Nov-2005
Author
Khrichkova T Yu
Gol'dberg V E
Matyash M G
Vysotskaya V V
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2005 Nov;140(5):635-9
Date
Nov-2005
Language
English
Publication Type
Article
Keywords
Antineoplastic Agents - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone Marrow Cells - cytology - drug effects
Breast Neoplasms - drug therapy
Cyclophosphamide - therapeutic use
Doxorubicin - therapeutic use
Erythrocytes - cytology
Fluorouracil - therapeutic use
Granulocytes - cytology
Hematopoietic Stem Cells - cytology
Hemoglobins - metabolism
Humans
Lung Neoplasms - drug therapy
Abstract
We studied toxic effects of various schemes of cytostatic treatment on central and peripheral pools of hemopoietic precursor cells in patients with III-IV stages of lung cancer and breast cancer. It was found that erythro- and granulomonocytopoietic precursors are characterized by high resistance to cytostatic treatment compared to morphologically discernible bone marrow elements, which is probably a evolutionary developed property of this cell type aimed at rapid recovery of the hemopoietic tissue.
PubMed ID
16758643 View in PubMed
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