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Age-related differences in the side effect profile of citalopram.

https://arctichealth.org/en/permalink/ahliterature53561
Source
Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):545-8
Publication Type
Article
Date
May-2003
Author
Yoram Barak
Marnina Swartz
Daniel Levy
Ronit Weizman
Author Affiliation
Psychogeriatric Department, Abarbanel Mental Health Center, 15 KKL Street, Bat-Yam 59100, Israel. mdybarak@netvision.net.il
Source
Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):545-8
Date
May-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Bradycardia - chemically induced
Chi-Square Distribution
Citalopram - adverse effects
Comparative Study
Confidence Intervals
Databases, Factual - statistics & numerical data
Headache - chemically induced
Humans
Middle Aged
Sweating - drug effects
Abstract
The authors evaluated the autonomic and cardiovascular side effects of citalopram with particular emphasis on their relation to the age of treated patients. The data that formed the basis for the U.S. Food and Drug Administration approval of citalopram were provided by Lundbeck (Copenhagen, Denmark). This database included placebo-controlled short- and long-term studies in major depressed patients. The list of side effects comprised all "heart rate and rhythm disorders" as well as "autonomic nervous system disorders" that had been reported by at least 5% more than that reported for the placebo group of subjects. The database encompassed 1344 subjects treated with citalopram (20-60 mg/day) for a period of no less than 6 weeks. Statistically significant age-related distribution was found for five side effects: bradycardia, nausea, diarrhea, sweating and headache. Bradycardia was more prevalent in elderly (>65 years) patients as compared to the younger population (2.4% vs. 0.2%, P
PubMed ID
12691792 View in PubMed
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