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A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.

https://arctichealth.org/en/permalink/ahliterature264224
Source
Lancet. 2015 Jun 6;385(9984):2255-63
Publication Type
Article
Date
Jun-6-2015
Author
Tiia Ngandu
Jenni Lehtisalo
Alina Solomon
Esko Levälahti
Satu Ahtiluoto
Riitta Antikainen
Lars Bäckman
Tuomo Hänninen
Antti Jula
Tiina Laatikainen
Jaana Lindström
Francesca Mangialasche
Teemu Paajanen
Satu Pajala
Markku Peltonen
Rainer Rauramaa
Anna Stigsdotter-Neely
Timo Strandberg
Jaakko Tuomilehto
Hilkka Soininen
Miia Kivipelto
Source
Lancet. 2015 Jun 6;385(9984):2255-63
Date
Jun-6-2015
Language
English
Publication Type
Article
Keywords
Aged
Cognition Disorders - epidemiology - prevention & control
Diet
Double-Blind Method
Exercise
Exercise Therapy
Humans
Male
Middle Aged
Neuropsychological Tests
Risk assessment
Vascular Diseases - epidemiology - prevention & control
Abstract
Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, we aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.
In a double-blind randomised controlled trial we enrolled individuals aged 60-77 years recruited from previous national surveys. Inclusion criteria were CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Dementia Risk Score of at least 6 points and cognition at mean level or slightly lower than expected for age. We randomly assigned participants in a 1:1 ratio to a 2 year multidomain intervention (diet, exercise, cognitive training, vascular risk monitoring), or a control group (general health advice). Computer-generated allocation was done in blocks of four (two individuals randomly allocated to each group) at each site. Group allocation was not actively disclosed to participants and outcome assessors were masked to group allocation. The primary outcome was change in cognition as measured through comprehensive neuropsychological test battery (NTB) Z score. Analysis was by modified intention to treat (all participants with at least one post-baseline observation). This trial is registered at ClinicalTrials.gov, number NCT01041989.
Between Sept 7, 2009, and Nov 24, 2011, we screened 2654 individuals and randomly assigned 1260 to the intervention group (n=631) or control group (n=629). 591 (94%) participants in the intervention group and 599 (95%) in the control group had at least one post-baseline assessment and were included in the modified intention-to-treat analysis. Estimated mean change in NTB total Z score at 2 years was 0·20 (SE 0·02, SD 0·51) in the intervention group and 0·16 (0·01, 0·51) in the control group. Between-group difference in the change of NTB total score per year was 0·022 (95% CI 0·002-0·042, p=0·030). 153 (12%) individuals dropped out overall. Adverse events occurred in 46 (7%) participants in the intervention group compared with six (1%) participants in the control group; the most common adverse event was musculoskeletal pain (32 [5%] individuals for intervention vs no individuals for control).
Findings from this large, long-term, randomised controlled trial suggest that a multidomain intervention could improve or maintain cognitive functioning in at-risk elderly people from the general population.
Academy of Finland, La Carita Foundation, Alzheimer Association, Alzheimer's Research and Prevention Foundation, Juho Vainio Foundation, Novo Nordisk Foundation, Finnish Social Insurance Institution, Ministry of Education and Culture, Salama bint Hamdan Al Nahyan Foundation, Axa Research Fund, EVO funding for University Hospitals of Kuopio, Oulu, and Turku and for Seinäjoki Central Hospital and Oulu City Hospital, Swedish Research Council, Swedish Research Council for Health, Working Life and Welfare, and af Jochnick Foundation.
Notes
Comment In: Nat Rev Neurol. 2015 May;11(5):24825799934
PubMed ID
25771249 View in PubMed
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Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study.

https://arctichealth.org/en/permalink/ahliterature115320
Source
Obesity (Silver Spring). 2013 Dec;21(12):2444-51
Publication Type
Article
Date
Dec-2013
Author
Per-Arne Svensson
Åsa Anveden
Stefano Romeo
Markku Peltonen
Sofie Ahlin
Maria Antonella Burza
Björn Carlsson
Peter Jacobson
Anna-Karin Lindroos
Hans Lönroth
Cristina Maglio
Ingmar Näslund
Kajsa Sjöholm
Hans Wedel
Bo Söderpalm
Lars Sjöström
Lena M S Carlsson
Author Affiliation
Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, SE-41345 Gothenburg, Sweden.
Source
Obesity (Silver Spring). 2013 Dec;21(12):2444-51
Date
Dec-2013
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects
Alcohol-Related Disorders - epidemiology
Body mass index
Case-Control Studies
Female
Follow-Up Studies
Gastric Bypass
Gastroplasty
Humans
Incidence
Male
Middle Aged
Obesity - surgery
Postoperative Care
Prospective Studies
Sweden - epidemiology
Abstract
Increased sensitivity to alcohol after gastric bypass has been described. The aim of this study was to investigate whether bariatric surgery is associated with alcohol problems.
The prospective, controlled Swedish Obese Subjects (SOS) study enrolled 2,010 obese patients who underwent bariatric surgery (68% vertical banded gastroplasty (VBG), 19% banding, and 13% gastric bypass) and 2,037 matched controls. Patients were recruited between 1987 and 2001. Data on alcohol abuse diagnoses, self-reported alcohol consumption, and alcohol problems were obtained from the National Patient Register and questionnaires. Follow-up time was 8-22 years.
During follow-up, 93.1% of the surgery patients and 96.0% of the controls reported alcohol consumption classified as low risk by the World Health Organization (WHO). However, compared to controls, the gastric bypass group had increased risk of alcohol abuse diagnoses (adjusted hazard ratio [adjHR] = 4.97), alcohol consumption at least at the WHO medium risk level (adjHR = 2.69), and alcohol problems (adjHR = 5.91). VBG increased the risk of these conditions with adjHRs of 2.23, 1.52, and 2.30, respectively, while banding was not different from controls.
Alcohol consumption, alcohol problems, and alcohol abuse are increased after gastric bypass and VBG.
PubMed ID
23520203 View in PubMed
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All-cause and disease-specific mortality among male, former elite athletes: an average 50-year follow-up.

https://arctichealth.org/en/permalink/ahliterature271045
Source
Br J Sports Med. 2015 Jul;49(13):893-7
Publication Type
Article
Date
Jul-2015
Author
Jyrki A Kettunen
Urho M Kujala
Jaakko Kaprio
Heli Bäckmand
Markku Peltonen
Johan G Eriksson
Seppo Sarna
Source
Br J Sports Med. 2015 Jul;49(13):893-7
Date
Jul-2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cause of Death
Dementia - mortality
Finland - epidemiology
Follow-Up Studies
Humans
Life expectancy
Male
Middle Aged
Myocardial Infarction - mortality
Neoplasms - mortality
Sports - statistics & numerical data
Stroke - mortality
Survival Analysis
Young Adult
Abstract
To investigate life expectancy and mortality among former elite athletes and controls.
HR analysis of cause-specific deaths sourced from the national death registry for former Finnish male endurance, team and power sports athletes (N=2363) and controls (N=1657). The median follow-up time was 50 years.
Median life expectancy was higher in the endurance (79.1 years, 95% CI 76.6 to 80.6) and team (78.8, 78.1 to 79.8) sports athletes than in controls (72.9, 71.8 to 74.3). Compared to controls, risk for total mortality adjusted for socioeconomic status and birth cohort was lower in the endurance ((HR 0.70, 95% CI 0.61 to 0.79)) and team (0.80, 0.72 to 0.89) sports athletes, and slightly lower in the power sports athletes (0.93, 0.85 to 1.03). HR for ischaemic heart disease mortality was lower in the endurance (0.68, 0.54 to 0.86) and team sports (0.73, 0.60 to 0.89) athletes. HR for stroke mortality was 0.52 (0.33 to 0.83) in the endurance and 0.59 (0.40 to 0.88) in the team sports athletes. Compared to controls, the risk for smoking-related cancer mortality was lower in the endurance (HR 0.20, 0.08 to 0.47) and power sports (0.40, 0.25 to 0.66) athletes. For dementia mortality, the power sports athletes, particularly boxers, had increased risk (HR 4.20, 2.30 to 7.81).
Elite athletes have 5-6 years additional life expectancy when compared to men who were healthy as young adults. Lower mortality for cardiovascular disease was in part due to lower rates of smoking, as tobacco-related cancer mortality was especially low.
PubMed ID
25183628 View in PubMed
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Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications.

https://arctichealth.org/en/permalink/ahliterature104186
Source
JAMA. 2014 Jun 11;311(22):2297-304
Publication Type
Article
Date
Jun-11-2014
Author
Lars Sjöström
Markku Peltonen
Peter Jacobson
Sofie Ahlin
Johanna Andersson-Assarsson
Åsa Anveden
Claude Bouchard
Björn Carlsson
Kristjan Karason
Hans Lönroth
Ingmar Näslund
Elisabeth Sjöström
Magdalena Taube
Hans Wedel
Per-Arne Svensson
Kajsa Sjöholm
Lena M S Carlsson
Author Affiliation
Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Source
JAMA. 2014 Jun 11;311(22):2297-304
Date
Jun-11-2014
Language
English
Publication Type
Article
Keywords
Adult
Bariatric Surgery
Blood glucose
Case-Control Studies
Diabetes Complications - prevention & control
Diabetes Mellitus, Type 2 - complications - surgery
Female
Humans
Male
Middle Aged
Obesity - complications - surgery
Prospective Studies
Recurrence
Sweden
Treatment Outcome
Weight Loss
Abstract
Short-term studies show that bariatric surgery causes remission of diabetes. The long-term outcomes for remission and diabetes-related complications are not known.
To determine the long-term diabetes remission rates and the cumulative incidence of microvascular and macrovascular diabetes complications after bariatric surgery.
The Swedish Obese Subjects (SOS) is a prospective matched cohort study conducted at 25 surgical departments and 480 primary health care centers in Sweden. Of patients recruited between September 1, 1987, and January 31, 2001, 260 of 2037 control patients and 343 of 2010 surgery patients had type 2 diabetes at baseline. For the current analysis, diabetes status was determined at SOS health examinations until May 22, 2013. Information on diabetes complications was obtained from national health registers until December 31, 2012. Participation rates at the 2-, 10-, and 15-year examinations were 81%, 58%, and 41% in the control group and 90%, 76%, and 47% in the surgery group. For diabetes assessment, the median follow-up time was 10 years (interquartile range [IQR], 2-15) and 10 years (IQR, 10-15) in the control and surgery groups, respectively. For diabetes complications, the median follow-up time was 17.6 years (IQR, 14.2-19.8) and 18.1 years (IQR, 15.2-21.1) in the control and surgery groups, respectively.
Adjustable or nonadjustable banding (n = 61), vertical banded gastroplasty (n = 227), or gastric bypass (n = 55) procedures were performed in the surgery group, and usual obesity and diabetes care was provided to the control group.
Diabetes remission, relapse, and diabetes complications. Remission was defined as blood glucose
PubMed ID
24915261 View in PubMed
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Association of Bariatric Surgery With Skin Cancer Incidence in Adults With Obesity: A Nonrandomized Controlled Trial.

https://arctichealth.org/en/permalink/ahliterature308440
Source
JAMA Dermatol. 2020 01 01; 156(1):38-43
Publication Type
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Date
01-01-2020
Author
Magdalena Taube
Markku Peltonen
Kajsa Sjöholm
Åsa Anveden
Johanna C Andersson-Assarsson
Peter Jacobson
Per-Arne Svensson
Martin O Bergo
Lena M S Carlsson
Author Affiliation
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Source
JAMA Dermatol. 2020 01 01; 156(1):38-43
Date
01-01-2020
Language
English
Publication Type
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Keywords
Adult
Bariatric Surgery - statistics & numerical data
Case-Control Studies
Female
Follow-Up Studies
Humans
Incidence
Male
Melanoma - epidemiology - prevention & control
Middle Aged
Obesity - epidemiology - therapy
Registries - statistics & numerical data
Risk factors
Skin Neoplasms - epidemiology - prevention & control
Sweden - epidemiology
Abstract
Obesity is a cancer risk factor, and bariatric surgery in patients with obesity is associated with reduced cancer risk. However, evidence of an association among obesity, bariatric surgery, and skin cancer, including melanoma, is limited.
To investigate the association of bariatric surgery with skin cancer (squamous cell carcinoma and melanoma) and melanoma incidence.
This nonrandomized controlled trial, the Swedish Obese Subjects (SOS) study, is ongoing at 25 surgical departments and 480 primary health care centers in Sweden and was designed to examine outcomes after bariatric surgery. The study included 2007 patients with obesity who underwent bariatric surgery and 2040 contemporaneously matched controls who received conventional obesity treatment. Patients were enrolled between September 1, 1987, and January 31, 2001. Data analysis was performed from June 29, 2018, to November 22, 2018.
Patients in the surgery group underwent gastric bypass (n?=?266), banding (n?=?376), or vertical banded gastroplasty (n?=?1365). The control group (n?=?2040) received the customary treatment for obesity at their primary health care centers.
The SOS study was cross-linked to the Swedish National Cancer Registry, the Cause of Death Registry, and the Registry of the Total Population for data on cancer incidence, death, and emigration.
The study included 4047 participants (mean [SD] age, 47.9 [6.1] years; 2867 [70.8%] female). Information on cancer events was available for 4042 patients. The study found that bariatric surgery was associated with a markedly reduced risk of melanoma (adjusted subhazard ratio, 0.43; 95% CI, 0.21-0.87; P?=?.02; median follow-up, 18.1 years) and risk of skin cancer in general (adjusted subhazard ratio, 0.59; 95% CI, 0.35-0.99; P?=?.047). The skin cancer risk reduction was not associated with baseline body mass index or weight; insulin, glucose, lipid, and creatinine levels; diabetes; blood pressure; alcohol intake; or smoking.
The results of this study suggest that bariatric surgery in individuals with obesity is associated with a reduced risk of skin cancer, including melanoma.
ClinicalTrials.gov identifier: NCT01479452.
PubMed ID
31664428 View in PubMed
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Association of serum 25-hydroxyvitamin D with lifestyle factors and metabolic and cardiovascular disease markers: population-based cross-sectional study (FIN-D2D).

https://arctichealth.org/en/permalink/ahliterature260969
Source
PLoS One. 2014;9(7):e100235
Publication Type
Article
Date
2014
Author
Maija E Miettinen
Leena Kinnunen
Jaana Leiviskä
Sirkka Keinänen-Kiukaanniemi
Eeva Korpi-Hyövälti
Leo Niskanen
Heikki Oksa
Timo Saaristo
Jaakko Tuomilehto
Mauno Vanhala
Matti Uusitupa
Markku Peltonen
Source
PLoS One. 2014;9(7):e100235
Date
2014
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - metabolism
Cardiovascular Diseases - blood - epidemiology - metabolism
Cross-Sectional Studies
Female
Finland - epidemiology
Glucose - metabolism
Humans
Life Style
Male
Metabolic Syndrome X - blood - epidemiology - metabolism
Middle Aged
Vitamin D - analogs & derivatives - blood
Abstract
Low serum 25-hydroxyvitamin D (25OHD) level has been associated with an increased risk of several chronic diseases. Our aim was to determine lifestyle and clinical factors that are associated with 25OHD level and to investigate connection of 25OHD level with metabolic and cardiovascular disease markers.
In total, 2868 Finnish men and women aged 45-74 years participated in FIN-D2D population-based health survey in 2007. Participants that had a serum sample available (98.4%; n?=?2822) were included in this study. 25OHD was measured with chemiluminescent microparticle immunoassay method.
The mean 25OHD level was 58.2 nmol/l in men (n?=?1348) and 57.1 nmol/l in women (n?=?1474). Mean 25OHD level was lower in the younger age groups than in the older ones (p
Notes
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PubMed ID
25000408 View in PubMed
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The association of work stress and night work with nutrient intake - a prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature311184
Source
Scand J Work Environ Health. 2020 09 01; 46(5):533-541
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
09-01-2020
Author
Katri Hemiö
Jaana Lindström
Markku Peltonen
Mikko Härmä
Katriina Viitasalo
Sampsa Puttonen
Author Affiliation
Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. katri.hemio@thl.fi.
Source
Scand J Work Environ Health. 2020 09 01; 46(5):533-541
Date
09-01-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Energy intake
Fatigue
Feeding Behavior
Female
Finland - epidemiology
Humans
Life Style
Male
Middle Aged
Nutrients
Occupational Stress - epidemiology
Prospective Studies
Shift Work Schedule
Abstract
Objectives In a prospective study among workers in an airline company, we explored whether change in work stress symptoms or night shifts was associated with nutrient intake. Methods Participants in a workplace type 2 diabetes (T2D) prevention study completed a questionnaire on lifestyle, work stress symptoms, work schedule, and food intake at baseline and after 2.4-years follow-up (211 men and 155 women, 93% with increased risk for T2D). Multiple linear regression models with covariates were used to explore the associations between change in work stress symptoms or night shifts and change in nutrient intake during the follow-up. Results Among men, an increase in stress and a decrease in perceived workability was associated with a higher proportion of energy (E%) from fat [ß 0.6, 95% confidence interval (CI) 0.07-1.11, ß 1.3, 95% CI 0.57-2.05] and saturated fat (ß 0.3, 95% CI 0.02-0.58, ß 0.5, 95% CI 0.14-0.90), respectively. Furthermore, a decrease in workability was associated with lower vitamin C intake (ß-9.2, 95% CI -16.56- -1.84) and an increase in sleepiness with higher E% from saturated fat (ß 0.7, 95% CI 0.00-0.15). Among women, an increase in work-related fatigue was associated with higher alcohol intake (ß 7.5, 95% CI 1.25-13.74) and an increase of night shifts was associated with higher E% from fat (ß 0.24, 95% CI 0.00-0.47) and saturated fat (ß 0.17, 95% CI 0.04-0.29). Conclusions Work stress symptoms were associated with a reduction in diet quality especially among men. The possible impact of work stress symptoms on workers' dietary habits should be acknowledged and the assessment of dietary habits should consequently be incorporated into occupational health examinations.
PubMed ID
32391566 View in PubMed
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Bariatric surgery and long-term cardiovascular events.

https://arctichealth.org/en/permalink/ahliterature128246
Source
JAMA. 2012 Jan 4;307(1):56-65
Publication Type
Article
Date
Jan-4-2012
Author
Lars Sjöström
Markku Peltonen
Peter Jacobson
C David Sjöström
Kristjan Karason
Hans Wedel
Sofie Ahlin
Åsa Anveden
Calle Bengtsson
Gerd Bergmark
Claude Bouchard
Björn Carlsson
Sven Dahlgren
Jan Karlsson
Anna-Karin Lindroos
Hans Lönroth
Kristina Narbro
Ingmar Näslund
Torsten Olbers
Per-Arne Svensson
Lena M S Carlsson
Author Affiliation
Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. lars.v.sjostrom@medfak.gu.se
Source
JAMA. 2012 Jan 4;307(1):56-65
Date
Jan-4-2012
Language
English
Publication Type
Article
Keywords
Adult
Bariatric Surgery
Cardiovascular Diseases - mortality - prevention & control
Case-Control Studies
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Myocardial Infarction - mortality - prevention & control
Obesity - surgery
Prospective Studies
Stroke - mortality - prevention & control
Sweden - epidemiology
Weight Loss
Abstract
Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking.
To study the association between bariatric surgery, weight loss, and cardiovascular events.
The Swedish Obese Subjects (SOS) study is an ongoing, nonrandomized, prospective, controlled study conducted at 25 public surgical departments and 480 primary health care centers in Sweden of 2010 obese participants who underwent bariatric surgery and 2037 contemporaneously matched obese controls who received usual care. Patients were recruited between September 1, 1987, and January 31, 2001. Date of analysis was December 31, 2009, with median follow-up of 14.7 years (range, 0-20 years). Inclusion criteria were age 37 to 60 years and a body mass index of at least 34 in men and at least 38 in women. Exclusion criteria were identical in surgery and control patients. Surgery patients underwent gastric bypass (13.2%), banding (18.7%), or vertical banded gastroplasty (68.1%), and controls received usual care in the Swedish primary health care system. Physical and biochemical examinations and database cross-checks were undertaken at preplanned intervals.
The primary end point of the SOS study (total mortality) was published in 2007. Myocardial infarction and stroke were predefined secondary end points, considered separately and combined.
Bariatric surgery was associated with a reduced number of cardiovascular deaths (28 events among 2010 patients in the surgery group vs 49 events among 2037 patients in the control group; adjusted hazard ratio [HR], 0.47; 95% CI, 0.29-0.76; P = .002). The number of total first time (fatal or nonfatal) cardiovascular events (myocardial infarction or stroke, whichever came first) was lower in the surgery group (199 events among 2010 patients) than in the control group (234 events among 2037 patients; adjusted HR, 0.67; 95% CI, 0.54-0.83; P
Notes
Comment In: Nat Rev Endocrinol. 2012 Mar;8(3):13022271190
Comment In: JAMA. 2012 Apr 18;307(15):1577; author reply 1577-822511678
Comment In: Nat Rev Cardiol. 2012 Mar;9(3):12622271018
Comment In: Praxis (Bern 1994). 2012 May 9;101(10):673-522565560
Comment In: JAMA. 2012 Jan 4;307(1):88-922215170
PubMed ID
22215166 View in PubMed
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Bariatric Surgery and the Incidence of Psoriasis and Psoriatic Arthritis in the Swedish Obese Subjects Study.

https://arctichealth.org/en/permalink/ahliterature290962
Source
Obesity (Silver Spring). 2017 12; 25(12):2068-2073
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Date
12-2017
Author
Cristina Maglio
Markku Peltonen
Anna Rudin
Lena M S Carlsson
Author Affiliation
Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Source
Obesity (Silver Spring). 2017 12; 25(12):2068-2073
Date
12-2017
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Keywords
Arthritis, Psoriatic - etiology - pathology
Bariatric Surgery - adverse effects - methods
Female
Humans
Incidence
Male
Middle Aged
Psoriasis - etiology - pathology
Sweden - epidemiology
Abstract
The aim of this study was to assess the effect of bariatric surgery (vertical gastroplasty, gastric banding, or gastric bypass) compared with usual care on the incidence of psoriasis and psoriatic arthritis (PsA) in the Swedish Obese Subjects study.
This report includes 1,991 subjects who underwent bariatric surgery and 2,018 controls with obesity from the SOS study; none of them had psoriasis or PsA at baseline. Information about psoriasis and PsA diagnosis was retrieved through the Swedish National Patient Register and questionnaires.
During follow-up for up to 26 years, bariatric surgery was associated with a lower incidence of psoriasis compared with usual care (number of events?=?174; hazard ratio 0.65; 95% CI: 0.47-0.89; P?=?0.008). Both smoking and a longer duration of obesity were independently associated with a higher risk for psoriasis. No significant difference was detected among the three surgical procedures in terms of lowering the risk of developing psoriasis. The association between bariatric surgery and psoriasis incidence was not influenced by baseline confounders. No significant difference in the risk of developing PsA (number of events?=?46) was detected when comparing the surgery and the control groups.
This study shows that bariatric surgery is associated with a lower risk of developing psoriasis compared with usual care.
Notes
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PubMed ID
29178583 View in PubMed
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Bariatric surgery and the incidence of rheumatoid arthritis - a Swedish Obese Subjects study.

https://arctichealth.org/en/permalink/ahliterature309351
Source
Rheumatology (Oxford). 2020 02 01; 59(2):303-309
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-01-2020
Author
Cristina Maglio
Yuan Zhang
Markku Peltonen
Johanna Andersson-Assarsson
Per-Arne Svensson
Christian Herder
Anna Rudin
Lena Carlsson
Author Affiliation
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Source
Rheumatology (Oxford). 2020 02 01; 59(2):303-309
Date
02-01-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Arthritis, Rheumatoid - epidemiology
Bariatric Surgery
Case-Control Studies
Female
Follow-Up Studies
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Obesity - surgery
Sweden - epidemiology
Abstract
The aim of this study was to determine the effect of bariatric surgery on the incidence of RA in participants of the Swedish Obese Subjects (SOS) study.
The SOS is a longitudinal study aiming to assess the effect of bariatric surgery on mortality and obesity-related diseases. This report includes 2002 subjects with obesity who underwent bariatric surgery and 2034 matched controls; none of them had RA at baseline. Cases of incident RA were identified through the Swedish National Patient Register by searching for International Classification of Diseases codes. Both intention-to-treat analyses and per-protocol analyses are reported. In the per-protocol analysis, participants from the control group who underwent bariatric surgery later on during follow-up were censored at the time of surgery.
During follow-up, 92 study participants developed RA. The median follow-up was 21 years (range 0-29). Bariatric surgery was neither associated with the incidence of RA in the intention-to-treat analysis [hazard ratio (HR) 0.92 (95% CI 0.59, 1.46), P = 0.74], nor in the per-protocol analysis [HR 0.86 (95% CI 0.54, 1.38), P = 0.53]. Weight change at the 2 year follow-up, expressed as the change in BMI compared with baseline, did not associate with the development of RA. Higher serum CRP levels and smoking associated with the future development of RA independent of other factors.
We did not detect any association between bariatric surgery and the incidence of RA in subjects affected by obesity followed up for up to 29 years.
(http://clinicaltrials.gov): NCT01479452.
Notes
CommentIn: Rheumatology (Oxford). 2020 Feb 1;59(2):275-276 PMID 31687773
PubMed ID
31321442 View in PubMed
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