Skip header and navigation

2 records – page 1 of 1.

Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort.

https://arctichealth.org/en/permalink/ahliterature123464
Source
Cancer Causes Control. 2012 Aug;23(8):1307-16
Publication Type
Article
Date
Aug-2012
Author
Andrea Markkula
Anna Bromée
Maria Henningson
Maria Hietala
Anita Ringberg
Christian Ingvar
Carsten Rose
Helena Jernström
Author Affiliation
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden.
Source
Cancer Causes Control. 2012 Aug;23(8):1307-16
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Body Composition
Body mass index
Breast - anatomy & histology
Breast Neoplasms - drug therapy - epidemiology - pathology - surgery
Cohort Studies
Disease-Free Survival
Female
Humans
Middle Aged
Neoplasm Recurrence, Local - epidemiology - pathology
Prognosis
Prospective Studies
Sweden - epidemiology
Waist-Hip Ratio
Abstract
Body mass index (BMI), waist-to-hip ratio (WHR), and tumor characteristics affect disease-free survival. Larger breast size may increase breast cancer risk, but its influence on disease-free survival is unclear. The purpose of this study was to elucidate whether breast size independently influenced disease-free survival in breast cancer patients.
Body measurements were obtained preoperatively from 772 breast cancer patients in a population-based ongoing cohort from southern Sweden. The research nurse measured breast volumes with plastic cups used by plastic surgeons doing breast reductions. Clinical data were obtained from patient charts and pathology reports.
Patients with a BMI = 25 kg/m(2) had larger tumors (p  0.85 had larger tumors (p = 0.013), more advanced histological grade (p = 0.0016), and more axillary nodal involvement (p = 0.012). Patients with right + left breast volume = 850 mL were more likely to have larger tumor sizes (p = 0.018), more advanced histological grade (p = 0.031), and more axillary nodal involvement (p = 0.025). There were 62 breast cancer events during the 7-year follow-up. Breast volume = 850 mL was associated with shorter disease-free survival (p = 0.004) and distant metastasis-free survival (p = 0.001) in patients with estrogen receptor (ER)-positive tumors independent of other anthropometric measurements and age. In patients with ER-positive tumors, breast size was an independent predictor of shorter disease-free (HR 3.64; 95 % CI 1.42-9.35) and distant metastasis-free survival (HR 6.33; 95 %CI 1.36-29.43), adjusted for tumor characteristics, BMI, age, and treatment.
A simple and cheap anthropometric measurement with standardized tools may help identify a subgroup of patients in need of tailored breast cancer therapy.
PubMed ID
22695757 View in PubMed
Less detail

Natural remedy use in a prospective cohort of breast cancer patients in southern Sweden.

https://arctichealth.org/en/permalink/ahliterature96847
Source
Acta Oncol. 2010 May 25;
Publication Type
Article
Date
May-25-2010
Author
Maria Hietala
Maria Henningson
Christian Ingvar
Per-Ebbe Jönsson
Carsten Rose
Helena Jernström
Author Affiliation
Department of Oncology, Clinical Sciences, Lund University, Sweden.
Source
Acta Oncol. 2010 May 25;
Date
May-25-2010
Language
English
Publication Type
Article
Abstract
Abstract Background. Complementary and alternative medicine (CAM) use is common among breast cancer patients. Several CAM therapies may have negative side effects or interact with conventional therapies. We studied biologically based CAM use with and without vitamins/minerals in relation to patient and tumor characteristics as well as treatment in an ongoing prospective cohort of 855 primary breast cancer patients. Methods. Patients from two hospitals in southern Sweden were included. Pre-operative and follow-up questionnaires containing questions on food intake, lifestyle, and concomitant medications, including natural remedies, were completed up to five years postoperatively. Clinical information was obtained from clinical records and tumor characteristics from pathology reports. Results. CAM and/or vitamins/minerals were used by 34.2% pre-operatively and by 57.9% during at least one visit. Over 100 different preparations were reported. At least eight of the commonly used preparations may interact with conventional breast cancer therapies. CAM users more often had a BMI
PubMed ID
20500030 View in PubMed
Less detail