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Socioeconomic factors from midlife predict mobility limitation and depressed mood three decades later; findings from the AGES-Reykjavik Study.

https://arctichealth.org/en/permalink/ahliterature116606
Source
BMC Public Health. 2013;13:101
Publication Type
Article
Date
2013
Author
Daniëlle A I Groffen
Annemarie Koster
Hans Bosma
Marjan van den Akker
Thor Aspelund
Kristín Siggeirsdóttir
Gertrudis I J M Kempen
Jacques Th M van Eijk
Gudny Eiriksdottir
Pálmi V Jónsson
Lenore J Launer
Vilmundur Gudnason
Tamara B Harris
Author Affiliation
Department of Social Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. D.Groffen@maastrichtuniversity.nl
Source
BMC Public Health. 2013;13:101
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cohort Studies
Depression - epidemiology
Female
Health Status Disparities
Humans
Iceland - epidemiology
Male
Middle Aged
Mobility Limitation
Risk factors
Socioeconomic Factors
Abstract
Taking into account our rapidly ageing population, older people are of particular interest in studying health inequalities. Most studies of older persons only include measures of current socioeconomic status (SES) and do not take into account data from earlier stages of life. In addition, only classic SES measures are used, while alternative measures, such as car ownership and house ownership, might equally well predict health. The present study aims to examine the effect of midlife socioeconomic factors on mobility limitation and depressed mood three decades later.
Data were from 4,809 men and women aged 33-65 years who participated in the Reykjavik Study (1967-1992) and who were re-examined in old age in the Age, Gene/Environment Susceptibility (AGES) -Reykjavik Study (2002-2006).
Education and occupation predicted mobility limitation and depressed mood. Independently, home and car ownership and the availability of housing features predicted mobility limitation. Shortages of food in childhood and lack of a car in midlife predicted depressed mood.
Socioeconomic factors from midlife and from childhood affect mobility limitation and depressed mood in old age. Prevention of health problems in old age should begin as early as midlife.
Notes
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PubMed ID
23379351 View in PubMed
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Surfactant proteins A and D in Eustachian tube epithelium.

https://arctichealth.org/en/permalink/ahliterature58617
Source
Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L660-7
Publication Type
Article
Date
Sep-2001
Author
R. Paananen
R. Sormunen
V. Glumoff
M. van Eijk
M. Hallman
Author Affiliation
Biocenter Oulu, University of Oulu, FIN-90014 Oulu, Finland. rpaanane@cc.oulu.fi
Source
Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L660-7
Date
Sep-2001
Language
English
Publication Type
Article
Keywords
Animals
Blotting, Western
Bronchoalveolar Lavage Fluid - chemistry
Epithelial Cells - cytology - metabolism
Eustachian Tube - anatomy & histology - cytology - metabolism
Glycoproteins - metabolism
In Situ Hybridization
Irrigation
Microscopy, Electron
Microscopy, Immunoelectron
Proteolipids - metabolism
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants - metabolism
Research Support, Non-U.S. Gov't
Swine
Tissue Distribution
Abstract
Surfactant protein (SP) A and SP-D are collectins that have roles in host defense. The Eustachian tube (ET) maintains the patency between the upper airways and the middle ear. Dysfunction of local mucosal immunity in ET may predispose infants to recurrent otitis media. We recently described preliminary evidence of the expression of SP-A and SP-D in the ET. Our present aim was to establish the sites of SP-A and SP-D expression within the epithelium of the ET in vivo. With in situ hybridization, electron microscopy, and immunoelectron microscopy, the cells responsible for SP-A and SP-D expression and storage were identified. SP-A expression was localized within the ET epithelium, and the protein was found in the electron-dense granules of microvillar epithelial cells. Being concentrated in the epithelial lining, only a few cells revealed intracellular SP-D, and it was not associated with granules. The SP-A and SP-D immunoreactivities in ET lavage fluid, as shown by Western blot analyses, were similar to those in bronchoalveolar lavage fluid. We propose that there are specialized cells in the ET epithelium expressing and secreting SP-A and SP-D. SP-A and SP-D may be important for antibody-independent protection of the middle ear against infections.
PubMed ID
11504694 View in PubMed
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