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Carboxyterminal telopeptide of type I collagen (ICTP) in predicting prognosis in epithelial ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature19716
Source
Gynecol Oncol. 2001 Jul;82(1):110-5
Publication Type
Article
Date
Jul-2001
Author
M. Simojoki
M. Santala
J. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Oulu, FIN-90220, Finland.
Source
Gynecol Oncol. 2001 Jul;82(1):110-5
Date
Jul-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
CA-125 Antigen - blood
Comparative Study
False Positive Reactions
Female
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms - blood - diagnosis - drug therapy
Peptide Fragments - blood
Predictive value of tests
Procollagen - blood
Prognosis
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Survival Analysis
Treatment Outcome
Abstract
OBJECTIVE: The aim of this study was to assess the prognostic value of serum carboxyterminal telopeptide of type I collagen (ICTP) in ovarian cancer. Serum CA125 was used as a reference marker. METHODS: Forty-five patients with epithelial ovarian cancer were monitored with serial measurements of serum concentrations of ICTP, a degradation product of type I collagen likely to come about via the matrix metalloproteinase pathway. RESULTS: The patients with a good prognosis had significantly lower serum ICTP concentrations than the patients with a poor prognosis both before the operation and at all the postoperative time points studied (3, 6, 9, 12, 18, and 24 months), whereas a corresponding difference in CA125 was first seen after a 12-month follow-up. In multivariate regression analysis, the 9-month serum ICTP concentration remained the only independent prognostic indicator of all biochemical, clinical, and histological variables. The postoperative serum ICTP concentration did not correlate with the clinical stage, the grade of differentiation, or the presence of residual tumor. In contrast to ICTP, postoperative serum CA125 correlated with the clinical stage and the presence of residual tumor. CONCLUSIONS: Because our ICTP test does not detect defectively cross-linked carboxyterminal telopeptides of type I collagen, which is the predominant form in malignant ovarian tissue, the excess ICTP of ovarian cancer patients must originate from the tissue around the tumor, where the malignancy is causing tissue damage. As an indicator of invasion, the serum ICTP test opens up new possibilities to assess the clinical behavior of ovarian cancer and, in the future, also the effect of possible antiproteinase treatment in ovarian cancer.
PubMed ID
11426971 View in PubMed
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The prognostic value of peritoneal cytology in ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature20675
Source
Eur J Gynaecol Oncol. 1999;20(5-6):357-60
Publication Type
Article
Date
1999
Author
M. Simojoki
M. Santala
S. Vuopala
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Eur J Gynaecol Oncol. 1999;20(5-6):357-60
Date
1999
Language
English
Publication Type
Article
Keywords
Adult
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Ovarian Neoplasms - mortality - pathology
Peritoneum - pathology
Prognosis
Retrospective Studies
Survival Analysis
Abstract
We studied the significance of peritoneal cytology as a prognostic factor in primary epithelial ovarian cancer. Intraperitoneal specimens for cytological examination were taken from 73 patients at primary operation for ovarian cancer. The prognostic value of cytological findings was analyzed by the Kaplan-Meier method. It was also correlated to clinical stage, tumor histology, histopathological grade, residual tumor, presence of ascites and age by using the chi2-test. The value of cytology in relation to other factors was assessed by Cox-multivariate analysis. In univariate analysis peritoneal cytological findings correlated significantly to survival. In Cox-multivariate analysis peritoneal cytology, histopathological grade and the age of the patient were found to be significant independent prognostic factors in epithelial ovarian cancer. According to this data peritoneal cytology can be considered as an important prognostic factor in ovarian cancer. Therefore it should be evaluated routinely in association with surgery of ovarian tumors.
PubMed ID
10609494 View in PubMed
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Serial determinations of aminoterminal propeptide of type III procollagen (PIIINP) and prognosis in ovarian cancer; comparison to CA125.

https://arctichealth.org/en/permalink/ahliterature20000
Source
Anticancer Res. 2000 Nov-Dec;20(6C):4655-60
Publication Type
Article
Author
M. Simojoki
M. Santala
J. Risteli
L. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, FIN-90220 Oulu, Finland.
Source
Anticancer Res. 2000 Nov-Dec;20(6C):4655-60
Language
English
Publication Type
Article
Keywords
Adult
Aged
CA-125 Antigen - blood
Comparative Study
Female
Humans
Middle Aged
Ovarian Neoplasms - blood - diagnosis - mortality - surgery
Peptide Fragments - blood
Predictive value of tests
Procollagen - blood
Prognosis
Regression Analysis
Survival Rate
Time Factors
Tumor Markers, Biological - blood
Abstract
During malignant growth many changes take place in the metabolism of fibrillar type III collagens in the connective tissues. The aminoterminal propeptide of type III procollagen (PIIINP) has been found to be often elevated in ovarian cancer. In the present study the prognostic value of serum PIIINP concentration in epithelial ovarian cancer is evaluated in relation to serum CA125. Fifty-six women were enrolled in the study. Serial venous blood samples were taken preoperatively and 6, 9 and 12 months after operation for PIIINP and CA125 determinations. The results were correlated to the three-year survival. In Kaplan-Meier survival analysis the preoperative (P = 0.0422), 9-month (P = 0.0062) and 12-month (P = 0.0062) serum PIIINP concentration distinguished between the patients with good and poor prognosis while CA125 did so only at 9- (P = 0.0005) and 12-month (P
PubMed ID
11205196 View in PubMed
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Type I and III collagen metabolites as predictors of clinical outcome in epithelial ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature20642
Source
Clin Cancer Res. 1999 Dec;5(12):4091-6
Publication Type
Article
Date
Dec-1999
Author
M. Santala
M. Simojoki
J. Risteli
L. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Source
Clin Cancer Res. 1999 Dec;5(12):4091-6
Date
Dec-1999
Language
English
Publication Type
Article
Keywords
Adult
Aged
Carcinoma - blood - pathology - surgery
Collagen - blood
Comparative Study
Female
Follow-Up Studies
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms - blood - pathology - surgery
Peptide Fragments - blood
Peptides - blood
Predictive value of tests
Procollagen - blood
Prognosis
Survival Analysis
Treatment Outcome
Tumor Markers, Biological - blood
Abstract
We evaluated the significance of biochemical tumor markers, ie, aminoterminal propeptide of type III procoliagen, trivalently cross-linked COOH-terminal telopeptide of type I collagen (ICTP), aminoterminal propeptide of type I procollagen, and CA 125 in the prediction of ovarian cancer outcome and compared them with several classical indicators of prognosis. The concentrations of biochemical markers were determined from the preoperative serum specimens of 55 patients with epithelial ovarian cancer. In the univariate analysis, all biochemical markers except PINP and all conventional prognostic indicators except histological subtype correlated significantly with survival. In the multivariate Cox analysis of biochemical markers, serum ICTP remained the only significant prognostic indicator of overall survival. Among all variables, clinical stage and ICTP were the only independent and significant determinants of prognosis. Because the content of trivalently cross-linked, mature type I collagen (the breakdown of which is detectable in the ICTP test) in malignant ovarian cancer tissue has been reported to be lower and that of bivalently cross-linked and non-cross-linked collagen has been reported to be higher than in benign tumors, the source of excess ICTP in the circulation of ovarian cancer patients is most likely the degradative damage of soft tissues surrounding the progressively growing malignant lesions. The serum ICTP concentration can thus be regarded as an indicator of the invasion of ovarian cancer. Such information is not available by conventional methods. Therefore, the ICTP test will improve the accuracy of predicting clinical outcome in this disease.
PubMed ID
10632345 View in PubMed
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Ultrasound-controlled removal of a dislocated intrauterine device in the first trimester of pregnancy: a report of 26 cases.

https://arctichealth.org/en/permalink/ahliterature64920
Source
Ultrasound Obstet Gynecol. 1992 Sep 1;2(5):345-8
Publication Type
Article
Date
Sep-1-1992
Author
P. Kirkinen
M. Simojoki
A. Kivelä
P. Jouppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland.
Source
Ultrasound Obstet Gynecol. 1992 Sep 1;2(5):345-8
Date
Sep-1-1992
Language
English
Publication Type
Article
Abstract
Intrauterine, ultrasound-guided removal of a copper-releasing intrauterine contraceptive device (IUCD) was carried out in 26 first-trimester pregnancies. In all the pregnancies, the string of the device had retracted into the uterine cavity. The total loss of pregnancies was 46%, while 36% of the initially uncomplicated single pregnancies ended in a spontaneous abortion. The time lag between the removal of the IUCD and clinical abortion was 21.5 days (range 3-48 days). A fundal location of the IUCD and failure to remove the IUCD by the first traction were common features in the abortion group. A total of 14 of the pregnancies resulted in a liveborn baby, and the incidence of complications after the 20th gestational week was not increased compared with the normal population.
PubMed ID
12796934 View in PubMed
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