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Carboxyterminal telopeptide of type I collagen (ICTP) in predicting prognosis in epithelial ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature19716
Source
Gynecol Oncol. 2001 Jul;82(1):110-5
Publication Type
Article
Date
Jul-2001
Author
M. Simojoki
M. Santala
J. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Oulu, FIN-90220, Finland.
Source
Gynecol Oncol. 2001 Jul;82(1):110-5
Date
Jul-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
CA-125 Antigen - blood
Comparative Study
False Positive Reactions
Female
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms - blood - diagnosis - drug therapy
Peptide Fragments - blood
Predictive value of tests
Procollagen - blood
Prognosis
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Survival Analysis
Treatment Outcome
Abstract
OBJECTIVE: The aim of this study was to assess the prognostic value of serum carboxyterminal telopeptide of type I collagen (ICTP) in ovarian cancer. Serum CA125 was used as a reference marker. METHODS: Forty-five patients with epithelial ovarian cancer were monitored with serial measurements of serum concentrations of ICTP, a degradation product of type I collagen likely to come about via the matrix metalloproteinase pathway. RESULTS: The patients with a good prognosis had significantly lower serum ICTP concentrations than the patients with a poor prognosis both before the operation and at all the postoperative time points studied (3, 6, 9, 12, 18, and 24 months), whereas a corresponding difference in CA125 was first seen after a 12-month follow-up. In multivariate regression analysis, the 9-month serum ICTP concentration remained the only independent prognostic indicator of all biochemical, clinical, and histological variables. The postoperative serum ICTP concentration did not correlate with the clinical stage, the grade of differentiation, or the presence of residual tumor. In contrast to ICTP, postoperative serum CA125 correlated with the clinical stage and the presence of residual tumor. CONCLUSIONS: Because our ICTP test does not detect defectively cross-linked carboxyterminal telopeptides of type I collagen, which is the predominant form in malignant ovarian tissue, the excess ICTP of ovarian cancer patients must originate from the tissue around the tumor, where the malignancy is causing tissue damage. As an indicator of invasion, the serum ICTP test opens up new possibilities to assess the clinical behavior of ovarian cancer and, in the future, also the effect of possible antiproteinase treatment in ovarian cancer.
PubMed ID
11426971 View in PubMed
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Elevated serum ICTP concentrations reflect poor prognosis in patients with ovarian carcinoma.

https://arctichealth.org/en/permalink/ahliterature23333
Source
Ann Med. 1995 Feb;27(1):57-61
Publication Type
Article
Date
Feb-1995
Author
M. Santala
L. Risteli
U. Puistola
J. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Ann Med. 1995 Feb;27(1):57-61
Date
Feb-1995
Language
English
Publication Type
Article
Keywords
Adult
Aged
CA-125 Antigen - blood
Collagen - analysis
Female
Humans
Middle Aged
Ovarian Neoplasms - diagnosis - therapy
Peptide Fragments - blood
Peptides - analysis
Procollagen - blood
Prognosis
Tumor Markers, Biological - blood
Abstract
The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced in ovarian carcinoma tissue and the peritoneal cavity by the tumour. CA 125 and the aminoterminal propeptide of type III procollagen (PIIINP) were also measured. The preoperative CA 125, PIIINP and ICTP concentrations were pathological in 16 (94%), nine (53%) and seven (41%) patients, respectively. There was a positive correlation between the PIIINP and ICTP levels in serum. After surgery and one course of cytotoxic chemotherapy, the median CA 125 concentration decreased whereas those of PIIINP and ICTP increased. During monitoring of the treatment response, patients with regressive disease showed lower CA 125 concentrations than those with stable or progressive disease. For PIIINP and ICTP there was no clear difference between these response categories, but altogether, simultaneously increasing serum CA 125, PIIINP and ICTP concentrations were consistently associated with poor prognosis.
PubMed ID
7742000 View in PubMed
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Elevated serum inhibin and tumor-associated trypsin inhibitor concentrations in a young woman with dysgerminoma of the ovary.

https://arctichealth.org/en/permalink/ahliterature21295
Source
Gynecol Oncol. 1998 Dec;71(3):465-8
Publication Type
Article
Date
Dec-1998
Author
M. Santala
H. Burger
A. Ruokonen
F. Stenbäck
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland. msantala@cc.oulu.fi
Source
Gynecol Oncol. 1998 Dec;71(3):465-8
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Adult
Dysgerminoma - blood
Female
Humans
Inhibins - blood
Ovarian Neoplasms - blood
Trypsin Inhibitor, Kazal Pancreatic - blood
Abstract
We describe a patient with dysgerminoma who had elevated serum inhibin, tumor-associated trypsin inhibitor (TATI), and CA 125 concentrations, which increased progressively during follow-up of the advancing disease. Inhibin levels correlated closely with disease behavior. In contrast to inhibin, serum TATI and CA 125 failed to reveal the presence of silent disease.
PubMed ID
9887252 View in PubMed
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Endometrial adenocarcinoma complicated by malignant pericardial effusion.

https://arctichealth.org/en/permalink/ahliterature23300
Source
Gynecol Oncol. 1995 Mar;56(3):444-5
Publication Type
Article
Date
Mar-1995
Author
M. Santala
U. Puistola
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, Oulu University Central Hospital, Finland.
Source
Gynecol Oncol. 1995 Mar;56(3):444-5
Date
Mar-1995
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - complications - secondary
Cardiac Tamponade - etiology
Endometrial Neoplasms - pathology
Female
Heart Neoplasms - complications - secondary
Humans
Middle Aged
Pericardial Effusion - etiology
Pericardium
Abstract
A case of malignant pericardial effusion associated with endometrial adenocarcinoma is presented. A total abdominal hysterectomy with bilateral salpingo-oophorectomy and partial omentectomy was performed 8 months before the occurrence of cardiac tamponade. The treatment of malignant pericardial effusion consisted of emergency pericardiocentesis and systemic chemotherapy and a clinical response for 6 months was achieved.
PubMed ID
7705682 View in PubMed
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Explosive rise of serum CA 125 following the rupture of ovarian endometrioma.

https://arctichealth.org/en/permalink/ahliterature21297
Source
Hum Reprod. 1998 Dec;13(12):3503-4
Publication Type
Article
Date
Dec-1998
Author
J. Johansson
M. Santala
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Hum Reprod. 1998 Dec;13(12):3503-4
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Endometriosis - pathology - physiopathology - surgery
Female
Humans
Middle Aged
Ovarian Cysts - pathology - physiopathology - surgery
Ovarian Diseases - pathology - physiopathology
Ovary - pathology
Rupture, Spontaneous
Abstract
Serum CA 125 concentration is seldom >100 IU/ml in endometriosis. We report a patient with ruptured endometrioma presenting with a very high CA 125 concentration, 9300 IU/ml. Elimination of endometriosis was followed by a sharp decrease in serum CA 125. We conclude that some of the CA 125 molecules from the ruptured endometriotic cyst may be transferred through the peritoneum, thereby increasing serum CA 125 concentration. The associated inflammatory reaction of the mesothelial cells of the peritoneum was probably the most important contributor to this phenomenon, as mesothelial cells are an important source of CA 125.
PubMed ID
9886540 View in PubMed
Less detail

Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary.

https://arctichealth.org/en/permalink/ahliterature19578
Source
Gynecol Oncol. 2001 Aug;82(2):389-91
Publication Type
Article
Date
Aug-2001
Author
M. Santala
E. Suvanto-Luukkonen
A. Kyllönen
A. Ruokonen
U. Puistola
Author Affiliation
Department of Obstetrics and Gynecology, University Hospital of Oulu, FIN-90220, Oulu, Finland. msantala@cc.oulu.fi
Source
Gynecol Oncol. 2001 Aug;82(2):389-91
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Adult
Female
Granulosa Cell Tumor - blood - complications - surgery
Humans
Hyperprolactinemia - blood - complications
Ovarian Neoplasms - blood - complications - surgery
Prolactin - blood
Abstract
BACKGROUND: Granulosa cell tumors are known to be hormonally active. They usually produce estrogen and inhibin, and the serum inhibin level is often considered a useful tumor marker during the follow-up of this illness. CASE: We present a case of malignant juvenile granulosa cell tumor associated with hyperprolactinemia. In our patient, the serum prolactin concentration closely reflected the behavior of the disease. CONCLUSION: Our findings are consistent with the assumption that prolactin was a tumor marker in this patient.
PubMed ID
11531301 View in PubMed
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Matrix metalloproteinases 2 and 9 and their tissue inhibitors in low malignant potential ovarian tumors.

https://arctichealth.org/en/permalink/ahliterature17354
Source
Tumour Biol. 2004 Jul-Aug;25(4):188-92
Publication Type
Article
Author
M. Määttä
M. Santala
Y. Soini
A. Talvensaari-Mattila
T. Turpeenniemi-Hujanen
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland.
Source
Tumour Biol. 2004 Jul-Aug;25(4):188-92
Language
English
Publication Type
Article
Keywords
Female
Gelatinase A - metabolism
Gelatinase B - metabolism
Humans
Immunohistochemistry
Neoplasm Staging
Ovarian Neoplasms - enzymology - pathology
Tissue Inhibitor of Metalloproteinase-2 - metabolism
Tissue Inhibitor of Metalloproteinases - metabolism
Abstract
OBJECTIVES: This study aimed to analyze the expression of matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) and their tissue inhibitors TIMP-1 and TIMP-2 in low malignant potential (LMP) ovarian tumors and to compare these values with those recorded for benign and malignant ovarian neoplasms. METHODS: A total of 53 ovarian tumors (16 benign, 15 LMP and 22 malignant) were evaluated by immunohistochemistry for the expression of MMP-2, MMP-9, TIMP-1 and TIMP-2. RESULTS: MMP-2 expression was found in 56% of the benign, 40% of the LMP, and 90% of the malignant ovarian tumors (benign vs. malignant, p = 0.021; LMP vs. malignant, p = 0.002). The expression of MMP-9, TIMP-1 and TIMP-2 was lower in the benign and LMP tumors compared with the malignant ones. CONCLUSION: The data suggest that, in relation to the expression of MMP-2, MMP-9, TIMP-1 and TIMP-2, LMP ovarian tumors are more similar to benign than to malignant ovarian tumors.
PubMed ID
15557756 View in PubMed
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New endocrine tumor markers of gynecologic malignancies. A review.

https://arctichealth.org/en/permalink/ahliterature20719
Source
Acta Obstet Gynecol Scand. 1999 Nov;78(10):833-7
Publication Type
Article
Date
Nov-1999
Author
A. Kauppila
M. Santala
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Source
Acta Obstet Gynecol Scand. 1999 Nov;78(10):833-7
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Activins
Chorionic Gonadotropin, beta Subunit, Human - urine
Female
Genital Neoplasms, Female - diagnosis - metabolism
Glycoprotein Hormones, alpha Subunit - urine
Humans
Inhibins - analysis
Tumor Markers, Biological - metabolism
PubMed ID
10577610 View in PubMed
Less detail

The prognostic value of peritoneal cytology in ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature20675
Source
Eur J Gynaecol Oncol. 1999;20(5-6):357-60
Publication Type
Article
Date
1999
Author
M. Simojoki
M. Santala
S. Vuopala
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Source
Eur J Gynaecol Oncol. 1999;20(5-6):357-60
Date
1999
Language
English
Publication Type
Article
Keywords
Adult
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Ovarian Neoplasms - mortality - pathology
Peritoneum - pathology
Prognosis
Retrospective Studies
Survival Analysis
Abstract
We studied the significance of peritoneal cytology as a prognostic factor in primary epithelial ovarian cancer. Intraperitoneal specimens for cytological examination were taken from 73 patients at primary operation for ovarian cancer. The prognostic value of cytological findings was analyzed by the Kaplan-Meier method. It was also correlated to clinical stage, tumor histology, histopathological grade, residual tumor, presence of ascites and age by using the chi2-test. The value of cytology in relation to other factors was assessed by Cox-multivariate analysis. In univariate analysis peritoneal cytological findings correlated significantly to survival. In Cox-multivariate analysis peritoneal cytology, histopathological grade and the age of the patient were found to be significant independent prognostic factors in epithelial ovarian cancer. According to this data peritoneal cytology can be considered as an important prognostic factor in ovarian cancer. Therefore it should be evaluated routinely in association with surgery of ovarian tumors.
PubMed ID
10609494 View in PubMed
Less detail

Serial determinations of aminoterminal propeptide of type III procollagen (PIIINP) and prognosis in ovarian cancer; comparison to CA125.

https://arctichealth.org/en/permalink/ahliterature20000
Source
Anticancer Res. 2000 Nov-Dec;20(6C):4655-60
Publication Type
Article
Author
M. Simojoki
M. Santala
J. Risteli
L. Risteli
A. Kauppila
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, FIN-90220 Oulu, Finland.
Source
Anticancer Res. 2000 Nov-Dec;20(6C):4655-60
Language
English
Publication Type
Article
Keywords
Adult
Aged
CA-125 Antigen - blood
Comparative Study
Female
Humans
Middle Aged
Ovarian Neoplasms - blood - diagnosis - mortality - surgery
Peptide Fragments - blood
Predictive value of tests
Procollagen - blood
Prognosis
Regression Analysis
Survival Rate
Time Factors
Tumor Markers, Biological - blood
Abstract
During malignant growth many changes take place in the metabolism of fibrillar type III collagens in the connective tissues. The aminoterminal propeptide of type III procollagen (PIIINP) has been found to be often elevated in ovarian cancer. In the present study the prognostic value of serum PIIINP concentration in epithelial ovarian cancer is evaluated in relation to serum CA125. Fifty-six women were enrolled in the study. Serial venous blood samples were taken preoperatively and 6, 9 and 12 months after operation for PIIINP and CA125 determinations. The results were correlated to the three-year survival. In Kaplan-Meier survival analysis the preoperative (P = 0.0422), 9-month (P = 0.0062) and 12-month (P = 0.0062) serum PIIINP concentration distinguished between the patients with good and poor prognosis while CA125 did so only at 9- (P = 0.0005) and 12-month (P
PubMed ID
11205196 View in PubMed
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12 records – page 1 of 2.