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28 records – page 1 of 3.

Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population.

https://arctichealth.org/en/permalink/ahliterature58782
Source
Am J Hum Genet. 2000 May;66(5):1569-79
Publication Type
Article
Date
May-2000
Author
M. Rämet
R. Haataja
R. Marttila
J. Floros
M. Hallman
Author Affiliation
Department of Pediatrics and Biocenter Oulu, University of Oulu, FIN-90014, Oulu, Finland.
Source
Am J Hum Genet. 2000 May;66(5):1569-79
Date
May-2000
Language
English
Publication Type
Article
Keywords
Alleles
Birth weight
Female
Finland
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genotype
Gestational Age
Glucocorticoids - therapeutic use
Haplotypes - genetics
Humans
Infant, Newborn
Infant, Premature
Introns - genetics
Logistic Models
Male
Matched-Pair Analysis
Proteolipids - genetics - physiology
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants - genetics - physiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Respiratory Distress Syndrome, Newborn - genetics
Risk factors
Sequence Deletion - genetics
Sex Characteristics
Abstract
Respiratory-distress syndrome (RDS) in the newborn is a major cause of neonatal mortality and morbidity. Although prematurity is the most-important risk factor for RDS, the syndrome does not develop in many premature infants. The main cause of RDS is a deficiency of pulmonary surfactant, which consists of phospholipids and specific proteins. The genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the surfactant protein A (SP-A) gene locus and RDS in the genetically homogeneous Finnish population. In the present study, 88 infants with RDS and 88 control infants that were matched for degree of prematurity, prenatal glucocorticoid therapy, and sex were analyzed for SP-A genotypes. We show that certain SP-A1 alleles (6A2 and 6A3) and an SP-A1/SP-A2 haplotype (6A2/1A0) were associated with RDS. The 6A2 allele was overrepresented and the 6A3 allele was underrepresented in infants with RDS. These associations were particularly strong among small premature infants born at gestational age
PubMed ID
10762543 View in PubMed
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Changing incidence and outcome of infants with respiratory distress syndrome in the 1990s: a population-based survey.

https://arctichealth.org/en/permalink/ahliterature58288
Source
Acta Paediatr. 2004 Feb;93(2):177-84
Publication Type
Article
Date
Feb-2004
Author
M. Koivisto
R. Marttila
M. Kurkinen-Räty
T. Saarela
M L Pokela
P. Jouppila
M. Hallman
Author Affiliation
Department of Paediatrics, University of Oulu, Oulu, Finland.
Source
Acta Paediatr. 2004 Feb;93(2):177-84
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Adult
Anthropometry
Female
Follow-Up Studies
Gestational Age
Humans
Incidence
Infant, Newborn
Population Surveillance
Pre-Eclampsia - epidemiology
Pregnancy
Prospective Studies
Questionnaires
Recurrence
Respiratory Distress Syndrome, Newborn - epidemiology - mortality - prevention & control
Survival Rate
Abstract
AIM: To evaluate the trends in the incidence, clinical course and outcome of respiratory distress syndrome (RDS) in the newborn in the Oulu University Hospital region in northern Finland. METHODS: In the population of 58 990 infants, the incidence rates of RDS specific to gestational age and birthweight in two consecutive periods, 1990-95 and 1996-99, were calculated. Clinical course and other neonatal morbidities were reported. All surviving infants were followed up until 1 y of corrected age. RESULTS: The overall incidence of RDS did not change significantly (8.7/1000 livebirths in 1990-95 vs 7.6 in 1996-99; p = 0.15), but the gestational age-adjusted incidence decreased between the two consecutive periods (p = 0.005). The frequency of infants with gestational age below 28 wk tended to increase towards the late 1990s, while their RDS incidence remained unchanged. RDS-related neonatal mortality decreased in parallel with neonatal mortality, accounting for 15% of all neonatal deaths. The duration of oxygen therapy shortened (8.0 vs 5.5 d) and the incidence of pneumothorax decreased (9.7 vs 4.1%), whereas the rate of chronic lung disease at 36 wk of postconceptional age (16.4 vs 16.7%) and at 1 y of corrected age (9.2 vs 8.2%) remained unchanged, as did also associated neurosensory morbidity (8.8 vs 9.5%). CONCLUSION: During the 1990s, the incidence of RDS shifted towards more immature infants and the gestational-age specific incidence decreased. The course of the disease shortened and acute complications decreased. The frequency of chronic pulmonary sequelae (and associated neurosensory morbidity) at the age of 1 y did not change significantly.
PubMed ID
15046270 View in PubMed
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A comparison of standard and compositional data analysis in studies addressing group differences in sedentary behavior and physical activity.

https://arctichealth.org/en/permalink/ahliterature296867
Source
Int J Behav Nutr Phys Act. 2018 06 15; 15(1):53
Publication Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Date
06-15-2018
Author
Nidhi Gupta
Svend Erik Mathiassen
Glòria Mateu-Figueras
Marina Heiden
David M Hallman
Marie Birk Jørgensen
Andreas Holtermann
Author Affiliation
National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark. ngu@nrcwe.dk.
Source
Int J Behav Nutr Phys Act. 2018 06 15; 15(1):53
Date
06-15-2018
Language
English
Publication Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Accelerometry - statistics & numerical data
Adult
Age Factors
Cross-Sectional Studies
Denmark
Exercise
Female
Humans
Male
Middle Aged
Sedentary Behavior
Sex Factors
Sleep
Surveys and Questionnaires
Abstract
Data on time spent in physical activity, sedentary behavior and sleep during a day is compositional in nature, i.e. they add up to a constant value. Compositional data have fundamentally different properties from unconstrained data in real space, and require other analytical procedures, referred to as compositional data analysis (CoDA). Most physical activity and sedentary behavior studies, however, still apply analytical procedures adapted to data in real space, which can lead to misleading results. The present study describes a comparison of time spent sedentary and in physical activity between age groups and sexes, and investigates the extent to which results obtained by CoDA differ from those obtained using standard analytical procedures.
Time spent sedentary, standing, and in physical activity (walking/running/stair climbing/cycling) during work and leisure was determined for 1-4 days among 677 blue-collar workers using accelerometry. Differences between sexes and age groups were tested using MANOVA, using both a standard and a CoDA approach based on isometric log-ratio transformed data.
When determining differences between sexes for different activities time at work, the effect size using standard analysis (?2?=?0.045, p?
PubMed ID
29903009 View in PubMed
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Cytokines, pulmonary surfactant and consequences of intrauterine infection.

https://arctichealth.org/en/permalink/ahliterature58873
Source
Biol Neonate. 1999 Jun;76 Suppl 1:2-9
Publication Type
Article
Date
Jun-1999
Author
M. Hallman
Author Affiliation
Department of Pediatrics, University of Oulu, Finland. mikko.hallman@oulu.fi
Source
Biol Neonate. 1999 Jun;76 Suppl 1:2-9
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Animals
Chorioamnionitis - complications
Cytokines
Female
Fetal Death - etiology
Humans
Infant, Newborn
Infant, Premature, Diseases - etiology
Obstetric Labor, Premature - etiology
Pregnancy
Pulmonary Surfactants - therapeutic use
Respiratory Distress Syndrome, Newborn - drug therapy - etiology
Abstract
Excess of inflammatory cytokines is implicated in the sequence of inflammatory diseases during the perinatal period. Specific cytokines induce spontaneous premature labor and accelerate fetal lung maturity in case of chorioamnionitis. In addition, they are involved in the pathogenesis of chronic lung disease, periventricular white matter damage, shock and multiorgan damage. Deficient cytokine response of the immature lung is associated with severe respiratory distress syndrome and persistent fetal circulation syndrome. Surfactant supplementation remains the cornerstone among therapies in the premature infant. Brief courses of glucocorticoids, antioxidants or inhaled nitric oxides remain to be fully evaluated as possible adjunct therapies shortly after birth in small premature infants with severe cardiorespiratory failure.
PubMed ID
10393386 View in PubMed
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Degree of lung maturity determines the direction of the interleukin-1- induced effect on the expression of surfactant proteins.

https://arctichealth.org/en/permalink/ahliterature63986
Source
Am J Respir Cell Mol Biol. 2000 Mar;22(3):280-8
Publication Type
Article
Date
Mar-2000
Author
V. Glumoff
O. Väyrynen
T. Kangas
M. Hallman
Author Affiliation
Department of Pediatrics and Biocenter Oulu, University of Oulu, Oulu, Finland.
Source
Am J Respir Cell Mol Biol. 2000 Mar;22(3):280-8
Date
Mar-2000
Language
English
Publication Type
Article
Keywords
Amniotic Fluid - chemistry
Animals
Blotting, Western
Cycloheximide - pharmacology
Dactinomycin - pharmacology
Female
Fetus - chemistry - physiology
Gene Expression Regulation, Developmental - drug effects - physiology
Interleukin-1 - pharmacology
Lung - chemistry - growth & development - physiology
Organ Culture Techniques
Pregnancy
Protein Synthesis Inhibitors - pharmacology
Proteolipids - analysis - genetics
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants - analysis - genetics
RNA, Messenger - analysis - genetics
Rabbits
Research Support, Non-U.S. Gov't
Abstract
Intra-amniotic interleukin (IL)-1 increases surfactant components in immature fetal lung, whereas high IL-1 after birth is associated with surfactant dysfunction. Our aim was to investigate whether the fetal age influences the responsiveness of surfactant proteins (SPs) to IL-1. Rabbit lung explants from fetuses at 19, 22, 27, and 30 d of gestation and 1-d-old newborns were cultured in serum-free medium in the presence of recombinant human (rh) IL-1alpha or vehicle. The influence of IL-1alpha on SP-A, -B, and -C messenger RNA (mRNA) content was dependent on the conceptional age. In very immature lung on Day 19, rhIL-1alpha (570 ng/ml for 20 h) increased SP-A, -B, and -C mRNA by 860+/-15%, 314+/-108%, and 64+/-17%, respectively. The increase in SP-A mRNA was evident within 4 to 6 h. IL-1alpha increased the SP-A concentration in alveolar epithelial cells and in the culture medium within 20 h. In contrast, at 27 to 30 d of gestation and in newborns, IL-1alpha decreased SP-C, -B, and -A mRNA by means of 64 to 67%, 48 to 59%, and 12 to 15%, respectively. SP-B protein decreased by 45 to 60%. The decrease in mRNA became evident within 8 to 12 h and was dependent on IL-1 concentration. On Day 27, IL-1alpha accelerated the degradation of SP-B mRNA in the presence of actinomycin D. IL-1 did not increase the degradation rate of SP-A mRNA unless both actinomycin D and cycloheximide were added to the explants. The present findings may explain some of the contrasting associations between inflammatory cytokines and lung diseases during the perinatal period. The determinants of the direction of the IL-1 effect on the expression of SPs remain to be identified.
PubMed ID
10696064 View in PubMed
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Differences in heart rate reserve of similar physical activities during work and in leisure time - A study among Danish blue-collar workers.

https://arctichealth.org/en/permalink/ahliterature296989
Source
Physiol Behav. 2018 03 15; 186:45-51
Publication Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Date
03-15-2018
Author
Pieter Coenen
Mette Korshøj
David M Hallman
Maaike A Huysmans
Allard J van der Beek
Leon M Straker
Andreas Holtermann
Author Affiliation
Department of Public and Occupational Health, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands; School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia. Electronic address: p.coenen@vumc.nl.
Source
Physiol Behav. 2018 03 15; 186:45-51
Date
03-15-2018
Language
English
Publication Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Accelerometry
Adolescent
Adult
Aged
Cardiorespiratory fitness
Cross-Sectional Studies
Denmark
Employment
Exercise - physiology
Female
Heart Rate - physiology
Heart Rate Determination
Humans
Leisure Activities
Male
Middle Aged
Occupations
Sex Factors
Young Adult
Abstract
Recent studies suggest that while leisure-time physical activity (LTPA) promotes general health, engaging in occupational physical activity (OPA) may have negative health consequences. It has been hypothesized that the different health effects from OPA and LTPA can be explained by differences in physical activity (PA) intensity in these two domains. To assess the intensity of OPA and LTPA, we aimed to study the percentage heart rate reserve (%HRR) during similar types of OPA and LTPA during workdays. Data from the NOMAD study on Danish blue-collar workers (n=124) with objective measurements of PA (using accelerometers) and heart rate (using heart rate monitors) for 4 workdays were analysed. Activities of sitting, standing, moving, walking, and stair climbing were identified and %HRR in each of these activities was determined for work and leisure. %HRR was significantly higher during OPA than LTPA. These differences were more pronounced in men than in women. Although not statistically significant in the fully adjusted model, we found indications that these differences were more pronounced in those with low compared to high fitness. To our knowledge, this is the first study with objective measurements showing that %HRR is higher during the same gross-body postural activities when performed at work compared to leisure-time during workdays. This elevated intensity may help explaining the negative health consequences of engagement in high levels of OPA. Future guidelines should distinguish OPA from LTPA, possibly by advising workers to remain active during their leisure time, in particular when they are highly active at work.
PubMed ID
29341873 View in PubMed
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Diminished inducible nitric oxide synthase expression in fulminant early-onset neonatal pneumonia.

https://arctichealth.org/en/permalink/ahliterature58775
Source
Pediatrics. 2000 May;105(5):1013-9
Publication Type
Article
Date
May-2000
Author
O. Aikio
K. Vuopala
M L Pokela
M. Hallman
Author Affiliation
Department of Pediatrics, University of Oulu, Oulu, Finland.
Source
Pediatrics. 2000 May;105(5):1013-9
Date
May-2000
Language
English
Publication Type
Article
Keywords
Humans
Infant, Newborn
Nitric Oxide Synthase - analysis - biosynthesis
Pneumonia - enzymology - pathology
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: Fulminant early-onset neonatal pneumonia is associated with ascending intrauterine infection (IUI), prematurity, persistent pulmonary hypertension (PPHN), and septicemia. Nitric oxide (NO) as an inflammatory mediator is included in antimicrobial defense and has a role in pathogenesis of septic shock. The aim was to study the role of inflammatory NO in neonatal pneumonia. METHODS: Lungs from 36 autopsies were studied: 12 had fulminant early-onset neonatal pneumonia, 5 pneumonia of later onset, and 19 controls had similar gestational and postnatal age. In addition, airway specimens from 21 intubated newborns were analyzed: 7 with fulminant early-onset pneumonia, 7 apparently noninfected infants born prematurely attributable to IUI, and 7 premature infants of similar gestation. Specimens were analyzed for inducible NO synthase (NOS2) and nitrotyrosine, an indicator of NO toxicity. The degree of staining was analyzed. RESULTS: In fulminant pneumonia, alveolar macrophages (AM) showed significantly less NOS2 immunoactivity than the controls. In the airway specimens, the infants with fulminant pneumonia 0 to 2 days after birth had significantly lower intracellular NOS2 and nitrotyrosine and significantly lower interleukin-1beta and surfactant protein-A than apparently noninfected IUI infants. NOS2 and the other indices increased significantly during the recovery. CONCLUSIONS: For the first time, we report NOS2 expression by macrophages from human neonates. In fulminant early-onset neonatal pneumonia, delayed production rather than excess of pulmonary inflammatory NO is associated with severe symptoms.
PubMed ID
10790456 View in PubMed
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Exhaled and nasal nitric oxide in mechanically ventilated preterm and term newborns.

https://arctichealth.org/en/permalink/ahliterature58455
Source
Acta Paediatr. 2002;91(10):1078-86
Publication Type
Article
Date
2002
Author
O. Aikio
M L Pokela
M. Hallman
Author Affiliation
Department of Pediatrics, University of Oulu, Finland.
Source
Acta Paediatr. 2002;91(10):1078-86
Date
2002
Language
English
Publication Type
Article
Keywords
Breath Tests
Chemiluminescent Measurements
Humans
Infant, Newborn
Infant, Premature - physiology
Nitric Oxide - analysis
Nose
Research Support, Non-U.S. Gov't
Respiration, Artificial
Respiratory Distress Syndrome, Newborn - physiopathology
Abstract
AIM: Nitric oxide (NO) is an important mediator required for neonatal pulmonary circulatory adaptation and for pulmonary defence. Both deficient and excessive NO production have been proposed to play a role in neonatal lung disease. This study aimed to establish a method that allows direct measurement of exhaled and nasal NO concentrations in newborn infants who require intubation and ventilation. METHODS: A rapid-response chemiluminescence NO analyser was used. Gas was sampled from the endotracheal intubation tube, and tidal volumes and flow rates were measured. The nasal NO was sampled from the non-intubated nostril. The accuracy of the method was validated using a lung model. NO levels from six preterm and six term/near-term newborns were studied. Measurements were performed on a daily basis during the first week. RESULTS: An expiration >0.2 s in duration with a flow rate >1.7 ml s(-1) could be accurately analysed for the presence of >1 parts per billion of NO. The very preterm infants with neonatal lung disease had a different postnatal NO output pattern from the lower and upper airways compared with the ventilated term/near-term infants. CONCLUSION: A novel method for measurement of exhaled NO of an intubated newborn is presented. The possible association of exhaled NO concentration with the development of chronic lung disease remains to be studied.
PubMed ID
12434894 View in PubMed
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Follow-up study of the early, randomised paracetamol trial to preterm infants, found no adverse reactions at the two-years corrected age.

https://arctichealth.org/en/permalink/ahliterature295437
Source
Acta Paediatr. 2018 Oct 16; :
Publication Type
Journal Article
Date
Oct-16-2018
Author
S Juujärvi
H Kallankari
P Pätsi
M Leskinen
T Saarela
M Hallman
O Aikio
Author Affiliation
PEDEGO Research Center and MRC Oulu, University of Oulu, Oulu, Finland.
Source
Acta Paediatr. 2018 Oct 16; :
Date
Oct-16-2018
Language
English
Publication Type
Journal Article
Abstract
We examined the long-term outcomes and safety of early intravenous paracetamol for ductus arteriosus closure at a corrected age of two years.
This was a follow-up of the 2013-2014 randomised, double-blind Preterm Infant's Paracetamol Study at Oulu University Hospital, Finland, which recruited 48 very preterm infants within 24 hours of birth. They received intravenous paracetamol or a placebo for four days. In 2015-2017, we followed up 44 infants (92%) at two years of corrected age. This included clinical and neurodevelopmental assessments and a parental medical history questionnaire.
The 44 infants (55% boys) were born at 235 -316 weeks of gestation. No differences in the cardiac parameters, including blood pressures and ultrasound scan results, were found. Neurodevelopmental stages, as quantified by the Griffiths test, were similar. No signs of autism were reported. Asthma medication was more common in the control group, but the difference was not significant. Atopy scores, numbers of infections and the use of public health services were similar between the two groups.
No long-term adverse reactions of early intravenous paracetamol were detected two years later. Larger trials are needed on the safety and efficacy of paracetamol prophylaxis for early ductal closure in very preterm infants.
PubMed ID
30325529 View in PubMed
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Health and the use of health care services in 5-year-old very-low-birth-weight infants.

https://arctichealth.org/en/permalink/ahliterature144955
Source
Acta Paediatr. 2010 Jul;99(7):1073-9
Publication Type
Article
Date
Jul-2010
Author
L. Rautava
U. Häkkinen
E. Korvenranta
S. Andersson
M. Gissler
M. Hallman
H. Korvenranta
J. Leipälä
M. Peltola
O. Tammela
L. Lehtonen
Author Affiliation
Department of Pediatrics, Turku University Hospital, Turku, Finland. liisi.rautava@utu.fi
Source
Acta Paediatr. 2010 Jul;99(7):1073-9
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Child Health Services - utilization
Child, Preschool
Finland - epidemiology
Follow-Up Studies
Gestational Age
Health status
Hospitals - classification
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology
Infant, Very Low Birth Weight
Morbidity
Questionnaires
Abstract
We aimed to study the effect of prematurity, time of birth and level of birth hospital on morbidity and the use of health care services at age 5.
This national study included all very-low-birth-weight infants (VLBWI,
PubMed ID
20219051 View in PubMed
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28 records – page 1 of 3.