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30 records – page 1 of 3.

31P-NMR study of skeletal muscle metabolism in patients with chronic respiratory impairment.

https://arctichealth.org/en/permalink/ahliterature5321
Source
Am Rev Respir Dis. 1992 Oct;146(4):1019-24
Publication Type
Article
Date
Oct-1992
Author
T. Kutsuzawa
S. Shioya
D. Kurita
M. Haida
Y. Ohta
H. Yamabayashi
Author Affiliation
Department of Respiratory Medicine, Tokai University School of Medicine, Isehara, Japan.
Source
Am Rev Respir Dis. 1992 Oct;146(4):1019-24
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Aged
Anaerobic Threshold - physiology
Energy Metabolism - physiology
Exercise - physiology
Forearm
Glycolysis - physiology
Humans
Hydrogen-Ion Concentration
Lung Diseases, Obstructive - metabolism
Magnetic Resonance Spectroscopy - diagnostic use
Male
Middle Aged
Muscles - metabolism
Phosphates - metabolism
Phosphocreatine - metabolism
Research Support, Non-U.S. Gov't
Abstract
To evaluate the energy metabolism of peripheral skeletal muscle during exercise in patients with chronic respiratory impairment, the 31P-nuclear magnetic resonance (NMR) spectra of forearm muscle were investigated in nine patients and nine age-matched control subjects. We calculated the phosphocreatine (PCr) to PCr + inorganic phosphate (PI) ratio, the time constant of PCr recovery and the intracellular pH. The exercise consisted of repetitive hand grips against a 2-kg load every 3 s for 6 min (0.33 W). The patients showed a marked decrease in the PCr/(PCr + PI) ratio and pH in the muscle during exercise in contrast to the control subjects whose PCr/(PCr + PI) showed a minor decrease without any change in pH. The relationship between PCr utilization and pH demonstrated that anaerobic glycolysis switched on earlier in patients with chronic respiratory impairment. A split PI peak was observed in five of nine patients during exercise. The PCr/(PCr + PI) ratio during the last minute of exercise correlated significantly with the vital capacity (% predicted), with the FEV1/FVC, with the body weight, with the maximum strength of hand grip, and with the muscle mass. The results indicate impaired oxidative phosphorylation and the early activation of anaerobic glycolysis in the muscles of patients with chronic respiratory impairment. Several factors related to chronic respiratory impairment, such as disuse, malnutrition and dysoxia, would contribute to the metabolic changes observed in the muscles examined.
PubMed ID
1416390 View in PubMed
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[A case of systemic lupus erythematosus with various central and peripheral neurological disorders presenting with motor paralytic bladder as a major manifestation]

https://arctichealth.org/en/permalink/ahliterature5604
Source
Ryumachi. 1995 Oct;35(5):821-6
Publication Type
Article
Date
Oct-1995
Author
T. Horiki
J. Moriuchi
R. Kouzuma
M. Haida
S. Watanabe
Y. Katsuoka
Y. Ichikawa
Author Affiliation
Department of Internal Medicine IV, Tokai University School of Medicine, Kanagawa.
Source
Ryumachi. 1995 Oct;35(5):821-6
Date
Oct-1995
Language
Japanese
Publication Type
Article
Keywords
Adult
Anti-Inflammatory Agents - administration & dosage
Antibodies, Antiphospholipid
Bladder Diseases - etiology
Central Nervous System Diseases - drug therapy - etiology
English Abstract
Female
Humans
Hypertension - etiology
Lupus Erythematosus, Systemic - complications - drug therapy
Methylprednisolone - administration & dosage
Peripheral Nervous System Diseases - drug therapy - etiology
Abstract
Myelopathy is a rare central nervous system manifestation in systemic lupus erythematosus (SLE). We present a case of SLE, who developed motor paralytic bladder and various other neurological abnormalities. A 29-year-old female with SLE was admitted to our hospital because of complete dysuria without any troubles on defecation. Accelerated hypertension had been noticed 2 weeks before the admission. Physical examinations revealed that she had muscle weakness in right brachial biceps, bilateral carpal extensor and flexor, and flexor muscles of bilateral lower extremities. Slight sensory disturbance was present on her soles. Bilateral Chaddok and Babinski's signs were positive. Electromyographic studies including nerve conduction velocities of her limbs were normal, however, neurogenic discharges were observed in anal sphincter muscles. Cystometry demonstrated atonic bladder, but any pathological findings such as lupus cystitis and interstitial cystitis were not observed in the biopsied specimens from her bladder. Antibodies to single-stranded DNA, U1 RNP, Sm and SS-A/Ro were positive in her serum, and lupus anticoagulant and anticardiolipin antibodies (IgG) were also detected. In her cerebral spinal fluid (CSF), elevated protein level and albuminocytologic dissociation were recognized, while glucose level was low. Magnetic resonance imaging (MRI) study detected high signal intensities in the inner part of medulla oblongata and in the spinal cord at second lumbar spine level. After two courses of methyl-prednisolone pulse therapy, the patient's neurological symptoms including dysuria had completely recovered and abnormal findings previously observed on MRI had also disappeared. After 7 months of the episode, she became normotensive. The proteins and glucose levels in her CSF had gradually returned to normal. Among patients with SLE, correlations of antiphospholipid antibodies with myelitis/myelopathy or accelerated hypertension have been reported. Therefore, possible roles of antiphospholipid antibodies were considered in the pathogenesis of neurologic abnormalities observed in our patient. In addition, low glucose level in CSF might be a good indicator for the diagnosis of lupus-associated myelopathy.
PubMed ID
8594661 View in PubMed
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Allergenic and immunogenic components of house dust mite, Dermatophagoides farinae.

https://arctichealth.org/en/permalink/ahliterature3845
Source
Ann Allergy. 1986 Feb;56(2):150-5
Publication Type
Article
Date
Feb-1986
Author
S. Nakada
M. Haida
T. Nakagawa
K. Ito
T. Miyamoto
Source
Ann Allergy. 1986 Feb;56(2):150-5
Date
Feb-1986
Language
English
Publication Type
Article
Keywords
Allergens
Animals
Antibodies, Anti-Idiotypic - analysis
Asthma - blood - immunology
Chromatography, Gel
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G - immunology
Mice
Mice, Inbred BALB C
Mites - immunology
Research Support, Non-U.S. Gov't
Skin Tests
Tissue Extracts - isolation & purification
Abstract
The house dust mite, Dermatophagoides farinae, was fractionated by a Sephadex G-200 column. Its allergenic (IgE-reacting) and immunogenic (IgG-reacting) components were investigated. By means of skin test, the molecular weight (MW) of major allergenic components of mite was found to be approximately 9,000 to 21,000 daltons. Immunogenic components were investigated by enzyme linked immunosorbent assay using each fraction as an antigen and mice plasma and human serum as antibodies. With mouse plasma, high IgG antibody titers were observed in fractions that contained the part of the mite with high MW (greater than 150,000). With human sera, high IgG antibody titers were observed in fractions that contained the part of the mite with MW more than 30,000. Heterogeneity of human IgG antibody responses against mite antigen was also suggested.
PubMed ID
3484919 View in PubMed
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Bone imaging in advanced gastric cancer.

https://arctichealth.org/en/permalink/ahliterature4012
Source
Clin Nucl Med. 1998 Jun;23(6):384
Publication Type
Article
Date
Jun-1998

[Clinical effect of alprazolam and trazodone on bronchial asthmatics with anxiety disorder]

https://arctichealth.org/en/permalink/ahliterature3834
Source
Arerugi. 1997 Oct;46(10):1058-71
Publication Type
Article
Date
Oct-1997
Author
M. Haida
K. Itoh
Author Affiliation
Department of Medicine and Physicalthrapy, University of Tokyo.
Source
Arerugi. 1997 Oct;46(10):1058-71
Date
Oct-1997
Language
Japanese
Publication Type
Article
Keywords
Adult
Aged
Alprazolam - adverse effects - therapeutic use
Anti-Anxiety Agents - administration & dosage - adverse effects - therapeutic use
Anxiety Disorders - complications
Asthma - drug therapy
English Abstract
Female
Humans
Male
Middle Aged
Trazodone - adverse effects - therapeutic use
Abstract
Onset as well as many symptoms of asthma are said to be related to autonomic dysfunction which often appear as a result of actual daily stress of the patients. Minor tranquilizers and anti-depressants are often successful in treating such symptoms, though precise effect of these drugs on asthma is not yet available, while many still hesitate to use these drug for fear of the anticholinergic effect which may hinder the efficient expectoration of sputum which could be critical during severe asthma attacks. In this study, these drugs were evaluated by the asthma score, peak flow, acetylcholine provocation test and the suppressive effect on lymphocytes. They could be beneficial in increasing the quality of asthma therapy if employed with necessary care.
PubMed ID
9404094 View in PubMed
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[Clinical usefulness of nuclear magnetic resonance imaging (MRI) in discriminating different pathological changes in two patients with lung cancer]

https://arctichealth.org/en/permalink/ahliterature4174
Source
Nihon Kyobu Shikkan Gakkai Zasshi. 1988 Jan;26(1):63-8
Publication Type
Article
Date
Jan-1988

Differentiation of lung cancer and radiation fibrosis using magnetic resonance images: a case study.

https://arctichealth.org/en/permalink/ahliterature4150
Source
Tokai J Exp Clin Med. 1990 Jul;15(4):293-8
Publication Type
Article
Date
Jul-1990
Author
S. Shioya
M. Haida
Y. Ono
T. Ohta
Y. Hayashi
T. Kurata
Author Affiliation
Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.
Source
Tokai J Exp Clin Med. 1990 Jul;15(4):293-8
Date
Jul-1990
Language
English
Publication Type
Article
Keywords
Diagnosis, Differential
Fibrosis
Humans
Lung - pathology - radiation effects
Lung Neoplasms - diagnosis - radiography
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Recurrence, Local
Radiation Injuries - diagnosis
Tomography, X-Ray Computed
Abstract
We used magnetic resonance imaging to differentiate residual and recurrent lung cancer from the surrounding radiation pulmonary fibrosis in a 62-year-old patient. The cancer's signal intensity was greater than the fibrotic lung tissue's intensity in an ECG-gated image with relatively short repetition and echo times and, also, in images with long repetition and echo times.
PubMed ID
2130536 View in PubMed
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Effect of chronic alcohol intake on energy metabolism in human muscle.

https://arctichealth.org/en/permalink/ahliterature5311
Source
Alcohol Clin Exp Res. 1996 Dec;20(9 Suppl):360A-362A
Publication Type
Article
Date
Dec-1996
Author
K. Yazaki
M. Haida
D. Kurita
Y. Shinohara
Author Affiliation
Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.
Source
Alcohol Clin Exp Res. 1996 Dec;20(9 Suppl):360A-362A
Date
Dec-1996
Language
English
Publication Type
Article
Keywords
Adult
Alcoholism - complications - physiopathology
Cerebellar Ataxia - physiopathology
Diplopia - physiopathology
Dysarthria - physiopathology
Energy Metabolism - drug effects - physiology
Ethanol - adverse effects
Humans
Isometric Contraction - physiology
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal - drug effects - physiopathology
Neurologic Examination
Phosphates - metabolism
Abstract
We investigated the effect of alcohol on muscle energy metabolism by using 31P magnetic resonance spectroscopy in 12 chronic alcoholics [6 with neurological signs and symptoms (such as cerebellar ataxia or diplopia) and 6 without neurological signs or symptoms], compared with five healthy subjects who also received acute alcohol loading. Intracellular pH and phosphocreatine (PCr) index [PCr/ (PCr + Pi)] were measured during rest, exercise, and recovery in the left flexor digitorum superficialis muscle. In healthy subjects, acute alcohol loading did not influence the changes of muscle pH and PCr index. Alcoholics with neurological signs showed marked decreases in muscle intracellular pH and PCr index during exercise and a marked delay of pH recovery after exercise. There was no delay of PCr index recovery. Alcoholics without neurological signs showed slight decreases in intracellular pH and PCr index, but rapid recovery of both intracellular pH and PCr index was observed. Marked decrease and delayed recovery in pH, but rapid recovery of PCr index, indicate that the muscle of patients with neurological signs produced lactate during and after exercise to maintain the ATP level, which implies that anaerobic metabolism is favored over aerobic metabolism in these patients.
PubMed ID
8986238 View in PubMed
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Effects of age on muscle energy metabolism and oxygenation in the forearm muscles.

https://arctichealth.org/en/permalink/ahliterature5289
Source
Med Sci Sports Exerc. 2001 Jun;33(6):901-6
Publication Type
Article
Date
Jun-2001
Author
T. Kutsuzawa
S. Shioya
D. Kurita
M. Haida
H. Yamabayashi
Author Affiliation
School of Health Sciences, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. tkutsu@is.icc.u-tokai.ac.jp
Source
Med Sci Sports Exerc. 2001 Jun;33(6):901-6
Date
Jun-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aging - physiology
Comparative Study
Energy Metabolism
Female
Forearm - blood supply - physiology
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal - physiology
Oxygen - metabolism
Phosphorus Isotopes - diagnostic use
Research Support, Non-U.S. Gov't
Spectroscopy, Near-Infrared
Abstract
PURPOSE: The effects of aging on muscle metabolism and oxygenation have not yet been elucidated. We evaluated the effects of aging on energy metabolism and oxygenation in sedentary healthy subjects by simultaneously measuring 31P-magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS). METHODS: Nine young (28.1 +/- 5.0 yr) and nine older (61.4 +/- 4.6 yr) healthy subjects were studied. The 31P-MR spectrum was obtained every 15 s during and after hand gripping exercise. Intracellular pH (pHi) and PCr/(PCr+Pi) [PCr: phosphocreatine, Pi: inorganic phosphate] were calculated as an index of energy metabolism. The time constant of the PCr/(PCr+Pi) recovery (tau PCr) was calculated. With NIRS, we evaluated the recovery rates of oxygenated (RHbO2) and deoxygenated hemoglobin (RHb) during the initial 10 s of recovery. RESULTS: The PCr/(PCr+Pi) and pHi at rest and at completion of the exercise and tau PCr did not differ between young and older subjects. However, RHbO2 and RHb were significantly slower in older subjects than in young subjects. CONCLUSIONS: The results suggest that muscle energy metabolism in the forearm muscle was not affected by aging. The slower RHbO2 and RHb in older subjects suggested impaired O2 supply, which was probably due to impaired peripheral circulation caused by the process of aging.
PubMed ID
11404654 View in PubMed
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Estimation of the malignancy of pleural effusions by electron spin resonance.

https://arctichealth.org/en/permalink/ahliterature4031
Source
Anal Biochem. 1996 Oct 1;241(1):47-50
Publication Type
Article
Date
Oct-1-1996
Author
K. Takeda
M. Haida
S. Shioya
T. Matsumori
Y. Kimura
K. Hasumi
Author Affiliation
ESR Laboratory, Electrochemical and Cancer Institute, Tokyo, Japan.
Source
Anal Biochem. 1996 Oct 1;241(1):47-50
Date
Oct-1-1996
Language
English
Publication Type
Article
Keywords
Electron Spin Resonance Spectroscopy
Humans
Neoplasms - diagnosis
Pleural Effusion, Malignant - diagnosis
Abstract
We conducted an electron spin resonance (ESR) study on human pleural effusions obtained from patients (n = 15) with and without cancer at 77 K. We detected two kinds of signals which are considered to be due to transition metal ions in metalloproteins such as Fe3+ in transferrin and Cu2+ in ceruloplasmin from their g values (g = 4.2 and 2.049) and line shapes. We found a significant difference in the signal intensity ratio, Cu2+/Fe3+, of the pleural effusions between cancer and noncancer patients by the Mann-Whitney U test (P
PubMed ID
8921164 View in PubMed
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30 records – page 1 of 3.