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Time trends and regional differences in registration, stage distribution, surgical management and survival of breast cancer in Denmark.

https://arctichealth.org/en/permalink/ahliterature18279
Source
Eur J Cancer. 2003 Aug;39(12):1783-93
Publication Type
Article
Date
Aug-2003
Author
A R Jensena
M. Ewertz
S. Cold
H H Storm
J. Overgaard
Author Affiliation
Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Norrebrogade 44, Building 5, DK-8000 Aarhus C, Denmark. anni@oncology.dk
Source
Eur J Cancer. 2003 Aug;39(12):1783-93
Date
Aug-2003
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Breast Neoplasms - mortality - pathology - surgery
Denmark - epidemiology
Epidemiologic Methods
Female
Humans
Middle Aged
Registries
Research Support, Non-U.S. Gov't
Residence Characteristics
Time Factors
Abstract
The aim of this study was to analyse time trends, stage at diagnosis, survival and registration of population-based cohorts of breast cancer patients in selected Danish counties (in total 2504) in 1986 and 1996-1997. In 1986, no differences in the extent of disease were observed between the counties. Patients from one county (Funen) had centralised surgery, significantly more lymph nodes removed and a better survival in the multivariate analysis. In 1996-1997, mammographical screening had been implemented in Funen, leading to a significantly better stage distribution, whereas stage remained unchanged in the other counties. In Funen, survival was significantly better than in the other counties in univariate, but not in multivariate analysis. Survival increased significantly with time only in Funen. Inclusion in clinical trials increased over time and the coverage of the database in the Danish Breast Cancer Cooperative Group (DBCG) was high. However, patients not notified in DBCG had, beside older age, also worse stage of disease distribution and less extensive surgery. A difference in survival was observed between the counties. In 1986, this may be explained by a centralised surgical system in one county, whereas in 1996-1997 improvements could be due to an early diagnosis and other as yet unknown factors. The DBCG database cannot be considered as representative of the Danish population of breast cancer patients.
PubMed ID
12888375 View in PubMed
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