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Adipose tissue fatty acids as biomarkers of dietary exposure in Danish men and women.

https://arctichealth.org/en/permalink/ahliterature24046
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Publication Type
Article
Date
May-1993
Author
A. Tjønneland
K. Overvad
E. Thorling
M. Ewertz
Author Affiliation
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Date
May-1993
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism
Adult
Biological Markers - analysis
Denmark - epidemiology
Diet - statistics & numerical data
Dietary Fats - administration & dosage
Fatty Acids - analysis
Female
Humans
Male
Middle Aged
Nutrition Surveys
Research Support, Non-U.S. Gov't
Abstract
Adipose tissue fatty acids, it has been proposed, reflect dietary intake. Using data from a validation study preceding a prospective study on diet, cancer, and health in Denmark, we were able to compare fatty acid profiles in adipose tissue biopsies from 86 individuals (23 men and 63 women) aged 40-64 y and dietary intake of fatty acids (as percentage of total fat) assessed by two 7-d weighed-diet records or by a semi-quantitative food frequency questionnaire. Correlation coefficients (Pearson r) between fatty acid concentrations in adipose tissue biopsies (as percentage of total peak area) and dietary intake of fatty acid (percentage of total fat), determined from the diet records for men and women, respectively, were as follows: polyunsaturated fatty acids r = 0.74 and r = 0.46; n - 3 fatty acids of marine origin: eicosapentaenoic acid r = 0.15 and r = 0.61, and docosahexaenoic acid r = 0.47 and r = 0.57. Correlation coefficients obtained by using the food frequency questionnaire were slightly lower for most fatty acids.
PubMed ID
8480677 View in PubMed
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Age at first birth, parity and risk of breast cancer: a meta-analysis of 8 studies from the Nordic countries.

https://arctichealth.org/en/permalink/ahliterature25102
Source
Int J Cancer. 1990 Oct 15;46(4):597-603
Publication Type
Article
Date
Oct-15-1990
Author
M. Ewertz
S W Duffy
H O Adami
G. Kvåle
E. Lund
O. Meirik
A. Mellemgaard
I. Soini
H. Tulinius
Author Affiliation
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copehagen.
Source
Int J Cancer. 1990 Oct 15;46(4):597-603
Date
Oct-15-1990
Language
English
Publication Type
Article
Keywords
Breast Neoplasms - epidemiology
Denmark
Female
Finland
Humans
Iceland
Maternal Age
Meta-Analysis
Norway
Parity
Research Support, Non-U.S. Gov't
Risk factors
Sweden
Abstract
Several large epidemiological studies in the Nordic countries have failed to confirm an association between age at first birth and breast cancer independent of parity. To assess whether lack of power or heterogeneity between the countries could explain this, a meta-analysis was performed of 8 population-based studies (3 cohort and 5 case-control) of breast cancer and reproductive variables in the Nordic countries, including a total of 5,568 cases. It confirmed that low parity and late age at first birth are significant and independent determinants of breast-cancer risk. Nulliparity was associated with a 30% increase in risk compared with parous women, and for every 2 births, the risk was reduced by about 16%. There was a significant trend of increasing risk with increasing age at first birth, women giving first birth after the age of 35 years having a 40% increased risk compared to those with a first birth before the age of 20 years. Tests for heterogeneity between studies were not significant for any of the examined variables. In the absence of bias, this suggests that several individual Nordic studies may have had too little power to detect the weak effect of age at first birth observed in the meta-analysis.
PubMed ID
2145231 View in PubMed
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Alcohol consumption and breast cancer risk in Denmark.

https://arctichealth.org/en/permalink/ahliterature12015
Source
Cancer Causes Control. 1991 Jul;2(4):247-52
Publication Type
Article
Date
Jul-1991
Author
M. Ewertz
Author Affiliation
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Source
Cancer Causes Control. 1991 Jul;2(4):247-52
Date
Jul-1991
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol Drinking
Breast Neoplasms - epidemiology - etiology
Case-Control Studies
Denmark - epidemiology
Dietary Fats - adverse effects
Female
Humans
Middle Aged
Research Support, Non-U.S. Gov't
Risk factors
Abstract
The influence of alcohol consumption on breast cancer risk was evaluated in a population-based case-control study, including 1,486 cases diagnosed over a one-year (1983-84) period in Denmark. Cases were identified from the files of the nationwide clinical trial of the Danish Breast Cancer Cooperative Group and the Danish Cancer Registry. The control group was an age-stratified random sample of 1,336 women from the general population. Data on risk factors were collected by self-administered questionnaires. The association of alcohol consumption with breast cancer risk varied with age and dietary fat intake. Among women aged 50-59 years, with a fat intake in the lowest quartile, the risk of breast cancer increased with increasing consumption of alcohol. A consumption of 24 g or more per day was associated with an 18-fold increased risk compared with abstainers. For women in other age groups, alcohol consumption had no significant association with breast cancer risk.
PubMed ID
1873455 View in PubMed
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The association between risk of breast cancer and age at first pregnancy and parity in Maribo County, Denmark.

https://arctichealth.org/en/permalink/ahliterature25347
Source
Acta Oncol. 1990;29(6):705-8
Publication Type
Article
Date
1990
Author
A. Mellemgaard
M. Ewertz
E. Lynge
Author Affiliation
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Source
Acta Oncol. 1990;29(6):705-8
Date
1990
Language
English
Publication Type
Article
Keywords
Adult
Breast Neoplasms - epidemiology - etiology
Denmark
Female
Humans
Maternal Age
Parity
Risk factors
Abstract
The effect of age at first pregnancy and number of pregnancies was examined in a cohort of 14,421 women where reproductive informations were collected as part of a cervical cancer screening program. A total of 352 cases occurred in the cohort. In subgroups of women defined by age at first pregnancy the relative risk of breast cancer was lower among women who were first pregnant before 25 years of age (RR = 0.85 vs 1.20). In subgroups of women defined by parity the relative risk decreased with increasing number of pregnancies from about unity among women with 0-3 pregnancies to 0.7 among women with 6 or more pregnancies.
PubMed ID
2223139 View in PubMed
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Breast cancer incidence by estrogen receptor status in Denmark from 1996 to 2007.

https://arctichealth.org/en/permalink/ahliterature119973
Source
Breast Cancer Res Treat. 2012 Nov;136(2):559-64
Publication Type
Article
Date
Nov-2012
Author
J. Bigaard
C. Stahlberg
M-B Jensen
M. Ewertz
N. Kroman
Author Affiliation
Department of Breast Surgery, Ringsted Hospital, Ringsted, Denmark. j.bigaard@dadlnet.dk
Source
Breast Cancer Res Treat. 2012 Nov;136(2):559-64
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Adult
Breast Neoplasms - epidemiology - metabolism
Denmark - epidemiology
Female
Humans
Incidence
Middle Aged
Receptors, Estrogen - metabolism
Retrospective Studies
Young Adult
Abstract
During the past 50 years, breast cancer incidence has increased by 2-3 % annually. Despite many years of testing for estrogen receptors (ER), evidence is scarce on breast cancer incidence by ER status. The aim of this paper was to investigate the increase in breast cancer incidence by ER status. Data were obtained from the clinical database of the Danish Breast Cancer Cooperative Group which holds nationwide data on diagnosis, including pathology, treatment, and follow-up on primary breast cancers since 1977. All Danish women
PubMed ID
23053655 View in PubMed
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Breast cancer incidence subsequent to surgical reduction of the female breast.

https://arctichealth.org/en/permalink/ahliterature26216
Source
Scand J Plast Reconstr Surg Hand Surg. 1987;21(2):209-12
Publication Type
Article
Date
1987
Author
K. Lund
M. Ewertz
G. Schou
Author Affiliation
Department of Plastic Surgery, University of Copenhagen, Hvidovre Hospital, Denmark.
Source
Scand J Plast Reconstr Surg Hand Surg. 1987;21(2):209-12
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Breast - surgery
Breast Neoplasms - epidemiology
Cross-Sectional Studies
Denmark
Female
Follow-Up Studies
Humans
Middle Aged
Postoperative Complications - epidemiology
Research Support, Non-U.S. Gov't
Abstract
The incidence of breast cancer was determined in 1245 women who were treated surgically for breast hypertrophy in Copenhagen, Denmark, between 1943 and 1971. Breast cancer cases were identified by a linkage to the Danish Cancer Registry. The expected number of breast cancers was estimated from age and calendar-time specific incidence rates in the Danish female population. A total of 18 breast cancers developed compared to 30.28 expected, yielding a relative risk (RR) of 0.59 (95% confidence interval (CI) 0.35-0.94). The greatest risk reduction was observed ten or more years after the plastic surgery operation in women who had 600 g or more of breast tissue removed (RR = 0.27; 95% CI 0.03-0.99). This suggests that the number of potential foci are important for cancer development in the breast.
PubMed ID
3500507 View in PubMed
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[Breast cancer in Denmark, 1943-1976. Cancer statistics no. 3]

https://arctichealth.org/en/permalink/ahliterature27155
Source
Ugeskr Laeger. 1981 Oct 12;143(42):2758-60
Publication Type
Article
Date
Oct-12-1981
Author
M. Ewertz
O M Jensen
Source
Ugeskr Laeger. 1981 Oct 12;143(42):2758-60
Date
Oct-12-1981
Language
Danish
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - mortality
Denmark
Female
Humans
Middle Aged
Registries
PubMed ID
7324222 View in PubMed
Less detail

Breast cancer in Denmark. Incidence, risk factors, and characteristics of survival.

https://arctichealth.org/en/permalink/ahliterature11792
Source
Acta Oncol. 1993;32(6):595-615
Publication Type
Article
Date
1993
Author
M. Ewertz
Author Affiliation
Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen.
Source
Acta Oncol. 1993;32(6):595-615
Date
1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology
Case-Control Studies
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Middle Aged
Registries
Research Support, Non-U.S. Gov't
Risk factors
Survival Rate
Abstract
In Denmark, incidence of female breast cancer remained constant from 1943 to around 1960, whereafter a steady increase has occurred, the level today being about 50% higher than in 1960. No equivalent rise has been observed for breast cancer mortality. Influence of hormonal and dietary factors on breast cancer risk and survival was evaluated in a combined population-based case-control and follow-up study, including 2,445 women, aged less than 70 years, diagnosed with breast cancer in Denmark between 1 March 1983 and 31 August 1984, identified from the files of the nation-wide clinical trial of the Danish Breast Cancer Co-operative Group (DBCG) and the Danish Cancer Registry. The control group was an age-stratified random sample of the general female population, selected from the Central Population Register. Data on risk factors were collected by self-administered questionnaires. Clinical and pathological tumour characteristics derived from DBCG. The case-control analysis confirmed an overall increased risk of breast cancer associated with urban residence, high social status, nulliparity, early age at menarche, late age at natural menopause, hormonal replacement therapy, high dietary fat intake, and high alcohol consumption in a subgroup. It failed to detect an association with age at first childbirth, oral contraceptives, smoking, intake of vegetables, tea, coffee, and sweeteners. Survival was determined by tumour size, skin invasion, number of positive lymph nodes, and grade. There was no relation between survival and reproductive or hormonal factors, dietary variables, alcohol consumption, or smoking. However, a complex relationship may exist between survival and body mass index.
PubMed ID
8260176 View in PubMed
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[Breast cancer in the Faeroe Islands during 1958-1987]

https://arctichealth.org/en/permalink/ahliterature24807
Source
Ugeskr Laeger. 1991 Jul 1;153(27):1939-41
Publication Type
Article
Date
Jul-1-1991
Author
S D Niclasen
M. Ewertz
B. Carstensen
M. Egholm
Author Affiliation
Institut for cancerepidemiologi, Kraeftens Bekaempelse, København.
Source
Ugeskr Laeger. 1991 Jul 1;153(27):1939-41
Date
Jul-1-1991
Language
Danish
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - mortality
Denmark - epidemiology
English Abstract
Female
Humans
Incidence
Middle Aged
Prognosis
Abstract
From 1958 to 1987, a total of 269 primary breast cancers were diagnosed in 261 women living in the Faroe Islands. The five-year survival was 46.7% (95% confidence interval 40.3-53.0%) and the median survival four years and three months. The incidence of breast cancer in the Faroe Islands remained constant from 1958 to 1972 after which an increase occurred. At present, one in 20 Faroe women will develop breast cancer before the age of 75 years. The time trend in breast cancer incidence is similar in the Faroe Islands and in Denmark, but the incidence is significantly lower in the Faroe Islands at a level corresponding to 2/3 of the Danish. This difference is presumed to be due to a different prevalence of risk factors for development breast cancer.
PubMed ID
1858177 View in PubMed
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47 records – page 1 of 5.