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Altered transfer of cholesteryl esters and phospholipids in plasma from alcohol abusers.

https://arctichealth.org/en/permalink/ahliterature10964
Source
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2940-7
Publication Type
Article
Date
Nov-1997
Author
M J Liinamaa
M L Hannuksela
Y A Kesäniemi
M J Savolainen
Author Affiliation
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland.
Source
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2940-7
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - blood
Alcoholism - blood
Apolipoproteins B - blood
Biological Transport
Carrier Proteins - blood
Cholesterol - blood
Cholesterol Esters - blood
Comparative Study
Glycoproteins
Humans
Lipoproteins, HDL - blood
Lipoproteins, VLDL - blood
Male
Membrane Proteins - blood
Middle Aged
Phospholipid Transfer Proteins
Phospholipids - blood
Research Support, Non-U.S. Gov't
Temperance
Triglycerides - blood
Abstract
The net mass transfer (NMT) of cholesteryl esters (CEs), triglycerides (TGs), and phospholipids (PLs) between lipoproteins was measured after incubation of fresh plasma for up to 2 hours from 18 male alcohol abusers and 17 male volunteer control subjects. In alcohol abusers the mean value of CE NMT was 3.7 nmol.mL-1.h-1 from apolipoprotein B-containing lipoproteins (apoB-containing lipoproteins) to HDL and in control subjects 8.7 nmol.mL-1.h-1 from HDL to apoB-containing lipoproteins. The NMT of PL was higher in alcohol abusers than in control subjects (35.0 vs 11.6 nmol.mL-1.h-1 from apoB-containing lipoproteins to HDL, respectively), and plasma PL transfer protein (TP) activity was 33% higher (P
PubMed ID
9409280 View in PubMed
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Low density lipoprotein derivatization by acetaldehyde affects lysine residues and the B/E receptor binding affinity.

https://arctichealth.org/en/permalink/ahliterature11956
Source
Alcohol Clin Exp Res. 1991 Dec;15(6):1050-5
Publication Type
Article
Date
Dec-1991
Author
K. Kervinen
M J Savolainen
M J Tikkanen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, University of Oulu, Finland.
Source
Alcohol Clin Exp Res. 1991 Dec;15(6):1050-5
Date
Dec-1991
Language
English
Publication Type
Article
Keywords
Acetaldehyde - blood - pharmacology
Alcohol Drinking - blood
Amino Acids - analysis
Dose-Response Relationship, Drug
Humans
LDL-Receptor Related Protein 1
Lipoproteins, LDL - blood - drug effects
Lysine - analysis
Receptors, Immunologic - analysis - drug effects
Receptors, LDL - analysis - drug effects
Research Support, Non-U.S. Gov't
Abstract
Acetaldehyde (AcA), the first metabolite in ethanol oxidation, forms covalent adducts with the free amino groups of various proteins. In this study, we examined how acetaldehyde modification affects the chemical and biological properties of the atherogenic low density lipoprotein (LDL). AcA modification did not alter the protein and lipid composition of LDL, but the AcA concentration used in the incubation correlated strongly with the electrophoretic mobility of acetaldehyde-treated LDL (AcA-LDL) (r = 0.97, p less than 0.001) and the percentage of the free amino groups in AcA-LDL (r = -0.90, p less than 0.01). Amino acid analysis of AcA-LDL showed that lysine was the predominant residue in LDL modified by AcA. Assays with monoclonal antibodies (MB47, 2b, 4G3, and C1.1) directed against different epitopes of the LDL apoprotein B suggested that AcA modification reduced the immunological recognition of the LDL receptor binding region and its vicinity. Also, the binding affinity of AcA-LDL to B/E receptors correlated negatively with the percentage of modified lysine residues in AcA-LDL (r = -0.96, p less than 0.001). The results suggest that AcA derivatizes the lysine residues of LDL, and thus decreases the B/E receptor binding affinity of LDL. However, major changes in LDL receptor binding were produced only with non-physiologically high concentrations of AcA, and, therefore, the role of the present findings in vivo remains uncertain.
PubMed ID
1789380 View in PubMed
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Social alcohol consumption and low Lp(a) lipoprotein concentrations in middle aged Finnish men: population based study.

https://arctichealth.org/en/permalink/ahliterature10917
Source
BMJ. 1998 Feb 21;316(7131):594-5
Publication Type
Article
Date
Feb-21-1998
Author
M. Paassilta
K. Kervinen
A O Rantala
M J Savolainen
M. Lilja
A. Reunanen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, University of Oulu, Finland.
Source
BMJ. 1998 Feb 21;316(7131):594-5
Date
Feb-21-1998
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - blood
Biological Markers - blood
Coronary Disease - blood - epidemiology
Cross-Sectional Studies
Finland - epidemiology
Humans
Lipoprotein(a) - blood
Male
Middle Aged
Notes
Comment In: BMJ. 1998 May 30;316(7145):16759603764
Comment In: BMJ. 1998 May 30;316(7145):16759643960
Comment In: BMJ. 1998 May 30;316(7145):1675-69643961
PubMed ID
9518912 View in PubMed
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