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The -1C to T polymorphism in the annexin A5 gene is not associated with the risk of acute myocardial infarction or sudden cardiac death in middle-aged Finnish males.

https://arctichealth.org/en/permalink/ahliterature53135
Source
Scand J Clin Lab Invest. 2005;65(2):133-40
Publication Type
Article
Date
2005
Author
K S Kaikkonen
S. Kakko
M L Kortelainen
J M Tapanainen
M J Savolainen
Y. Antero Kesäniemi
H V Huikuri
E R Savolainen
Author Affiliation
Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland.
Source
Scand J Clin Lab Invest. 2005;65(2):133-40
Date
2005
Language
English
Publication Type
Article
Keywords
5' Untranslated Regions - genetics
Adult
Aged
Annexin A5 - genetics
Death, Sudden, Cardiac - epidemiology - etiology
Finland - epidemiology
Genetic markers
Genetic Predisposition to Disease
Genetic Screening
Humans
Male
Middle Aged
Myocardial Infarction - epidemiology - genetics
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Risk factors
Abstract
OBJECTIVE: A common polymorphism (-1C to T) in the translation initiation sequence of annexin A5 (ANV) gene has recently been associated with a decreased risk of acute myocardial infarction (AMI). The aim of the present study was to analyze the association between the ANV genepolymorphism and the risk of AMI and ischemic sudden cardiac death (SCD) in middle-aged Finnish males. MATERIAL AND METHODS: A case-control study involving three distinct groups of subjects was carried out: (1) victims of SCD (n=98), (2) survivors of AMI (n=212), and (3) randomly selected control subjects without any history of coronary heart disease (n=243). The ANV polymorphism was genotyped in each study group. RESULTS: Among the control group of healthy Finnish males the prevalence rates of the CC, CT, and TT genotypes were 83.1%, 15.2%, and 1.6%, respectively. Among the survivors of AMI, the prevalence rates of CC, CT, and TT were 79.7%, 20.3%, and 0%, respectively, and among the victims of SCD 83.7%, 16.3%, and 0%, respectively. No significant differences in the genotype or allele distributions were observed between the study groups. CONCLUSION: The -1C to T polymorphism in the ANV gene is not associated with the risk of AMI or SCD in middle-aged Finnish males.
PubMed ID
16025836 View in PubMed
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Altered transfer of cholesteryl esters and phospholipids in plasma from alcohol abusers.

https://arctichealth.org/en/permalink/ahliterature10964
Source
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2940-7
Publication Type
Article
Date
Nov-1997
Author
M J Liinamaa
M L Hannuksela
Y A Kesäniemi
M J Savolainen
Author Affiliation
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland.
Source
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2940-7
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - blood
Alcoholism - blood
Apolipoproteins B - blood
Biological Transport
Carrier Proteins - blood
Cholesterol - blood
Cholesterol Esters - blood
Comparative Study
Glycoproteins
Humans
Lipoproteins, HDL - blood
Lipoproteins, VLDL - blood
Male
Membrane Proteins - blood
Middle Aged
Phospholipid Transfer Proteins
Phospholipids - blood
Research Support, Non-U.S. Gov't
Temperance
Triglycerides - blood
Abstract
The net mass transfer (NMT) of cholesteryl esters (CEs), triglycerides (TGs), and phospholipids (PLs) between lipoproteins was measured after incubation of fresh plasma for up to 2 hours from 18 male alcohol abusers and 17 male volunteer control subjects. In alcohol abusers the mean value of CE NMT was 3.7 nmol.mL-1.h-1 from apolipoprotein B-containing lipoproteins (apoB-containing lipoproteins) to HDL and in control subjects 8.7 nmol.mL-1.h-1 from HDL to apoB-containing lipoproteins. The NMT of PL was higher in alcohol abusers than in control subjects (35.0 vs 11.6 nmol.mL-1.h-1 from apoB-containing lipoproteins to HDL, respectively), and plasma PL transfer protein (TP) activity was 33% higher (P
PubMed ID
9409280 View in PubMed
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Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature48515
Source
Clin Genet. 1993 Oct;44(4):177-84
Publication Type
Article
Date
Oct-1993
Author
O. Ukkola
M J Savolainen
P I Salmela
K. von Dickhoff
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, Biocenter Oulu, Finland.
Source
Clin Genet. 1993 Oct;44(4):177-84
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Adult
Apolipoproteins B - analysis - genetics
Apolipoproteins E - analysis - genetics
Coronary Disease - complications - epidemiology - genetics
DNA - analysis
Diabetes Mellitus, Type 2 - diagnosis - genetics
Female
Humans
Male
Middle Aged
Polymorphism, Genetic - genetics
Research Support, Non-U.S. Gov't
Retinal Diseases - diagnosis
Abstract
The relationship between diabetic macroangiopathy or microangiopathy and apolipoprotein B (apoB) polymorphism was studied in 139 male and 129 female patients with non-insulin-dependent diabetes (NIDDM) mellitus, comprising consecutive patients with poor diabetic control (HBA1 13.2% +/- 2.7 (SD)) referred to our hospital. Plasma cholesterol and triglyceride concentrations were higher in the patients who were homozygous for the X2 allele (presence of XbaI cleavage site). Patients with the X1 allele (absence of XbaI cleavage site) tended to have a higher frequency of macroangiopathy, although the differences were not statistically significant. There was no difference in the prevalence of microangiopathy between the groups. In subjects with only an R1 allele (= R+; homozygous for the presence of EcoRI cleavage site) the prevalence of coronary heart disease (CHD) was observed to be high (61.9%) as compared to the subjects possessing an R2 allele (= R-; homozygous or heterozygous for the absence of the EcoRI cleavage site) (46.7%; p
PubMed ID
8261646 View in PubMed
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Apolipoprotein E and B polymorphisms--longevity factors assessed in nonagenarians.

https://arctichealth.org/en/permalink/ahliterature54937
Source
Atherosclerosis. 1994 Jan;105(1):89-95
Publication Type
Article
Date
Jan-1994
Author
K. Kervinen
M J Savolainen
J. Salokannel
A. Hynninen
J. Heikkinen
C. Ehnholm
M J Koistinen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, University of Oulu, Finland.
Source
Atherosclerosis. 1994 Jan;105(1):89-95
Date
Jan-1994
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alleles
Apolipoproteins B - genetics
Apolipoproteins E - genetics
Female
Gene Frequency
Genotype
Humans
Lipoprotein(a) - blood
Longevity - genetics
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Abstract
To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (apo E) and B (apo B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control groups. The frequency of the epsilon 4 allele of apo E was significantly lower in the nonagenarians than in the middle-aged and young adults (P
PubMed ID
8155090 View in PubMed
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Apolipoprotein E phenotype, cholesterol and breast and prostate cancer.

https://arctichealth.org/en/permalink/ahliterature20132
Source
J Epidemiol Community Health. 2000 Dec;54(12):938-9
Publication Type
Article
Date
Dec-2000

Apolipoprotein E phenotype determines the effect of alcohol on blood pressure in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature10774
Source
Am J Hypertens. 1998 Nov;11(11 Pt 1):1334-43
Publication Type
Article
Date
Nov-1998
Author
H. Kauma
M J Savolainen
A O Rantala
M. Lilja
K. Kervinen
A. Reunanen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland. heikki.kauma@oulu.fi
Source
Am J Hypertens. 1998 Nov;11(11 Pt 1):1334-43
Date
Nov-1998
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Apolipoproteins E - genetics
Blood Pressure - drug effects
Ethanol - pharmacology
Female
Humans
Insulin Resistance
Male
Middle Aged
Phenotype
Research Support, Non-U.S. Gov't
Abstract
Apolipoprotein E (apoE) has an essential role in lipoprotein metabolism, but recent studies have also revealed other functions associated with it, eg, neurologic and malignant diseases. We studied the association between apoE phenotypes E2/3, E3/3, and E4/3 and blood pressure after adjustment for covariates, as well as the association between phenotypes and adjusted plasma glucose and insulin levels in the standard oral glucose tolerance test in a random middle-aged population-based cohort of 259 men and 267 women. Systolic blood pressure was associated with apoE phenotype in the men with moderate or heavy alcohol consumption (>115 g/week), the mean systolic blood pressure value being 16 mm Hg higher in the E2/3 and 11 mm Hg higher in the E3/3 phenotypes than in the E4/3 phenotype, P = .04. No association was seen in occasional drinkers or teetotalers (lowest tertile
Notes
Comment In: Am J Hypertens. 1999 Sep;12(9 Pt 1):946-710509555
Comment In: Am J Hypertens. 1999 Sep;12(9 Pt 1):949-5010509558
PubMed ID
9832177 View in PubMed
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Association between angiotensin converting enzyme gene polymorphism and carotid atherosclerosis.

https://arctichealth.org/en/permalink/ahliterature52730
Source
J Hypertens. 1996 Oct;14(10):1183-7
Publication Type
Article
Date
Oct-1996
Author
H. Kauma
M. Päivänsalo
M J Savolainen
A O Rantala
T R Kiema
M. Lilja
A. Reunanen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, University of Oulu, Finland.
Source
J Hypertens. 1996 Oct;14(10):1183-7
Date
Oct-1996
Language
English
Publication Type
Article
Keywords
Adult
Arteriosclerosis - enzymology - genetics
Carotid Artery Diseases - enzymology - genetics
Female
Genotype
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Risk factors
Variation (Genetics)
Abstract
OBJECTIVE: Variations in the angiotensin converting enzyme (ACE) gene have been implicated in cardiovascular pathology. Therefore, the association between the intima-media thickness (IMT) of the carotid artery and the insertion/ deletion (I/D) polymorphism of the ACE gene was investigated. SUBJECTS: Three hundred men and 300 women were selected randomly from the middle-aged population living in the town Oulu, Finland, of whom 515 subjects (85.8%) participated. METHODS: The IMT of the carotid arteries was determined by bilateral B-mode ultrasonography. IMT values were adjusted for gender, age, height, plasma low-density lipoprotein cholesterol level, smoking and systolic blood pressure. The I/D polymorphism of the ACE gene was determined by polymerase chain reaction. RESULTS: Among non-smokers, the subjects with the DD genotype had significantly higher carotid IMT than did those with II or ID. The association was found also in combined IMT plaque values. In the total population the association was weaker and it was absent in current smokers. Genotype could explain 1.3-2.7% of the variance of carotid IMT in non-smokers. No association between the amount or size of carotid plaques and genotype was observed. CONCLUSIONS: Variations at the ACE gene locus contribute to the degree of the early changes in carotid atherosclerosis in the population. The gene effect is, however, masked by stronger effects of environmental factors such as smoking. The lack of association between atherosclerotic plaques and genotypes may reflect different mechanisms being involved in plaque development and early arterial wall thickening.
PubMed ID
8906516 View in PubMed
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Association of lipoprotein cholesterol and triglycerides with the severity of coronary artery disease in men and women.

https://arctichealth.org/en/permalink/ahliterature54588
Source
Atherosclerosis. 1996 Dec 20;127(2):213-20
Publication Type
Article
Date
Dec-20-1996
Author
T. Korhonen
M J Savolainen
M J Koistinen
M. Ikäheimo
M K Linnaluoto
K. Kervinen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine, University of Oulu, Finland.
Source
Atherosclerosis. 1996 Dec 20;127(2):213-20
Date
Dec-20-1996
Language
English
Publication Type
Article
Keywords
Adult
Aged
Apolipoproteins E - blood - genetics
Biological Markers - blood
Cholesterol - blood
Comparative Study
Coronary Angiography
Coronary Disease - blood - physiopathology - radiography
Female
Humans
Immunoblotting
Immunoradiometric Assay
Lipoproteins - blood
Male
Middle Aged
Research Support, Non-U.S. Gov't
Risk factors
Severity of Illness Index
Sex Factors
Triglycerides - blood
Abstract
The differences between the lipid profiles of male and female patients and the effect of plasma lipids on the extent of coronary artery disease were evaluated in 122 angiographically assessed coronary artery disease patients (95 males and 27 females) and 60 controls. Both male and female patients had lower HDL-cholesterol and higher total cholesterol, LDL-cholesterol, triglyceride, VLDL-cholesterol and VLDL-triglyceride concentrations than the controls. The VLDL lipid values did not differ significantly between the male patients with different extent of CAD, whereas the VLDL lipid values of female patients tended to increase with an increasing severity of CAD. High Lp(a) (> or = 35 mg/dl) values were more prevalent in patients with > 50% coronary stenosis compared to patients with
PubMed ID
9125311 View in PubMed
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Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men.

https://arctichealth.org/en/permalink/ahliterature10550
Source
Eur J Clin Invest. 2000 Jan;30(1):18-25
Publication Type
Article
Date
Jan-2000
Author
S. Kakko
M. Tamminen
M. Päivänsalo
H. Kauma
A O Rantala
M. Lilja
A. Reunanen
Y A Kesäniemi
M J Savolainen
Author Affiliation
University of Oulu, Oulu, Finland. sakari.kakko@oulu.fi
Source
Eur J Clin Invest. 2000 Jan;30(1):18-25
Date
Jan-2000
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Carotid Artery Diseases - genetics
Carrier Proteins - genetics
Female
Genotype
Glycoproteins
Humans
Linkage Disequilibrium
Lipoproteins, HDL Cholesterol - blood
Male
Middle Aged
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Tunica Intima - pathology
Abstract
BACKGROUND: The cholesteryl ester transfer protein (CETP) is involved in the reverse cholesterol transport and is therefore a candidate gene for atherosclerosis. DESIGN: The prevalences of the I405V and the R451Q polymorphisms were studied in a population sample of 515 men and women. Genotypes were determined by PCR and carotid atherosclerosis by ultrasonography as the mean intima-media thickness (IMT) of the carotid arteries. RESULTS: The Q451 allele was associated with significantly lower intima media thickness in men (P = 0.001). The Q451 allele was, in our earlier study, associated with high plasma CETP activity in men. The VV405 genotype was associated with lower plasma CETP activity compared with the II405 genotype (P
PubMed ID
10619997 View in PubMed
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Dietary and other non-pharmacological treatments in patients with drug-treated hypertension and control subjects.

https://arctichealth.org/en/permalink/ahliterature10480
Source
J Intern Med. 2000 Mar;247(3):318-24
Publication Type
Article
Date
Mar-2000
Author
M L Silaste
R. Junes
A O Rantala
H. Kauma
M. Lilja
M J Savolainen
A. Reunanen
Y A Kesäniemi
Author Affiliation
Department of Internal Medicine and the Biocentre Oulu, University of Oulu, Oulu, Finland. Marja-Leena.Silaste@oulu.fi
Source
J Intern Med. 2000 Mar;247(3):318-24
Date
Mar-2000
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Cross-Sectional Studies
Diet
Diet Records
Female
Finland
Humans
Hypertension - diet therapy - drug therapy - therapy
Life Style
Male
Middle Aged
Research Support, Non-U.S. Gov't
Risk factors
Abstract
OBJECTIVE: To study the nutrient intakes and other lifestyle patterns of drug-treated hypertensives and control subjects. DESIGN: A cross-sectional population-based epidemiological study. SETTING: The participating study subjects visited the research laboratory of the Department of Internal Medicine of the University of Oulu, Oulu, Finland. PARTICIPANTS: A total of 1045 Finnish men and women aged 40-60 years, of whom 716 (69%) completed 7-day food records. MAIN OUTCOME MEASURES: Intakes of energy, protein, total fat, saturated, monounsaturated and polyunsaturated fatty acids, carbohydrate, alcohol, fibre, calcium, magnesium, potassium and sodium were assessed from 7-day food records. The study also included measurements of blood pressure, blood glucose and plasma lipids, and anthropometric variables. Information about alcohol consumption, smoking habits and physical activity was collected by interviewing. RESULTS: Obesity was common amongst the hypertensive subjects, whose body mass indices were significantly higher than those of the control subjects. Only minor differences existed in the energy intake levels and nutrient intakes of the hypertensive and control cohorts, but the control subjects performed more physical activity than the hypertensive subjects. The dietary recommendations concerning the intakes of total and saturated fats, carbohydrate and fibre were poorly met by both the hypertensive and the control subjects. Alcohol consumption was high amongst the hypertensive men, especially amongst the smokers. CONCLUSIONS: Non-pharmacological treatment, including dietary management, of hypertensive patients at high risk for cardiovascular complications seems still to be inadequate. Additional well-focused efforts are needed to intensify the dietary treatment as well as to reduce alcohol consumption and smoking amongst hypertensives.
PubMed ID
10762447 View in PubMed
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45 records – page 1 of 5.