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Cause-specific mortality among spouses of Parkinson disease patients.

https://arctichealth.org/en/permalink/ahliterature257409
Source
Epidemiology. 2014 Mar;25(2):225-32
Publication Type
Article
Date
Mar-2014
Author
Malene Nielsen
Johnni Hansen
Beate Ritz
Helene Nordahl
Eva Schernhammer
Lene Wermuth
Naja Hulvej Rod
Author Affiliation
From the aDepartment of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark; bDanish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark; cSchool of Public Health, UCLA, Los Angeles, CA; dHarvard School of Public Health, Department of Epidemiology, Boston, MA; eDepartment of Neurology, Odense University Hospital, Odense, Denmark; and fThe Copenhagen Stress Research Center, Copenhagen, Denmark.
Source
Epidemiology. 2014 Mar;25(2):225-32
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Caregivers
Cause of Death
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Parkinson Disease
Proportional Hazards Models
Registries
Sex Factors
Spouses
Abstract
Caring for a chronically ill spouse is stressful, but the health effects of caregiving are not fully understood. We studied the effect on mortality of being married to a person with Parkinson disease.
All patients in Denmark with a first-time hospitalization for Parkinson disease between 1986 and 2009 were identified, and each case was matched to five population controls. We further identified all spouses of those with Parkinson disease (n = 8,515) and also the spouses of controls (n = 43,432). All spouses were followed in nationwide registries until 2011.
Among men, being married to a Parkinson disease patient was associated with a slightly higher risk of all-cause mortality (hazard ratio = 1.06 [95% confidence interval = 1.00-1.11]). Mortality was particularly high for death due to external causes (1.42 [1.09-1.84]) including suicide (1.89 [1.05-3.42]) and death from undefined symptoms/abnormal findings (1.25 [1.07-1.47]). Censoring at the time of death of the patient attenuated the findings for all-cause mortality in husbands (1.02 [0.95-1.09]), indicating that part of the association is with bereavement. Still, living with a person with Parkinson disease 5 years after first Parkinson hospitalization was associated with higher risk of all-cause mortality for both husbands (1.15 [1.07-1.23]) and wives (1.11 [1.04-1.17]).
Caring for a spouse with a serious chronic illness is associated with a slight but consistent elevation in mortality risk.
PubMed ID
24378369 View in PubMed
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Clinical characteristics of Parkinson's disease among Inuit in Greenland and inhabitants of the Faroe Islands and Als (Denmark).

https://arctichealth.org/en/permalink/ahliterature6014
Source
Mov Disord. 2004 Jul;19(7):821-4
Publication Type
Article
Date
Jul-2004
Author
Lene Wermuth
Nick Bünger
Paul von Weitzel-Mudersback
Henning Pakkenberg
Bernard Jeune
Author Affiliation
Department of Neurology, Sonderborg Hospital, Denmark. l_wermuth@dadlnet.dk
Source
Mov Disord. 2004 Jul;19(7):821-4
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Aged
Brain Chemistry
Catchment Area (Health)
Denmark - epidemiology
Female
Food Habits
Greenland - epidemiology
Humans
Hydrocarbons, Chlorinated
Hypokinesia - epidemiology - physiopathology
Insecticides - analysis
Inuits
Male
Middle Aged
Parkinson Disease - epidemiology - ethnology - physiopathology
Prevalence
Research Support, Non-U.S. Gov't
Tremor - epidemiology - physiopathology
Abstract
In earlier studies, we found high age-adjusted prevalences of Parkinson's disease (PD) in the Faroe Islands (209 per 100,000 inhabitants) and in Greenland (187.5 per 100,000 inhabitants) compared to the age-adjusted prevalence on the island of Als in the southern part of Denmark (98.3 per 100,000 inhabitants). We thoroughly examined patients with suspected parkinsonism using internationally accepted diagnostic criteria. In the present study, we found no significant clinical differences between patients with PD in the three areas, despite this high difference in prevalence. However, comparing the age at examination and age at treatment, the patients were younger in Greenland, a higher proportion of patients had cognitive decline, and they had a higher mean Hoehn and Yahr rating score, although they received a lower levodopa dose. A higher proportion of the patients in Greenland were newly diagnosed than in the other two areas.
PubMed ID
15254942 View in PubMed
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Diabetes and the risk of developing Parkinson's disease in Denmark.

https://arctichealth.org/en/permalink/ahliterature136125
Source
Diabetes Care. 2011 May;34(5):1102-8
Publication Type
Article
Date
May-2011
Author
Eva Schernhammer
Johnni Hansen
Kathrine Rugbjerg
Lene Wermuth
Beate Ritz
Author Affiliation
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. eva.schernhammer@channing.harvard.edu
Source
Diabetes Care. 2011 May;34(5):1102-8
Date
May-2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Denmark - epidemiology
Diabetes Mellitus - epidemiology - physiopathology
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Parkinson Disease - epidemiology - etiology
Risk factors
Abstract
Insulin contributes to normal brain function. Previous studies have suggested associations between midlife diabetes and neurodegenerative diseases, including Parkinson's disease. Using Danish population registers, we investigated whether a history of diabetes or the use of antidiabetes drugs was associated with Parkinson's disease.
From the nationwide Danish Hospital Register hospital records, we identified 1,931 patients with a first-time diagnosis of Parkinson's disease between 2001 and 2006. We randomly selected 9,651 population control subjects from the Central Population Registry and density matched them by birth year and sex. Pharmacy records comprising all antidiabetes and anti-Parkinson drug prescriptions in Denmark were available. Odds ratios (ORs) were estimated by logistic regression models.
Having diabetes, as defined by one or more hospitalizations and/or outpatient visits for the condition, was associated with a 36% increased risk of developing Parkinson's disease (OR 1.36 [95% CI 1.08-1.71]). Similarly, diabetes defined by the use of any antidiabetes medications was associated with a 35% increased Parkinson's disease risk (1.35 [1.10-1.65]). When diabetes was defined as the use of oral antidiabetes medications, effect estimates were stronger in women (2.92 [1.34-6.36]), whereas when diabetes was defined as any antidiabetes drug prescription, patients with early-onset Parkinson's disease were at highest risk (i.e., Parkinson's disease diagnosed before the age of 60 years; 3.07 [1.65-5.70]).
We found that a diagnosis of, or treatment received for, diabetes was significantly associated with an increased risk of developing Parkinson's disease, especially younger-onset Parkinson's disease. Our results suggest a common pathophysiologic pathway between the two diseases. Future studies should take age at Parkinson's disease onset into account.
Notes
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PubMed ID
21411503 View in PubMed
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[Educational specialists' function in Southern Denmark].

https://arctichealth.org/en/permalink/ahliterature154475
Source
Ugeskr Laeger. 2008 Oct 27;170(44):3533-6
Publication Type
Article
Date
Oct-27-2008
Author
Lene Wermuth
Bente Sørensen
Inger Fog
Thomas Hertel
Tom Bonnesen
Ejler Ejlersen
Author Affiliation
Neurologisk Afdeling, Odense Universitetshospital, DK-5000 Odense C. l_wermuth@dadlnet.dk
Source
Ugeskr Laeger. 2008 Oct 27;170(44):3533-6
Date
Oct-27-2008
Language
Danish
Publication Type
Article
Keywords
Clinical Competence
Denmark
Education, Medical, Continuing - methods
Education, Medical, Graduate - methods
Humans
Job Satisfaction
Questionnaires
Teaching - methods
Abstract
A new educational training concept was introduced with the latest Danish national reform of specialist training of doctors in 2004. We performed a questionnaire survey, the aim of which was to explore the result of the implementation so far and to get ideas facilitating a sharper focus of our efforts to further develop the educational reform. The results showed high commitment within the system and also pointed to management support as an essential prerequisite for job satisfaction. The development and assessment of the specialist training, however, need further observation.
PubMed ID
18976617 View in PubMed
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Gout and the risk of Parkinson's disease in Denmark.

https://arctichealth.org/en/permalink/ahliterature115892
Source
Eur J Epidemiol. 2013 Apr;28(4):359-60
Publication Type
Article
Date
Apr-2013
Author
Eva Schernhammer
Jiaheng Qiu
Lene Wermuth
Christina Funch Lassen
Soren Friis
Beate Ritz
Source
Eur J Epidemiol. 2013 Apr;28(4):359-60
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Case-Control Studies
Denmark - epidemiology
Drug Prescriptions - statistics & numerical data
Female
Gout - drug therapy - epidemiology - metabolism
Gout Suppressants - adverse effects - therapeutic use
Humans
Logistic Models
Male
Middle Aged
Parkinson Disease - diagnosis - epidemiology
Population Surveillance
Registries
Risk factors
Uric Acid - metabolism
Notes
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PubMed ID
23456139 View in PubMed
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Lifestyle, family history, and risk of idiopathic Parkinson disease: a large Danish case-control study.

https://arctichealth.org/en/permalink/ahliterature264567
Source
Am J Epidemiol. 2015 May 15;181(10):808-16
Publication Type
Article
Date
May-15-2015
Author
Line Kenborg
Christina F Lassen
Beate Ritz
Klaus K Andersen
Jane Christensen
Eva S Schernhammer
Johnni Hansen
Lene Wermuth
Naja H Rod
Jørgen H Olsen
Source
Am J Epidemiol. 2015 May 15;181(10):808-16
Date
May-15-2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alcohol drinking - epidemiology
Caffeine
Case-Control Studies
Denmark - epidemiology
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Parkinson Disease - epidemiology - prevention & control
Risk
Smoking - adverse effects - epidemiology
Abstract
The relationship between Parkinson disease (PD) and smoking has been examined in several studies, but little is known about smoking in conjunction with other behaviors and a family history of PD. Using unconditional logistic regression analysis, we studied individual and joint associations of these factors with idiopathic PD among 1,808 Danish patients who were diagnosed in 1996-2009 and matched to 1,876 randomly selected population controls. Although there was a downward trend in duration of smoking, this was not observed for daily tobacco consumption. A moderate intake of caffeine (3.1-5 cups/day) was associated with a lower odds ratio for PD (0.45, 95% confidence interval: 0.34, 0.62), as was a moderate intake of alcohol (3.1-7 units/week) (odds ratio = 0.60, 95% confidence interval: 0.58, 0.84); a higher daily intake did not reduce the odds further. When these behaviors were studied in combination with smoking, the odds ratios were lower than those for each one alone. Compared with never smokers with no family history of PD, never smokers who did have a family history had an odds ratio of 2.81 (95% confidence interval: 1.91, 4.13); for smokers with a family history, the odds ratio was 1.60 (95% confidence interval: 1.15, 2.23). In conclusion, duration of smoking seems to be more important than intensity in the relationship between smoking and idiopathic PD. The finding of lower risk estimates for smoking in combination with caffeine or alcohol requires further confirmation.
Notes
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PubMed ID
25925389 View in PubMed
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Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease.

https://arctichealth.org/en/permalink/ahliterature135116
Source
Neuroepidemiology. 2011;36(3):155-61
Publication Type
Article
Date
2011
Author
Angelika D Manthripragada
Eva S Schernhammer
Jiaheng Qiu
Soren Friis
Lene Wermuth
Jorgen H Olsen
Beate Ritz
Author Affiliation
Department of Epidemiology, School of Public Health, UCLA, Los Angeles, CA 90095–1772, USA.
Source
Neuroepidemiology. 2011;36(3):155-61
Date
2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin - therapeutic use
Case-Control Studies
Denmark - epidemiology
Female
Humans
Male
Middle Aged
Parkinson Disease - drug therapy - epidemiology - prevention & control
Registries
Risk factors
Abstract
Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease (PD).
We investigated associations between use of aspirin, nonaspirin NSAIDs, and acetaminophen and PD in a large population-based case-control study using Danish health and pharmacy registries. We identified 1,931 PD cases reported in hospital or outpatient clinic records who had received a primary diagnosis of PD between 2001 and 2006, and 9,651 age- and sex-matched controls from the Danish population register. Prescription medication use was documented in a pharmacy database covering all residents of Denmark since 1995.
Adjusting for age, sex, use of cardiovascular disease drugs, diagnosis of chronic pulmonary obstructive disorder, and Charlson comorbidity scores, and excluding prescriptions filled within 5 years before diagnosis, we found no evidence for an association between PD and either aspirin use (OR = 0.97; 95% CI 0.82, 1.14) or nonaspirin NSAID use (OR = 0.97; 95% CI 0.86, 1.09), regardless of intensity of use; further, there was no association between use of ibuprofen or acetaminophen and PD.
Our findings provide no evidence for a protective effect of nonaspirin and aspirin NSAID prescription drug use shortly before PD onset.
Notes
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PubMed ID
21508649 View in PubMed
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Statin use and Parkinson's disease in Denmark.

https://arctichealth.org/en/permalink/ahliterature96351
Source
Mov Disord. 2010 Jul 15;25(9):1210-6
Publication Type
Article
Date
Jul-15-2010
Author
Beate Ritz
Angelika D Manthripragada
Lei Qian
Eva Schernhammer
Lene Wermuth
Jorgen Olsen
Soren Friis
Author Affiliation
Department of Epidemiology, UCLA School of Public Health, Los Angeles, California 90095-1772, USA. britz@ucla.edu
Source
Mov Disord. 2010 Jul 15;25(9):1210-6
Date
Jul-15-2010
Language
English
Publication Type
Article
Abstract
The objective of this study was to investigate whether statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor) use is associated with risk of Parkinson's disease (PD) in Denmark. We identified 1,931 patients with a first time diagnosis of PD reported in hospital or outpatient clinic records between 2001 and 2006. We density matched to these patients 9,651 population controls by birth year and sex relying on the Danish population register. For every participant, we identified pharmacy records of statin and anti-Parkinson drug prescriptions since 1995 and before index date from a prescription medication use database for all Danish residents. Whenever applicable, the index dates for cases and their corresponding controls were advanced to the date of first recorded prescription for anti-Parkinson drugs. In our primary analyses, we excluded all statin prescriptions 2-years before PD diagnosis. Employing logistic regression adjusting for age, sex, diagnosis of chronic obstructive pulmonary disease, and Charlson comorbidity, we observed none to slightly inverse associations between PD diagnosis and statin prescription drug use. Inverse associations with statin use were only observed for short-term (
PubMed ID
20629142 View in PubMed
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8 records – page 1 of 1.