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IMMUNE REGULATION AND VASCULAR INFLAMMATION IN GENETIC HYPERTENSION.

https://arctichealth.org/en/permalink/ahliterature96053
Source
Am J Physiol Heart Circ Physiol. 2009 Dec 31;
Publication Type
Article
Date
Dec-31-2009
Author
Viel Emilie C
Lemarié Catherine A
Benkirane Karim
Paradis Pierre
Schiffrin Ernesto L
Author Affiliation
Lady Davis institute for medical research-Sir Mortimer B. Davis-Jewish General Hospital, McGill University.
Source
Am J Physiol Heart Circ Physiol. 2009 Dec 31;
Date
Dec-31-2009
Language
English
Publication Type
Article
Abstract
Immune cells have been implicated in the pathogenesis of hypertension. We hypothesized that under the influence of chromosome 2 (chr2), T lymphocytes contribute to vascular inflammation in genetic salt-sensitive hypertension. Normotensive (Brown Norway), hypertensive (Dahl salt-sensitive) and consomic rats (SSBN2, in which chr2 has been transferred from Brown Norway to Dahl rats) were studied. Systolic blood pressure measured by tail-cuff and aortic preproendothelin mRNA measured by RT-qPCR were elevated in Dahl rats compared with Brown Norway rats, and were reduced in SSBN2 compared with Dahl rats (P
PubMed ID
20044442 View in PubMed
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