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Apolipoprotein B/A-I ratio related to visceral but not to subcutaneous adipose tissue in elderly Swedes.

https://arctichealth.org/en/permalink/ahliterature144309
Source
Atherosclerosis. 2010 Aug;211(2):656-9
Publication Type
Article
Date
Aug-2010
Author
Charlotte Ebeling Barbier
Lars Lind
Håkan Ahlström
Anders Larsson
Lars Johansson
Author Affiliation
Department of Radiology, Uppsala University Hospital, 75185 Uppsala, Sweden. Charlotte.Ebeling Barbier@radiol.uu.se
Source
Atherosclerosis. 2010 Aug;211(2):656-9
Date
Aug-2010
Language
English
Publication Type
Article
Keywords
Adipose Tissue - pathology
Aged
Apolipoprotein A-I - metabolism
Apolipoproteins B - metabolism
Cohort Studies
Female
Humans
Intra-Abdominal Fat - pathology
Magnetic Resonance Imaging - methods
Male
Random Allocation
Regression Analysis
Sex Factors
Subcutaneous Fat - pathology
Sweden
Abstract
To investigate whether the amount of visceral (VAT) or subcutaneous adipose tissue (SAT) independently of the other can determine the apolipoprotein (apo)B/A-I ratio.
VAT and SAT areas were assessed using magnetic resonance imaging in 247 randomly selected 70-year-old men and women who did not use lipid-lowering drugs. Their adipose tissue areas were compared to their apoB and apo A-I levels and to their apoB/A-I ratios.
The VAT area and the gender were significantly related to the apoB/A-I ratio whereas the SAT area was not. There was a positive relationship between the VAT area and the apoB/A-I ratio.
A positive relationship was established between the amount of VAT and the apoB/A-I ratio, whereas there was no relationship between the amount of SAT and the apoB/A-I ratio. This observation supports the notion that VAT is metabolically active.
PubMed ID
20382384 View in PubMed
Less detail

Bilirubin and UGT1A1*28 are not associated with lower risk for ischemic stroke in a prospective nested case-referent setting.

https://arctichealth.org/en/permalink/ahliterature140054
Source
Cerebrovasc Dis. 2010;30(6):590-6
Publication Type
Article
Date
2010
Author
Kim Ekblom
Stefan L Marklund
Lars Johansson
Pia Osterman
Göran Hallmans
Lars Weinehall
Per-Gunnar Wiklund
Johan Hultdin
Author Affiliation
Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden. kim.ekblom@medbio.umu.se
Source
Cerebrovasc Dis. 2010;30(6):590-6
Date
2010
Language
English
Publication Type
Article
Keywords
Bilirubin - blood
Biological Markers - blood
Brain Ischemia - blood - enzymology - genetics
Case-Control Studies
Chi-Square Distribution
Female
Gene Frequency
Genetic Predisposition to Disease
Glucuronosyltransferase - genetics
Humans
Linear Models
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Genetic
Prospective Studies
Risk assessment
Risk factors
Stroke - blood - enzymology - genetics
Sweden
Abstract
Bilirubin, an antioxidant, has been associated with reduced cardiovascular disease risk. A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%. Earlier studies reporting a protective effect of bilirubin on stroke have not included analysis of UGT1A1*28. The purpose of this study is to investigate if bilirubin and UGT1A1*28 are protective against ischemic stroke in a prospective case-referent setting.
Cases with first-ever ischemic stroke (n = 231; median lag time 4.9 years) and 462 matched referents from the Northern Sweden Health and Disease Study Cohort were included. Plasma bilirubin was measured and UGT1A1*28 was analyzed by fragment analysis.
Plasma bilirubin was lower in cases than in referents, but the difference reached significance only for women. The UGT1A1*28 polymorphism (allele frequency 30%) showed a strong gene-dose relationship with bilirubin levels both among cases and referents, but was not associated with risk for stroke. Among multiple other variables analyzed, the strongest correlation with bilirubin was found for plasma iron.
There was no evidence for a protective effect of the UGT1A1*28 polymorphism against stroke and consequently neither for bilirubin. The findings suggest that other factors influencing the risk for stroke might also affect bilirubin levels.
PubMed ID
20948202 View in PubMed
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Brachial artery hyperaemic blood flow velocity in relation to established indices of vascular function and global atherosclerosis: the Prospective Investigation of the Vasculature in Uppsala Seniors study.

https://arctichealth.org/en/permalink/ahliterature125384
Source
Clin Physiol Funct Imaging. 2012 May;32(3):227-33
Publication Type
Article
Date
May-2012
Author
Susann J Järhult
Tomas Hansen
Håkan Ahlström
Lars Johansson
Johan Sundström
Lars Lind
Author Affiliation
Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. susann.jarhult@medsci.uu.se
Source
Clin Physiol Funct Imaging. 2012 May;32(3):227-33
Date
May-2012
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Atherosclerosis - physiopathology - ultrasonography
Blood Flow Velocity
Brachial Artery - physiopathology - ultrasonography
Compliance
Endothelium, Vascular - physiopathology
Female
Hemodynamics
Humans
Hyperemia - physiopathology - ultrasonography
Linear Models
Magnetic Resonance Angiography
Male
Prospective Studies
Regional Blood Flow
Sex Factors
Sweden
Ultrasonography, Doppler
Vasodilation
Whole Body Imaging
Abstract
Systolic to diastolic blood flow velocity (SDFV) ratio in the brachial artery recently proved to be related to cardiovascular risk and carotid atherosclerosis. We hypothesized that the SDFV ratio was related to established markers of vascular function and global atherosclerosis.
Established markers of endothelial function in forearm resistance vessels, flow-mediated vasodilation and arterial stiffness were assessed in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study including 1016 individuals aged 70. Whole-body magnetic resonance angiography was performed in a random 306 of the participants. Atherosclerotic lesions were summarized in a total atherosclerotic score (TAS). Before and during hyperaemia of the brachial artery, systolic and diastolic blood flow velocities were measured by Doppler.
The SDFV ratio was positively related to endothelium-independent vasodilatation, while inverse relations were found to flow-mediated dilation, common carotid artery distensibility and the stroke volume to pulse pressure ratio. Endothelium-dependent vasodilatation and total peripheral resistance index were not significantly related to the SDFV ratio. The SDFV ratio (P = 0·015) and the blood flow increase (BFI) during hyperaemia (P = 0·020) were both significantly related to TAS after gender adjustment. When adjusted for the Framingham risk score, both the SDFV ratio (P = 0·057) and BFI (P = 0·078) lost somewhat in significance.
The SDFV ratio was related to established markers of both vasodilation and arterial compliance, and to global atherosclerosis. Future larger studies have to evaluate whether the SDFV ratio is related to global atherosclerosis independently of traditional risk factors.
PubMed ID
22487158 View in PubMed
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Characterization of patients with atrial fibrillation not treated with oral anticoagulants.

https://arctichealth.org/en/permalink/ahliterature263161
Source
Scand J Prim Health Care. 2014 Dec;32(4):226-31
Publication Type
Article
Date
Dec-2014
Author
Cecilia Johansson
Lovisa Hägg
Lars Johansson
Jan-Håkan Jansson
Source
Scand J Prim Health Care. 2014 Dec;32(4):226-31
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Anticoagulants - administration & dosage - adverse effects - therapeutic use
Atrial Fibrillation - drug therapy - epidemiology
Cardiovascular Diseases - drug therapy
Child
Child, Preschool
Cross-Sectional Studies
Female
Guideline Adherence
Humans
Infant
Infant, Newborn
Male
Middle Aged
Retrospective Studies
Risk factors
Sweden - epidemiology
Young Adult
Abstract
An underuse of oral anticoagulants (OAC) in patients with atrial fibrillation (AF) has been suggested, as only 50% of all patients with AF receive OAC treatment. Whether this is due to contraindications, lack of an indication to treat, or an expression of underuse is sparsely investigated. This study therefore aimed to characterize individuals without OAC treatment in a real-life population of patients with AF.
Retrospective cross-sectional study. The medical records were scrutinized in order to identify the type of AF, risk factors for embolism and bleeding, and other factors of importance for OAC treatment.
The municipalities of Skellefteå and Norsjö, northern Sweden.
A total of 2274 living residents with at least one verified episode of AF on or before December 31, 2010.
Prevalence of treatment with OAC and documented reasons to withhold OAC treatment.
Among all 2274 patients with AF, 1187 (52%) were not treated with OAC. Of the untreated patients, 19% had no indication or had declined or had experienced adverse effects other than bleeding on warfarin treatment. The most common reason to withhold OAC was presence of risk factors for bleeding, found in 38% of all untreated patients. Furthermore, a documented reason could be identified to withhold OAC in 75%.
Among patients with AF without OAC treatment a reason could be identified to withhold OAC in 75%. The underuse of OAC is estimated to be 25%.
Notes
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Cites: Europace. 2010 Oct;12(10):1360-42020876603
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PubMed ID
25464863 View in PubMed
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Circulating levels of persistent organic pollutants in relation to visceral and subcutaneous adipose tissue by abdominal MRI.

https://arctichealth.org/en/permalink/ahliterature115189
Source
Obesity (Silver Spring). 2013 Feb;21(2):413-8
Publication Type
Article
Date
Feb-2013
Author
Vendela Roos
Monika Rönn
Samira Salihovic
Lars Lind
Bert van Bavel
Joel Kullberg
Lars Johansson
Håkan Ahlström
P Monica Lind
Author Affiliation
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Source
Obesity (Silver Spring). 2013 Feb;21(2):413-8
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
Aged
Cross-Sectional Studies
Dichlorodiphenyl Dichloroethylene
Environmental pollutants - blood
Female
Hexachlorobenzene - blood
Humans
Hydrocarbons, Chlorinated - blood
Intra-Abdominal Fat - drug effects - metabolism
Linear Models
Magnetic Resonance Spectroscopy
Male
Obesity - chemically induced - pathology
Overweight - chemically induced - pathology
Pesticides - blood
Polychlorinated biphenyls - blood
Prospective Studies
Questionnaires
Subcutaneous Fat - drug effects - metabolism
Sweden
Abstract
We and others have shown relationships between circulating levels of persistent organic pollutants (POPs) and different measures of obesity in both cross-sectional and prospective studies. Since viscerally located fat seems to be the most harmful type, we investigated whether plasma POP levels were more closely related to visceral adipose tissue (VAT) than to subcutaneous adipose tissue (SAT).
Thousand hundred and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study; 23 POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry. Abdominal magnetic resonance imaging, measuring VAT and SAT, respectively, was performed in a representative subsample of 287 subjects.
The less chlorinated polychlorinated biphenyl (PCB) congeners (105 and 118), and the pesticides dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and trans-nonachlordane (TNC) were positively related to both VAT and SAT, whereas the more highly chlorinated PCBs (153, 156, 157, 169, 170, 180, 194, 206, and 209) were inversely related to both VAT and SAT. PCB189 was related to the VAT/SAT ratio in an inverted U-shaped manner (P = 0.0008).
In conclusion, the results were in accordance with our previous studies using waist circumference and fat mass as obesity measure. However, the novel finding that PCB189 was related to the VAT/SAT ratio deserves further investigation since exposure to this PCB congener, which has previously been linked to diabetes development, might thereby play a role in the distribution of abdominal adipose tissue.
PubMed ID
23532994 View in PubMed
Less detail

C-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study.

https://arctichealth.org/en/permalink/ahliterature151353
Source
Cerebrovasc Dis. 2009;27(6):544-51
Publication Type
Article
Date
2009
Author
Jonas Andersson
Lars Johansson
Per Ladenvall
Per-Gunnar Wiklund
Birgitta Stegmayr
Christina Jern
Kurt Boman
Author Affiliation
Department of Medicine and Geriatrics, Skellefteå County Hospital, Skellefteå, Sweden. jonas.so.andersson@vll.se
Source
Cerebrovasc Dis. 2009;27(6):544-51
Date
2009
Language
English
Publication Type
Article
Keywords
C-Reactive Protein - genetics - metabolism
Case-Control Studies
Cerebral Hemorrhage - blood - epidemiology - ethnology
Female
Humans
Male
Middle Aged
Multivariate Analysis
Polymorphism, Genetic - genetics
Predictive value of tests
Prospective Studies
Risk factors
Stroke - blood - epidemiology - ethnology
Sweden
Abstract
C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, and intracerebral hemorrhage (ICH) in a prospective study. A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke.
The study was a prospective population-based case-referent study nested within the Northern Sweden Cohorts. We defined 308 cases of ischemic stroke and 61 ICH. Two controls for each case were defined from the same cohort.
The OR for the highest (>3 mg/l) versus lowest group (T polymorphism and any stroke subtype.
PubMed ID
19390179 View in PubMed
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Cystatin C and creatinine as markers of bleeding complications, cardiovascular events and mortality during oral anticoagulant treatment.

https://arctichealth.org/en/permalink/ahliterature112423
Source
Thromb Res. 2013 Aug;132(2):e77-82
Publication Type
Article
Date
Aug-2013
Author
Marcus Lind
Jan-Håkan Jansson
Torbjörn K Nilsson
Lisbeth Slunga Järvholm
Lars Johansson
Author Affiliation
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: Marcus.lind@vll.se.
Source
Thromb Res. 2013 Aug;132(2):e77-82
Date
Aug-2013
Language
English
Publication Type
Article
Keywords
Administration, Oral
Aged
Anticoagulants - administration & dosage - adverse effects
Biological Markers - blood
Cardiovascular Diseases - blood - mortality
Cohort Studies
Creatinine - blood - metabolism
Cystatin C - blood - metabolism
Female
Hemorrhage - blood - mortality
Humans
Longitudinal Studies
Male
Prognosis
Risk factors
Sweden - epidemiology
Abstract
Impaired kidney function has been linked to both ischemic events as well as bleeding complications in several clinical conditions. Our aim was to investigate if cystatin C, creatinine and calculated glomerular filtration rate (eGFR) were related to future risk of bleeding complications, cardiovascular events or all-cause mortality during oral anticoagulant treatment.
In a cohort study, 719 patients on long-term vitamin K antagonist (VKA) treatment were followed for a mean of 4.2 years. Blood sampling was taken at inclusion and patients were followed prospectively. Cystatin C and creatinine were analysed and eGFR was calculated. All medical records were reviewed. Major bleeding events, myocardial infarctions, strokes, arterial emboli, and deaths were recorded and classified.
After adjustment for age, no association between cystatin C, creatinine or eGFR and major bleeding was found. Cystatin C was independently associated with cardiovascular events (hazard ratio 1.50 (95% CI: 1.27-1.77)) and all-cause mortality (hazard ratio 1.62 (95% CI: 1.38-1.90)).Creatinine was only associated with all-cause mortality, while eGFR was not associated with any of the outcomes.
Our findings underscore the superiority of cystatin C as a marker of cardiovascular risk compared to creatinine or eGFR. VKA-treated patients with increased cystatin C levels should be considered to be at an increased risk of cardiovascular events, and not bleeding complications.
PubMed ID
23834818 View in PubMed
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Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial.

https://arctichealth.org/en/permalink/ahliterature125327
Source
Am J Clin Nutr. 2012 May;95(5):1003-12
Publication Type
Article
Date
May-2012
Author
Helena Bjermo
David Iggman
Joel Kullberg
Ingrid Dahlman
Lars Johansson
Lena Persson
Johan Berglund
Kari Pulkki
Samar Basu
Matti Uusitupa
Mats Rudling
Peter Arner
Tommy Cederholm
Håkan Ahlström
Ulf Risérus
Author Affiliation
Department of Public Health, Uppsala University, Uppsala, Sweden.
Source
Am J Clin Nutr. 2012 May;95(5):1003-12
Date
May-2012
Language
English
Publication Type
Article
Keywords
Adiponectin - metabolism
Adipose Tissue - metabolism
Adult
Aged
Blood Glucose - drug effects
Body Weight - drug effects
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Down-Regulation
Fatty Acids - administration & dosage
Fatty Acids, Omega-6 - administration & dosage
Female
Humans
Inflammation - prevention & control
Insulin - blood
Linear Models
Lipid Peroxidation - drug effects
Lipids - blood
Male
Middle Aged
Obesity, Abdominal - prevention & control
Proprotein Convertases - blood - genetics
Receptors, Interleukin-1 - metabolism
Serine Endopeptidases - blood - genetics
Sweden
Abstract
Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been proposed to promote inflammation-a yet unproven theory.
We investigated the effects of PUFAs on liver fat, systemic inflammation, and metabolic disorders.
We randomly assigned 67 abdominally obese subjects (15% had type 2 diabetes) to a 10-wk isocaloric diet high in vegetable n-6 PUFA (PUFA diet) or SFA mainly from butter (SFA diet), without altering the macronutrient intake. Liver fat was assessed by MRI and magnetic resonance proton (1H) spectroscopy (MRS). Proprotein convertase subtilisin/kexin type-9 (PCSK9, a hepatic LDL-receptor regulator), inflammation, and adipose tissue expression of inflammatory and lipogenic genes were determined.
A total of 61 subjects completed the study. Body weight modestly increased but was not different between groups. Liver fat was lower during the PUFA diet than during the SFA diet [between-group difference in relative change from baseline; 16% (MRI; P
Notes
Comment In: Am J Clin Nutr. 2012 Oct;96(4):944-5; author reply 945-622996625
PubMed ID
22492369 View in PubMed
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Endothelium-dependent vasodilation is related to the occurrence of cortical brain infarcts at MR imaging: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

https://arctichealth.org/en/permalink/ahliterature281048
Source
Clin Physiol Funct Imaging. 2017 Mar;37(2):194-197
Publication Type
Article
Date
Mar-2017
Author
Lars Lind
Ruta Nylander
Lars Johansson
Joel Kullberg
Håkan Ahlström
Elna-Marie Larsson
Source
Clin Physiol Funct Imaging. 2017 Mar;37(2):194-197
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Acetylcholine - administration & dosage
Age Factors
Aged
Aged, 80 and over
Aging - pathology
Brachial Artery - diagnostic imaging - physiopathology
Cerebral Cortex - diagnostic imaging
Cerebral Infarction - diagnostic imaging - etiology - physiopathology
Endothelium, Vascular - diagnostic imaging - physiopathology
Female
Forearm - blood supply
Humans
Magnetic Resonance Imaging
Male
Predictive value of tests
Prospective Studies
Regional Blood Flow
Risk factors
Stroke, Lacunar - diagnostic imaging - etiology - physiopathology
Sweden
Ultrasonography
Vascular Resistance
Vasodilation
Vasodilator Agents - administration & dosage
Abstract
Infarcts in the brain can be divided into larger cortical and smaller deep lacunar infarcts. The pathogenesis differs between these two types of infarctions.
This study aims to investigate the relationship between measures of endothelium-dependent vasodilation (EDV) and occurrence of cortical and lacunar infarcts in a population-based sample.
In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 subjects aged 70 were evaluated by the invasive forearm technique with acetylcholine (EDV) and brachial artery ultrasound to assess flow-mediated vasodilation (FMD). Six to seven years later MRI of the brain was performed, and the prevalence of cortical and lacunar infarcts was visually assessed in 407 randomly selected subjects.
Lacunar infarcts were found in 22% and cortical infarcts in 5·9% of the subjects. EDV and FMD were both significantly related to the occurrence of cortical, but not lacunar infarcts. In a model adjusting for gender, waist circumference, body mass index, fasting blood glucose, systolic and diastolic blood pressure, HDL and LDL cholesterol, serum triglycerides, smoking, antihypertensive treatment and statin use, both EDV and FMD were independent predictors of cortical infarcts (P = 0·035 and P = 0·008, respectively).
Endothelium-dependent vasodilation in both forearm resistance vessels and the brachial artery was related to the occurrence of cortical, but not lacunar, infarcts at MRI in a population-based sample independently of traditional risk factors.
PubMed ID
26303051 View in PubMed
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ER visits predict premature death among teenagers.

https://arctichealth.org/en/permalink/ahliterature123790
Source
Accid Anal Prev. 2012 Sep;48:397-400
Publication Type
Article
Date
Sep-2012
Author
Lars Johansson
Hans Stenlund
Per-Olof Bylund
Anders Eriksson
Author Affiliation
Department of Community Medicine and Rehabilitation, Section of Forensic Medicine, Umeå University, POB 7616, SE-907 12 Umeå, Sweden. lars.a.johansson@vll.se
Source
Accid Anal Prev. 2012 Sep;48:397-400
Date
Sep-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Emergency Service, Hospital - statistics & numerical data
Female
Humans
Male
Mortality, Premature
Questionnaires
Registries
Risk factors
Substance-Related Disorders - mortality
Suicide - statistics & numerical data
Sweden - epidemiology
Wounds and Injuries - epidemiology
Young Adult
Abstract
The purpose of this study was to investigate if teenagers visiting an emergency room because of injury have an increased risk of premature death ahead and, if so, identify possible risk factors and suggest preventive measures.
In January 2010, the personal identity numbers of 12,812 teenagers who had visited the emergency room at the University Hospital in Umeå, Sweden, during 1993 through 2006 because of injury were checked against the National Cause of Death Register in Sweden. Standardised mortality ratio and confidence intervals were calculated. For the unnatural deaths that took place in Sweden, the police report, autopsy protocol, and hospital records, if present, were studied.
Thirty-eight fatalities were included giving a standardised mortality ratio of 1.44 (95% CI: 1.02-1.98). A majority of the decedents were males (n=32, 84%) and the median age at the time of death was 21 years. Twenty-three deaths were caused by unintentional injuries and ten by intentional injuries (all suicides), while five deaths were categorised as undetermined whether intentional or not. Seventy-four percent tested positive for either alcohol or drugs or a combination at the post mortem examination. Nine males and one female committed suicide, five tested positive for alcohol (one also for drugs), while four tested negative at the post mortem examination. One died abroad and in this case we lack information on alcohol and drugs.
Teenagers visiting an emergency room due to injury experience an increased risk of premature death by unnatural cause and those at risk are especially males. The use of alcohol and drugs often seems to contribute to their untimely deaths. Identifying those at risk when they visit the emergency room for an injury and to take preventive actions at this stage could be a way to reduce the number of fatalities.
PubMed ID
22664705 View in PubMed
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34 records – page 1 of 4.