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13 records – page 1 of 2.

Abdominal complaints in general practice.

https://arctichealth.org/en/permalink/ahliterature178352
Source
Scand J Prim Health Care. 2004 Sep;22(3):157-62
Publication Type
Article
Date
Sep-2004
Author
Per Olav Vandvik
Pål Kristensen
Lars Aabakken
Per G Farup
Author Affiliation
Department of Medicine, Innlandet Hospital Health Authority, NO-2819 Gjøvik, Norway. per.vandvic@start.no
Source
Scand J Prim Health Care. 2004 Sep;22(3):157-62
Date
Sep-2004
Language
English
Publication Type
Article
Keywords
Abdominal Pain - diagnosis - epidemiology
Adult
Aged
Cross-Sectional Studies
Family Practice - standards - statistics & numerical data
Female
Gastrointestinal Diseases - diagnosis - epidemiology
Humans
Male
Middle Aged
Norway - epidemiology
Questionnaires
Workload
Abstract
The study evaluates the prevalence and diagnoses of abdominal complaints in general practice, and compares characteristics and symptoms of patients with functional gastrointestinal disorders (FGIDs) and organic diseases.
A cross-sectional study.
Nine centres with 26 participating general practitioners (GPs) in Norway.
3097 out of 3369 consecutive adult patients answered a questionnaire regarding abdominal complaints IN the last 3 months. Those who consulted for the complaints were eligible for this study.
The GPs' diagnoses and patients' characteristics were reported in questionnaires.
460 out of 1499 patients with abdominal complaints consulted for these complaints; 392 were included in this study. The GPs diagnosed an FGID in 167 (42.6%) patients, organic disease in 145 (37.0%), and made no diagnosis in 80 (20.4%). Stress-related symptoms were a statistically significant predictor of a FGID (OR 1.95) and weight loss predicted in addition organic disease (OR 2.7) in 128 patients with a verified diagnosis.
Abdominal complaints are a common problem in general practice. The distinction between FGID, which accounted for half of the diagnoses, and organic disease was difficult. The only significant predictor for FGID was stress-related symptoms.
Notes
Comment In: Scand J Prim Health Care. 2005 Jun;23(2):126; author reply 126-716036553
PubMed ID
15370792 View in PubMed
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APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations.

https://arctichealth.org/en/permalink/ahliterature150954
Source
J Cancer Res Clin Oncol. 2009 Oct;135(10):1463-70
Publication Type
Article
Date
Oct-2009
Author
Per Arne Andresen
Ketil Heimdal
Kristin Aaberg
Katrine Eklo
Kristin Eklo
Sarah Ariansen
Alexandra Silye
Olav Fausa
Lars Aabakken
Stefan Aretz
Tor J Eide
Tobias Gedde-Dahl
Author Affiliation
Pathology Division, University Hospital of Oslo-Rikshospitalet, N0027 Oslo, Norway. per.arne.andresen@rikshospitalet.no
Source
J Cancer Res Clin Oncol. 2009 Oct;135(10):1463-70
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Adenoma - genetics
Adenomatous Polyposis Coli - genetics
Adenomatous Polyposis Coli Protein - genetics
Chromatography, High Pressure Liquid
Colorectal Neoplasms - genetics
Family
Genotype
Germ-Line Mutation - genetics
Humans
Norway
Phenotype
Abstract
Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease caused by mutations in the adenomatous polyposis coli (APC) gene. Massive formation of colorectal adenomas, of which some will inevitably develop into adenocarcinomas, is the hallmark of the disease. Characterization of causative APC mutations allows presymptomatic diagnosis, close follow-up and prophylactic intervention in families. To date more than 900 different germline mutations have been characterized worldwide demonstrating allelic heterogeneity.
The germline mutation spectrum of APC identified in 69 apparently unrelated Norwegian FAP families are presented and discussed with reference to clinical phenotype and novel mutation rate.
Different methods have been used over the years. However, all mutations were confirmed detectable by an implemented denaturing high-performance liquid chromatography screening approach. Multiplex ligation-dependent probe amplification analysis was employed for potential gross rearrangements.
Fifty-three distinctive mutations were detected, of which 22 have been detected in Norway exclusively. Except for two major deletion mutations encompassing the entire APC, all mutations resulted in premature truncation of translation caused by non-sense (31%) or change in reading frame (69%).
A high ratio of novel APC mutations continues to contribute to APC mutation heterogeneity causing FAP. This is the first comprehensive report of APC germline mutation spectrum in Norway.
Notes
Erratum In: J Cancer Res Clin Oncol. 2009 Oct;135(10):1471Eklo, Kristin [corrected to Eklo, Katrine]
PubMed ID
19444466 View in PubMed
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[Clinical use of COX inhibitors--a consensus]

https://arctichealth.org/en/permalink/ahliterature29180
Source
Tidsskr Nor Laegeforen. 2006 Feb 23;126(5):591-5
Publication Type
Article
Date
Feb-23-2006
Author
Asmund Reikvam
Sofie Hexeberg
Tore Kristian Kvien
Lars Slørdal
Lars Aabakken
Lars Engebretsen
Berit Flatø
Njål Idsø
Villy Johnsen
Synnøve Kalstad
Steinar Madsen
Knut Mikkelsen
Ingrid Os
Johan REder
Author Affiliation
Institutt for farmakoterapi, Universitetet i Oslo, Postboks 1065 Blindern, 0316 Oslo. asmund.reikvam@medisin.uio.no
Source
Tidsskr Nor Laegeforen. 2006 Feb 23;126(5):591-5
Date
Feb-23-2006
Language
Norwegian
Publication Type
Article
Keywords
Adult
Aged
Cardiovascular Diseases - chemically induced
Child
Chronic Disease
Comorbidity
Consensus
Cyclooxygenase 2 Inhibitors - administration & dosage - adverse effects - contraindications
Cyclooxygenase Inhibitors - administration & dosage - adverse effects - contraindications
English Abstract
Gastrointestinal Diseases - chemically induced
Humans
Musculoskeletal Diseases - drug therapy
Norway
Practice Guidelines
Risk factors
Abstract
BACKGROUND: Many physicians have been uncertain about treatment options following reports that linked cyclooxygenase (COX) inhibitors to serious cardiovascular events and the subsequent withdrawal of two selective COX-2 inhibitors. Therefore, on June 14, 2005, the Norwegian Medicines Agency and the Department of Pharmacotherapeutics, University of Oslo, held an expert meeting on COX inhibitors. METHODS: Presentations and discussions based on existing literature and statements from European (EMEA) and American (FDA) medicine authorities. This constitutes the basis for the current recommendations. RESULTS AND INTERPRETATION: COX inhibitors have solely symptomatic effects, and there are no differences in analgesic and anti-inflammatory efficacy between the various COX-inhibitors. These drugs should, if possible, be used at the lowest effective dose and for as short a time as possible. Some of the COX-2 selective inhibitors show a lower incidence of gastrointestinal side effects than unselective COX inhibitors, but this advantage can be outweighed by increased occurrence of cardiovascular side effects. Generally, the cardiovascular adverse effects are more serious, and more often irreversible, than the gastrointestinal adverse effects. Patients with established or increased risk of cardiovascular disease should not use COX-2-selective inhibitors. In general, COX inhibitors should, if possible, not be administered to individuals with previous peptic ulcer disease, hypertension, heart failure, or kidney disease. There is a need for more data on the effect and safety of COX inhibitors.
PubMed ID
16505867 View in PubMed
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Contemporary use of endoscopic retrograde cholangiopancreatography (ERCP): A Norwegian prospective, multicenter study.

https://arctichealth.org/en/permalink/ahliterature101652
Source
Scand J Gastroenterol. 2011 Sep;46(9):1144-1151
Publication Type
Article
Date
Sep-2011
Author
Tom Glomsaker
Kjetil Søreide
Geir Hoff
Lars Aabakken
Jon Arne Søreide
Author Affiliation
Department of Surgery , Stavanger University Hospital, Stavanger , Norway.
Source
Scand J Gastroenterol. 2011 Sep;46(9):1144-1151
Date
Sep-2011
Language
English
Publication Type
Article
Abstract
Abstract Objective. Novel imaging modalities have supplanted endoscopic retrograde cholangiopancreatography (ERCP) for the diagnosis of hepatobiliary pancreatic diseases, but the use of ERCP as a diagnostic and therapeutic tool in current clinical practice is not well known. The main objective of this study was to describe and evaluate contemporary use of ERCP in Norway. Material and methods. Prospective and consecutive data were collected between January 2007 and December 2009 from voluntary institutional reports of ERCP activity at participating hospitals in the Gastronet database. Results. A total of 3840 procedures at 14 hospitals were registered during the study period. Data from 3809 procedures (53% females) were available for evaluation. Patients were =60 years of age in 2567 (67%) procedures. High co-morbidity (ASA score =3) was present in 32% of patients. The main indication for ERCP was evaluation and therapy of bile duct-related disorders. Successful bile duct cannulation was achieved in 93%. Pre-cut sphincterotomy was performed in 5% of procedures, and a guide wire to facilitate duct access was employed in 63%. Sphincterotomy, treatment for common bile duct stones (CBDS), and an insertion or change of bile duct stents were the most commonly employed procedures. Complications occurred in 10% of the patients, with a procedure-related mortality of 1%. Conclusions. In Norway, ERCP is predominantly performed for CBDS and biliary strictures in elderly patients with associated co-morbidity. Patient selection, indications, and procedures are in concert with international guidelines and recommendations. Disease patterns in Norway differ slightly from those observed in central Europe and North America.
PubMed ID
21692712 View in PubMed
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Conventional treatment regimens for ulcerative colitis alleviate fatigue - an observational cohort study.

https://arctichealth.org/en/permalink/ahliterature283272
Source
Scand J Gastroenterol. 2016 Oct;51(10):1213-9
Publication Type
Article
Date
Oct-2016
Author
Tore Grimstad
Katrine B Norheim
Jan Terje Kvaløy
Kjetil Isaksen
Kristian Leitao
Arne Carlsen
Lars N Karlsen
Lars Aabakken
Roald Omdal
Source
Scand J Gastroenterol. 2016 Oct;51(10):1213-9
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Biomarkers - analysis
C-Reactive Protein - analysis
Cohort Studies
Colitis, Ulcerative - complications - drug therapy
Colonoscopy
Fatigue - epidemiology
Feces - chemistry
Female
Hemoglobins - analysis
Humans
Leukocyte L1 Antigen Complex - analysis
Male
Mesalamine - administration & dosage
Middle Aged
Norway
Regression Analysis
Severity of Illness Index
Young Adult
Abstract
The aim of the study was to investigate the course of fatigue in a conventional inflammatory bowel disease treatment setting.
Eighty-two patients with newly diagnosed ulcerative colitis were included in an observational cohort study and received conventional non-biological drug treatment for 3 months. Colonoscopy was performed at diagnosis and after 3 months, disease activity was assessed by Mayo score and measurements of serum C-reactive protein (CRP) and fecal calprotectin levels. Fatigue was evaluated using the fatigue visual analog scale (fVAS). Mood was assessed with the hospital anxiety and depression scale (HADS). Associations between fVAS scores and time; age; CRP, fecal calprotectin, hemoglobin, and ferritin levels; and Mayo scores, Mayo endoscopic scores, and HADS depression subscale (HADS-D) scores were explored.
Median fVAS scores decreased, as did Mayo scores and CRP and fecal calprotectin concentrations. HADS-D scores remained unchanged, whereas hemoglobin levels increased after 3 months. Increased fVAS scores were associated with higher ferritin, Mayo and HADS-D scores. There were no associations between fVAS scores and CRP, fecal calprotectin, or Mayo endoscopic scores. Colonic disease distribution did not influence fatigue significantly.
Disease activity and fatigue improved after 3 months of conventional ulcerative colitis treatment. Over time, more severe fatigue was associated with more ulcerative colitis symptoms, but not with objective disease activity markers or colonic disease distribution. A clinical setting of standard treatment regimens and medical attention may alleviate fatigue in IBD patients.
PubMed ID
27310658 View in PubMed
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Endoscopy assistants influence the quality of colonoscopy.

https://arctichealth.org/en/permalink/ahliterature300386
Source
Endoscopy. 2018 09; 50(9):871-877
Publication Type
Journal Article
Date
09-2018
Author
Øyvind Holme
Ina Borgenheim Pedersen
Asle W Medhus
Lars Aabakken
Tom Glomsaker
Jan Magnus Kvamme
Magnus Løberg
Michael Bretthauer
Birgitte Seip
Øystein Kjellevold
Anita Jørgensen
Siv Furholm
Geir Hoff
Thomas de Lange
Author Affiliation
Department of Medicine, Sorlandet Hospital, Kristiansand, Norway.
Source
Endoscopy. 2018 09; 50(9):871-877
Date
09-2018
Language
English
Publication Type
Journal Article
Keywords
Allied Health Personnel - standards - statistics & numerical data
Clinical Competence - standards
Colonic Diseases - diagnosis - epidemiology
Colonoscopy - adverse effects - methods - standards - statistics & numerical data
Female
Humans
Male
Middle Aged
Norway - epidemiology
Patient Preference - statistics & numerical data
Quality Assurance, Health Care - methods
Quality Improvement - organization & administration
Quality Indicators, Health Care - statistics & numerical data
Registries - statistics & numerical data
Abstract
Colonoscopy performance varies between endoscopists, but little is known about the impact of endoscopy assistants on key performance indicators. We used a large prospective colonoscopy quality database to perform an exploratory study to evaluate differences in selected quality indicators between endoscopy assistants.
All colonoscopies reported to the Norwegian colonoscopy quality assurance register Gastronet can be used to trace individual endoscopy assistants. We analyzed key quality indicators (cecum intubation rate, polyp detection rate, colonoscopies rated as severely painful, colonoscopies with sedation or analgesia, and satisfaction with information) for colonoscopies performed between 1 January 2013 and 31 December 2014.?Differences between individual assistants were analyzed by fitting multivariable logistic regression models, with the best performing assistant at each participating hospital as reference. All models were adjusted for the endoscopist.
63 endoscopy assistants from 12 hospitals assisted in 15 365 colonoscopies. Compared with their top performing peers from the same hospital, one assistant was associated with cecum intubation failure, four with poor polyp detection, nine with painful colonoscopy, 16 with administration of sedation or analgesics during colonoscopy, and three with patient dissatisfaction about information given relating to the colonoscopy. The number of procedures during the study period or lifetime experience as an endoscopy assistant were not associated with any quality indicator.
In this exploratory study, there was little variation on important colonoscopy quality indicators between endoscopy assistants. However, there were differences among assistants that may be clinically important. Endoscopy assistants should be subject to quality surveillance similarly to endoscopists.
Notes
CommentIn: Endoscopy. 2018 Sep;50(9):837-838 PMID 30157537
CommentIn: Endoscopy. 2018 Sep;50(9):941 PMID 30157540
PubMed ID
29444529 View in PubMed
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Gastronet survey on the use of one- or two-person technique for colonoscopy insertion.

https://arctichealth.org/en/permalink/ahliterature133746
Source
BMC Gastroenterol. 2011;11:73
Publication Type
Article
Date
2011
Author
Geir Hoff
Moritz Volker
Michael Bretthauer
Lars Aabakken
Ole Høie
Thomas Delange
Ingrid Berset
Øystein Kjellevold
Tom Glomsaker
Gert Huppertz-Hauss
Ove Lange
Per Sandvei
Author Affiliation
Dept of Medicine, Telemark Hospital, 3710 Skien, Norway.
Source
BMC Gastroenterol. 2011;11:73
Date
2011
Language
English
Publication Type
Article
Keywords
Aged
Colonoscopy - methods - standards
Data Collection
Female
Humans
Male
Middle Aged
Norway
Quality Assurance, Health Care
Task Performance and Analysis
Abstract
Usually, colonoscopy insertion is performed by the colonoscopist (one-person technique). Quite common in the early days of endoscopy, the assisting nurse is now only rarely doing the insertion (two-person technique). Using the Norwegian national endoscopy quality assurance (QA) programme, Gastronet, we wanted to explore the extent of two-person technique practice and look into possible differences in performance and QA output measures.
100 colonoscopists in 18 colonoscopy centres having reported their colonoscopies to Gastronet between January and December 2009 were asked if they practiced one- or two-person technique during insertion of the colonoscope. They were categorized accordingly for comparative analyses of QA indicators.
75 endoscopists responded to the survey (representing 9368 colonoscopies) - 62 of them (83%) applied one-person technique and 13 (17%) two-person technique. Patients age and sex distributions and indications for colonoscopy were also similar in the two groups. Caecal intubation was 96% in the two-person group compared to 92% in the one-person group (p
Notes
Cites: N Engl J Med. 2010 May 13;362(19):1795-80320463339
Cites: Endoscopy. 2010 Aug;42(8):639-4620669075
Cites: Cancer. 1978 Dec;42(6):2839-48728878
Cites: Scand J Gastroenterol. 1985 Aug;20(6):677-834035287
Cites: Eur J Radiol. 2007 Mar;61(3):409-1417169521
Cites: Dig Dis Sci. 2005 Jan;50(1):47-5115712636
Cites: Am J Gastroenterol. 2006 Apr;101(4):721-3116494586
Cites: Scand J Gastroenterol. 2006 Apr;41(4):481-716635918
Cites: Gastrointest Endosc. 2007 Jan;65(1):145-5017185095
Cites: Br Med Bull. 1986 Jul;42(3):265-93545376
PubMed ID
21672243 View in PubMed
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Hepatitis C treatment at three Norwegian hospitals 2000-2011.

https://arctichealth.org/en/permalink/ahliterature272900
Source
Tidsskr Nor Laegeforen. 2015 Dec 1;135(22):2052-8
Publication Type
Article
Date
Dec-1-2015
Author
Kjetil Isaksen
Lars Aabakken
Tore Grimstad
Lars Karlsen
Per Kristian Sandvei
Olav Dalgard
Source
Tidsskr Nor Laegeforen. 2015 Dec 1;135(22):2052-8
Date
Dec-1-2015
Language
English
Norwegian
Publication Type
Article
Keywords
Adult
Age Factors
Antiviral Agents - administration & dosage - therapeutic use
Drug Therapy, Combination
Female
Genotype
Hepacivirus - genetics - isolation & purification
Hepatitis C, Chronic - drug therapy - ethnology - genetics - transmission
Hospitals
Humans
Interferon-alpha - administration & dosage - therapeutic use
Liver Cirrhosis - etiology
Male
Middle Aged
Norway
Polyethylene Glycols - administration & dosage - therapeutic use
Recombinant Proteins - administration & dosage - therapeutic use
Retrospective Studies
Ribavirin - administration & dosage - therapeutic use
Sex Factors
Substance Abuse, Intravenous - complications - virology
Treatment Outcome
Viral Load
Abstract
In the period 2000?–?2011, chronic hepatitis C virus infection (HCV infection) was primarily treated with a combination of pegylated interferon and ribavirin. New antiviral drugs, which are effective but very expensive, are in the process of replacing this regimen. We have investigated the results pegylated interferon and ribavirin have yielded in ordinary clinical practice and examined the part this treatment may play in the near future.
We included in this retrospective study HCV-RNA-positive, treatment-naive patients at Stavanger University Hospital, Akershus University Hospital and Østfold Hospital who received at least one dose of pegylated interferon in combination with ribavirin in the period 2000?–?2011. The primary endpoint was sustained virologic response (SVR). Predictors for SVR were identified by means of logistic regression analysis.
Of 588 included patients, 69.6% (409/588) achieved SVR, 14.3% (84/588) suffered relapse and 16.1% (95/588) showed non-response. In a multivariate analysis, genotypes 2 or 3 and low age at treatment start were independent predictors of SVR. A total of 85.4% of patients aged = 40 years with genotype 2 or 3 had SVR.
We found good results for treatment of young patients with genotype 2 or 3 with pegylated interferon and ribavirin. Low age and viral genotype were predictors of sustained virologic response (SVR).
PubMed ID
26627293 View in PubMed
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A national audit of temporal trends in endoscopic retrograde cholangiopancreatography in Norway.

https://arctichealth.org/en/permalink/ahliterature141315
Source
Scand J Gastroenterol. 2011 Jan;46(1):116-21
Publication Type
Article
Date
Jan-2011
Author
Tom Glomsaker
Kjetil Søreide
Lars Aabakken
Jon Arne Søreide
Author Affiliation
Department of Surgery, Stavanger University Hospital, Stavanger, Norway.
Source
Scand J Gastroenterol. 2011 Jan;46(1):116-21
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Cholangiopancreatography, Endoscopic Retrograde - statistics & numerical data - trends
Clinical Audit
Humans
Norway
Retrospective Studies
Time Factors
Abstract
The introduction of non-invasive imaging for biliary-pancreatic diseases has changed the indications and volumes of endoscopic retrograde cholangiopancreatography (ERCP) over time. This study aimed to provide national figures on ERCP in Norway over the last decade.
Data from four national surveys on ERCP activity collected from 1998 to 2009 at the surgical and medical departments of all Norwegian hospitals were analyzed for variations in volumes among centers, regions, and specialties over time.
A total of 42,260 procedures were reported (average 3842 procedures per year, range 3492-4632). The number of hospitals with ERCP decreased from 41 to 35 and the annual number of procedures decreased by 13% (from 4632 to 4036), but the number of ERCP endoscopists remained stable at ~100. The proportion of procedures performed by surgeons decreased from 40% to 32% (p
Notes
Erratum In: Scand J Gastroenterol. 2011 Jan;46(1):121
PubMed ID
20735155 View in PubMed
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[Pain in connection with colonoscopy in Norway].

https://arctichealth.org/en/permalink/ahliterature113565
Source
Tidsskr Nor Laegeforen. 2013 May 28;133(10):1074-8
Publication Type
Article
Date
May-28-2013
Author
Øyvind Holme
Volker Moritz
Michael Bretthauer
Birgitte Seip
Tom Glomsaker
Thomas de Lange
Lars Aabakken
Asbjørn Stallemo
Ole Høie
Stein Dahler
Per Kristian Sandvei
Njaal Stray
Carl Magnus Ystrøm
Geir Hoff
Author Affiliation
Medisinsk avdeling, Sørlandet sykehus, Kristiansand, Norway. oyvind.holme@sshf.no
Source
Tidsskr Nor Laegeforen. 2013 May 28;133(10):1074-8
Date
May-28-2013
Language
Norwegian
Publication Type
Article
Keywords
Aged
Analgesics - therapeutic use
Colonoscopy - adverse effects - statistics & numerical data
Drug Utilization - standards - statistics & numerical data
Female
Hospitals - statistics & numerical data
Humans
Hypnotics and Sedatives - therapeutic use
Male
Meperidine - therapeutic use
Middle Aged
Norway
Pain - diagnosis - epidemiology - etiology - prevention & control
Pain Measurement
Prospective Studies
Questionnaires
Abstract
Colonoscopies are common examinations at Norwegian hospitals. In contrast to many other countries, the majority of colonoscopies in Norway are conducted without routine sedation or analgesia. We wanted to investigate whether current Norwegian practice offers adequate pain relief.
The material consists of prospectively recorded outpatient colonoscopies in the period January 2003-December 2011 performed at Norwegian hospitals in the quality assurance network for gastrointestinal endoscopy (Gastronet). We analysed demographic patient data and data from colonoscopies. Patients' experience of pain (none, slight, moderate or severe pain) in connection with the examination was established with the aid of a validated questionnaire.
Data from 61,749 colonoscopies (55% on women) performed at 29 different hospitals were analysed. Colonoscopies were perceived as moderately or very painful by 33% of the patients (41% of the women, 24% of the men, p
PubMed ID
23712171 View in PubMed
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13 records – page 1 of 2.