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Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden.

https://arctichealth.org/en/permalink/ahliterature96683
Source
Epidemiol Infect. 2010 Jun 14;:1-11
Publication Type
Article
Date
Jun-14-2010
Author
F. Widén
L. Sundqvist
A. Matyi-Toth
G. Metreveli
S. Belák
G. Hallgren
H. Norder
Author Affiliation
Joint R&D Division, Department of Virology, Immunobiology and Parasitology, Statens Veterinärmedicinska Anstalt & Department of Biomedicine and Veterinary Public Health, The Swedish University of Agricultural Sciences and the OIE Collaborating Centre for the Application of Biotechnology-based Methods for the Diagnosis of Infectious Diseases in Veterinary Medicine, Uppsala, Sweden.
Source
Epidemiol Infect. 2010 Jun 14;:1-11
Date
Jun-14-2010
Language
English
Publication Type
Article
Abstract
SUMMARYHepatitis E infections in humans are usually acquired in endemic countries in Asia or Africa. In Sweden 17 cases infected in Europe, between 1993 and 2009, were identified. All had clinical hepatitis E with unknown source of infection. Hepatitis E virus (HEV) was identified in faecal samples from 63 piglets in 12 pig farms in Sweden. HEV was also identified in blood from 13 out of 159 investigated Swedish wild boars from nine counties. Partial HEV genomes from humans, pigs and wild boars were sequenced and compared by phylogeny. The results showed close relatedness between HEV strains from piglets from the same farm and from wild boars from the same county. HEV strains from humans showed relatedness with strains from pigs and wild boars from the same county. This study showed that HEV strains form geographical clusters in the phylogenetic tree. The methods used in this study may thus be used for tracing the origin of an infecting strain. Furthermore, this study indicated that there are endemic sources of human HEV infections in Sweden.
PubMed ID
20546635 View in PubMed
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Outbreak of Salmonella Enteritidis phage type 13a infection in Sweden linked to imported dried-vegetable spice mixes, December 2014 to July 2015.

https://arctichealth.org/en/permalink/ahliterature267899
Source
Euro Surveill. 2015;20(30)
Publication Type
Article
Date
2015
Author
C. Jernberg
M. Hjertqvist
C. Sundborger
E. Castro
M. Lofdahl
A. Pääjärvi
L. Sundqvist
E. Löf
Source
Euro Surveill. 2015;20(30)
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Bacteriophage Typing
Child
Child, Preschool
Disease Outbreaks
Female
Food Handling
Food Microbiology
Humans
Infant
Male
Middle Aged
Population Surveillance
Restaurants
Salmonella Food Poisoning - epidemiology - microbiology - prevention & control
Salmonella Phages - classification
Salmonella enteritidis - isolation & purification
Spices - microbiology
Sweden - epidemiology
Vegetables - microbiology
Young Adult
Abstract
From 24 December to 24 July 2015, 174 cases were reported in a nationwide salmonellosis outbreak in Sweden: 108 cases were connected to a single restaurant. A spice mix, containing dried vegetables from the restaurant tested positive for the outbreak strain. Additional spice mixes with similar content from different suppliers also tested positive. The outbreak investigation suggests there could be a risk of contaminated products being also on the market in other countries.
PubMed ID
26250070 View in PubMed
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Use of monozygotic twins in search for breast cancer susceptibility loci.

https://arctichealth.org/en/permalink/ahliterature19500
Source
Twin Res. 2001 Aug;4(4):251-9
Publication Type
Article
Date
Aug-2001
Author
A. Försti
Q. Jin
L. Sundqvist
M. Söderberg
K. Hemminki
Author Affiliation
Department of Biosciences at Novum, Karolinska Institute, SE-14157 Huddinge, Sweden. asta.forsti@cnt.ki.se
Source
Twin Res. 2001 Aug;4(4):251-9
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alleles
BRCA2 Protein - isolation & purification
Binomial Distribution
Breast Neoplasms - epidemiology - genetics
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Confidence Intervals
Diseases in Twins - epidemiology - genetics
Female
Genes, BRCA1 - physiology
Genetic Markers - genetics
Genetic Predisposition to Disease - epidemiology - genetics
Genetic Screening
Humans
Loss of Heterozygosity - genetics
Middle Aged
Registries
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Twins, Monozygotic - genetics
Abstract
We have used Swedish monozygotic twins concordant for breast cancer to study genetic changes associated with the development of breast cancer. Because loss of heterozygosity (LOH) at a specific genomic region may reflect the presence of a tumour suppressor gene, loss of the same allele in both of the twins concordant for breast cancer may pinpoint a tumour suppressor gene that confers a strong predisposition to breast cancer. DNA samples extracted from the matched tumour and normal tissues of nine twin pairs were analysed for allelic imbalance using a set of microsatellite markers on chromosomes 1, 13, 16 and 17, containing loci with known tumour suppressor genes. The two main regions, where more twin pairs than expected had lost the same allele, were located at 16qtel', including markers D16S393, D16S305 and D16S413, and at 17p13, distal to the p53 locus. Our results show that the monozygotic twin model can be used to suggest candidate regions of potential tumour suppressor genes, even with a limited number of twin pairs.
PubMed ID
11665305 View in PubMed
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