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Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.

https://arctichealth.org/en/permalink/ahliterature113714
Source
Obesity (Silver Spring). 2013 Sep;21(9):1815-22
Publication Type
Article
Date
Sep-2013
Author
S M Kaye
M. Maranghi
L H Bogl
J. Kaprio
A. Hakkarainen
J. Lundbom
N. Lundbom
A. Rissanen
M R Taskinen
K H Pietiläinen
Author Affiliation
Obesity Research Unit, Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Source
Obesity (Silver Spring). 2013 Sep;21(9):1815-22
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Abdominal Fat
Adult
Apolipoproteins B - blood
Body mass index
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Exercise
Fatty Liver - blood - complications - genetics - metabolism
Female
Finland
Humans
Liver - metabolism
Male
Multivariate Analysis
Obesity - blood - complications - genetics - metabolism
Subcutaneous Fat
Twins, Monozygotic
Young Adult
Abstract
The effects of acquired obesity on lipid profile and lipoprotein composition in rare BMI-discordant monozygotic (MZ) twin pairs were studied.
Abdominal fat distribution, liver fat (magnetic resonance imaging and spectroscopy), fasting serum lipid profile (ultracentrifugation, gradient gel-electrophoresis, and colorimetric enzymatic methods), and lifestyle factors (questionnaires and diaries) were assessed in 15 BMI-discordant (within-pair difference [?] in BMI >3 kg/m2) and nin concordant (?BMI
PubMed ID
23696329 View in PubMed
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Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults.

https://arctichealth.org/en/permalink/ahliterature117107
Source
Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1071-8
Publication Type
Article
Date
Nov-2013
Author
L H Bogl
K H Pietiläinen
A. Rissanen
A J Kangas
P. Soininen
R J Rose
M. Ala-Korpela
J. Kaprio
Author Affiliation
The Finnish Twin Cohort Study, Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. Electronic address: leonie-helen.bogl@helsinki.fi.
Source
Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1071-8
Date
Nov-2013
Language
English
Publication Type
Article
Keywords
Adult
Animals
Biological Markers - blood
Cohort Studies
Coronary Disease - epidemiology - etiology - prevention & control
Cross-Sectional Studies
Diet - adverse effects
Docosahexaenoic Acids - blood
Fast Foods - adverse effects
Female
Finland - epidemiology
Fishes
Food Habits
Health promotion
Humans
Lipoproteins - blood - chemistry
Longitudinal Studies
Male
Nutrition Policy
Particle Size
Patient compliance
Seafood
Young Adult
Abstract
Nutritional epidemiology is increasingly shifting its focus from studying single nutrients to the exploration of the whole diet utilizing dietary pattern analysis. We analyzed associations between habitual diet (including macronutrients, dietary patterns, biomarker of fish intake) and lipoprotein particle subclass profile in young adults.
Complete dietary data (food-frequency questionnaire) and lipoprotein subclass profile (via nuclear magnetic resonance spectroscopy) were available for 663 subjects from the population-based FinnTwin12 study (57% women, age: 21-25 y). The serum docosahexaenoic to total fatty acid ratio was used as a biomarker of habitual fish consumption. Factor analysis identified 5 dietary patterns: "Fruit and vegetables", "Meat", "Sweets and desserts", "Junk food" and "Fish". After adjustment for sex, age, body mass index, waist circumference, physical activity, smoking status and alcohol intake, the "Junk food" pattern was positively related to serum triglycerides (r = 0.12, P = 0.002), a shift in the subclass distribution of VLDL toward larger particles (r = 0.12 for VLDL size, P
PubMed ID
23333726 View in PubMed
Less detail