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A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats.

https://arctichealth.org/en/permalink/ahliterature101034
Source
Diabetes Obes Metab. 2011 May 25;
Publication Type
Article
Date
May-25-2011
Author
Michael Feigh
Kim Henriksen
Kim V Andreassen
Christina Hansen
Jan Erik Henriksen
Henning Beck-Nielsen
Claus Christiansen
Morten Asser Karsdal
Author Affiliation
Nordic Bioscience, Herlev, Denmark Department of Endocrinology M, Diabetes Research Centre, Odense University Hospital, Odense, Denmark.
Source
Diabetes Obes Metab. 2011 May 25;
Date
May-25-2011
Language
English
Publication Type
Article
Abstract
Aim. To investigate the effects of acute and chronic administration of a novel oral formulation of salmon calcitonin (sCT) on glycemic control, glucose homeostasis and body weight regulation in diet-induced obese (DIO) rats - an animal model of obesity-related insulin resistance and type 2 diabetes. Methods. DIO rats were acutely given a single dose of oral sCT (0.5 and 2 mg/kg), its oral vehicle 5-CNAC or injectable sCT (5 and 10 µg/kg) (n = 8), followed by oral glucose tolerance test (OGTT). Other DIO rats were chronic treated twice daily with oral vehicle 5-CNAC (n = 6), oral sCT (0.5 mg/kg and 2 mg/kg) or injectable sCT (10 µg/kg) (n = 8). Fasting and postprandial glucose and pancreatic hormones, body weight and insulin sensitivity were assessed. Results. A single dose of oral sCT acutely reduced glucose and insulin area under the curve during OGTT by approximately 65% and 85%, respectively, compared to vehicle (p
PubMed ID
21615667 View in PubMed
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