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Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study.

https://arctichealth.org/en/permalink/ahliterature288056
Source
Behav Genet. 2017 May;47(3):265-277
Publication Type
Article
Date
May-2017
Author
Tom Rosenström
Eivind Ystrom
Fartein Ask Torvik
Nikolai Olavi Czajkowski
Nathan A Gillespie
Steven H Aggen
Robert F Krueger
Kenneth S Kendler
Ted Reichborn-Kjennerud
Source
Behav Genet. 2017 May;47(3):265-277
Date
May-2017
Language
English
Publication Type
Article
Keywords
Adult
Antisocial Personality Disorder - genetics
Diagnostic and Statistical Manual of Mental Disorders
Diseases in Twins - genetics
Environment
Female
Genotype
Humans
Male
Norway
Phenotype
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Young Adult
Abstract
Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level. Multivariate biometric models, including both independent and common pathways, were compared. A single phenotypic factor was found, and the best-fitting biometric model was a single-factor common pathway model, with common-factor heritability of 51% (95% CI 40-67%). In other words, both genetic and environmental correlations between the ASPD criteria could be accounted for by a single common latent variable. The findings support the validity of ASPD as a unidimensional diagnostic construct.
Notes
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PubMed ID
28108863 View in PubMed
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A population based twin study of DSM-5 maladaptive personality domains.

https://arctichealth.org/en/permalink/ahliterature292277
Source
Personal Disord. 2017 Oct; 8(4):366-375
Publication Type
Journal Article
Twin Study
Date
Oct-2017
Author
Susan C South
Robert F Krueger
Gun Peggy Knudsen
Eivind Ystrom
Nikolai Czajkowski
Steven H Aggen
Michael C Neale
Nathan A Gillespie
Kenneth S Kendler
Ted Reichborn-Kjennerud
Author Affiliation
Department of Psychological Sciences, Purdue University.
Source
Personal Disord. 2017 Oct; 8(4):366-375
Date
Oct-2017
Language
English
Publication Type
Journal Article
Twin Study
Keywords
Adult
Diagnostic and Statistical Manual of Mental Disorders
Diseases in Twins - diagnosis
Female
Humans
Male
Middle Aged
Models, Psychological
Norway
Personality
Personality Disorders - diagnosis
Twins - psychology
Abstract
Personality disorders (PDs) can be partly captured by dimensional traits, a viewpoint reflected in the most recent Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) Alternative (Section III) Model for PD classification. The current study adds to the literature on the Alternative Model by examining the magnitude of genetic and environmental influences on 6 domains of maladaptive personality: negative emotionality, detachment, antagonism, disinhibition, compulsivity, and psychoticism. In a large, population-based sample (N = 2,293) of Norwegian male and female twin pairs, we investigated (a) if the domains demonstrated measurement invariance across gender at the phenotypic level, meaning that the relationships between the items and the latent factor were equivalent in men and women; and (b) if genetic and environmental influences on variation in these domains were equivalent across gender. Multiple group confirmatory factor modeling provided evidence that all 6 domain scale measurement models were gender-invariant. The best fitting biometric model for 4 of the 6 domains (negative emotionality, detachment, disinhibition, and compulsivity) was one in which genetic and environmental influences could be set invariant across gender. Evidence for sex differences in psychoticism was mixed, but the only clear evidence for quantitative sex differences was for the antagonism scale, with greater genetic influences found for men than women. Genetic influences across domains were moderate overall (19-37%), in line with previous research using symptom-based measures of PDs. This study adds to the very limited knowledge currently existing on the etiology of maladaptive personality traits. (PsycINFO Database Record
PubMed ID
27797545 View in PubMed
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Prediction of alcohol use disorder using personality disorder traits: a twin study.

https://arctichealth.org/en/permalink/ahliterature294336
Source
Addiction. 2018 Jan; 113(1):15-24
Publication Type
Journal Article
Observational Study
Twin Study
Date
Jan-2018
Author
Tom Rosenström
Fartein Ask Torvik
Eivind Ystrom
Nikolai Olavi Czajkowski
Nathan A Gillespie
Steven H Aggen
Robert F Krueger
Kenneth S Kendler
Ted Reichborn-Kjennerud
Author Affiliation
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Source
Addiction. 2018 Jan; 113(1):15-24
Date
Jan-2018
Language
English
Publication Type
Journal Article
Observational Study
Twin Study
Keywords
Adult
Alcoholism - epidemiology - genetics - psychology
Antisocial Personality Disorder - epidemiology - genetics - psychology
Borderline Personality Disorder - epidemiology - genetics - psychology
Comorbidity
Conduct Disorder - epidemiology - genetics - psychology
Female
Humans
Impulsive Behavior
Male
Middle Aged
Norway - epidemiology
Odds Ratio
Personality
Personality Disorders - epidemiology - genetics - psychology
Prospective Studies
Risk assessment
Twins, Dizygotic
Twins, Monozygotic
Young Adult
Abstract
The DSM-IV personality disorders (PDs) are comorbid with alcohol use disorder (AUD) and with each other. It remains unclear which PD criteria are most likely to drive onset and recurrence of AUD and which are merely confounded with those criteria. We determine which individual PD criteria predict AUD and the degree of underlying genetic and/or environmental aetiology.
A prospective observational twin study.
Norway 1999-2011.
A total of 2528 and 2275 Norwegian adult twins in waves 1 and 2 variable-selection analyses, and 2785 in biometric analyses.
DSM-IV PDs and their 80 criteria were assessed using a structured personal interview, and AUD using the World Health Organization's Composite International Diagnostic Interview.
In a variable-selection analysis, two PD criteria were associated with AUD even after taking all the other criteria into account: criterion 8 of antisocial PD (childhood conduct disorder) and criterion 4 of borderline PD (self-damaging impulsive behaviours). Adjusting for each other, their respective odds ratios were 3.4 [confidence interval (CI) = 2.1-5.4] and 5.0 (CI = 3.3-7.7). Endorsement strength of the criteria was associated with AUD in a dose-response manner and they explained 5.5% of variation in AUD risk-more than the full diagnoses of antisocial and borderline PDs together (0.5%). The association between borderline criterion 4 and AUD 10 years later derived mainly from their overlapping genetic factors, whereas the association between antisocial criterion 8 and AUD 10 years later was due to both genetic and non-genetic factors.
Conduct disorder and self-harming impulsivity are the foremost risk traits for alcohol use disorder among the 80 personality disorder criteria of DSM-IV, predicting alcohol use disorder more effectively than personality disorder diagnoses. The twin-study analysis suggested that conduct disorder represents a joint genetic and developmental risk for alcohol use disorder and that impulsivity is a genetic risk.
Notes
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PubMed ID
28734091 View in PubMed
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Testing Genetic and Environmental Associations Between Personality Disorders and Cocaine Use: A Population-Based Twin Study.

https://arctichealth.org/en/permalink/ahliterature295880
Source
Twin Res Hum Genet. 2018 02; 21(1):24-32
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Date
02-2018
Author
Nathan A Gillespie
Steven H Aggen
Amanda E Gentry
Michael C Neale
Gun P Knudsen
Robert F Krueger
Susan C South
Nikolai Czajkowski
Ragnar Nesvåg
Eivind Ystrom
Tom H Rosenström
Fartein A Torvik
Ted Reichborn-Kjennerud
Kenneth S Kendler
Author Affiliation
Department of Psychiatry,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Source
Twin Res Hum Genet. 2018 02; 21(1):24-32
Date
02-2018
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Keywords
Adult
Antisocial Personality Disorder - genetics
Cocaine-Related Disorders - genetics - psychology
Cross-Sectional Studies
Diseases in Twins - genetics
Female
Gene-Environment Interaction
Humans
Male
Multivariate Analysis
Norway
Personality Disorders - genetics
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Young Adult
Abstract
Until now, data have not been available to elucidate the genetic and environmental sources of comorbidity between all 10 DSM-IV personality disorders (PDs) and cocaine use. Our aim was to determine which PD traits are linked phenotypically and genetically to cocaine use. Cross-sectional data were obtained in a face-to-face interview between 1999 and 2004. Subjects were 1,419 twins (µage = 28.2 years, range = 19-36) from the Norwegian Institute of Public Health Twin Panel, with complete lifetime cocaine use and criteria for all 10 DSM-IV PDs. Stepwise multiple and Least Absolute Shrinkage and Selection Operator (LASSO) regressions were used to identify PDs related to cocaine use. Twin models were fitted to estimate genetic and environmental associations between the PD traits and cocaine use. In the multiple regression, antisocial (OR = 4.24, 95% CI [2.66, 6.86]) and borderline (OR = 2.19, 95% CI [1.35, 3.57]) PD traits were significant predictors of cocaine use. In the LASSO regression, antisocial, borderline, and histrionic were significant predictors of cocaine use. Antisocial and borderline PD traits each explained 72% and 25% of the total genetic risks in cocaine use, respectively. Genetic risks in histrionic PD were not significantly related to cocaine use. Importantly, after removing criteria referencing substance use, antisocial PD explained 65% of the total genetic variance in cocaine use, whereas borderline explained only 4%. Among PD traits, antisocial is the strongest correlate of cocaine use, for which the association is driven largely by common genetic risks.
Notes
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PubMed ID
29369040 View in PubMed
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