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Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations.

https://arctichealth.org/en/permalink/ahliterature141020
Source
Environ Health. 2010;9:56
Publication Type
Article
Date
2010
Author
Bogdan J Wojtyniak
Daniel Rabczenko
Bo A G Jönsson
Valentyna Zvezday
Henning S Pedersen
Lars Rylander
Gunnar Toft
Jan K Ludwicki
Katarzyna Góralczyk
Anna Lesovaya
Lars Hagmar
Jens Peter Bonde
Author Affiliation
Department-Centre of Monitoring and Analyses of Population Health, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland. bogdan@pzh.gov.pl
Source
Environ Health. 2010;9:56
Date
2010
Language
English
Publication Type
Article
Keywords
Biological Markers - blood
Birth Weight - drug effects
Cohort Studies
Dichlorodiphenyl Dichloroethylene - blood - toxicity
Environmental Pollutants - blood - toxicity
European Continental Ancestry Group
Female
Gestational Age
Greenland
Humans
Hydrocarbons, Chlorinated - blood - toxicity
Infant, Newborn
Infant, Premature - growth & development
Inuits
Male
Maternal Exposure - adverse effects
Poland
Pregnancy
Pregnant Women
Prenatal Exposure Delayed Effects
Ukraine
Abstract
Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies.
Blood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors.
The median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1.
In utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent.
Notes
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PubMed ID
20819217 View in PubMed
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Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations.

https://arctichealth.org/en/permalink/ahliterature3408
Source
Environ Health. 2005;4:27
Publication Type
Article
Date
2005
Author
Bo A G Jönsson
Lars Rylander
Christian Lindh
Anna Rignell-Hydbom
Aleksander Giwercman
Gunnar Toft
Henning S Pedersen
Jan K Ludwicki
Katarzyna Góralczyk
Valentyna Zvyezday
Marcello Spanò
Davide Bizzaro
Eva C Bonefeld-Jörgensen
Gian Carlo Manicardi
Jens Peter Bonde
Lars Hagmar
Author Affiliation
Department of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden. bo_a.jonsson@med.lu.se
Source
Environ Health. 2005;4:27
Date
2005
Language
English
Publication Type
Article
Abstract
BACKGROUND: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. METHOD: In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. RESULTS: The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. CONCLUSION: CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations.
PubMed ID
16283941 View in PubMed
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