Skip header and navigation

Refine By

5 records – page 1 of 1.

Alteplase therapy in acute ischemic stroke: a Danish pilot study.OFF.

https://arctichealth.org/en/permalink/ahliterature222194
Source
Z Kardiol. 1993;82 Suppl 2:105-8
Publication Type
Article
Date
1993
Author
G. Boysen
K. Overgaard
B. Sperling
H. Pedersen
J. Gam
K. Ellemann
Author Affiliation
Department of Neurology, University Hospital, Rigshospitalet, Odense, Denmark.
Source
Z Kardiol. 1993;82 Suppl 2:105-8
Date
1993
Language
English
Publication Type
Article
Keywords
Cerebral Infarction - drug therapy - mortality - radionuclide imaging
Denmark
Feasibility Studies
Humans
Intracranial Embolism and Thrombosis - drug therapy - mortality - radionuclide imaging
Neurologic Examination - drug effects
Organotechnetium Compounds - diagnostic use
Oximes - diagnostic use
Pilot Projects
Survival Rate
Technetium Tc 99m Exametazime
Thrombolytic Therapy
Tissue Plasminogen Activator - adverse effects - therapeutic use
Tomography, Emission-Computed, Single-Photon
Abstract
In the period from October 1990 to December 1991, 23 patients with acute ischemic stroke were treated with recombinant tissue plasminogen activator (rt-PA) at a median of 205 min (range 78-355 min) after symptom onset. In this open pilot study rt-PA was given intravenously after an acute CT scan had not shown acute changes. In 12 patients regional cerebral blood flow was measured intravenously using 99mTc-HMPAO before and within 24 h after thrombolytic therapy. Reperfusion of the ischemic area was obtained in 10 patients. In these patients clinical improvement was greater the shorter the delay from symptom onset to initiation of treatment. Three of the 23 patients died, one of a parenchymatous hematoma, one of a large middle cerebral artery infarct, and one of acute myocardial infarction.
PubMed ID
8328185 View in PubMed
Less detail

[Diabetic hyperosmolar non-ketotic coma. A retrospective study from a central hospital of patients admitted over a 20-year period]

https://arctichealth.org/en/permalink/ahliterature48850
Source
Ugeskr Laeger. 1986 Mar 10;148(11):648-50
Publication Type
Article
Date
Mar-10-1986

Epidemiology and treatment of diabetic ketoacidosis in a community population.

https://arctichealth.org/en/permalink/ahliterature48883
Source
Diabetes Care. 1984 Nov-Dec;7(6):528-32
Publication Type
Article
Author
K. Ellemann
J N Soerensen
L. Pedersen
B. Edsberg
O O Andersen
Source
Diabetes Care. 1984 Nov-Dec;7(6):528-32
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood Glucose - metabolism
Cross-Sectional Studies
Denmark
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Ketoacidosis - drug therapy - epidemiology
Female
Humans
Insulin - therapeutic use
Male
Middle Aged
Prognosis
Risk
Social Class
Abstract
We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing incidence confined to urban areas. Precipitating factors were not somatic in 53% of the cases. Patients in the lowest social class (V) were in a higher risk group, experiencing ketoacidosis more often and having a higher frequency of severe acidosis. Forty-nine percent of the patients have had a diabetes duration of more than 5 yr. The lethality rate decreased from the period 1943-1963 and was 4.7% in the investigation period 1960-1979.
PubMed ID
6439530 View in PubMed
Less detail

Thrombolytic therapy in acute ischemic stroke. A Danish pilot study.

https://arctichealth.org/en/permalink/ahliterature220144
Source
Stroke. 1993 Oct;24(10):1439-46
Publication Type
Article
Date
Oct-1993
Author
K. Overgaard
B. Sperling
G. Boysen
H. Pedersen
J. Gam
K. Ellemann
A. Karle
P. Arlien-Søborg
T S Olsen
C. Videbaek
Author Affiliation
Department of Neurology, University Hospital, Rigshospitalet, Copenhagen, Denmark.
Source
Stroke. 1993 Oct;24(10):1439-46
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Brain - blood supply
Brain Ischemia - drug therapy - radiography
Cerebral Angiography
Denmark
Feasibility Studies
Female
Humans
Infusions, Intravenous
Injections, Intravenous
Male
Middle Aged
Pilot Projects
Recombinant Proteins - therapeutic use
Regional Blood Flow - drug effects
Thrombolytic Therapy
Tissue Plasminogen Activator - administration & dosage - therapeutic use
Tomography, X-Ray Computed
Abstract
In a feasibility and safety study of thrombolytic therapy in acute ischemic stroke, we explored the usefulness of measurements of regional cerebral blood flow.
Twenty-three patients with acute ischemic stroke were treated with 100 mg recombinant tissue plasminogen activator infused intravenously over 1 hour. Thrombolytic therapy was initiated 78 to 355 minutes after onset of symptoms.
Angiography 16 to 24 hours after treatment in 17 patients showed patient intracranial arteries in 12, partial occlusion of the middle cerebral artery in 3, and total occlusion of the middle cerebral artery in 2. rCBF with 99mTc-hexamethylpropyleneamine oxime intravenously was measured 5 minutes before and within 24 hours after thrombolytic therapy in 12 patients. 10 of the 12 patients showed brain tissue reperfusion and 2, with angiographically documented middle cerebral artery occlusion, showed no reperfusion, thus documenting a relationship between reperfusion measured by regional cerebral blood flow and angiographic patency (P = .015). Three patients died. Patients who were reperfused within 24 hours (documented by repeated regional cerebral blood flow measurements) showed greater clinical improvement on the Scandinavian Stroke Scale the sooner their thrombolytic therapy was started and the more severe their neurological deficits.
Acute cerebral ischemia can be documented by rCBF measurements without delay of thrombolytic therapy, and repeated rCBF measurements can reveal whether cerebral reperfusion has occurred. In our study, early reperfusion was associated with clinical improvement.
PubMed ID
8378943 View in PubMed
Less detail

Tingling/numbness in the hands of computer users: neurophysiological findings from the NUDATA study.

https://arctichealth.org/en/permalink/ahliterature9324
Source
Int Arch Occup Environ Health. 2004 Oct;77(7):521-5
Publication Type
Article
Date
Oct-2004
Author
E. Overgaard
L P A Brandt
K. Ellemann
S. Mikkelsen
J H Andersen
Author Affiliation
Department of Occupational Medicine, Herning Hospital, Gl. Landevej 61, 7400, Herning, Denmark, erik.overgaard@dadlnet.dk.
Source
Int Arch Occup Environ Health. 2004 Oct;77(7):521-5
Date
Oct-2004
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Computers
Denmark
Electrophysiology
Fingers
Hand
Humans
Hypesthesia - physiopathology
Nerve Compression Syndromes - physiopathology
Occupational Diseases - physiopathology
Prospective Studies
Sensory Thresholds
Somatosensory Disorders - physiopathology
Vibration
Abstract
OBJECTIVES: To investigate whether tingling/numbness of the hands and fingers among computer users is associated with elevated vibration threshold as a sign of early nerve compression. METHODS: Within the Danish NUDATA study, vibratory sensory testing with monitoring of the digital vibration threshold at seven frequencies on the second and fifth fingers of both hands was performed on 20 cases with unilateral tingling/numbness in the hands and fingers, and 20 gender- and age-matched controls. Both cases and controls were identified from questionnaire information about tingling/numbness at least once a week or daily within the last 3 months. Participants with more than slight muscular pain or disorders of the neck and upper extremities, excessive alcohol consumption, previous injuries of the upper extremities, or concurrent medical diseases were excluded. The two groups had a similar amount of work with mouse, keyboard, and computer. RESULTS: Seven of the 20 cases (35%) had elevated vibration thresholds, compared with 3 of the 20 controls (15%); this difference was not statistically significant (chi2=2.13, P=0.14). Compared with controls, cases had increased perception threshold for all frequencies, but the difference was statistically significant for only 2 out of 14 measurements. Comparison between left and right hand threshold values within the case group did not show any significant difference at any frequency. CONCLUSIONS: The results indicate that tingling/numbness of the hands and fingers among computer users cannot be explained by nerve compression.
PubMed ID
15558303 View in PubMed
Less detail