Skip header and navigation

Refine By

4 records – page 1 of 1.

Alterations in T-lymphocyte subsets among Danish haemophiliacs: relation to source of factor VIII preparations and high dose factor VIII treatment.

https://arctichealth.org/en/permalink/ahliterature39856
Source
Scand J Haematol. 1984 May;32(5):544-51
Publication Type
Article
Date
May-1984
Author
J. Gerstoft
K. Bentsen
E. Scheibel
J. Dalsgård-Nielsen
J. Gormsen
E. Dickmeiss
Source
Scand J Haematol. 1984 May;32(5):544-51
Date
May-1984
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alanine Transaminase - metabolism
Antibodies, Viral - analysis
Child
Child, Preschool
Cytomegalovirus - isolation & purification
Denmark
Drug Industry
Europe
Factor VIII - therapeutic use
Hemophilia A - immunology
Humans
Immunoglobulin G - analysis
Infant
Liver - enzymology
Middle Aged
T-Lymphocytes, Helper-Inducer - classification
T-Lymphocytes, Regulatory - classification
United States
Abstract
Screening of 43 healthy Danish haemophiliacs revealed a significantly lower helper/suppressor (H/S) ratio than in controls. 8 of the haemophiliacs had an H/S ratio less than or equal to 1.0. A significant negative correlation occurred between the total lifetime factor VIII treatment and the H/S ratio. However, high-dose factor VIII treatment given to patients with antibodies against factor VIII was not associated with immunological abnormalities. Children had a significantly higher H/S ratio than the adult haemophiliacs. Patients exclusively treated with Danish cryoprecipitate during the last year had a significantly higher H/S ratio than patients receiving preparations from other sources. This difference might, however, be explained by lower age and lower total lifetime dose in the group receiving Danish preparations. Haemophiliacs treated with American preparations did not differ immunologically from those treated with preparations of other origin. Total serum IgG was increased in 23% of the patients. This parameter was negatively correlated with the H/S ratio. The possible relation of the observed immunological alterations among otherwise healthy haemophiliacs to the acquired immune deficiency syndrome warrants further attention.
PubMed ID
6328639 View in PubMed
Less detail

Correlation between urinary 1-hydroxypyrene and ambient air pyrene measured with an inhalable aerosol sampler and a total dust sampler in an electrode paste plant.

https://arctichealth.org/en/permalink/ahliterature67590
Source
Sci Total Environ. 1998 Mar 5;212(1):59-67
Publication Type
Article
Date
Mar-5-1998
Author
R K Bentsen
K. Halgard
H. Notø
H L Daae
S. Ovrebø
Author Affiliation
Department of Toxicology, National Institute of Occupational Health, Oslo, Norway.
Source
Sci Total Environ. 1998 Mar 5;212(1):59-67
Date
Mar-5-1998
Language
English
Publication Type
Article
Keywords
Adult
Aerosols
Air Pollutants, Occupational - analysis
Air Pollution, Indoor - analysis
Chromatography, High Pressure Liquid - methods
Dust - analysis
Electrodes
Environmental Monitoring - methods
Humans
Middle Aged
Mutagens - analysis
Norway
Polycyclic Hydrocarbons, Aromatic - analysis
Pyrenes - analysis - pharmacokinetics
Research Support, Non-U.S. Gov't
Smoking
Abstract
The aim of this study was to investigate whether the use of an inhalable aerosol sampler would improve the correlation between urinary 1-hydroxypyrene and occupational pyrene exposure compared to measurements with a total dust sampler in an electrode paste plant. PAHs were collected on a filter and adsorbent by a 37-mm closed-face total aerosol sampler and an open-face sampler for inhalable aerosol from the Institute of Occupational Medicine (IOM). 1-Hydroxypyrene in pre- and post-shift urine samples was quantitated by high performance liquid chromatography (HPLC). In this study, the use of the IOM sampler resulted in approximately four times higher concentrations of particulate PAH and pyrene than the total dust sampler. The correlation between pyrene levels measured with the two samplers was good with a correlation coefficient of 0.83. The correlation between workplace air pyrene and 1-hydroxypyrene in post-shift urine was poor (r = -0.12), but a small non-significant improvement was found with the IOM sampler (r = 0.11). In this factory the use of an inhalable aerosol sampler had only marginal effect on the correlation between 1-hydroxypyrene in urine and breathing zone pyrene. These results indicate that skin exposure is an important route of PAH uptake in this plant.
PubMed ID
9525047 View in PubMed
Less detail

The effect of dust-protective respirator mask and the relevance of work category on urinary 1-hydroxypyrene concentration in PAH exposed electrode paste plant workers.

https://arctichealth.org/en/permalink/ahliterature67585
Source
Ann Occup Hyg. 1998 Feb;42(2):135-44
Publication Type
Article
Date
Feb-1998
Author
R K Bentsen
H. Notø
K. Halgard
S. Ovrebø
Author Affiliation
Department of Toxicology, National Institute of Occupational Health, Oslo, Norway.
Source
Ann Occup Hyg. 1998 Feb;42(2):135-44
Date
Feb-1998
Language
English
Publication Type
Article
Keywords
Biological Markers
Dust - analysis
Humans
Male
Mutagens - metabolism
Norway
Occupational Exposure - prevention & control
Polycyclic Hydrocarbons, Aromatic - analysis
Pyrenes - metabolism
Regression Analysis
Research Support, Non-U.S. Gov't
Respiratory Protective Devices
Statistics, nonparametric
Abstract
Large amounts of polycyclic-aromatic hydrocarbons (PAH) are found in the work environment of electrode paste workers. Inhalation and skin uptake are both important routes for PAH exposure. We have studied the effect of dust-protective respirator masks by measuring urinary 1-hydroxypyrene as a biomarker for PAH exposure. Eighteen workers divided into work categories at the factory were monitored by personal air sampling and urinary 1-hydroxypyrene every work shift for two consecutive weeks. In the second week of the study, the workers were encouraged to wear respirator masks persistently, which resulted in a significant reduction in urinary 1-hydroxypyrene in end-of-shift samples (paired t-test, P = 0.009). When correcting urinary 1-hydroxypyrene for ambient air pyrene we found on average 41% reduction in urinary 1-hydroxypyrene concentration in the second week of the intervention study. There was a work-category dependent variation in the correlation between end-of-shift urinary 1-hydroxypyrene samples and pyrene measured in the breathing zone of the workers, most likely due to variable skin uptake of pyrene; the overall correlation coefficient was 0.26 (P = 0.015). The 1-hydroxypyrene concentration in pre- and post-shift urine samples varied between 0.7 and 69.6 mumol/mol creatinine in the normal work week, and depended on the work category. The particulate PAH exposure ranged from 0.6 to 21.4 micrograms/m3. The ratio of particulate pyrene to benzo[a]pyrene varied from 1.6 to 8.0 amongst the various work categories within the same plant. Multiple regression analysis showed that smoking and work day are explanatory variables for the concentration of 1-hydroxypyrene in urine. Thirty-nine percent of the variation in the urinary 1-hydroxypyrene level at the end of shift could be explained by the independent variables pyrene concentration in air, smoking habits, work day, use of respiratory mask, work category and age.
PubMed ID
9559574 View in PubMed
Less detail

T lymphocyte subsets in homosexual men from Copenhagen.

https://arctichealth.org/en/permalink/ahliterature8804
Source
Eur J Clin Invest. 1984 Aug;14(4):301-5
Publication Type
Article
Date
Aug-1984
Author
J. Gerstoft
C S Petersen
S. Kroon
S. Ullman
K. Bentsen
E. Dickmeiss
J O Nielsen
H. Mogens
K. Andersen
I. Lorenzen
Source
Eur J Clin Invest. 1984 Aug;14(4):301-5
Date
Aug-1984
Language
English
Publication Type
Article
Keywords
Acquired Immunodeficiency Syndrome - immunology - transmission
Antibodies, Viral - analysis
Cytomegalovirus - immunology - isolation & purification
Denmark
Gonorrhea - immunology
Homosexuality
Humans
Male
Syphilis - immunology
T-Lymphocytes - immunology
Abstract
Screening of sixty-six asymptomatic homosexual men from Copenhagen revealed significantly lower Leu-3a/Leu-2a ratios as compared to controls. Ten (15%) of the homosexuals had a ratio less than or equal to 1.0. The low Leu-3a/Leu-2a ratios were the result of an increase in the absolute number of Leu-2a cells. Homosexuals with many partners and those who had been sexual partners of patients with the acquired immuno-deficiency syndrome (AIDS) had significantly lower ratios than those without these features. Cytomegalovirus was isolated from urine and/or sputum of 15% and this was associated with a Leu-3a/Leu-2a ratio less than or equal to 1.0. The observed immunological abnormalities could either represent latent infection with the putative AIDS agent or alternatively be caused by repeated infections and/or exposure to allogenic spermatocytes or lymphocytes.
PubMed ID
6090151 View in PubMed
Less detail