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11 records – page 1 of 2.

Association between mean intraocular pressure, disease stability and cost of treating glaucoma in Canada.

https://arctichealth.org/en/permalink/ahliterature178719
Source
Curr Med Res Opin. 2004 Aug;20(8):1245-51
Publication Type
Article
Date
Aug-2004
Author
Colin Vicente
John Walker
Yvonne Buys
Thomas R Einarson
David Covert
Michael Iskedjian
Author Affiliation
PharmIdeas Research and Consulting Inc., Oakville, ON, Canada.
Source
Curr Med Res Opin. 2004 Aug;20(8):1245-51
Date
Aug-2004
Language
English
Publication Type
Article
Keywords
Canada
Disease Progression
Female
Glaucoma, Open-Angle - economics - physiopathology - therapy
Health Care Costs
Humans
Intraocular Pressure - physiology
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Abstract
A retrospective analysis determined the association between intraocular pressure (IOP) control levels (mean and last IOP) and disease stability, and the association between IOP and yearly treatment cost in primary open angle glaucoma (POAG).
Data were collected from POAG patients, referred to a tertiary glaucoma clinic. All IOP measurements, visual field mean deviation (VF) scores, physicians' impressions, and resources used (physician visits, procedures, and medications) were recorded and costed using standard resource unit cost lists from the Ministry of Health's perspective. Patients were categorized by the average VF score of their first three visits [mild ( or = 5 dB to or = 12 dB)]. Pearson's r quantified the association between IOP control levels and stability, where stability was defined by the physician's subjective impression of the patient's disease. Spearman's rho was determined to quantify association between mean IOP and yearly treatment cost within VF categories.
Four hundred and eleven charts were reviewed of which 265 were acceptable for analysis. A negative relationship was determined between the probability of reaching stability and mean IOP in all three VF severity groups. Pearson's r was -0.68 (p
PubMed ID
15324527 View in PubMed
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Cost-effectiveness of treprostinil versus epoprostenol in patients with pulmonary arterial hypertension: a Canadian analysis.

https://arctichealth.org/en/permalink/ahliterature171679
Source
Can Respir J. 2005 Nov-Dec;12(8):419-25
Publication Type
Article
Author
T R Einarson
John T Granton
Colin Vicente
John Walker
Greg Engel
Michael Iskedjian
Author Affiliation
Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Source
Can Respir J. 2005 Nov-Dec;12(8):419-25
Language
English
Publication Type
Article
Keywords
Administration, Oral
Antihypertensive Agents - economics - therapeutic use
Canada
Cost Control
Cost Savings
Cost-Benefit Analysis
Economics, Pharmaceutical
Epoprostenol - analogs & derivatives - economics - therapeutic use
Female
Humans
Hypertension, Pulmonary - drug therapy - economics
Male
Monte Carlo Method
Treatment Outcome
Abstract
Pulmonary arterial hypertension (PAH) is associated with substantial morbidity and mortality, exerting a tremendous health and economic impact on patients. In the present study, an economic evaluation of patients with PAH treated with either treprostinil or epoprostenol was performed.
A cost-minimization analysis (a cost-effectiveness subtype) was performed under the assumption that treprostinil and epoprostenol were clinically equivalent. Two cohorts of 60 patients, treated with treprostinil or epoprostenol, were evaluated over three years by using a dynamic spreadsheet model. The evaluation included both the provincial ministries of health and societal perspectives. Resource valuation data for drugs, medical supplies, consultations, and surgical and diagnostic procedures were obtained from standard lists. Costs of hospitalizations and adverse events were derived from published sources. Additional outpatient costs were considered equivalent and, therefore, were excluded from the analysis. Costs are presented in 2003 Canadian dollars discounted at 3%. Sensitivity analyses were performed testing all uncertainties in the model.
In the base-case analysis (over three years), treatment with treprostinil resulted in an expected savings of 2,610,642 US dollars and 2,781,438 US dollars from the ministries of health and societal perspectives, respectively. On a per-patient level, treatment with treprostinil resulted in an average annual savings of 14,504 US dollars and 15,452 US dollars, respectively. The greatest savings with treprostinil came from reduced hospitalizations. Multivariate sensitivity analyses estimated cost savings in greater than 99% of scenarios.
By initiating and continuing treprostinil treatment over a three-year period, the economic burden associated with PAH may be reduced compared with epoprostenol treatment.
PubMed ID
16331313 View in PubMed
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Cost of glaucoma in Canada: analyses based on visual field and physician's assessment.

https://arctichealth.org/en/permalink/ahliterature182586
Source
J Glaucoma. 2003 Dec;12(6):456-62
Publication Type
Article
Date
Dec-2003
Author
Michael Iskedjian
John Walker
Colin Vicente
Graham E Trope
Yvonne Buys
Thomas R Einarson
David Covert
Author Affiliation
PharmIdeas Research and Consulting Inc. Canada. skedji@phamideas.com
Source
J Glaucoma. 2003 Dec;12(6):456-62
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Canada
Cost of Illness
Delivery of Health Care - economics
Economics, Medical
Female
Follow-Up Studies
Glaucoma, Open-Angle - diagnosis - economics - physiopathology - therapy
Health Care Costs
Health Resources - utilization
Humans
Intraocular Pressure
Male
Middle Aged
Ophthalmology - economics
Retrospective Studies
Visual Fields
Abstract
A longitudinal, retrospective study investigated the cost of primary open angle glaucoma (POAG).
Patient files from two tertiary care glaucoma practices were reviewed. Patients diagnosed with POAG and >/=2.5 years of follow-up data were included. Data collected included visual field mean deviation, physician's assessment, and resource utilization (physician visits, procedures, and medications). Costs, reported in 2001 Canadian dollars, were compared between groups, based on initial visual field mean deviation, including mild (/=12 dB), and based on physician's assessment, including controlled, uncontrolled, or patients initially uncontrolled for 12 months who become controlled.
Of 411 patient charts extracted, 265 were included; 35 were excluded for ocular comorbidities and 111 patients with insufficient follow-up. Mean (standard deviation) yearly costs overall (N = 265) and for mild (n = 90), moderate (n = 91), and severe (n = 84) groups were $508 ($278), $408 ($266), $512 ($288), and $609 ($243), respectively. Differences between mean yearly costs were statistically significant for all three groups (P
PubMed ID
14646678 View in PubMed
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The Manitoba Inflammatory Bowel Disease Cohort Study: prolonged symptoms before diagnosis--how much is irritable bowel syndrome?

https://arctichealth.org/en/permalink/ahliterature169637
Source
Clin Gastroenterol Hepatol. 2006 May;4(5):614-20
Publication Type
Article
Date
May-2006
Author
Twila Burgmann
Ian Clara
Lesley Graff
John Walker
Lisa Lix
Patricia Rawsthorne
Cory McPhail
Linda Rogala
Norine Miller
Charles Noah Bernstein
Author Affiliation
University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada.
Source
Clin Gastroenterol Hepatol. 2006 May;4(5):614-20
Date
May-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Biopsy, Needle
Cohort Studies
Diagnosis, Differential
Early Diagnosis
Endoscopy, Gastrointestinal - methods
Female
Humans
Immunohistochemistry
Inflammatory Bowel Diseases - diagnosis - epidemiology
Intestinal Mucosa - pathology
Irritable Bowel Syndrome - diagnosis - epidemiology
Male
Manitoba - epidemiology
Middle Aged
Prognosis
Prospective Studies
Risk assessment
Severity of Illness Index
Sex Distribution
Time Factors
Abstract
The Manitoba Inflammatory Bowel Disease (IBD) Cohort Study is a population-based prospective cohort study of recently diagnosed IBD (n=396). At enrollment, 162 (41%) indicated gastrointestinal symptom>or=3 years before diagnosis. We aimed to determine whether coexistence of irritable bowel syndrome (IBS) had a role in symptoms before IBD diagnosis.
Patients were interviewed about symptoms and investigations before IBD diagnosis. Patients were assessed retrospectively for preexisting IBS.
Of 112 patients interviewed, 58% had Crohn's disease, 37% UC, 3% proctitis, and 2% indeterminant colitis. Symptoms at IBD diagnosis were considered the same (7%), worse (43%), different (20%), or both worse and different (30%) than at initial onset. Mean time between initial symptoms and diagnosis was 11 years (range, 3-48 years). Increasing age at IBD diagnosis correlated with a longer period after initial symptoms and diagnosis of IBD (r=.32, Por=3 years before diagnosis, 14% were considered to have likely or possible IBS.
These data suggest that older patients and those with likely and possible preexisting IBS are more likely to experience longer symptom duration before diagnosis of IBD. The prevalence rate of IBS was similar to estimated base rates in the general population.
PubMed ID
16630762 View in PubMed
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Measures of relative importance for health-related quality of life.

https://arctichealth.org/en/permalink/ahliterature135017
Source
Qual Life Res. 2012 Feb;21(1):1-11
Publication Type
Article
Date
Feb-2012
Author
Tolulope T Sajobi
Lisa M Lix
Ian Clara
John Walker
Lesley A Graff
Patricia Rawsthorne
Norine Miller
Linda Rogala
Rachel Carr
Charles N Bernstein
Author Affiliation
School of Public Health, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Source
Qual Life Res. 2012 Feb;21(1):1-11
Date
Feb-2012
Language
English
Publication Type
Article
Keywords
Adult
Canada
Cohort Studies
Female
Health status
Humans
Inflammatory Bowel Diseases - physiopathology - psychology
Logistic Models
Male
Middle Aged
Quality of Life - psychology
Questionnaires - standards
Abstract
In health-related quality of life (HRQOL) studies, data are often collected on multiple domains for two or more groups of study participants. Quantitative measures of relative importance, which are used to rank order the domains based on their ability to discriminate between groups, are an alternative to multiple tests of significance on the group differences. This study describes relative importance measures based on logistic regression (LR) and multivariate analysis of variance (MANOVA) models.
Relative importance measures are illustrated using data from the Manitoba Inflammatory Bowel Disease (IBD) Cohort Study. Study participants with self-reported active (n = 244) and inactive (n = 105) disease were compared on 12 HRQOL domains from the Inflammatory Bowel Disease Questionnaire (IBDQ) and Medical Outcomes Study 36-item Short-Form (SF-36) Questionnaire.
All but two relative importance measures ranked the IBDQ bowel symptoms and emotional health domains as most important.
MANOVA-based importance measures are recommended for multivariate normal data and when group covariances are equal, while LR measures are recommended for non-normal data and when the correlations among the domains are small. Relative importance measures can be used in exploratory studies to identify a small set of domains for further research.
PubMed ID
21516478 View in PubMed
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Mental health and the city: intra-urban mobility among individuals with schizophrenia.

https://arctichealth.org/en/permalink/ahliterature169956
Source
Health Place. 2007 Jun;13(2):310-23
Publication Type
Article
Date
Jun-2007
Author
Geoffrey DeVerteuil
Aynslie Hinds
Lisa Lix
John Walker
Renee Robinson
Leslie L Roos
Author Affiliation
Department of Environment & Geography, University of Manitoba, Isbister 211, Winnipeg, Man., Canada R3T 2N2. geoff_deverteuil@umanitoba.ca
Source
Health Place. 2007 Jun;13(2):310-23
Date
Jun-2007
Language
English
Publication Type
Article
Keywords
Adult
Aged
Canada
Cohort Studies
Female
Humans
Male
Middle Aged
Population Dynamics
Schizophrenia
Urban Population
Abstract
Intra-urban residential mobility of a cohort with schizophrenia was compared to a matched cohort with no mental illness using population-based administrative data. The percentage of individuals with one or more changes in postal code in the three-year mobility study period was examined, along with measures of the movement between different intra-urban areas. The schizophrenia cohort was more likely to move than the matched cohort; however, this depends on their age, income level, and area of residence at baseline. Age, gender, marital status, income quintile, and use of physicians and hospitalizations were associated with mobility. Individuals in the schizophrenia cohort were significantly more likely to move from the suburb to the inner city, and significantly less likely to move from the inner city to the suburb than those with no mental illness. Implications of the findings and directions for future research are discussed, with particular attention paid to the utility of administrative data for further mental health research.
PubMed ID
16580246 View in PubMed
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Mitochondrial DNA mutations in patients with postlingual, nonsyndromic hearing impairment.

https://arctichealth.org/en/permalink/ahliterature178963
Source
Eur J Hum Genet. 2005 Jan;13(1):26-33
Publication Type
Article
Date
Jan-2005
Author
Howard T Jacobs
Timothy P Hutchin
Timo Käppi
Greta Gillies
Kia Minkkinen
John Walker
Karen Thompson
Anja T Rovio
Massimo Carella
Salvatore Melchionda
Leopoldo Zelante
Paolo Gasparini
Ilmari Pyykkö
Zahid H Shah
Massimo Zeviani
Robert F Mueller
Author Affiliation
Institute of Medical Technology & Tampere University Hospital, Tampere, Finland. howard.t.jacobs@uta.fi
Source
Eur J Hum Genet. 2005 Jan;13(1):26-33
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Age of Onset
Aged
Aged, 80 and over
DNA Mutational Analysis
DNA, Mitochondrial - genetics
Female
Finland
Great Britain
Haplotypes - genetics
Hearing Loss - epidemiology - genetics
Humans
Italy
Language Disorders - epidemiology - genetics
Male
Middle Aged
Mutation - genetics
Polymorphism, Single Nucleotide - genetics
Abstract
Mitochondrial mutations have previously been reported anecdotally in families with maternally inherited, nonsyndromic hearing impairment. To ascertain the contribution of mitochondrial mutations to postlingual but early-onset, nonsyndromic hearing impairment, we screened patients collected from within two different populations (southern Italy and UK) for previously reported mtDNA mutations associated with hearing disorders. Primer extension (SNP analysis) was used to screen for specific mutations, revealing cases of heteroplasmy and its extent. The most frequently implicated tRNA genes, Leu(UUR) and Ser(UCN), were also sequenced in all Italian patients. All tRNA genes were sequenced in those UK patients showing the clearest likelihood of maternal inheritance. Causative mtDNA mutations were found in approximately 5% of patients in both populations, representing almost 10% of cases that were clearly familial. Age of onset, where known, was generally before adulthood, and hearing loss was typically progressive. Haplogroup analysis revealed a possible excess of haplogroup cluster HV in the patients, compared with population controls, but of borderline statistical significance. In contrast, we did not find any of the previously reported mtDNA mutations, nor a significant deviation from haplogroup cluster frequencies typical of the control population, in patients with late adult-onset hearing loss (age-related hearing impairment) from the UK or Finland.
PubMed ID
15292920 View in PubMed
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The Overseas Service Veteran (OSV) At Home Pilot: how choice of care may affect use of nursing home beds and waiting lists.

https://arctichealth.org/en/permalink/ahliterature175202
Source
Can J Aging. 2004;23(4):367-9
Publication Type
Article
Date
2004
Author
David Pedlar
John Walker
Author Affiliation
Veterans Affairs Canada, P.O. Box 7700, Charlottetown, PEI, C1A 8M9. dave.pedlar@vac-acc.gc.ca
Source
Can J Aging. 2004;23(4):367-9
Date
2004
Language
English
Publication Type
Article
Keywords
Canada
Choice Behavior
Humans
Long-Term Care - utilization
Nursing Homes - utilization
Pilot Projects
Veterans
Waiting Lists
Abstract
In 1999 Veterans Affairs Canada (VAC) implemented the Overseas Service Veterans (OSV) At Home Pilot Project in response to the problem that a growing number of clients were on waiting lists for beds in long-term care facilities. The At Home pilot offered certain clients on waiting lists, who met nursing-level care and military-service requirements, access to home care and treatment services for which they had previously been ineligible. A review of the pilot showed that a large majority of clients preferred to remain at home, with support, rather than accept a long-term care placement, even when a bed became available. The pilot has helped reduce waiting times for nursing home beds and may have important implications for reducing costs and the demand for long-term care beds.
PubMed ID
15838819 View in PubMed
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Prevalence and prognostic significance of malnutrition in patients with cancers of the head and neck.

https://arctichealth.org/en/permalink/ahliterature299403
Source
Clin Nutr. 2019 Apr 04; :
Publication Type
Journal Article
Date
Apr-04-2019
Author
Catherine Kubrak
Lisa Martin
Leah Gramlich
Rufus Scrimger
Naresh Jha
Brock Debenham
Neil Chua
John Walker
Vickie E Baracos
Author Affiliation
Department of Oncology, Division of Palliative Care Medicine, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada.
Source
Clin Nutr. 2019 Apr 04; :
Date
Apr-04-2019
Language
English
Publication Type
Journal Article
Abstract
Head and neck cancer (HNC) are at high nutritional risk; however the prevalence and severity of malnutrition in contemporary patients with HNC are unclear. Diagnostic criteria for cancer-associated weight loss grading (WLG) (Grades 0 to 4) [1] have been validated and are recommended in oncology nutrition clinical practice guidelines [2-3]. The aim was to determine the prevalence using WLG in HNC patients and determine the extent to which reduced dietary intake (DI) explained variation of WLG.
A population-based cohort of HNC patients (N = 1756) in northern Alberta, Canada included consecutive new patients, 2004-2016. At referral to the regional cancer center weight history and DI categories were collected. Multinomial logistic regression (MLR) identified predictors of weight loss (WL) severity. Overall survival (OS) in relation to WL Grade and DI was determined by multivariable Cox proportional hazard.
WL was absent in 42.9% and the remainder had Grade 1 (18%), Grade 2 (14.7%), Grade 3 (15.9%) and Grade 4 (8.5%) WL. Independent predictors of WLG in adjusted MLR model, included stage (P 
PubMed ID
31000341 View in PubMed
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Prevalence and prognostic significance of malnutrition in patients with cancers of the head and neck.

https://arctichealth.org/en/permalink/ahliterature309568
Source
Clin Nutr. 2020 03; 39(3):901-909
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
03-2020
Author
Catherine Kubrak
Lisa Martin
Leah Gramlich
Rufus Scrimger
Naresh Jha
Brock Debenham
Neil Chua
John Walker
Vickie E Baracos
Author Affiliation
Department of Oncology, Division of Palliative Care Medicine, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada.
Source
Clin Nutr. 2020 03; 39(3):901-909
Date
03-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Head and neck cancer (HNC) are at high nutritional risk; however the prevalence and severity of malnutrition in contemporary patients with HNC are unclear. Diagnostic criteria for cancer-associated weight loss grading (WLG) (Grades 0 to 4) [1] have been validated and are recommended in oncology nutrition clinical practice guidelines [2-3]. The aim was to determine the prevalence using WLG in HNC patients and determine the extent to which reduced dietary intake (DI) explained variation of WLG.
A population-based cohort of HNC patients (N = 1756) in northern Alberta, Canada included consecutive new patients, 2004-2016. At referral to the regional cancer center weight history and DI categories were collected. Multinomial logistic regression (MLR) identified predictors of weight loss (WL) severity. Overall survival (OS) in relation to WL Grade and DI was determined by multivariable Cox proportional hazard.
WL was absent in 42.9% and the remainder had Grade 1 (18%), Grade 2 (14.7%), Grade 3 (15.9%) and Grade 4 (8.5%) WL. Independent predictors of WLG in adjusted MLR model, included stage (P 
PubMed ID
31000341 View in PubMed
Less detail

11 records – page 1 of 2.